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ISCIII

Instituto de Salud Carlos III
Country: Spain
115 Projects, page 1 of 23
  • Funder: EC Project Code: 237175
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  • Funder: EC Project Code: 274817
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  • Funder: EC Project Code: 731366
    Overall Budget: 1,996,720 EURFunder Contribution: 1,996,720 EUR

    The potential of Personalised Medicine (PM) is to improve prevention, diagnosis and treatment of diseases by taking into account individuals' genotypes and phenotypes as well as other biomedical, life style and environmental data. In the last decade, significant advancements have been made especially for cancer or rare diseases. However, due to fragmentation and high upfront-investments the implementation of PM remains challenging, besides the various ongoing research and implementation actions on European, national and regional level. To overcome these hurdles, the International Consortium for Personalised Medicine (ICPerMed) is currently being initiated as a joint endeavour of the European Commission (EC) and more than 20 Member States. ICPerMed aims at aligning present as well as future efforts in all areas of PM by fostering international coordination of research and innovation funding. For this purpose, ICPerMed will develop and operate a European platform for collaboration between funders of PM research. It will promote an interdisciplinary approach to PM and generate policies, best practices, guidelines, and standards. ICPerMed secretariat will substantially contribute to the success of ICPerMed by efficiently coordinating all consortium activities, by implementing an effective dissemination plan and by assisting in the development of a sustainability strategy. By monitoring ongoing research funding activities in Europe and beyond, the secretariat will serve as the basis for evidence-informed allocation of research funding. ICPerMed secretariat will provide professional support in organising ICPerMed events and the meetings of ICPerMed bodies. In addition, ICPerMed secretariat will guide the dialogue with relevant stakeholders and initiatives. The organisational and logistical support of a secretariat will maximise the unique and long-term impact of ICPerMed by strengthening Europe's leading role in the successful implementation of PM in the global context.

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  • Funder: EC Project Code: 305938
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  • Funder: EC Project Code: 101057127
    Overall Budget: 2,768,240 EURFunder Contribution: 2,768,240 EUR

    The WHO Classification of Tumours (WCT) underpins cancer diagnosis, and hence treatment and care of cancer patients, as well as research into cancer epidemiology, prevention, diagnosis, and treatment. However, decisions for such a global reference tool are not always informed by the best available evidence, and risks of incorporating misinformation into the clinical decisions pathway exist. We aim to develop a tool that maps existing evidence, showing gaps, identifying pockets of low-level evidence, and synthesis of reliable evidence. The tool will map the evidence base of the WCT in order to facilitate evidence-based decision-making in pathology, and promote the application of higher research standards in the field. We will adapt the recently developed Evidence Gap Map (EGM) methodology, first time ever to be used in biomedicine. The resulting EGMs will increase the discoverability and use of studies by the WCT decision-makers, research commissioners, researchers and others. Our WCT-EVI-MAP project is organized in three subsequent phases, where we will apply a stepwise approach to: first, develop a framework and define evidence levels based on expert consensus; second, elaborate a series of Megamaps in iterative cycles describing evidence of all tumour types; third, perform a descriptive analysis of the use of evidence in a continuous updated exercise. To overcome identified challenges, several strategies are proposed, such as using recent advances in technologies, following a strict multidisciplinary approach and integrating this project into the WCT strategic planning for the 6th edition. We believe that the WCT EVI-MAP will represent a ground-breaking advance for the WCT and research in the field, and will accelerate progress in cancer diagnosis and management. Integration of evidence-based medicine methods has been shown to have a positive impact in other specialized medical fields and our project represents a first step towards an evidence-based pathology.

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