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    Authors: Petro, Booysen; Katalin A, Wilkinson; Dylan, Sheerin; Robyn, Waters; +2 Authors

    SARS-CoV-2 and

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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ Frontiers in Immunol...arrow_drop_down
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  • Authors: Shatha A, Albalawi; Raneem A, Albalawi; Amaal A, Albalawi; Raghad F, Alanazi; +6 Authors

    Due to their unique properties and their potential therapeutic and prophylactic applications, heavy metals have attracted the interest of many researchers, especially during the outbreak of COVID-19. Indeed, zinc (Zn) and copper (Cu) have been widely used during viral infections. Zn has been reported to prevent excessive inflammatory response and cytokine storm, improve the response of the virus to Type I interferon (IFN-1), and enhance the production of IFN-a to counteract the antagonistic effect of SARS-CoV-2 virus protein on IFN. Additionally, Zn has been found to promote the proliferation and differentiation of T and B lymphocytes, thereby improving immune function, inhibiting RNA-dependent RNA polymerase (RdRp) in SARS- CoV-2 reducing the viral replication and stabilizing the cell membrane by preventing the proteolytic processing of viral polyprotein and proteases enzymes. Interestingly, Zn deficiency has been correlated with enhanced SARS-CoV-2 viral entry through interaction between the ACE2 receptor and viral spike protein. Along with zinc, Cu possesses strong virucidal capabilities and is known to be effective at neutralizing a variety of infectious viruses, including the poliovirus, influenza virus, HIV type 1, and other enveloped or nonenveloped, single- or double-stranded DNA and RNA viruses. Cu-related antiviral action has been linked to different pathways. First, it may result in permanent damage to the viral membrane, envelopes, and genetic material of viruses. Second, Cu produces reactive oxygen species to take advantage of the redox signaling mechanism to eradicate the virus. The present review focused on Zn and Cu in the treatment and prevention of viral infection. Moreover, the application of metals such as Cu and gold in nanotechnology for the development of antiviral therapies and vaccines has been also discussed.

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    Authors: Y, Akkoyunlu; B, Kalaycioglu; I, Yurtsever; A, Eren; +3 Authors

    SARS-CoV-2 primarily infects the respiratory tract and leads to severe pneumonia by binding to the ACE-2 receptor. The virus can also interact with ACE-2 receptors expressed in other tissues as in thyroid. This study predicted the complications involving the thyroid in patients with suspected SARS-CoV-2.Patients with suspected SARS-CoV-2 infection between March 11, 2020-May 31, 2020 were retrospectively evaluated. Sixty-nine patients who were radiologically diagnosed as COVID-19 according to thoracic CT and had previously performed thoracic CT before November 2019 were included in the study according to the exclusion and inclusion criteria. Age and gender-matched controls (No. 69) were selected with normal thoracic CT whose PCR tests were also negative. Thyroid densities of participants were calculated and compared from the previous and current thoracic CTs. Results were also compared with the control group.Participants were composed of 69 patients (39 male, mean age 64.35 years). Thyroid densities were significantly decreased from 89HU to 76HU for whole gland, from 88HU to 76HU for right lobes and from 87.5HU to 75.5HU for left lobes at current thoracic CTs performed during COVID-19 (p0.001, p0.001, p0.001 respectively). The decrease in densities of the whole thyroid gland, both left and right lobes, was correlated with mortality (p0.001). The changes in thyroid densities were not correlated with age nor gender. The decreases in HU values of thyroid densities for whole gland, left and right lobes, were correlated with mortality (p0.001, p0.001, and p0.001 respectively).COVID-19 is a multi-systemic disease that threatens vital organs, including the thyroid. Future studies are needed to investigate the association between SARS-CoV-2 and other complications.

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    Authors: Pellicciari, I.;
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    Authors: Mariana Guenther; Letícia Kelly de Souza Sales; Gabriel Felipe de Souza Acioli;

    O isolamento social decorrente da pandemia da Covid-19, necessário para a contenção da transmissão do vírus, causou intensas mudanças em nossos hábitos e rotinas em todo o planeta, afetando a economia, a educação de crianças e jovens, e a saúde física e mental de todos. O objetivo deste estudo foi analisar os efeitos ambientais do isolamento social através de uma revisão narrativa da literatura, e a partir dessa análise produzir um material audiovisual que promova a educação ambiental através da divulgação científica, suscitando, através dessa experiência pandêmica, a reflexão sobre nossos impactos ambientais e as soluções possíveis para minimizá-los.

