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description Publicationkeyboard_double_arrow_right Article 2023 Switzerland, NetherlandsPublisher:MDPI AG Maisonneuve, Emeline; de Bruin, Odette; Favre, Guillaume; Goncé, Anna; Donati, Serena; Engjom, Hilde; Hurley, Eimir; Al-Fadel, Nouf; Siiskonen, Satu; Bloemenkamp, Kitty; Nordeng, Hedvig; Sturkenboom, Miriam; Baud, David; Panchaud, Alice;The lack of inclusion of pregnant women in clinical trials evaluating the effectiveness of medicines to treat COVID-19 has made it difficult to establish evidence-based treatment guidelines for pregnant women. Our aim was to provide a review of the evolution and updates of the national guidelines on medicines used in pregnant women with COVID-19 published by the obstetrician and gynecologists’ societies in thirteen countries in 2020–2022. Based on the results of the RECOVERY (Randomized Evaluation of COVID-19 Therapy) trial, the national societies successively recommended against prescribing hydroxychloroquine, lopinavir–ritonavir and azithromycin. Guidelines for remdesivir differed completely between countries, from compassionate or conditional use to recommendation against. Nirmatrelvir–ritonavir was authorized in Australia and the UK only in research settings and was no longer recommended in the UK at the end of 2022. After initial reluctance to use corticosteroids, the results of the RECOVERY trial have enabled the recommendation of dexamethasone in case of severe COVID-19 since mid-2020. Some societies recommended prescribing tocilizumab to pregnant patients with hypoxia and systemic inflammation from June 2021. Anti-SARS-CoV-2 monoclonal antibodies were authorized at the end of 2021 with conditional use in some countries, and then no longer recommended in Belgium and the USA at the end of 2022. The gradual convergence of the recommendations, although delayed compared to the general population, highlights the importance of the inclusion of pregnant women in clinical trials and of international collaboration to improve the pharmacological treatment of pregnant women with COVID-19.
Norwegian Open Resea... arrow_drop_down Bern Open Repository and Information System (BORIS)Article . 2023 . Peer-reviewedData sources: Bern Open Repository and Information System (BORIS)Bern Open Repository and Information System (BORIS)Article . 2023 . Peer-reviewedData sources: Bern Open Repository and Information System (BORIS)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!more_vert Norwegian Open Resea... arrow_drop_down Bern Open Repository and Information System (BORIS)Article . 2023 . Peer-reviewedData sources: Bern Open Repository and Information System (BORIS)Bern Open Repository and Information System (BORIS)Article . 2023 . Peer-reviewedData sources: Bern Open Repository and Information System (BORIS)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 Spain, NetherlandsPublisher:Centers for Disease Control and Prevention (CDC) Funded by:EC | VetBioNet, EC | ZAPIEC| VetBioNet ,EC| ZAPIRodon, Jordi; Mykytyn, Anna Z; Te, Nigeer; Okba, Nisreen M A; Lamers, Mart M; Pailler-García, Lola; Cantero, Guillermo; Albulescu, Irina; Bosch, Berend-Jan; Peiris, Malik; Bensaid, Albert; Vergara-Alert, Júlia; Haagmans, Bart L; Segalés, Joaquim; Virologie;This study was performed as part of the Zoonotic Anticipation and Preparedness Initiative (ZAPI project) (Innovative Medicines initiative [IMI] grant 115760), with assistance and financial support from IMI and the European Commission and contributions from EFPIA partners. J.R. was partially supported by the VetBioNet project (EU Grant Agreement INFRA-2016-1 Nº731014) and the crowdfunding initiative #Yomecorono, available online at https://www.yomecorono.com (accessed on June 16, 2022). IRTA is supported by CERCA Programme/Generalitat de Catalunya. Middle East respiratory syndrome coronavirus (MERS-CoV) clade B viruses are found in camelids and humans in the Middle East, but clade C viruses are not. We provide experimental evidence for extended shedding of MERS-CoV clade B viruses in llamas, which might explain why they outcompete clade C strains in the Arabian Peninsula. info:eu-repo/semantics/publishedVersion
NARCIS; Utrecht Univ... arrow_drop_down NARCIS; Utrecht University RepositoryArticle . 2023NARCIS; Emerging Infectious DiseasesArticle . 2023ZENODO; Recolector de Ciencia Abierta, RECOLECTA; Emerging Infectious DiseasesArticle . 2023 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 3 citations 3 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert NARCIS; Utrecht Univ... arrow_drop_down NARCIS; Utrecht University RepositoryArticle . 2023NARCIS; Emerging Infectious DiseasesArticle . 2023ZENODO; Recolector de Ciencia Abierta, RECOLECTA; Emerging Infectious DiseasesArticle . 2023 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 NetherlandsPublisher:Frontiers Media SA Sophie H. Bots; Judit Riera-Arnau; Judit Riera-Arnau; Svetlana V. Belitser; Davide Messina; Maria Aragón; Ema Alsina; Ema Alsina; Ian J. Douglas; Carlos E. Durán; Carlos E. Durán; Patricia García-Poza; Rosa Gini; Ron M. C. Herings; Consuelo Huerta; Malede Mequanent Sisay; Malede Mequanent Sisay; Mar Martín-Pérez; Ivonne Martin; Ivonne Martin; Jetty A. Overbeek; Olga Paoletti; Meritxell Pallejà-Millán; Anna Schultze; Patrick Souverein; Karin M. A. Swart; Felipe Villalobos; Olaf H. Klungel; Miriam C. J. M. Sturkenboom; Miriam C. J. M. Sturkenboom;COVID-19 vaccine; Adverse drug reaction; Myocarditis Vacuna contra el COVID-19; Reacció adversa a fàrmacs; Miocarditis Vacuna contra el COVID-19; Reacción adversa a medicamentos; Miocarditis Background: Estimates of the association between COVID-19 vaccines and myo-/pericarditis risk vary widely across studies due to scarcity of events, especially in age- and sex-stratified analyses. Methods: Population-based cohort study with nested self-controlled risk interval (SCRI) using healthcare data from five European databases. Individuals were followed from 01/01/2020 until end of data availability (31/12/2021 latest). Outcome was first myo-/pericarditis diagnosis. Exposures were first and second dose of Pfizer, AstraZeneca, Moderna, and Janssen COVID-19 vaccines. Baseline incidence rates (IRs), and vaccine- and dose-specific IRs and rate differences were calculated from the cohort The SCRI calculated calendar time-adjusted IR ratios (IRR), using a 60-day pre-vaccination control period and dose-specific 28-day risk windows. IRRs were pooled using random effects meta-analysis. Findings: Over 35 million individuals (49·2% women, median age 39–49 years) were included, of which 57·4% received at least one COVID-19 vaccine dose. Baseline incidence of myocarditis was low. Myocarditis IRRs were elevated after vaccination in those aged < 30 years, after both Pfizer vaccine doses (IRR = 3·3, 95%CI 1·2-9.4; 7·8, 95%CI 2·6-23·5, respectively) and Moderna vaccine dose 2 (IRR = 6·1, 95%CI 1·1-33·5). An effect of AstraZeneca vaccine dose 2 could not be excluded (IRR = 2·42, 95%CI 0·96-6·07). Pericarditis was not associated with vaccination. Interpretation: mRNA-based COVID-19 vaccines and potentially AstraZeneca are associated with increased myocarditis risk in younger individuals, although absolute incidence remains low. More data on children (≤ 11 years) are needed. The project received support from the European Medicines Agency (EMA/2018/23/PE).
