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description Publicationkeyboard_double_arrow_right Article 2021 EnglishAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=CSC_________::530fe7a1de7dc34c5e052411d60d9d2d&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=CSC_________::530fe7a1de7dc34c5e052411d60d9d2d&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020Embargo end date: 15 Dec 2020 United Kingdom EnglishPublisher:Springer Science and Business Media LLC Funded by:NIH | Defining Pathways from Ge..., NIH | Regulation of Cardiac Dev..., WT | Wellcome Trust Sanger Ins... +3 projectsNIH| Defining Pathways from Gene Mutation to Heart Failure ,NIH| Regulation of Cardiac Development in Health and Disease ,WT| Wellcome Trust Sanger Institute - generic account for deposition of all core- funded research papers. ,EC| CodingHeart ,WT| An Extended Pilot for the Human Cell Atlas: Adult tissues, human development and inflammation-mediated pathologies ,CIHRLitviňuková, Monika; Talavera-López, Carlos; Maatz, Henrike; Reichart, Daniel; Worth, Catherine L.; Lindberg, Eric L.; Kanda, Masatoshi; Polanski, Krzysztof; Heinig, Matthias; Lee, Michael; Nadelmann, Emily R.; Roberts, Kenny; Tuck, Liz; Fasouli, Eirini S.; DeLaughter, Daniel M.; McDonough, Barbara; Wakimoto, Hiroko; Gorham, Joshua M.; Samari, Sara; Mahbubani, Krishnaa T.; Saeb-Parsy, Kourosh; Patone, Giannino; Boyle, Joseph J.; Zhang, Hongbo; Zhang, Hao; Viveiros, Anissa; Oudit, Gavin Y.; Bayraktar, Omer Ali; Seidman, J. G.; Seidman, Christine E.; Noseda, Michela; Hubner, Norbert; Teichmann, Sarah A.;Abstract: Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and therapeutic strategies require a deeper understanding of the molecular processes involved in the healthy heart. Knowledge of the full repertoire of cardiac cells and their gene expression profiles is a fundamental first step in this endeavour. Here, using state-of-the-art analyses of large-scale single-cell and single-nucleus transcriptomes, we characterize six anatomical adult heart regions. Our results highlight the cellular heterogeneity of cardiomyocytes, pericytes and fibroblasts, and reveal distinct atrial and ventricular subsets of cells with diverse developmental origins and specialized properties. We define the complexity of the cardiac vasculature and its changes along the arterio-venous axis. In the immune compartment, we identify cardiac-resident macrophages with inflammatory and protective transcriptional signatures. Furthermore, analyses of cell-to-cell interactions highlight different networks of macrophages, fibroblasts and cardiomyocytes between atria and ventricles that are distinct from those of skeletal muscle. Our human cardiac cell atlas improves our understanding of the human heart and provides a valuable reference for future studies.
Nature arrow_drop_down Institutional Repository for Molecular Medicine (MDC)Article . 2020 . Peer-reviewedData sources: Institutional Repository for Molecular Medicine (MDC)Spiral - Imperial College Digital RepositoryArticle . 2020License: CC BYData sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.17863/cam.62173&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!visibility 61visibility views 61 download downloads 174 Powered bymore_vert Nature arrow_drop_down Institutional Repository for Molecular Medicine (MDC)Article . 2020 . Peer-reviewedData sources: Institutional Repository for Molecular Medicine (MDC)Spiral - Imperial College Digital RepositoryArticle . 2020License: CC BYData sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.17863/cam.62173&type=result"></script>'); --> </script>
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description Publicationkeyboard_double_arrow_right Article 2021 EnglishAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=CSC_________::530fe7a1de7dc34c5e052411d60d9d2d&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=CSC_________::530fe7a1de7dc34c5e052411d60d9d2d&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020Embargo end date: 15 Dec 2020 United Kingdom EnglishPublisher:Springer Science and Business Media LLC Funded by:NIH | Defining Pathways from Ge..., NIH | Regulation of Cardiac Dev..., WT | Wellcome Trust Sanger Ins... +3 projectsNIH| Defining Pathways from Gene Mutation to Heart Failure ,NIH| Regulation of Cardiac Development in Health and Disease ,WT| Wellcome Trust Sanger Institute - generic account for deposition of all core- funded research papers. ,EC| CodingHeart ,WT| An Extended Pilot for the Human Cell Atlas: Adult tissues, human development and inflammation-mediated pathologies ,CIHRLitviňuková, Monika; Talavera-López, Carlos; Maatz, Henrike; Reichart, Daniel; Worth, Catherine L.; Lindberg, Eric L.; Kanda, Masatoshi; Polanski, Krzysztof; Heinig, Matthias; Lee, Michael; Nadelmann, Emily R.; Roberts, Kenny; Tuck, Liz; Fasouli, Eirini S.; DeLaughter, Daniel M.; McDonough, Barbara; Wakimoto, Hiroko; Gorham, Joshua M.; Samari, Sara; Mahbubani, Krishnaa T.; Saeb-Parsy, Kourosh; Patone, Giannino; Boyle, Joseph J.; Zhang, Hongbo; Zhang, Hao; Viveiros, Anissa; Oudit, Gavin Y.; Bayraktar, Omer Ali; Seidman, J. G.; Seidman, Christine E.; Noseda, Michela; Hubner, Norbert; Teichmann, Sarah A.;Abstract: Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and therapeutic strategies require a deeper understanding of the molecular processes involved in the healthy heart. Knowledge of the full repertoire of cardiac cells and their gene expression profiles is a fundamental first step in this endeavour. Here, using state-of-the-art analyses of large-scale single-cell and single-nucleus transcriptomes, we characterize six anatomical adult heart regions. Our results highlight the cellular heterogeneity of cardiomyocytes, pericytes and fibroblasts, and reveal distinct atrial and ventricular subsets of cells with diverse developmental origins and specialized properties. We define the complexity of the cardiac vasculature and its changes along the arterio-venous axis. In the immune compartment, we identify cardiac-resident macrophages with inflammatory and protective transcriptional signatures. Furthermore, analyses of cell-to-cell interactions highlight different networks of macrophages, fibroblasts and cardiomyocytes between atria and ventricles that are distinct from those of skeletal muscle. Our human cardiac cell atlas improves our understanding of the human heart and provides a valuable reference for future studies.
Nature arrow_drop_down Institutional Repository for Molecular Medicine (MDC)Article . 2020 . Peer-reviewedData sources: Institutional Repository for Molecular Medicine (MDC)Spiral - Imperial College Digital RepositoryArticle . 2020License: CC BYData sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.17863/cam.62173&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!visibility 61visibility views 61 download downloads 174 Powered bymore_vert Nature arrow_drop_down Institutional Repository for Molecular Medicine (MDC)Article . 2020 . Peer-reviewedData sources: Institutional Repository for Molecular Medicine (MDC)Spiral - Imperial College Digital RepositoryArticle . 2020License: CC BYData sources: Spiral - Imperial College Digital Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.17863/cam.62173&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu