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89 research outcomes, page 1 of 9
  • publication . Article . Preprint . Other literature type . 2021
    Open Access
    Authors:
    Andrea Di Gioacchino; Petr Šulc; Anastassia V. Komarova; Benjamin D Greenbaum; Rémi Monasson; Simona Cocco;
    Publisher: Elsevier BV
    Project: NIH | Modulating anti-HIV immun... (7R01AI081848-04)

    SARS-CoV-2 infection can lead to acute respiratory syndrome in patients, which can be due in part to dysregulated immune signalling. We analyze here the occurrences of CpG dinucleotides, which are putative pathogen-associated molecular patterns, along the viral sequence...

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  • publication . Article . Other literature type . 2021
    Open Access English
    Authors:
    B. Brett Finlay; Katherine R. Amato; Meghan B. Azad; Martin J. Blaser; Thomas C. G. Bosch; Hiutung Chu; Maria Gloria Dominguez-Bello; Stanislav Dusko Ehrlich; Eran Elinav; Naama Geva-Zatorsky; ...
    Persistent Identifiers
    Publisher: HAL CCSD

    International audience; The COVID-19 pandemic has the potential to affect the human microbiome in infected and uninfected individuals, having a substantial impact on human health over the long term. This pandemic intersects with a decades-long decline in microbial diver...

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  • publication . Article . 2021
    Open Access
    Authors:
    Athanase Benetos; Tsung Po Lai; Simon Toupance; Carlos Labat; Simon Verhulst; Sylvie Gautier; Marie-Noëlle Ungeheuer; Christine Perret-Guillaume; Daniel Levy; Ezra Susser; ...
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)

    <jats:title>Abstract</jats:title> <jats:p>Profound T-cell lymphopenia is the hallmark of severe coronavirus disease 2019 (COVID-19). T-cell proliferation is telomere length (TL) dependent and telomeres shorten with age. Older COVID-19 patients, we hypothesize, are, ther...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Min Wen Ku; Maryline Bourgine; Authié P; Lopez J; Nemirov K; Moncoq F; Noirat A; Benjamin Vesin; Fabien Nevo; Catherine Blanc; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | EVAg (653316), EC | PASTEURDOC (665807)

    Highlights A lentiviral vector encoding for Spike shows preclinical efficacy as a COVID-19 vaccine. Targeting the immune response to the upper respiratory tract provides critical protection. Intranasal vaccination induces protective mucosal immunity against SARS-CoV-2 i...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Gordon, David,; Hiatt, Joseph; Bouhaddou, Mehdi; Rezelj, Veronica,; Ulferts, Svenja; Braberg, Hannes; Jureka, Alexander,; Obernier, Kirsten; Guo, Jeffrey,; Batra, Jyoti; ...
    Persistent Identifiers
    Publisher: American Association for the Advancement of Science
    Project: NIH | Development and Testing o... (5R35GM122481-02), NIH | STRUCTURE AND FUNCTION OF... (5R01GM024485-12), NIH | MEDICAL SCIENTIIST TRAINI... (5T32GM007618-27), NIH | Gene Expression Profiling... (5P01AI063302-03), UKRI | Understanding signalling ... (MC_UU_12016/2), NIH | Structural Basis of Vesic... (1R01NS089713-01A1), UKRI | Elucidating the role of S... (BB/S009566/1), NIH | Protein secretion in bact... (1R01AI128214-01A1), NIH | Cytoscape: A Modeling Pla... (5R01HG009979-15), NIH | Discovery of novel, ubiqu... (5R01AI120694-02)

    How lethal coronaviruses engage hosts Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is closely related to the deadly coronaviruses SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV). Considerable efforts are focused on developing treat...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Delphine Sterlin; Alexis Mathian; Makoto Miyara; Audrey Mohr; François Anna; Laetitia Claër; Paul Quentric; Jehane Fadlallah; Hervé Devilliers; Pascale Ghillani; ...
    Persistent Identifiers
    Publisher: HAL CCSD

    Humoral immune responses are typically characterized by primary IgM antibody responses followed by secondary antibody responses associated with immune memory and composed of IgG, IgA, and IgE. Here, we measured acute humoral responses to SARS-CoV-2, including the freque...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Paul Bastard; Lindsey B. Rosen; Qian Zhang; Eleftherios Michailidis; Hans-Heinrich Hoffmann; Yu Zhang; Karim Dorgham; Quentin Philippot; Jérémie Rosain; Vivien Béziat; ...
    Project: NIH | Developing, Demonstrating... (5UL1TR001866-03), ANR | IFN-COVID19 (ANR-20-COVI-0064), NIH | Type I interferon-stimula... (5R01AI091707-05), NIH | NHGRI Genome Sequencing P... (5U24HG008956-02), NIH | Yale Center for Mendelian... (5UM1HG006504-07), NIH | Inborn errors of immunity... (5R01AI088364-07), NIH | Modulation of Human Dendr... (5U19AI111825-02)

    COVID Human Genetic Effort Laurent Abel1, Alessandro Aiuti2, Saleh Al Muhsen3, Fahd Al-Mulla4, Mark S. Anderson5, Andrés Augusto Arias6, Hagit Baris Feldman7, Dusan Bogunovic8, Alexandre Bolze9, Anastasiia Bondarenko10, Ahmed A. Bousfiha11, Petter Brodin12, Yenan Bryces...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Hung Thai-Van; David Bakhos; Didier Bouccara; Natalie Loundon; Mathieu Marx; Thierry Mom; Isabelle Mosnier; Stéphane Roman; C. Villerabel; Christophe Vincent; ...
    Persistent Identifiers
    Publisher: HAL CCSD

    International audience; Objectives: Access to diagnosis and treatments for auditory disorders and related pathologies has regressed in France during the COVID-19 pandemic, posing a risk to the patient's chance of recovery. This best practice recommendations guide aims t...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Ludivine Grzelak; Sarah Temmam; Cyril Planchais; Caroline Demeret; Laura Tondeur; Christèle Huon; Florence Guivel-Benhassine; Isabelle Staropoli; Maxime Chazal; Jeremy Dufloo; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: ANR | CHIKV-Viro-Immuno (ANR-14-CE14-0015), EC | RECoVER (101003589), ANR | TIMTAMDEN (ANR-14-CE14-0029)

    Different serological assays measuring anti–SARS-CoV-2 antibodies and their neutralizing activity in samples from individuals with severe and mild COVID-19 are compared.

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  • publication . Article . 2020
    Open Access English
    Authors:
    Dae-Kyum Kim; Jennifer J. Knapp; Da Kuang; Aditya Chawla; Patricia Cassonnet; Hunsang Lee; Dayag Sheykhkarimli; Payman Samavarchi-Tehrani; Hala Abdouni; Ashyad Rayhan; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: CIHR , EC | PREPARE (602525)

    <jats:title>Abstract</jats:title> <jats:p>The world is facing a global pandemic of COVID-19 caused by the SARS-CoV-2 coronavirus. Here we describe a collection of codon-optimized coding sequences for SARS-CoV-2 cloned into Gateway-compatible entry vectors, which enable ...

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89 research outcomes, page 1 of 9