NARCIS; Utrecht Univ... arrow_drop_down NARCIS; Utrecht University RepositoryArticle . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 11 citations 11 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert NARCIS; Utrecht Univ... arrow_drop_down NARCIS; Utrecht University RepositoryArticle . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint , Other literature type 2022 NetherlandsPublisher:Cold Spring Harbor Laboratory Funded by:EC | Sugar-Enable, NIH | 3-O-sulfation of heparan ..., NIH | Training +1 projectsEC| Sugar-Enable ,NIH| 3-O-sulfation of heparan sulfate as a regular of protein function ,NIH| Training ,NWO| Combining chemical synthesis and analysis to reveal the biology regulated by protein glycosylationTomris, Ilhan; Unione, Luca; Nguyen, Linh; Zaree, Pouya; Bouwman, Kim M.; Liu, Lin; Li, Zeshi; Fok, Jelle A.; Ríos Carrasco, María; van der Woude, Roosmarijn; Kimpel, Anne L. M.; Linthorst, Mirte W.; Kilavuzoglu, Sinan E.; Verpalen, Enrico C. J. M.; Caniels, Tom G.; Sanders, Rogier W.; Heesters, Balthasar A.; Pieters, Roland J.; Jiménez-Barbero, Jesús; Klassen, John S.; Boons, Geert-Jan; de Vries, Robert P.;pmc: PMC9580382 , PMC10178783
handle: 1874/424494
AbstractSARS-CoV-2 viruses engage ACE2 as a functional receptor with their spike protein. The S1 domain of the spike protein contains a C-terminal receptor-binding domain (RBD) and an N-terminal domain (NTD). The NTD of other coronaviruses includes a glycan-binding cleft. However, for the SARS-CoV-2 NTD protein-glycan binding was only observed weakly for sialic acids with highly sensitive methods. Amino acid changes in the NTD of Variants of Concern (VoC) shows antigenic pressure, which can be an indication of NTD-mediated receptor binding. Trimeric NTD proteins of SARS-CoV-2, Alpha, Beta, Delta, and Omicron did not reveal a receptor binding capability. Unexpectedly, the SARS-CoV-2 Beta subvariant strain (501Y.V2-1) NTD binding to Vero E6 cells was sensitive to sialidase pretreatment. Glycan microarray analyses identified a putative 9-O-acetylated sialic acid as a ligand, which was confirmed by catch-and-release ESI-MS, STD-NMR analyses, and a graphene-based electrochemical sensor. The Beta (501Y.V2-1) variant attained an enhanced glycan binding modality in the NTD with specificity towards 9-O-acetylated structures, suggesting a dual-receptor functionality of the SARS-CoV-2 S1 domain, which was quickly selected against. These results indicate that SARS-CoV-2 can probe additional evolutionary space, allowing binding to glycan receptors on the surface of target cells.Graphical abstractSynopsisCoronaviruses utilize their N-terminal domain (NTD) for initial reversible low-affinity interaction to (sialylated) glycans. This initial low-affinity/high-avidity engagement enables viral surfing on the target membrane, potentially followed by a stronger secondary receptor interaction. Several coronaviruses, such as HKU1 and OC43, possess a hemagglutinin-esterase for viral release after sialic acid interaction, thus allowing viral dissemination. Other coronaviruses, such as MERS-CoV, do not possess a hemagglutinin-esterase, but interact reversibly to sialic acids allowing for viral surfing and dissemination. The early 501Y.V2-1 subvariant of the Beta SARS-CoV-2 Variant of Concern has attained a receptor-binding functionality towards 9-O-acetylated sialic acid using its NTD. This binding functionality was selected against rapidly, most likely due to poor dissemination. Ablation of sialic acid binding in more recent SARS-CoV-2 Variants of Concern suggests a fine balance of sialic acid interaction of SARS-CoV-2 is required for infection and/or transmission.
ACS Chemical Biology arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 3 citations 3 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert ACS Chemical Biology arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Netherlands, SpainPublisher:American Association for the Advancement of Science (AAAS) Funded by:EC | EVA-GLOBAL, EC | MANCOEC| EVA-GLOBAL ,EC| MANCODu, Wenjuan; Hurdiss, Daniel L; Drabek, Dubravka; Mykytyn, Anna Z; Kaiser, Franziska K; González-Hernández, Mariana; Muñoz-Santos, Diego; Lamers, Mart M; van Haperen, Rien; Li, Wentao; Drulyte, Ieva; Wang, Chunyan; Sola, Isabel; Armando, Federico; Beythien, Georg; Ciurkiewicz, Malgorzata; Baumgärtner, Wolfgang; Guilfoyle, Kate; Smits, Tony; van der Lee, Joline; van Kuppeveld, Frank J M; van Amerongen, Geert; Haagmans, Bart L; Enjuanes, Luis; Osterhaus, Albert D M E; Grosveld, Frank; Bosch, Berend-Jan; Virologie; dI&I I&I-1; Bedrijfsvoering;The ongoing evolution of SARS-CoV-2 has resulted in the emergence of Omicron, which displays striking immune escape potential through mutations at key antigenic sites on the spike protein. Many of these mutations localize to the spike protein ACE2 receptor-binding domain, annulling the neutralizing activity of therapeutic antibodies that were effective against other Variants of Concern (VOCs) earlier in the pandemic. Here, we identified a receptor-blocking human monoclonal antibody, 87G7, that retained potent in vitro neutralizing activity against SARS-CoV-2 variants including the Alpha, Beta, Gamma, Delta and Omicron (BA.1/BA.2) VOCs. Using cryo-electron microscopy and site-directed mutagenesis experiments, we showed that 87G7 targets a patch of hydrophobic residues in the ACE2-binding site that are highly conserved in SARS-CoV-2 variants, explaining its broad neutralization capacity. 87G7 protected mice and/or hamsters prophylactically against challenge with all current SARS-CoV-2 VOCs, and showed therapeutic activity against SARS-CoV-2 challenge in both animal models. Our findings demonstrate that 87G7 holds promise as a prophylactic or therapeutic agent for COVID-19 that is more resilient to SARS-CoV-2 antigenic diversity. The MANCO project has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No 101003651). This work made use of the Dutch national e-infrastructure with the support of the SURF Cooperative using grant no. EINF-2453. This research was funded by the Deutsche Forschungsgemeinschaft (DFG; German Research Foundation) -398066876/GRK 2485/1; BMBF (Federal Ministry of Education and Research) project entitled RAPID (Risk assessment in re-pandemic respiratory infectious diseases), 01KI1723G, Ministry of Science and Culture of Lower Saxony in Germany (14 - 76103-184 CORONA-15/20) Peer reviewed
NARCIS; Utrecht Univ... arrow_drop_down NARCIS; Utrecht University RepositoryArticle . 2022Science ImmunologyOther literature type . Article . 2022 . Peer-reviewedRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2022 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1126/sciimmunol.abp9312&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 30 citations 30 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 40visibility views 40 download downloads 258 Powered bymore_vert NARCIS; Utrecht Univ... arrow_drop_down NARCIS; Utrecht University RepositoryArticle . 2022Science ImmunologyOther literature type . Article . 2022 . Peer-reviewedRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2022 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 NetherlandsPublisher:Wiley Publicly fundedSepp, Stoo; Wong, Mona; Hoogerheide, Vincent; Castro-Alonso, Juan Cristobal; Leerstoel van Gog; Education and Learning: Development in Interaction;doi: 10.1111/jcal.12715
handle: 1874/423643
AbstractBackgroundAs a result of the COVID‐19 pandemic, many teachers found themselves making a rapid and often challenging shift from in‐person classroom teaching to teaching in an online environment. As teachers continue to learn about working in this new environment, research in cognitive and learning sciences, specifically findings from cognitive load theory and related areas, can provide meaningful strategies for teaching in this ‘new normal’.ObjectivesThis paper describes 12 tips derived from contemporary research in educational psychology, focusing particularly on empirically supported strategies that teachers may apply in their online classroom to ensure that learning is optimized.Implications for PracticeThese strategies are generalizable across age groups and learning areas, and are categorized into one of two themes: approaches to optimize the design of online learning materials, and instructional strategies to support student learning. A discussion follows, outlining how teachers may apply these strategies in different contexts, with a brief overview of emerging efforts that aim to bridge cognitive load theory and self‐regulated learning research.
NARCIS; Utrecht Univ... arrow_drop_down Journal of Computer Assisted LearningArticle . 2022 . Peer-reviewedLicense: CC BY NCData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routeshybrid 5 citations 5 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert NARCIS; Utrecht Univ... arrow_drop_down Journal of Computer Assisted LearningArticle . 2022 . Peer-reviewedLicense: CC BY NCData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/jcal.12715&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Netherlands, Spain, SpainPublisher:Springer Science and Business Media LLC Funded by:EC | ZAPI, EC | VetBioNetEC| ZAPI ,EC| VetBioNetRodon, Jordi; Mykytyn, Anna Z; Cantero, Guillermo; Albulescu, Irina C; Bosch, Berend-Jan; Brix, Alexander; Audonnet, Jean-Christophe; Bensaid, Albert; Vergara-Alert, Júlia; Haagmans, Bart L; Segalés, Joaquim; Virologie; dI&I I&I-1;Ongoing outbreaks of Middle East respiratory syndrome coronavirus (MERS-CoV) continue posing a global health threat. Vaccination of livestock reservoir species is a recommended strategy to prevent spread of MERS-CoV among animals and potential spillover to humans. Using a direct-contact llama challenge model that mimics naturally occurring viral transmission, we tested the efficacy of a multimeric receptor binding domain (RBD) particle-display based vaccine candidate. While MERS-CoV was transmitted to naïve animals exposed to virus-inoculated llamas, immunization induced robust virus-neutralizing antibody responses and prevented transmission in 1/3 vaccinated, in-contact animals. Our exploratory study supports further improvement of the RBD-based vaccine to prevent zoonotic spillover of MERS-CoV. info:eu-repo/semantics/publishedVersion
ZENODO; One Health O... arrow_drop_down NARCIS; Utrecht University RepositoryArticle . 2022One Health OutlookArticle . 2022Recolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2022License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s42522-022-00068-9&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 3 citations 3 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert ZENODO; One Health O... arrow_drop_down NARCIS; Utrecht University RepositoryArticle . 2022One Health OutlookArticle . 2022Recolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2022License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s42522-022-00068-9&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Spain, United Kingdom, NetherlandsPublisher:Elsevier BV Allendorf, Valerie; Denzin, Nicolai; Conraths, Franz J; Boden, Lisa A; Elvinger, François; Magouras, Ioannis; Stegeman, Arjan; Wood, James L N; Urueña, Ana Carvajal; Grace, Katherine E F; Stärk, Katharina D C; FAH veterinaire epidemiologie; dFAH AVR; dFAH I&I;[EN]Due to the zoonotic origin of SARS-Coronavirus 2 (SARS-CoV-2), the potential for its transmission from humans back to animals and the possibility that it might establish ongoing infection pathways in other animal species has been discussed. Cats are highly susceptible to SARS-CoV-2 and were shown experimentally to transmit the virus to other cats. Infection of cats has been widely reported. Domestic cats in COVID-19-positive households could therefore be a part of a human to animal to human transmission pathway. Here, we report the results of a qualitative risk assessment focusing on the potential of cat to human transmission in such settings. The assessment was based on evidence available by October 2021. After the introduction of SARS-CoV-2 to a household by a human, cats may become infected and infected cats may pose an additional infection risk for other members of the household. In order to assess this additional risk qualitatively, expert opinion was elicited within the framework of a modified Delphi procedure. The conclusion was that the additional risk of infection of an additional person in a household associated with keeping a domestic cat is very low to negligible, depending on the intensity of cat-to-human interactions. The separation of cats from humans suffering from SARS-CoV-2 infection should contribute to preventing further transmission. SI This work was funded by the German Federal Ministry of Education and Research within the COVMon Project, being part of the InfectControl2020 Initiative (BMBF grant no. 03COV16D).