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    Revista Brasileira de Educação Ambiental (RevBEA)
    Article . 2022 . Peer-reviewed
    License: CC BY NC ND
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      Revista Brasileira de Educação Ambiental (RevBEA)
      Article . 2022 . Peer-reviewed
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    Authors: Mochamad Vrans Romi; Rr. Chusnu Syarifa Diah Kusuma; Hernansi Biso; Christina Bagenda; +1 Authors

    Organizational citizenship behavior bukanlah hal baru dalam dunia kerja khususnya beberapa bidang khusus yang juga menerapkan perilaku organisasi. Pada dasarnya, organizational citizenship behavior sangat membantu dalam mengatur, mengontrol, dan menyelesaikan berbagai persoalan sekaligus meningkatkan komunikasi antar peranan dalam kelompok kerja. Selain itu, perusahaan saat ini perlu meningkatkan kemampuan organisasi untuk beradaptasi dengan perubahan lingkungan yang semakin kompleks. Tujuan utama penelitian yakni menganalisis menganalisis faktor-faktor yang mempengaruhi organizational citizenship behavior karyawan pasca pandemi Covid-19. Sampel dalam penelitian ini berjumlah 210 responden yang ditentukan dengan pendekatan convenience sampling. Pengumpulan data menggunakan instrumen kuesioner yang kemudian dibagikan secara online. Analisis data menggunakan aplikasi SPSS dengan menampilkan hasil pengolahan data melalui uji instrumen penelitian dengan uji validitas dan reabilitas, analisis regresi berganda, koefisien determinasi dan uji hipotesis. Berdasarkan hasil analisis data menyimpulkan quality of work life, organizational culture dan job satisfaction berpengaruh positif dan signifikan terhadap organizational citizenship behavior. Implikasi penelitian menginformasikan perilaku menolong karyawan dapat meningkatkan semangat dan keeratan serta perasaan saling memiliki diantara anggota kelompok sehingga akan meningkatkan kinerja organisasi dan membantu organisasi menarik dan mempertahankan karyawan yang baik.The globalization era that every nation faces have made the world open and connected. This requires the awareness and readiness of human resources that openness becomes something real. On the other hand, companies need to encourage better employee engagement to increase HR awareness within the organization's scope. The main objective of the research is to analyze the effect of organizational trust and organizational justice on the employee engagement of millennial workers. The sample in this study amounted to 150 respondents, who were determined by the convenience sampling approach. Data collection uses a questionnaire instrument which is then distributed online. Data analysis uses the SPSS application by displaying data processing results through research instrument tests with validity and reliability tests, multiple regression analysis, coefficient of determination, and hypothesis testing. Based on the data analysis results, organizational trust and justice positively and significantly affect employee engagement. The research information implies that increasing engagement can be carried out with encouragement from company leaders through mutual trust, mutual understanding, mutual respect, and learning to live in differences among fellow employees in their workplaces.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ SULTANIST Jurnal Man...arrow_drop_down
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    SULTANIST Jurnal Manajemen dan Keuangan
    Article . 2023 . Peer-reviewed
    License: CC BY NC SA
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      SULTANIST Jurnal Manajemen dan Keuangan
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    Authors: Arnot, Megan; Brandl, Eva; Campbell, O L K; Chen, Yuan; +11 Authors

