Powered by OpenAIRE graph
Found an issue? Give us feedback

VUB

Vrije Universiteit Brussel
Country: Belgium
Funder
Top 100 values are shown in the filters
Results number
arrow_drop_down
522 Projects, page 1 of 105
  • Funder: EC Project Code: 204582
    more_vert
  • Funder: EC Project Code: 204509
    more_vert
  • Funder: EC Project Code: 861913
    Funder Contribution: 150,000 EUR

    Pannexin1 (Panx1) channels mediate the exchange of biochemical messengers between the cytosol of a cell and its extracellular environment. This type of cellular communication underlies cell death and inflammation, both which are associated with a plethora of diseases. Closing pannexin channels therefore seems an interesting therapeutic strategy. In this respect, the ERC Starting Grant project CONNECT has demonstrated that peptide-based inhibition of Panx1 channels counteracts the manifestation of acute and chronic liver disease. However, these peptides cope with stability issues thus impeding clinical application. No other types of appropriate Panx1 channel inhibitors are available today despite their promising therapeutic potential. The present CONNECT-2-CLINIC project will meet this urgent need by generating specific and in vivo-applicable Panx1 channel inhibitors. For this purpose, nanobodies targeted towards Panx1 will be produced using unprecedented protocols that combine DNA immunization with new nanodisc technology. Panx1 nanobodies will be tested in vitro for their capacity to inhibit Panx1 channels and to reduce cell death and inflammation. They will be subsequently tested in a human-relevant mouse model of cholestatic liver disease. This technology track will be aligned by a 3-phase business track in order to analyze and create market value. By doing so, the CONNECT-2-CLINIC project will provide solid proof-of-concept for further pharmaceutical development and clinical application.

    more_vert
  • Funder: EC Project Code: 101067623
    Funder Contribution: 150,000 EUR

    In most high-performance analytical instruments, which are used to carry out blood analysis, for example, the first step is separation, in which the various components in a sample to be examined are divided into groups before being presented to a detector. Further improvement of the process is limited due to the slow spontaneous transport of the components in the traditionally exploited, naturally occurring, diffusion process. In the context of ERC Starting Grant EVODIS, the µFlow group of Prof. Wim De Malsche of VUB was able to generate a vortex mixing effect between channel walls of microdevices, in order to accelerate the mass transport rate much more than what is possible by pure diffusion only, therewith reducing dispersion. This effect was achieved by applying an oscillating electric field. In EVO-LC these lateral vortices will be integrated in an HPLC column to realize an improvement in chromatographic efficiency by a factor of 2-3 under relevant chromatographic conditions. As part of the ERC POC a demonstrator for such miniaturized HPLC column will be built. The new column promises faster and higher-performance separations in a miniaturized system, which can be used in analytical labs, but also for patients in a point-of-care setting. One possible application is the analysis of haemoglobin levels for better diagnosis and monitoring of diabetes.

    more_vert
  • Funder: EC Project Code: 101088378
    Overall Budget: 1,961,450 EURFunder Contribution: 1,961,450 EUR

    MERLIT is the first systematic, diachronic and comparative investigation of meritocratic narratives in literature. Meritocratic thinking manifests itself in powerful narratives across the globe, from the constitutionally embedded “pursuit of happiness” to neoliberal narratives of self-enhancement. MERLIT investigates forms of these narratives, which are embraced for their seemingly empowering and universalist appeal, but also criticised for their enmeshment with structures of domination and privilege. MERLIT explores how meritocratic narratives are written, how they are written into cultures, but also how they are written back to in text forms that have shaped the zeitgeist of particular moments respectively. Although research into meritocratic thinking is a vibrant interdisciplinary field, it is characterised (1) by a lack of investigations into the formal principles underpinning – or challenging – meritocratic articulations, (2) by a narrow focus on (white) Western contexts and (3) by a concentration on recent developments. To counter these gaps, (1) MERLIT explores in six work packages how practices of writing have played, and continue to play, crucial roles in shaping meritocratic articulations but also critiques thereof; (2) MERLIT expands the contextual focus of existing scholarship by engaging with radical writing practices from the Global South and a range of transculturally entangled anglophone contexts; eventually, (3) MERLIT challenges perceptions of meritocratic thinking and its critiques as recent phenomena by engaging with changing forms of articulating value, merit and success from the 17th century to the present. Situated at the intersections of literary history, new formalist theory and cultural translation, MERLIT not only offers a literary history of meritocratic thought, but significantly advances our understanding of the workings of a set of hegemonic forms in and through writing, and of the formative, worldmaking role of literature.

    more_vert
Powered by OpenAIRE graph
Found an issue? Give us feedback

Do the share buttons not appear? Please make sure, any blocking addon is disabled, and then reload the page.

Content report
No reports available
Funder report
No option selected
arrow_drop_down

Do you wish to download a CSV file? Note that this process may take a while.

There was an error in csv downloading. Please try again later.