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!visibility 8visibility views 8 download downloads 4 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 United States, Netherlands, ItalyPublisher:SAGE Publications Funded by:UKRI | Future Energy & Trans..., UKRI | KELVIN: Computer Vision B...UKRI| Future Energy & Transport Tool ,UKRI| KELVIN: Computer Vision Based Biomarkers of Motor Dysfunction in Parkinson’s DiseaseAuthors: Padilla-Walker, Laura M.; Van der graaff, Jolien; Workman, Katey; Carlo, Gustavo; +16 AuthorsPadilla-Walker, Laura M.; Van der graaff, Jolien; Workman, Katey; Carlo, Gustavo; Branje, Susan; Carrizales, Alexia; Gerbino, Maria; Gülseven, Zehra; Hawk, Skyler T.; Luengo kanacri, Paula; Mesurado, Belén; Samper-García, Paula; Shen, Yuh-ling; Taylor, Laura K.; Trach, Jessica; Van zalk, Maarten H. W.; Žukauskienė, Rita; Leerstoel Branje; Adolescent development: Characteristics and determinants; Leerstoel Meeus;handle: 11573/1644444 , 1874/425572
Evidence suggests an impact of the COVID-19 pandemic on mental health, particularly among emerging adults. However, theories on altruism born of suffering or adversarial growth suggest that we might also see prosocial behavior as a function of the pandemic, which may protect against mental health challenges. Because cultural values are central in determining prosocial behavior, the current study explored how cultural values were differentially associated with adaptive prosocial behaviors that might protect against mental health challenges. Participants for the current study included 5,682 young people aged 18–25 years from 14 different countries around the world (68% female, 62% college students). Path analyses suggested that there were few differences in patterns as a function of culture, but revealed that horizontal individualism and horizontal and vertical collectivism were indirectly associated with lower levels of depression via prosocial behavior toward family members. Discussion focuses on the importance of coping by strengthening family relationships via prosocial behavior during the pandemic.
NARCIS; Utrecht Univ... arrow_drop_down NARCIS; Utrecht University RepositoryArticle . 2022Archivio della ricerca- Università di Roma La Sapienza; International Journal of Behavioral DevelopmentArticle . 2022 . Peer-reviewedLicense: SAGE TDMeScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of CaliforniaArchivio della ricerca- Università di Roma La SapienzaArticle . 2022Data sources: Archivio della ricerca- Università di Roma La Sapienzaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesbronze 8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert NARCIS; Utrecht Univ... arrow_drop_down NARCIS; Utrecht University RepositoryArticle . 2022Archivio della ricerca- Università di Roma La Sapienza; International Journal of Behavioral DevelopmentArticle . 2022 . Peer-reviewedLicense: SAGE TDMeScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of CaliforniaArchivio della ricerca- Università di Roma La SapienzaArticle . 2022Data sources: Archivio della ricerca- Università di Roma La Sapienzaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 NetherlandsPublisher:Informa UK Limited Funded by:EC | ZAPIEC| ZAPIRodriguez-Conde, Sara; Inman, Sophie; Lindo, Viv; Amery, Leanne; Tang, Alison; Okorji-Obike, Uche; Du, Wenjuan; Bosch, Berend-Jan; Wichgers Schreur, Paul J; Kortekaas, Jeroen; Sola, Isabel; Enjuanes, Luis; Kerry, Laura; Mahal, Katharina; Hulley, Martyn; Daramola, Olalekan; Virologie; dI&I I&I-1; LS Infectiebiologie (Bacteriologie);Transgenic human monoclonal antibodies derived from humanized mice against different epitopes of the Middle East respiratory syndrome coronavirus (MERS-CoV), and chimeric llama-human bispecific heavy chain-only antibodies targeting the Rift Valley fever virus (RVFV), were produced using a CHO-based transient expression system. Two lead candidates were assessed for each model virus before selecting and progressing one lead molecule. MERS-7.7G6 was used as the model antibody to demonstrate batch-to-batch process consistency and, together with RVFV-107-104, were scaled up to 200 L. Consistent expression titers were obtained in different batches at a 5 L scale for MERS-7.7G6. Although lower expression levels were observed for MERS-7.7G6 and RVFV-107-104 during scale up to 200 L, product quality attributes were consistent at different scales and in different batches. In addition to this, peptide mapping data suggested no detectable sequence variants for any of these candidates. Functional assays demonstrated comparable neutralizing activity for MERS-7.7G6 and RVFV-107-104 generated at different production scales. Similarly, MERS-7.7G6 batches generated at different scales were shown to provide comparable protection in mouse models. Our study demonstrates that a CHO-based transient expression process is capable of generating consistent product quality at different production scales and thereby supports the potential of using transient gene expression to accelerate the manufacturing of early clinical material.