    AbstractThe COVID-19 pandemic has brought science into the public eye and to the attention of governments more than ever before. Much of this attention is on work in epidemiology, virology and public health, with most behavioural advice in public health focusing squarely on ‘proximate’ determinants of behaviour. While epidemiological models are powerful tools to predict the spread of disease when human behaviour is stable, most do not incorporate behavioural change. The evolutionary basis of our preferences and the cultural evolutionary dynamics of our beliefs drive behavioural change, so understanding these evolutionary processes can help inform individual and government decision-making in the face of a pandemic.Lay summary: The COVID-19 pandemic has brought behavioural sciences into the public eye: Without vaccinations, stopping the spread of the virus must rely on behaviour change by limiting contact between people. On the face of it, “stop seeing people” sounds simple. In practice, this is hard. Here we outline how an evolutionary perspective on behaviour change can provide additional insights. Evolutionary theory postulates that our psychology and behaviour did not evolve to maximize our health or that of others. Instead, individuals are expected to act to maximise their inclusive fitness (i.e, spreading our genes) – which can lead to a conflict between behaviours that are in the best interests for the individual, and behaviours that stop the spread of the virus. By examining the ultimate explanations of behaviour related to pandemic-management (such as behavioural compliance and social distancing), we conclude that “good of the group” arguments and “one size fits all” policies are unlikely to encourage behaviour change over the long-term. Sustained behaviour change to keep pandemics at bay is much more likely to emerge from environmental change, so governments and policy makers may need to facilitate significant social change – such as improving life experiences for disadvantaged groups.

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    Evolution, Medicine and Public Health
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      Evolution, Medicine and Public Health
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    Authors: Yerry Soumokil; Muhammad Syafar; Andi Yusuf;

    Pendahuluan: kepuasan pasien merupakan “outcome” layanan kesehatan. Tentang peningkatan mutu layanan kesehatan. Tujuan: mengetahui bagaimana kepuasan pasien tengah wabah Covid19 yang dirawat. Metode: penelitian ini menggunakan penelitian kuantitatif, dengan pendekatan cross sectional study yang bertujuan untuk mengetahui hubungan kedua variabel yaitu variabel independen kualitas pelayanan dan variabel dependen kepuasan pasien yang dilakukan secara bersamaan. Hasil: menunjukan bahwa kehandalan, jaminan, bukti fisik, empati dan tanggap menghasilan nilai p=0,000 hal ini berarti ada hubungan antara semua variabel dengan kepuasan pasien. Kesimpulan: bahwa ada hubungan antara kehandalan, jaminan, bukti fisik, empati dan tanggap dengan kepuasan pasien. Peningkatan mutu/kualitas pelayanan sangat diperlukan untuk keahlian sesuai bidang keilmuan masing-masing pada seluruh tenaga pemberi pelayanan kesehatan.

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    JURNAL ILMIAH KESEHATAN SANDI HUSADA
    Article . 2021 . Peer-reviewed
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    JURNAL ILMIAH KESEHATAN SANDI HUSADA
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      JURNAL ILMIAH KESEHATAN SANDI HUSADA
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      JURNAL ILMIAH KESEHATAN SANDI HUSADA
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    Authors: B. Somvanshi, Sandeep; B. Kharat, Prashant; S. Saraf, Tukaram; B. Somwanshi, Saurabh; +2 Authors

    ABSTRACT The enduring outbreak of the corona virus disease (COVID-19) originated from China illustrates global concerns owing to their infective nature and time-consuming incubation. Even though diagnostic tools based on RT-PCR are being extensively employed at present, well-timed and precise diagnostics are still restricted because of the long-period and exhaustive man-power requirement. To tackle this problem, we herewith report the fabrication of the surface functionalised magnetic nanoparticles (MNP’s) and viral RNA-extraction protocol for potential detection of COVID-19. The zinc ferrite nanoparticles were prepared by combustion synthesis and its surface was functionalised by silica and carboxyl-modified polyvinyl alcohol. The MNP’s were characterized to confirm the nano-scale appearance and functionalization. The proposed model may provide the ability to extract the viral RNA from several specimens through automation process. In light of ease and proficiency, this protocol may significantly lessen the operation period and necessities for the present molecular-level diagnostic of COVID-19.

