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ABSTRACT A significant cyclic sesquiterpenoid known as Zerumbone was extracted from Zingiber roseum using the volume liquid chromatographic (VLC) technique. It’s a naturally occurring phytochemical having a variety of physiological properties, including antioxidant, anti-ulcer, and antiproliferative action. This study's major goal was to evaluate Zerumbone's anti-inflammatory effectiveness against the inflammation receptors-Secretory Phospholipase A2 (sPLA2), Cyclooxygenase-2 (COX-2), Tumor Necrosis Factor (TNF-alpha), and Inducible Nitric Oxide Synthase 4 using various in-silico methods. The targeted receptors were obtained from Protein Data Bank, and the ligand was accessed in the Pubchem database. Utilizing the Autodock PyRx platform, which supports Autodock Vina, molecular docking was carried out. Even in the computational prediction, it was revealed that this substance was non-toxic. Receptors exhibiting the highest binding affinity for our ligand were further investigated using molecular dynamics (MD) simulations with WebGRO, CABS-flex, and iMODS web servers. The molecular docking outcomes showed that our ligand molecule exhibited the highest binding affinity for the sPLA2 receptor. MD simulation studies also showed good leads to sPLA2. In conclusion, our outcomes suggest that Zerumbone is an important inhibitor of sPLA2 and might be further utilized as a potential anti-inflammatory agent. Keywords: Zerumbone, Inflammation, Docking, QSAR, ADMET, MD Simulation References Harvey, A., Strategies for discovering drugs from previously unexplored natural products. Drug discovery today, 2000. 5(7): p. 294-300. Bakhotmah, B.A. and H.A. Alzahrani, Self-reported use of complementary and alternative medicine (CAM) products in topical treatment of diabetic foot disorders by diabetic patients in Jeddah, Western Saudi Arabia. BMC Research Notes, 2010. 3(1): p. 1-8. 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Suspension of face-to-face instruction in schools during the COVID-19 pandemic has led to concerns about consequences for students’ learning. So far, data to study this question have been limited. Here we evaluate the effect of school closures on primary school performance using exceptionally rich data from The Netherlands (n ≈ 350,000). We use the fact that national examinations took place before and after lockdown and compare progress during this period to the same period in the 3 previous years. The Netherlands underwent only a relatively short lockdown (8 wk) and features an equitable system of school funding and the world’s highest rate of broadband access. Still, our results reveal a learning loss of about 3 percentile points or 0.08 standard deviations. The effect is equivalent to one-fifth of a school year, the same period that schools remained closed. Losses are up to 60% larger among students from less-educated homes, confirming worries about the uneven toll of the pandemic on children and families. Investigating mechanisms, we find that most of the effect reflects the cumulative impact of knowledge learned rather than transitory influences on the day of testing. Results remain robust when balancing on the estimated propensity of treatment and using maximum-entropy weights or with fixed-effects specifications that compare students within the same school and family. The findings imply that students made little or no progress while learning from home and suggest losses even larger in countries with weaker infrastructure or longer school closures.

A obra é resultado de experiências vivenciadas no âmbito do estágio supervisionado no curso de Pedagogia da Universidade Estadual da Região Tocantina do Maranhão, em período pandêmico. Traz reflexões sobre os desafios da garantia do direito à educação bem como das implicações na formação e na prática docente durante a pandemia de covid-19.

This study, which aims to examine the distance education experiences of people who work as teachers but who are also parents during the COVID-19 pandemic uses descriptive phenomenology, an approach used in qualitative research. The analysis revealed six main themes that explain the distance education experiences of parent-teachers -- students' academic learning environment, teacher-student communication, use of EIN (education information network) and live lessons, family support, advantages and limitations of distance education, and teachers' views on distance education. The study concluded that the academic learning environment students have during distance learning is inadequate, that the quality and duration of student-teacher communication during distance learning is inadequate, that the quality of teacher-student communication favored students in private schools over teacher parent-children communication, that parent-teachers possessed negative views about distance education, and that distance learning led to unequal opportunities among students..