NARCIS; Utrecht Univ... arrow_drop_down NARCIS; Utrecht University RepositoryArticle . 2022NARCIS; Utrecht University RepositoryArticle . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 3 citations 3 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert NARCIS; Utrecht Univ... arrow_drop_down NARCIS; Utrecht University RepositoryArticle . 2022NARCIS; Utrecht University RepositoryArticle . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article 2023 Switzerland, NetherlandsPublisher:MDPI AG Maisonneuve, Emeline; de Bruin, Odette; Favre, Guillaume; Goncé, Anna; Donati, Serena; Engjom, Hilde; Hurley, Eimir; Al-Fadel, Nouf; Siiskonen, Satu; Bloemenkamp, Kitty; Nordeng, Hedvig; Sturkenboom, Miriam; Baud, David; Panchaud, Alice;The lack of inclusion of pregnant women in clinical trials evaluating the effectiveness of medicines to treat COVID-19 has made it difficult to establish evidence-based treatment guidelines for pregnant women. Our aim was to provide a review of the evolution and updates of the national guidelines on medicines used in pregnant women with COVID-19 published by the obstetrician and gynecologists’ societies in thirteen countries in 2020–2022. Based on the results of the RECOVERY (Randomized Evaluation of COVID-19 Therapy) trial, the national societies successively recommended against prescribing hydroxychloroquine, lopinavir–ritonavir and azithromycin. Guidelines for remdesivir differed completely between countries, from compassionate or conditional use to recommendation against. Nirmatrelvir–ritonavir was authorized in Australia and the UK only in research settings and was no longer recommended in the UK at the end of 2022. After initial reluctance to use corticosteroids, the results of the RECOVERY trial have enabled the recommendation of dexamethasone in case of severe COVID-19 since mid-2020. Some societies recommended prescribing tocilizumab to pregnant patients with hypoxia and systemic inflammation from June 2021. Anti-SARS-CoV-2 monoclonal antibodies were authorized at the end of 2021 with conditional use in some countries, and then no longer recommended in Belgium and the USA at the end of 2022. The gradual convergence of the recommendations, although delayed compared to the general population, highlights the importance of the inclusion of pregnant women in clinical trials and of international collaboration to improve the pharmacological treatment of pregnant women with COVID-19.
Norwegian Open Resea... arrow_drop_down Bern Open Repository and Information System (BORIS)Article . 2023 . Peer-reviewedData sources: Bern Open Repository and Information System (BORIS)Bern Open Repository and Information System (BORIS)Article . 2023 . Peer-reviewedData sources: Bern Open Repository and Information System (BORIS)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!more_vert Norwegian Open Resea... arrow_drop_down Bern Open Repository and Information System (BORIS)Article . 2023 . Peer-reviewedData sources: Bern Open Repository and Information System (BORIS)Bern Open Repository and Information System (BORIS)Article . 2023 . Peer-reviewedData sources: Bern Open Repository and Information System (BORIS)add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 Spain, NetherlandsPublisher:Centers for Disease Control and Prevention (CDC) Funded by:EC | VetBioNet, EC | ZAPIEC| VetBioNet ,EC| ZAPIRodon, Jordi; Mykytyn, Anna Z; Te, Nigeer; Okba, Nisreen M A; Lamers, Mart M; Pailler-García, Lola; Cantero, Guillermo; Albulescu, Irina; Bosch, Berend-Jan; Peiris, Malik; Bensaid, Albert; Vergara-Alert, Júlia; Haagmans, Bart L; Segalés, Joaquim; Virologie;This study was performed as part of the Zoonotic Anticipation and Preparedness Initiative (ZAPI project) (Innovative Medicines initiative [IMI] grant 115760), with assistance and financial support from IMI and the European Commission and contributions from EFPIA partners. J.R. was partially supported by the VetBioNet project (EU Grant Agreement INFRA-2016-1 Nº731014) and the crowdfunding initiative #Yomecorono, available online at https://www.yomecorono.com (accessed on June 16, 2022). IRTA is supported by CERCA Programme/Generalitat de Catalunya. Middle East respiratory syndrome coronavirus (MERS-CoV) clade B viruses are found in camelids and humans in the Middle East, but clade C viruses are not. We provide experimental evidence for extended shedding of MERS-CoV clade B viruses in llamas, which might explain why they outcompete clade C strains in the Arabian Peninsula. info:eu-repo/semantics/publishedVersion
NARCIS; Utrecht Univ... arrow_drop_down NARCIS; Utrecht University RepositoryArticle . 2023NARCIS; Emerging Infectious DiseasesArticle . 2023ZENODO; Recolector de Ciencia Abierta, RECOLECTA; Emerging Infectious DiseasesArticle . 2023 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 3 citations 3 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert NARCIS; Utrecht Univ... arrow_drop_down NARCIS; Utrecht University RepositoryArticle . 2023NARCIS; Emerging Infectious DiseasesArticle . 2023ZENODO; Recolector de Ciencia Abierta, RECOLECTA; Emerging Infectious DiseasesArticle . 2023 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 NetherlandsPublisher:Frontiers Media SA Sophie H. Bots; Judit Riera-Arnau; Judit Riera-Arnau; Svetlana V. Belitser; Davide Messina; Maria Aragón; Ema Alsina; Ema Alsina; Ian J. Douglas; Carlos E. Durán; Carlos E. Durán; Patricia García-Poza; Rosa Gini; Ron M. C. Herings; Consuelo Huerta; Malede Mequanent Sisay; Malede Mequanent Sisay; Mar Martín-Pérez; Ivonne Martin; Ivonne Martin; Jetty A. Overbeek; Olga Paoletti; Meritxell Pallejà-Millán; Anna Schultze; Patrick Souverein; Karin M. A. Swart; Felipe Villalobos; Olaf H. Klungel; Miriam C. J. M. Sturkenboom; Miriam C. J. M. Sturkenboom;COVID-19 vaccine; Adverse drug reaction; Myocarditis Vacuna contra el COVID-19; Reacció adversa a fàrmacs; Miocarditis Vacuna contra el COVID-19; Reacción adversa a medicamentos; Miocarditis Background: Estimates of the association between COVID-19 vaccines and myo-/pericarditis risk vary widely across studies due to scarcity of events, especially in age- and sex-stratified analyses. Methods: Population-based cohort study with nested self-controlled risk interval (SCRI) using healthcare data from five European databases. Individuals were followed from 01/01/2020 until end of data availability (31/12/2021 latest). Outcome was first myo-/pericarditis diagnosis. Exposures were first and second dose of Pfizer, AstraZeneca, Moderna, and Janssen COVID-19 vaccines. Baseline incidence rates (IRs), and vaccine- and dose-specific IRs and rate differences were calculated from the cohort The SCRI calculated calendar time-adjusted IR ratios (IRR), using a 60-day pre-vaccination control period and dose-specific 28-day risk windows. IRRs were pooled using random effects meta-analysis. Findings: Over 35 million individuals (49·2% women, median age 39–49 years) were included, of which 57·4% received at least one COVID-19 vaccine dose. Baseline incidence of myocarditis was low. Myocarditis IRRs were elevated after vaccination in those aged < 30 years, after both Pfizer vaccine doses (IRR = 3·3, 95%CI 1·2-9.4; 7·8, 95%CI 2·6-23·5, respectively) and Moderna vaccine dose 2 (IRR = 6·1, 95%CI 1·1-33·5). An effect of AstraZeneca vaccine dose 2 could not be excluded (IRR = 2·42, 95%CI 0·96-6·07). Pericarditis was not associated with vaccination. Interpretation: mRNA-based COVID-19 vaccines and potentially AstraZeneca are associated with increased myocarditis risk in younger individuals, although absolute incidence remains low. More data on children (≤ 11 years) are needed. The project received support from the European Medicines Agency (EMA/2018/23/PE).
