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SARS-CoV-2 reinfection rate is low. The relative severity of the first and second episodes of infection remains poorly studied. In this study, we aimed at assessing the frequency of SARS-CoV-2 reinfections and comparing the severity of the first and second episodes of infection. We retrospectively included patients with SARS-CoV-2 positive RT-PCR at least 90 days after clinical recovery from a COVID-19 episode and with at least one negative RT-PCR after the first infection. Whole genome sequencing and variant-specific RT-PCR were performed and clinical symptoms and severity of infection were retrospectively documented from medical files. A total of 209 COVID-19 reinfected patients were identified, accounting for 0.4% of positive cases diagnosed from 19 March 2020 to 24 August 2021. Serology was performed in 64 patients, of whom 39 (60.1%) had antibodies against SARS-CoV-2 when sampled at the early stage of their second infection. Only seven patients (3.4%) were infected twice with the same variant. We observed no differences in clinical presentation, hospitalization rate, and transfer to ICU when comparing the two episodes of infections. Our results suggest that the severity of the second episode of COVID-19 is in the same range as that of the first infection, including patients with antibodies.

Le Dossier "La motivation de la peine", Actes du colloque de Clermont-Ferrand du 20 mai 2022, F. Safi (dir.) ; Le Commentaire "Les risques contractuels face au Covid-19 : le maintien de l’obligation de régler les loyers des baux commerciaux. Commentaire des arrêts du 30 juin 2022, n°21-19.889 – n°21-20.127 – n°21-20.190", par E. Roumeau ; Les Chroniques "Un an de droit de l’environnement (2021)", avec le Master 2 Droit public approfondi, Ecole de droit-UCA, sous la direction de Ch-A. Dubreuil - "Chronique de jurisprudence de droit notarial", avec le Master 2 Droit notarial 2021-2022, Faculté de droit de Dijon-Université de Bourgogne, sous la direction de V. Bonnet

International audience; The aim of this study is to determine the trajectories of global convention cities, in order to identify and explain the strong interactions between urban policies and changes and the dynamics of hosting international conferences around the world. To accomplish this aim, the major convention cities are calibrated so that their relative positions over 24 years alongside their policies for urban change can be analyzed. To do this, we undertake a factorial correspondence analysis (FCA) combined with ascending hierarchical classification to establish a hierarchical ranking and a typology. The hosting dynamics observed reveal the strong links between material and nonmaterial urban changes and a city’s attractiveness as a convention destination. At present, the situation still reflects the effects of the COVID-19 global pandemic. It has already had technical, technological, and health-related consequences for convention processes. These new factors need to be considered in further studies on convention tourism and urban changes

ImportanceThe Conséquences de la pandémie de COVID-19 sur la santé mentale des étudiants (COSAMe) survey was conducted among university students in France during the COVID-19 pandemic and found that although there was a slight decrease in anxiety, depression, and stress between the first lockdown (T1) and 1 month after it ended (T2), the prevalence of suicidal ideation had increased between these periods and 1 in 5 students had probable posttraumatic stress disorder (PTSD) at T2. These results emphasize the need to explore the long-term consequences of the COVID-19 pandemic.ObjectivesTo measure the prevalence of mental health symptoms among university students in France 15 months after the first lockdown (T3) and to identify factors associated with outcomes.Design, Setting, and ParticipantsThis cross-sectional study reports data from the third measurement time of the repeated COSAMe survey, which took place from July 21 to August 31, 2021, through an online questionnaire sent to all French university students.Main Outcomes and MeasuresThe prevalence of suicidal thoughts, PTSD (PTSD Checklist for the Diagnostic and Statistical Manual of Mental Disorders [Fifth Edition] [PCL-5]), stress (Perceived Stress Scale), anxiety (State-Trait Anxiety Inventory), and depression (Beck Depression Inventory) at T3 were gender- and degree-standardized and compared with prevalence rates at T1 and T2. Multivariable logistic regression analyses identified risk factors.ResultsA total of 44 898 students completed the questionnaires. They were mainly women (31 728 [70.7%]), and the median (IQR) age was 19 (18-21) years. Standardized prevalence rates of stress, anxiety, depression, suicidal thoughts, and PTSD were 20.6% (95% CI, 20.2%-21.0%), 23.7% (95% CI, 23.3%-24.1%), 15.4% (95% CI, 15.1%-15.8%), 13.8% (95% CI, 13.5%-14.2%), and 29.8% (95% CI, 29.4%-30.2%), respectively. Compared with the decreased prevalence rates at T2, there was an increase at T3 for stress (2.5% increase), anxiety (13.9% increase), and depression (22.2% increase). The prevalence of suicidal ideation continued to increase from T1 (10.6%) to T3 (13.8%), and the prevalence of probable PTSD increased from 1 in 5 students to 1 in 3 students between T2 and T3. Female and nonbinary participants; participants without children and living in an urban area; and those with financial difficulties, a chronic condition, psychiatric history, COVID-19 history, social isolation, and low perceived quality of information received were at risk of all poor outcomes at T3 (eg, stress among women: adjusted OR, 2.18; 95% CI, 2.05-2.31; suicidal thoughts among nonbinary respondents: adjusted OR, 5.09; 95% CI, 4.32-5.99; anxiety among students with children: adjusted OR, 0.68; 95% CI, 0.56-0.81; depression among students living in a rural area: adjusted OR, 0.80; 95% CI, 0.75-0.85).Conclusions and RelevanceThese results suggest severe long-lasting consequences associated with the pandemic on the mental health of students. Prevention and care access should be a priority.

