Global and national surveillance of SARS-CoV-2 epidemiology is mostly based on targeted schemes focused on testing individuals with symptoms. These tested groups are often unrepresentative of the wider population and exhibit test positivity rates that are biased upwards...

The COVID-19 pandemic has been associated with the highest death rate in the UK for over 10 years. There has been a marked shift of place of death into the community across the UK between March 2020 and 2021. Deaths at home increased by 67% during the first wave of the ...

High-quality randomised clinical trials testing moderately fractionated breast radiotherapy have clearly shown that local control and survival is at least as effective as with 2 Gy daily fractions with similar or reduced normal tissue toxicity. Fewer treatment visits ar...

Measured health output in the UK declined sharply during the Covid-19 pandemic, despite the evident large increase in some National Health Service (NHS) activities such as critical care, and the new test and trace and vaccination programmes. We explain the measurement m...

Abstract Background Restrictions on face-to-face contact, due to COVID-19, led to a rapid adoption of technology to remotely deliver cardiac rehabilitation (CR). Some technologies, including Active+me, were used without knowing their benefits. We assessed changes in pat...

Accurate assessment of SARS-CoV-2 immunity is critical in evaluating vaccine efficacy and devising public health policies. Whilst the exact nature of effective immunity remains incompletely defined, SARS-CoV-2-specific T-cell responses are a critical feature that will l...

AbstractBackgroundThe role of children and young people (CYP) in transmission of SARS-CoV-2 in household and educational settings remains unclear. We undertook a systematic review and meta-analysis of contact-tracing and population-based studies at low risk of bias.Meth...

Achieving reductions in global anthropogenic emissions necessary to mitigate the worst effects of climate change will require significant reductions in energy demand. However, there are concerns that energy demand reductions involving lifestyle and behavioural changes m...

Background Since the COVID-19 pandemic began, there have been concerns related to the preparedness of healthcare workers (HCWs). This study aimed to describe the level of awareness and preparedness of hospital HCWs at the time of the first wave. Methods This multinat...

Background. The global COVID-19 pandemic has triggered a fundamental reexamination of how human psychological research can be conducted both safely and robustly in a new era of digital working and physical distancing. Online web-based testing has risen to the fore as a ...