NARCIS; Utrecht Univ... arrow_drop_down NARCIS; Utrecht University RepositoryArticle . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 11 citations 11 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert NARCIS; Utrecht Univ... arrow_drop_down NARCIS; Utrecht University RepositoryArticle . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint , Other literature type 2022 NetherlandsPublisher:Cold Spring Harbor Laboratory Funded by:EC | Sugar-Enable, NIH | 3-O-sulfation of heparan ..., NIH | Training +1 projectsEC| Sugar-Enable ,NIH| 3-O-sulfation of heparan sulfate as a regular of protein function ,NIH| Training ,NWO| Combining chemical synthesis and analysis to reveal the biology regulated by protein glycosylationTomris, Ilhan; Unione, Luca; Nguyen, Linh; Zaree, Pouya; Bouwman, Kim M.; Liu, Lin; Li, Zeshi; Fok, Jelle A.; Ríos Carrasco, María; van der Woude, Roosmarijn; Kimpel, Anne L. M.; Linthorst, Mirte W.; Kilavuzoglu, Sinan E.; Verpalen, Enrico C. J. M.; Caniels, Tom G.; Sanders, Rogier W.; Heesters, Balthasar A.; Pieters, Roland J.; Jiménez-Barbero, Jesús; Klassen, John S.; Boons, Geert-Jan; de Vries, Robert P.;pmc: PMC9580382 , PMC10178783
handle: 1874/424494
AbstractSARS-CoV-2 viruses engage ACE2 as a functional receptor with their spike protein. The S1 domain of the spike protein contains a C-terminal receptor-binding domain (RBD) and an N-terminal domain (NTD). The NTD of other coronaviruses includes a glycan-binding cleft. However, for the SARS-CoV-2 NTD protein-glycan binding was only observed weakly for sialic acids with highly sensitive methods. Amino acid changes in the NTD of Variants of Concern (VoC) shows antigenic pressure, which can be an indication of NTD-mediated receptor binding. Trimeric NTD proteins of SARS-CoV-2, Alpha, Beta, Delta, and Omicron did not reveal a receptor binding capability. Unexpectedly, the SARS-CoV-2 Beta subvariant strain (501Y.V2-1) NTD binding to Vero E6 cells was sensitive to sialidase pretreatment. Glycan microarray analyses identified a putative 9-O-acetylated sialic acid as a ligand, which was confirmed by catch-and-release ESI-MS, STD-NMR analyses, and a graphene-based electrochemical sensor. The Beta (501Y.V2-1) variant attained an enhanced glycan binding modality in the NTD with specificity towards 9-O-acetylated structures, suggesting a dual-receptor functionality of the SARS-CoV-2 S1 domain, which was quickly selected against. These results indicate that SARS-CoV-2 can probe additional evolutionary space, allowing binding to glycan receptors on the surface of target cells.Graphical abstractSynopsisCoronaviruses utilize their N-terminal domain (NTD) for initial reversible low-affinity interaction to (sialylated) glycans. This initial low-affinity/high-avidity engagement enables viral surfing on the target membrane, potentially followed by a stronger secondary receptor interaction. Several coronaviruses, such as HKU1 and OC43, possess a hemagglutinin-esterase for viral release after sialic acid interaction, thus allowing viral dissemination. Other coronaviruses, such as MERS-CoV, do not possess a hemagglutinin-esterase, but interact reversibly to sialic acids allowing for viral surfing and dissemination. The early 501Y.V2-1 subvariant of the Beta SARS-CoV-2 Variant of Concern has attained a receptor-binding functionality towards 9-O-acetylated sialic acid using its NTD. This binding functionality was selected against rapidly, most likely due to poor dissemination. Ablation of sialic acid binding in more recent SARS-CoV-2 Variants of Concern suggests a fine balance of sialic acid interaction of SARS-CoV-2 is required for infection and/or transmission.