Online ahead of print.; International audience; We analysed the influenza epidemic that occurred in Australia during the 2022 winter using an age-structured dynamic transmission model, which accounts for past epidemics to estimate the population susceptibility to an influenza infection. We applied the same model to five European countries. Our analysis suggests Europe might experience an early and moderately large influenza epidemic. Also, differences may arise between countries, with Germany and Spain experiencing larger epidemics, than France, Italy and the United Kingdom, especially in children.

PurposeThe aim of this study was to examine the early stages of the COVID-19 outbreak and the international communication management of Chinese diplomats as a case for extending the definition of intermestic public diplomacy. The goal was to reveal how Beijing subtly used both domestic and foreign social media to organize a network for communication about COVID-19 and purposefully soften the highly centralized and hierarchical political propaganda of the Communist Party of China (CPC).Design/methodology/approachBased on the literature on digital public diplomacy, the authors applied the existing concept of intermestic to Chinese politics in order to demonstrate the digitalization of public diplomacy, along with its forms and strategies under an authoritarian regime. A hybrid methodology combining quantitative network analysis and qualitative discourse analysis permits examination of China's intermestic online communication network dynamics, shedding light on how such an intermestic practice promoted Chinese values and power to international publics in the early stages of the COVID-19 crisis.FindingsThe authors’ findings extend the implications of intermestic public diplomacy from a democratic context to an authoritarian one. By analyzing the content of public diplomacy and para-diplomatic social media accounts in China and abroad at the beginning of the COVID-19 crisis, the authors outlined China's early crisis management, explaining its intermestic public diplomacy transmission modes and strategies. Moreover, the authors identified changes in the narrative strategies of Chinese diplomats and journalists during this process.Social implicationsThe findings of this study underline that Beijing established a narrative-making virtual communication structure for disseminating favorable Chinese strategic narratives and voices through differentiated communication on domestic and foreign social media platforms. Such intermestic communication strategies were particularly evident and even further weaponized by Beijing in its large-scale Wolf Warrior diplomacy in the spring of 2020. Thus, the study’s findings help readers understand how China digitalized its public diplomacy, its digital communication patterns and strategies.Originality/valueOn the one hand, geopolitical uncertainty and the popularity of social media have contributed to the evolution of the intermestic model of public diplomacy. This model allows actors to coordinate homogenous and differentiated communication practices to deploy their influence. On the other hand, the authors did not examine how intermestic audiences perceive and receive public diplomacy practices. In future studies, scholars should measure the agenda-setting capacity of diplomatic actors by examining the effects of such intermestic communication efforts.

AbstractThe COVID-19 Disease Map project is a large-scale community effort uniting 277 scientists from 130 Institutions around the globe. We use high-quality, mechanistic content describing SARS-CoV-2-host interactions and develop interoperable bioinformatic pipelines for novel target identification and drug repurposing. Community-driven and highly interdisciplinary, the project is collaborative and supports community standards, open access, and the FAIR data principles. The coordination of community work allowed for an impressive step forward in building interfaces between Systems Biology tools and platforms. Our framework links key molecules highlighted from broad omics data analysis and computational modeling to dysregulated pathways in a cell-, tissue- or patient-specific manner. We also employ text mining and AI-assisted analysis to identify potential drugs and drug targets and use topological analysis to reveal interesting structural features of the map. The proposed framework is versatile and expandable, offering a significant upgrade in the arsenal used to understand virus-host interactions and other complex pathologies.

International audience; This commentary puts into perspective two of the articles in this issue, which analyse the impact of the COVID‑19 crisis on the allocation of time within families in France: one is written by Ariane Pailhé, Anne Solaz and Lionel Wilner and the other written by Hugues Champeaux and Francesca Marchetta. Both reveal that family arrangements appeared generally flexible, since time use changed significantly in the context of the crisis, leading to men becoming much more involved in household chores and parenting in particular. However, far from being unprecedented, this flexibility is compatible with a traditional division of roles according to gender. The changes observed may result from a model in which the man plays the role of a secondary worker in domestic production, who can be mobilised in the event of the unavailability of the primary worker, the woman. Decisions made by families in France are still anchored to gender norms; not only does this constitute a waste of resources, it also generates temporal inequalities that may manifest as intra‑family conflicts.

International audience; Stay-at-home policies during the COVID-19 pandemic challenged household members who faced forced cohabitation and increased housework (domestic chores and childcare). Based on individual data collected online from partnered women during the spring 2020 in France, we study the lockdown effects on housework division and conflicts between partners. We find that during the lockdown, couples experienced minor changes in the allocation of housework, mainly carried out by women. Simultaneously, men increased their participation in the production of household goods mainly through "enjoyable" or "quasi-leisure" activities. Our results suggest that the gendered connotation of domestic work can be context-dependent and not stable over time. Tensions between partners, reported by women, increased during the lockdown, and appear to be strongly correlated with an unequal division of housework. Overall, our results suggest that this period did not structurally affect the gender stereotypes at home.