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    Authors: Petro, Booysen; Katalin A, Wilkinson; Dylan, Sheerin; Robyn, Waters; +2 Authors

    SARS-CoV-2 and

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  • Authors: Shatha A, Albalawi; Raneem A, Albalawi; Amaal A, Albalawi; Raghad F, Alanazi; +6 Authors

    Due to their unique properties and their potential therapeutic and prophylactic applications, heavy metals have attracted the interest of many researchers, especially during the outbreak of COVID-19. Indeed, zinc (Zn) and copper (Cu) have been widely used during viral infections. Zn has been reported to prevent excessive inflammatory response and cytokine storm, improve the response of the virus to Type I interferon (IFN-1), and enhance the production of IFN-a to counteract the antagonistic effect of SARS-CoV-2 virus protein on IFN. Additionally, Zn has been found to promote the proliferation and differentiation of T and B lymphocytes, thereby improving immune function, inhibiting RNA-dependent RNA polymerase (RdRp) in SARS- CoV-2 reducing the viral replication and stabilizing the cell membrane by preventing the proteolytic processing of viral polyprotein and proteases enzymes. Interestingly, Zn deficiency has been correlated with enhanced SARS-CoV-2 viral entry through interaction between the ACE2 receptor and viral spike protein. Along with zinc, Cu possesses strong virucidal capabilities and is known to be effective at neutralizing a variety of infectious viruses, including the poliovirus, influenza virus, HIV type 1, and other enveloped or nonenveloped, single- or double-stranded DNA and RNA viruses. Cu-related antiviral action has been linked to different pathways. First, it may result in permanent damage to the viral membrane, envelopes, and genetic material of viruses. Second, Cu produces reactive oxygen species to take advantage of the redox signaling mechanism to eradicate the virus. The present review focused on Zn and Cu in the treatment and prevention of viral infection. Moreover, the application of metals such as Cu and gold in nanotechnology for the development of antiviral therapies and vaccines has been also discussed.

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    Authors: Y, Akkoyunlu; B, Kalaycioglu; I, Yurtsever; A, Eren; +3 Authors

    SARS-CoV-2 primarily infects the respiratory tract and leads to severe pneumonia by binding to the ACE-2 receptor. The virus can also interact with ACE-2 receptors expressed in other tissues as in thyroid. This study predicted the complications involving the thyroid in patients with suspected SARS-CoV-2.Patients with suspected SARS-CoV-2 infection between March 11, 2020-May 31, 2020 were retrospectively evaluated. Sixty-nine patients who were radiologically diagnosed as COVID-19 according to thoracic CT and had previously performed thoracic CT before November 2019 were included in the study according to the exclusion and inclusion criteria. Age and gender-matched controls (No. 69) were selected with normal thoracic CT whose PCR tests were also negative. Thyroid densities of participants were calculated and compared from the previous and current thoracic CTs. Results were also compared with the control group.Participants were composed of 69 patients (39 male, mean age 64.35 years). Thyroid densities were significantly decreased from 89HU to 76HU for whole gland, from 88HU to 76HU for right lobes and from 87.5HU to 75.5HU for left lobes at current thoracic CTs performed during COVID-19 (p0.001, p0.001, p0.001 respectively). The decrease in densities of the whole thyroid gland, both left and right lobes, was correlated with mortality (p0.001). The changes in thyroid densities were not correlated with age nor gender. The decreases in HU values of thyroid densities for whole gland, left and right lobes, were correlated with mortality (p0.001, p0.001, and p0.001 respectively).COVID-19 is a multi-systemic disease that threatens vital organs, including the thyroid. Future studies are needed to investigate the association between SARS-CoV-2 and other complications.

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    Authors: Pellicciari, I.;
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    Authors: Mariana Guenther; Letícia Kelly de Souza Sales; Gabriel Felipe de Souza Acioli;

    O isolamento social decorrente da pandemia da Covid-19, necessário para a contenção da transmissão do vírus, causou intensas mudanças em nossos hábitos e rotinas em todo o planeta, afetando a economia, a educação de crianças e jovens, e a saúde física e mental de todos. O objetivo deste estudo foi analisar os efeitos ambientais do isolamento social através de uma revisão narrativa da literatura, e a partir dessa análise produzir um material audiovisual que promova a educação ambiental através da divulgação científica, suscitando, através dessa experiência pandêmica, a reflexão sobre nossos impactos ambientais e as soluções possíveis para minimizá-los.

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    Revista Brasileira de Educação Ambiental (RevBEA)
    Article . 2022 . Peer-reviewed
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