ACS Chemical Biology arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 3 citations 3 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert ACS Chemical Biology arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Netherlands, SpainPublisher:American Association for the Advancement of Science (AAAS) Funded by:EC | EVA-GLOBAL, EC | MANCOEC| EVA-GLOBAL ,EC| MANCODu, Wenjuan; Hurdiss, Daniel L; Drabek, Dubravka; Mykytyn, Anna Z; Kaiser, Franziska K; González-Hernández, Mariana; Muñoz-Santos, Diego; Lamers, Mart M; van Haperen, Rien; Li, Wentao; Drulyte, Ieva; Wang, Chunyan; Sola, Isabel; Armando, Federico; Beythien, Georg; Ciurkiewicz, Malgorzata; Baumgärtner, Wolfgang; Guilfoyle, Kate; Smits, Tony; van der Lee, Joline; van Kuppeveld, Frank J M; van Amerongen, Geert; Haagmans, Bart L; Enjuanes, Luis; Osterhaus, Albert D M E; Grosveld, Frank; Bosch, Berend-Jan; Virologie; dI&I I&I-1; Bedrijfsvoering;The ongoing evolution of SARS-CoV-2 has resulted in the emergence of Omicron, which displays striking immune escape potential through mutations at key antigenic sites on the spike protein. Many of these mutations localize to the spike protein ACE2 receptor-binding domain, annulling the neutralizing activity of therapeutic antibodies that were effective against other Variants of Concern (VOCs) earlier in the pandemic. Here, we identified a receptor-blocking human monoclonal antibody, 87G7, that retained potent in vitro neutralizing activity against SARS-CoV-2 variants including the Alpha, Beta, Gamma, Delta and Omicron (BA.1/BA.2) VOCs. Using cryo-electron microscopy and site-directed mutagenesis experiments, we showed that 87G7 targets a patch of hydrophobic residues in the ACE2-binding site that are highly conserved in SARS-CoV-2 variants, explaining its broad neutralization capacity. 87G7 protected mice and/or hamsters prophylactically against challenge with all current SARS-CoV-2 VOCs, and showed therapeutic activity against SARS-CoV-2 challenge in both animal models. Our findings demonstrate that 87G7 holds promise as a prophylactic or therapeutic agent for COVID-19 that is more resilient to SARS-CoV-2 antigenic diversity. The MANCO project has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No 101003651). This work made use of the Dutch national e-infrastructure with the support of the SURF Cooperative using grant no. EINF-2453. This research was funded by the Deutsche Forschungsgemeinschaft (DFG; German Research Foundation) -398066876/GRK 2485/1; BMBF (Federal Ministry of Education and Research) project entitled RAPID (Risk assessment in re-pandemic respiratory infectious diseases), 01KI1723G, Ministry of Science and Culture of Lower Saxony in Germany (14 - 76103-184 CORONA-15/20) Peer reviewed
NARCIS; Utrecht Univ... arrow_drop_down NARCIS; Utrecht University RepositoryArticle . 2022Science ImmunologyOther literature type . Article . 2022 . Peer-reviewedRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2022 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1126/sciimmunol.abp9312&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 30 citations 30 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 40visibility views 40 download downloads 258 Powered bymore_vert NARCIS; Utrecht Univ... arrow_drop_down NARCIS; Utrecht University RepositoryArticle . 2022Science ImmunologyOther literature type . Article . 2022 . Peer-reviewedRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2022 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1126/sciimmunol.abp9312&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 NetherlandsPublisher:Wiley Publicly fundedSepp, Stoo; Wong, Mona; Hoogerheide, Vincent; Castro-Alonso, Juan Cristobal; Leerstoel van Gog; Education and Learning: Development in Interaction;doi: 10.1111/jcal.12715
handle: 1874/423643
AbstractBackgroundAs a result of the COVID‐19 pandemic, many teachers found themselves making a rapid and often challenging shift from in‐person classroom teaching to teaching in an online environment. As teachers continue to learn about working in this new environment, research in cognitive and learning sciences, specifically findings from cognitive load theory and related areas, can provide meaningful strategies for teaching in this ‘new normal’.ObjectivesThis paper describes 12 tips derived from contemporary research in educational psychology, focusing particularly on empirically supported strategies that teachers may apply in their online classroom to ensure that learning is optimized.Implications for PracticeThese strategies are generalizable across age groups and learning areas, and are categorized into one of two themes: approaches to optimize the design of online learning materials, and instructional strategies to support student learning. A discussion follows, outlining how teachers may apply these strategies in different contexts, with a brief overview of emerging efforts that aim to bridge cognitive load theory and self‐regulated learning research.
NARCIS; Utrecht Univ... arrow_drop_down Journal of Computer Assisted LearningArticle . 2022 . Peer-reviewedLicense: CC BY NCData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/jcal.12715&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 5 citations 5 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert NARCIS; Utrecht Univ... arrow_drop_down Journal of Computer Assisted LearningArticle . 2022 . Peer-reviewedLicense: CC BY NCData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/jcal.12715&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Netherlands, Spain, SpainPublisher:Springer Science and Business Media LLC Funded by:EC | ZAPI, EC | VetBioNetEC| ZAPI ,EC| VetBioNetRodon, Jordi; Mykytyn, Anna Z; Cantero, Guillermo; Albulescu, Irina C; Bosch, Berend-Jan; Brix, Alexander; Audonnet, Jean-Christophe; Bensaid, Albert; Vergara-Alert, Júlia; Haagmans, Bart L; Segalés, Joaquim; Virologie; dI&I I&I-1;Ongoing outbreaks of Middle East respiratory syndrome coronavirus (MERS-CoV) continue posing a global health threat. Vaccination of livestock reservoir species is a recommended strategy to prevent spread of MERS-CoV among animals and potential spillover to humans. Using a direct-contact llama challenge model that mimics naturally occurring viral transmission, we tested the efficacy of a multimeric receptor binding domain (RBD) particle-display based vaccine candidate. While MERS-CoV was transmitted to naïve animals exposed to virus-inoculated llamas, immunization induced robust virus-neutralizing antibody responses and prevented transmission in 1/3 vaccinated, in-contact animals. Our exploratory study supports further improvement of the RBD-based vaccine to prevent zoonotic spillover of MERS-CoV. info:eu-repo/semantics/publishedVersion
ZENODO; One Health O... arrow_drop_down NARCIS; Utrecht University RepositoryArticle . 2022One Health OutlookArticle . 2022Recolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2022License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s42522-022-00068-9&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 3 citations 3 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert ZENODO; One Health O... arrow_drop_down NARCIS; Utrecht University RepositoryArticle . 2022One Health OutlookArticle . 2022Recolector de Ciencia Abierta, RECOLECTA; Dipòsit Digital de Documents de la UABArticle . 2022License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s42522-022-00068-9&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Spain, United Kingdom, NetherlandsPublisher:Elsevier BV Allendorf, Valerie; Denzin, Nicolai; Conraths, Franz J; Boden, Lisa A; Elvinger, François; Magouras, Ioannis; Stegeman, Arjan; Wood, James L N; Urueña, Ana Carvajal; Grace, Katherine E F; Stärk, Katharina D C; FAH veterinaire epidemiologie; dFAH AVR; dFAH I&I;[EN]Due to the zoonotic origin of SARS-Coronavirus 2 (SARS-CoV-2), the potential for its transmission from humans back to animals and the possibility that it might establish ongoing infection pathways in other animal species has been discussed. Cats are highly susceptible to SARS-CoV-2 and were shown experimentally to transmit the virus to other cats. Infection of cats has been widely reported. Domestic cats in COVID-19-positive households could therefore be a part of a human to animal to human transmission pathway. Here, we report the results of a qualitative risk assessment focusing on the potential of cat to human transmission in such settings. The assessment was based on evidence available by October 2021. After the introduction of SARS-CoV-2 to a household by a human, cats may become infected and infected cats may pose an additional infection risk for other members of the household. In order to assess this additional risk qualitatively, expert opinion was elicited within the framework of a modified Delphi procedure. The conclusion was that the additional risk of infection of an additional person in a household associated with keeping a domestic cat is very low to negligible, depending on the intensity of cat-to-human interactions. The separation of cats from humans suffering from SARS-CoV-2 infection should contribute to preventing further transmission. SI This work was funded by the German Federal Ministry of Education and Research within the COVMon Project, being part of the InfectControl2020 Initiative (BMBF grant no. 03COV16D).