The Indonesian state is experiencing the Covid 19 Virus Pandemic which has an impact on the economy to food for the people, the government of the Republic of Indonesia has mandated national food security since 2015 with the aim that the country can survive in difficult situations such as a pandemic. The implementation of this policy has been stated through the Ministry of Agriculture with the Sustainable Food Garden (P2L) program since 2017, the District Government has only started the program since it was affected by the Covid 19 virus pandemic with Pasirkaliki Village as a pilot. Pasirkaliki Village has successfully implemented the Sustainable Food Garden Program (P2L) through planting a thousand chili seeds, the success of this implementation does not have a significant impact if you look at the initial goal of the Sustainable Food Garden program, namely food security. With the qualitative method of correlational qualitative research, researchers want to know the extent to which a variable is related to other variables. This method aims to find out whether or not there is a relationship. If so, how closely related and how significant is the relationship.

Coronavirus outbreak, which was first reported in Wuhan, China on December 31, 2019 has been sending ripples across the globe and has amplified to the stature of an international health crisis. With lakhs of deaths and new cases being reported in a span of six months in varied countries, the virus has forced governments and administrations to take precautionary measures such as complete lockdown of the cities, and strict isolation for the reported cases. In this regard, my project seeks to study the devastating effect that this isolating and threatening lockdown has had on the Indian Economy, as well as the role of digital connectivity in supporting the economic base of India during the crisis. For this, I have studied the economic effects of digitalisation on the existing structures of Indian businesses, and have analyzed them in light of various factors that determine growth. The project is not just aimed at conducting a first-hand study of this rare crisis that the world is facing, but is also an innovative attempt to gauge the digital potential of Indian economy and present the data for the industries to revise and review their digital structures.

BY-COVID Work Package 3 is focused on services for the discovery and integration of COVID-19 data by delivering a flexible, tiered metadata discovery system across different domains, metadata standards, and maturity/robustness levels of data sources. This will enable the linking of FAIR data and metadata on SARS-CoV-2 and COVID-19, on other related viruses and diseases, and on socio-economic consequences, across research fields, from omics, clinical, and epidemiological research, to social sciences and humanities. In a series of work package meetings and a workshop, with participation from all other work packages, we have surveyed community metadata standards used by (potential) BY-COVID-19 portal resources (4.1), defined a flexible, three-tiered approach to metadata indexing in the COVID-19 portal (section 4.2), derived common metadata attributes for record level discovery (4.3) and established a workflow with FAIRsharing for resource level metadata capture and exchange (4.4). This work establishes the basis for the further development of the COVID-19 Portal metadata discovery and provides a path for integration of metadata from multi-domain partners in BY-COVID, as well as our ISIDORe sibling project, and relevant external resources. To ensure smooth integration of partner-provided metadata, we will run a technical workshop open to all partners, discussing workflows, metadata attributes and formats, and support tools. Contributor: Morris Swertz (UMCG/BBMRI)

El mundo cada vez es más complejo y preocupado por los recursos que la compone, la actual pandemia COVID-19 evidencia que no sólo las empresas sino también los países se ven envueltos en una competición a todos los niveles para convertirse en referencia impactando en las 3 dimensiones (económica, social y ambiental). El propósito de la presente investigación fue analizar las principales motivaciones que llevan las empresas con certificación B en América Latina. La metodología fue cualitativa bajo el método de teoría fundamentada, la unidad de análisis estuvo correspondida por 183 empresas bajo criterios de exclusión como: Pertenecer a las industrias de educación, turismo y hotelería, y apoyo a los emprendimientos, pertenecer a solo países de Latinoamérica y tener la certificación B. Los principales hallazgos fueron que las Empresas B responsables desarrollan una economía más inclusiva, sostenible y respetuosa con el medio ambiente en beneficio de la sociedad, que van más allá de la noción de Responsabilidad Social Empresarial. Las conclusiones evidencian que estas empresas se alejan de las empresas tradicionales, puesto que combinan el desarrollo social y el crecimiento económico posicionando a los países que tienen este tipo de empresas como referentes.

В статье исследуется влияние коронавирусной инфекции COVID-19 на органы чувств.