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UNITO

University of Turin
Country: Italy
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366 Projects, page 1 of 74
  • Funder: EC Project Code: 101068795
    Funder Contribution: 265,099 EUR

    Several works by Ernesto Neto present huge, warm-colored, pleasantly smelling Lycra tunnels. They are cases of installation art (IA): the public is supposed to enter the tunnels and interact with the physical environment, experiencing the works from within. Works of IA resemble buildings because they envelop the public, but they differ in that, as with paintings and sculptures, they do not have a sheltering function. This raises a philosophical question: what states of mind are distinctive of our engagement with IA? The goal of this project is to develop the first full-fledged philosophical account of our engagement with IA, arguing that, typically, the imagination plays a crucial role in it, by pursuing 5 research and innovation objectives: (1) showing that IA prompts imaginings of a specific kind; (2) arguing that IA can be defined in terms of its imagining-arousing function; (3) arguing against the prevalent view that IA doesn't have a representational or fictional dimension; (4) investigating the link between the imaginings aroused by IA, on the one hand, and abstract painting, on the other hand; (5) integrating the proposal within a broader account of fiction. The project’s goal is relevant to aestheticians and art theorists, because IA dominates contemporary art, and to art practitioners and public, because it can help improve the design, exhibition, and communication of IA. I, Elisa Caldarola (Philosophy PhD), will carry out the proposed research through investigations in the philosophy of fiction and of art, in art theory, in depiction theory, and the philosophy of mind, working at The Graduate Center, City University of New York (Philosophy Program) under the supervision of Prof. Jonathan Gilmore, and at the Department of Philosophy and Education Sciences, University of Turin, under the supervision of Prof. Alberto Voltolini. I shall publish 5 papers in top-level journals, present my work at 8 conferences and at outreach events.

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  • Funder: EC Project Code: 101020342
    Overall Budget: 2,489,230 EURFunder Contribution: 2,489,230 EUR

    This project will test for the first time the hypothesis that therapeutic inactivation of DNA repair pathways in cancer cells can be exploited for patient benefit by reawakening an anti-tumor immune response. Genomic instability and molecular heterogeneity, which occur in cancer cells with DNA repair deficiencies, fuel tumour progression and are associated with poor outcome. An exception is represented by Mismatch repair (MMR) deficient cancers as these tumours are exceedingly genetically heterogeneous but show favourable prognosis and remarkable response to immunotherapy. The molecular basis for the clinical outcome of MMR deficient cancers has long remained a mystery. Only recently it has become apparent that their biological properties are associated with increased levels of mutations, which unleash adaptive immunity and trigger immunosurveillance. We have reported that when MMR is impaired, cancers cells grow in immune-deficient mice but are unable to do so in immune competent animals. MMR inactivation increased the mutational burden and led to dynamic mutational profiles, resulting in persistent renewal of neoantigens and engagements of antigen-specific T cells. These data suggest an unprecedented high risk-high gain approach: the pharmacological blockade of proteins involved in DNA-repair as an anticancer therapy. This unconventional strategy builds on the concept that the immune system can identify and selectively target tumor cells carrying DNA alterations. Using in vitro and in vivo functional assays we will systematically assess whether and how inactivation of DNA repair genes provokes an immune response and restrict cancer growth. Notably, TARGET will discover and develop inhibitors of MMR and other DNA repair proteins that induce tumor immunity. The identification of DNA repair pathways which, when disabled, reawaken the immune system will provide transformative knowledge and could lead to the development of an entirely new class of anticancer drugs.

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  • Funder: FCT Project Code: PD/BD/105849/2014
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  • Funder: FCT Project Code: SFRH/BD/29220/2006
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  • Funder: EC Project Code: 845420
    Overall Budget: 183,473 EURFunder Contribution: 183,473 EUR

    This project aims at carrying out a comparative, multi-generational and interdisciplinary analysis of European emigrants’ descendants’ “return” from Chile to Spain and Italy. Italian and Spanish legislation and return programmes give a preferential right to entry and to nationality acquisition to foreign citizens of emigrant descent. These legal frameworks generate massive migrations that can be called the “return of the heirs” - as those who “come back” have inherited a privileged legal status, based on the “legal myth” of ethnically motivated return migration. Almost invisible in research and in the public sphere, these migrations raise urgent issues regarding European identity, citizenship, belonging and family heritage. Indeed, an unquestioned gap between the right to enter and the right to return to European countries informs present-day policies, as more and more countries base their nationality laws on jus sanguinis, giving family inheritance a central role in access to citizenship rights. This programme aims to answer this research question: how is belonging transmitted and re-created in families of emigrant descent and how is it linked to the changing nationality and return laws of the countries their ancestors came from? Its objective is to identify and compare different patterns of belonging production and transmission in families of emigrant descent, with regard to gender, nationhood, ethnicity, regional identity and law. To pursue this goal, the research will be based on a six months ethnographic regional fieldwork in Chile, Italy and Spain and on a qualitative analysis of data conducted with an interdisciplinary approach. The research project will be carried out at the Dipartimento Culture, Politica e Società of UniTo, an interdisciplinary department which will offer me training on the transversal themes on which I need to enhance my skills and will help me strengthen my competencies in dissemination and communication of research to different publics.

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