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.onehlt.2022.100381&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!visibility 8visibility views 8 download downloads 4 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.onehlt.2022.100381&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 United States, Netherlands, ItalyPublisher:SAGE Publications Funded by:UKRI | Future Energy & Trans..., UKRI | KELVIN: Computer Vision B...UKRI| Future Energy & Transport Tool ,UKRI| KELVIN: Computer Vision Based Biomarkers of Motor Dysfunction in Parkinson’s DiseaseAuthors: Padilla-Walker, Laura M.; Van der graaff, Jolien; Workman, Katey; Carlo, Gustavo; +16 AuthorsPadilla-Walker, Laura M.; Van der graaff, Jolien; Workman, Katey; Carlo, Gustavo; Branje, Susan; Carrizales, Alexia; Gerbino, Maria; Gülseven, Zehra; Hawk, Skyler T.; Luengo kanacri, Paula; Mesurado, Belén; Samper-García, Paula; Shen, Yuh-ling; Taylor, Laura K.; Trach, Jessica; Van zalk, Maarten H. W.; Žukauskienė, Rita; Leerstoel Branje; Adolescent development: Characteristics and determinants; Leerstoel Meeus;handle: 11573/1644444 , 1874/425572
Evidence suggests an impact of the COVID-19 pandemic on mental health, particularly among emerging adults. However, theories on altruism born of suffering or adversarial growth suggest that we might also see prosocial behavior as a function of the pandemic, which may protect against mental health challenges. Because cultural values are central in determining prosocial behavior, the current study explored how cultural values were differentially associated with adaptive prosocial behaviors that might protect against mental health challenges. Participants for the current study included 5,682 young people aged 18–25 years from 14 different countries around the world (68% female, 62% college students). Path analyses suggested that there were few differences in patterns as a function of culture, but revealed that horizontal individualism and horizontal and vertical collectivism were indirectly associated with lower levels of depression via prosocial behavior toward family members. Discussion focuses on the importance of coping by strengthening family relationships via prosocial behavior during the pandemic.
NARCIS; Utrecht Univ... arrow_drop_down NARCIS; Utrecht University RepositoryArticle . 2022Archivio della ricerca- Università di Roma La Sapienza; International Journal of Behavioral DevelopmentArticle . 2022 . Peer-reviewedLicense: SAGE TDMeScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of CaliforniaArchivio della ricerca- Università di Roma La SapienzaArticle . 2022Data sources: Archivio della ricerca- Università di Roma La Sapienzaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/01650254221084098&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert NARCIS; Utrecht Univ... arrow_drop_down NARCIS; Utrecht University RepositoryArticle . 2022Archivio della ricerca- Università di Roma La Sapienza; International Journal of Behavioral DevelopmentArticle . 2022 . Peer-reviewedLicense: SAGE TDMeScholarship - University of CaliforniaArticle . 2022Data sources: eScholarship - University of CaliforniaArchivio della ricerca- Università di Roma La SapienzaArticle . 2022Data sources: Archivio della ricerca- Università di Roma La Sapienzaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/01650254221084098&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 NetherlandsPublisher:Informa UK Limited Funded by:EC | ZAPIEC| ZAPIRodriguez-Conde, Sara; Inman, Sophie; Lindo, Viv; Amery, Leanne; Tang, Alison; Okorji-Obike, Uche; Du, Wenjuan; Bosch, Berend-Jan; Wichgers Schreur, Paul J; Kortekaas, Jeroen; Sola, Isabel; Enjuanes, Luis; Kerry, Laura; Mahal, Katharina; Hulley, Martyn; Daramola, Olalekan; Virologie; dI&I I&I-1; LS Infectiebiologie (Bacteriologie);Transgenic human monoclonal antibodies derived from humanized mice against different epitopes of the Middle East respiratory syndrome coronavirus (MERS-CoV), and chimeric llama-human bispecific heavy chain-only antibodies targeting the Rift Valley fever virus (RVFV), were produced using a CHO-based transient expression system. Two lead candidates were assessed for each model virus before selecting and progressing one lead molecule. MERS-7.7G6 was used as the model antibody to demonstrate batch-to-batch process consistency and, together with RVFV-107-104, were scaled up to 200 L. Consistent expression titers were obtained in different batches at a 5 L scale for MERS-7.7G6. Although lower expression levels were observed for MERS-7.7G6 and RVFV-107-104 during scale up to 200 L, product quality attributes were consistent at different scales and in different batches. In addition to this, peptide mapping data suggested no detectable sequence variants for any of these candidates. Functional assays demonstrated comparable neutralizing activity for MERS-7.7G6 and RVFV-107-104 generated at different production scales. Similarly, MERS-7.7G6 batches generated at different scales were shown to provide comparable protection in mouse models. Our study demonstrates that a CHO-based transient expression process is capable of generating consistent product quality at different production scales and thereby supports the potential of using transient gene expression to accelerate the manufacturing of early clinical material.
NARCIS; Utrecht Univ... arrow_drop_down NARCIS; Utrecht University RepositoryArticle . 2022NARCIS; Utrecht University RepositoryArticle . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/19420862.2022.2052228&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 3 citations 3 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert NARCIS; Utrecht Univ... arrow_drop_down NARCIS; Utrecht University RepositoryArticle . 2022NARCIS; Utrecht University RepositoryArticle . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/19420862.2022.2052228&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu