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52 research outcomes, page 1 of 6
  • publication . Article . Other literature type . 2021
    Open Access English
    Authors:
    Laura Di Domenico; Giulia Pullano; Chiara E. Sabbatini; Pierre-Yves Boëlle; Vittoria Colizza;
    Publisher: Nature Publishing Group UK
    Project: EC | MOOD (874850), ANR | DataRedux (ANR-19-CE46-0008), ANR | SPHINx (ANR-17-CE36-0008)

    As countries in Europe implement strategies to control the COVID-19 pandemic, different options are chosen regarding schools. Through a stochastic age-structured transmission model calibrated to the observed epidemic in Île-de-France in the first wave, we explored scena...

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  • publication . Preprint . 2021
    Open Access English
    Authors:
    Koltai, Júlia; Vásárhelyi, Orsolya; Röst, Gergely; Karsai, Márton;
    Project: ANR | DataRedux (ANR-19-CE46-0008), EC | SoBigData-PlusPlus (871042)

    The unprecedented behavioural responses of societies have been evidently shaping the COVID-19 pandemic, yet it is a significant challenge to accurately monitor the continuously changing social mixing patterns in real-time. Contact matrices, usually stratified by age, su...

  • publication . Article . Preprint . 2021
    Open Access English
    Authors:
    Loïc Berger; Nicolas Berger; Valentina Bosetti; Itzhak Gilboa; Lars Peter Hansen; Christopher I Jarvis; Massimo Marinacci; Richard Smith;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: ANR | IPS (ANR-11-IDEX-0003), ANR | ECODEC (ANR-11-LABX-0047), ANR | INDUCED (ANR-17-CE03-0008), EC | RISICO (336703), EC | INDIMACRO (670337)

    International audience; Policymaking during a pandemic can be extremely challenging. As COVID-19 is a new disease and its global impacts are unprecedented, decisions are taken in a highly uncertain, complex, and rapidly changing environment. In such a context, in which ...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Giulia Pullano; Eugenio Valdano; Nicola Scarpa; Stefania Rubrichi; Vittoria Colizza;
    Persistent Identifiers
    Publisher: Elsevier
    Project: EC | MOOD (874850), EC | RECoVER (101003589), ANR | EVALCOVID-19 (ANR-20-COVI-0007), ANR | DataRedux (ANR-19-CE46-0008)

    International audience; Background: On March 17, 2020, French authorities implemented a nationwide lockdown to respond to the COVID-19 epidemic and curb the surge of patients requiring critical care. Assessing the effect of lockdown on individual displacements is essent...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Mathieu Roche;
    Persistent Identifiers
    Project: ANR | DIGITAG (ANR-16-CONV-0004), EC | MOOD (874850)

    International audience; The vocabulary used in news on a disease such as COVID-19 changes according the period [4]. This aspect is discussed on the basis of MEDISYS-sourced media datasets via two studies. The first focuses on terminology extraction and the second on per...

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  • publication . Article . Preprint . 2020
    Open Access English
    Authors:
    Peter Czuppon; Florence Débarre; Antonio Gonçalves; Olivier Tenaillon; Alan S. Perelson; Jérémie Guedj; François Blanquart;
    Persistent Identifiers
    Publisher: Public Library of Science (PLoS)
    Project: EC | PolyPath (844369), ANR | TheoGeneDrive (ANR-19-CE45-0009), ANR | TheraCoV (ANR-20-COVI-0018)

    Repurposed drugs that are safe and immediately available constitute a first line of defense against new viral infections. Despite limited antiviral activity against SARS-CoV-2, several drugs are being tested as medication or as prophylaxis to prevent infection. Using a ...

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  • publication . Preprint . 2020
    Open Access English
    Authors:
    Czuppon, Peter; Schertzer, Emmanuel; Blanquart, François; Débarre, Florence;
    Project: EC | PolyPath (844369), ANR | TheoGeneDrive (ANR-19-CE45-0009)

    Emerging epidemics and local infection clusters are initially prone to stochastic effects that can substantially impact the epidemic trajectory. While numerous studies are devoted to the deterministic regime of an established epidemic, mathematical descriptions of the i...

  • publication . Preprint . Other literature type . 2020
    Open Access English
    Authors:
    Peter Czuppon; Florence Débarre; Antonio Gonçalves; Olivier Tenaillon; Alan S. Perelson; Jeremie Guedj; François Blanquart;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | PolyPath (844369), ANR | TheoGeneDrive (ANR-19-CE45-0009), ANR | TheraCoV (ANR-20-COVI-0018)

    Abstract Repurposed drugs that are immediately available and have a good safety profile constitute a first line of defense against new viral infections. Despite a limited antiviral activity against SARS-CoV-2, several drugs serve as candidates for application, not only ...

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  • publication . Preprint . Other literature type . 2020
    Open Access English
    Authors:
    Federico Cocozza; Ester Piovesana; Nathalie Névo; Xavier Lahaye; Julian Buchrieser; Olivier Schwartz; Nicolas Manel; Mercedes Tkach; Clotilde Théry; Lorena Martin-Jaular;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | TRAIN-EV (722148), ANR | NUCLEONDRIA (ANR-19-CE15-0018), ANR | PSL (ANR-10-IDEX-0001), ANR | DCBIOL (ANR-11-LABX-0043)

    16 SARS-CoV-2 entry is mediated by binding of the spike protein (S) to the surface 17 receptor ACE2 and subsequent priming by TMPRRS2 allowing membrane fusion. 18 Here, we produced extracellular vesicles (EVs) exposing ACE2 and demonstrate that 19 ACE2-EVs are efficient...

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  • publication . Preprint . 2020
    English
    Authors:
    Lefrancq, Noémie; Paireau, Juliette; Hozé, Nathanaël; Courtejoie, Noémie; Yazdanpanah, Yazdan; Bouadma, Lila; Boëlle, Pierre-Yves; Chereau, Fanny; Salje, Henrik; Cauchemez, Simon;
    Publisher: HAL CCSD
    Project: ANR | INCEPTION (ANR-16-CONV-0005), EC | ARBODYNAMIC (804744), EC | VEO (874735)

    As SARS-CoV-2 continues to spread, a thorough characterization of healthcare needs and patient outcomes is essential to inform planning; however, these analyses are complicated by ongoing changes in patient profiles. Here we develop age and sex adjusted models to analyz...

52 research outcomes, page 1 of 6