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56 research outcomes, page 1 of 6
  • publication . Article . Other literature type . 2021
    Open Access English
    Authors:
    Andrea Di Gioacchino; Petr Šulc; Anastassia V. Komarova; Benjamin D Greenbaum; Rémi Monasson; Simona Cocco;
    Publisher: Oxford University Press
    Project: NIH | Modulating anti-HIV immun... (7R01AI081848-04)

    SARS-CoV-2 infection can lead to acute respiratory syndrome in patients, which can be due in part to dysregulated immune signalling. We analyze here the occurrences of CpG dinucleotides, which are putative pathogen-associated molecular patterns, along the viral sequence...

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  • publication . Preprint . Other literature type . 2021
    Open Access English
    Authors:
    Arnaud Fontanet; Laura Tondeur; Yoann Madec; Rebecca Grant; Camille Besombes; Nathalie Jolly; Sandrine Fernandes Pellerin; Marie-Noëlle Ungeheuer; Isabelle Cailleau; Lucie Kuhmel; ...
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory
    Project: ANR | INCEPTION (ANR-16-CONV-0005)

    <jats:title>Summary</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>The Oise department in France has been heavily affected by COVID-19 in early 2020.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Between 30 March and 4 April 2020...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Gordon, David,; Hiatt, Joseph; Bouhaddou, Mehdi; Rezelj, Veronica,; Ulferts, Svenja; Braberg, Hannes; Jureka, Alexander,; Obernier, Kirsten; Guo, Jeffrey,; Batra, Jyoti; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: NIH | Development and Testing o... (5R35GM122481-02), UKRI | Elucidating the role of S... (BB/S009566/1), NIH | STRUCTURE AND FUNCTION OF... (5R01GM024485-12), NIH | Cytoscape: A Modeling Pla... (5R01HG009979-15), NIH | Structural Basis of Vesic... (1R01NS089713-01A1), UKRI | Understanding signalling ... (MC_UU_12016/2), NIH | Discovery of novel, ubiqu... (5R01AI120694-02), NIH | Gene Expression Profiling... (5P01AI063302-03), NIH | MEDICAL SCIENTIIST TRAINI... (5T32GM007618-27), NIH | Protein secretion in bact... (1R01AI128214-01A1)

    <jats:p>The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a grave threat to public health and the global economy. SARS-CoV-2 is closely related to the more lethal but less transmissible coronaviruses SARS-CoV-1 and Middle ...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Sterlin, Delphine; Mathian, Alexis; Miyara, Makoto; Mohr, Audrey; Anna, François; Claër, Laetitia; Quentric, Paul; Fadlallah, Jehane; Devilliers, Hervé; Ghillani, Pascale; ...
    Persistent Identifiers
    Publisher: American Association for the Advancement of Science (AAAS)

    Humoral immune responses are typically characterized by primary IgM antibody responses followed by secondary antibody responses associated with immune memory and composed of IgG, IgA, and IgE. Here, we measured acute humoral responses to SARS-CoV-2, including the freque...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Paul Bastard; Lindsey B. Rosen; Qian Zhang; Eleftherios Michailidis; Hans-Heinrich Hoffmann; Yu Zhang; Karim Dorgham; Quentin Philippot; Jérémie Rosain; Vivien Béziat; ...
    Publisher: HAL CCSD
    Project: NIH | Type I interferon-stimula... (5R01AI091707-05), ANR | IFN-COVID19 (ANR-20-COVI-0064), NIH | Yale Center for Mendelian... (5UM1HG006504-07), NIH | Modulation of Human Dendr... (5U19AI111825-02), NIH | Inborn errors of immunity... (5R01AI088364-07), NIH | Developing, Demonstrating... (5UL1TR001866-03), NIH | NHGRI Genome Sequencing P... (5U24HG008956-02)

    In a large immunological and genomics study of COVID-19 patients, autoantibodies to type 1 interferons correlated with outcomes.

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  • publication . Article . 2020
    Open Access English
    Authors:
    Kim, Dae-Kyum; Knapp, Jennifer J.; Kuang, Da; Chawla, Aditya; Cassonnet, Patricia; Lee, Hunsang; Sheykhkarimli, Dayag; Samavarchi-Tehrani, Payman; Abdouni, Hala; Rayhan, Ashyad; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: CIHR , EC | PREPARE (602525)

    International audience; The world is facing a global pandemic of COVID-19 caused by the SARS-CoV-2 coronavirus. Here we describe a collection of codon-optimized coding sequences for SARS-CoV-2 cloned into Gateway-compatible entry vectors, which enable rapid transfer int...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Mavian, Carla; Pond, Sergei Kosakovsky; Marini, Simone; Magalis, Brittany Rife; Vandamme, Anne-Mieke; Dellicour, Simon; Scarpino, Samuel V; Houldcroft, Charlotte; Villabona-Arenas, Julian; Paisie, Taylor K; ...
    Publisher: National Academy of Sciences
    Project: NIH | HIV Dynamic Modelling for... (1R21AI138815-01)

    NA

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  • publication . Article . Other literature type . 2020
    Open Access English
    Authors:
    Sophie Vichier-Guerre; Therese C. Ku; Sylvie Pochet; Katherine L. Seley-Radtke;
    Publisher: HAL CCSD
    Project: NIH | A Flexible Approach to In... (5R21AI118470-02)

    Abstract The structurally unique “fleximer” nucleosides were originally designed to investigate how flexibility in a nucleobase could potentially affect receptor–ligand recognition and function. Recently they have been shown to have low‐to‐sub‐micromolar levels of activ...

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  • publication . Article . Preprint . 2020
    Open Access English
    Authors:
    Crawford, Katharine H.D.; Eguia, Rachel; Dingens, Adam S.; Loes, Andrea N.; Malone, Keara D.; Wolf, Caitlin R.; Chu, Helen Y.; Tortorici, M. Alejandra; Veesler, David; Murphy, Michael; ...
    Persistent Identifiers
    Publisher: MDPI AG
    Project: NIH | Engineering Humoral Immun... (1DP2DA040254-01), NIH | Structural Studies of Cor... (5R01GM120553-03), NIH | Prospectively characteriz... (1R01AI141707-01)

    International audience; SARS-CoV-2 enters cells using its Spike protein, which is also the main target of neutralizing antibodies. Therefore, assays to measure how antibodies and sera affect Spike-mediated viral infection are important for studying immunity. Because SAR...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Zhang, Yifeng; Thery, Fabien; Wu, Nicholas C.; Luhmann, Emma K.; Dussurget, Olivier; Foecke, Mariko; Bredow, Clara; Jiménez-Fernández, Daniel; Leandro, Kevin; Beling, Antje; ...
    Project: EC | BacCellEpi (670823)

    ISG15 is a ubiquitin-like modifier that can be upregulated in response to bacterial infections. Here, the authors use proteomics to identify endogenous ISGylation substrates in the liver of Listeria monocytogenes infected mice and show that ISGylation alters basal and i...

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56 research outcomes, page 1 of 6