research product . Other ORP type . 2020

The role of genomics in understanding COVID-19 outbreaks in long term care facilities

Aggarwal, Dinesh; Myers, Richard; Hamilton, William L; Bharucha, Tehmina; Tumelty, Niamh M; Brown, Colin S; Meader, Emma J; Connor, Tom; Smith, Darren L; Bradley, Declan T; ...
Open Access English
  • Published: 23 Nov 2020
  • Country: United Kingdom
Abstract
A review was undertaken of all genomic epidemiology studies on COVID-19 in long term care facilities (LTCF) that have been published to date. It was found that staff and residents were usually infected with identical, or near identical, SARS-CoV-2 genomes. Outbreaks usually involved one predominant lineage, and the same lineages persisted in LTCFs despite infection control measures. Outbreaks were most commonly due to single or few introductions followed by spread rather than a series of seeding events from the community into LTCFs. Sequencing of samples taken consecutively from the same cases showed persistence of the same genome sequence indicating that the se...
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