Background: Updatable understanding of the onset and progression of individuals COVID-19 trajectories underpins pandemic mitigation efforts. In order to identify and characterise individual trajectories, we defined and validated ten COVID-19 phenotypes from linked elect...

The involvement of immunoglobulin (Ig) G3 in the humoral immune response to SARS-CoV-2 infection has been implicated in the pathogenesis of acute respiratory distress syndrome (ARDS) in COVID-19. The exact molecular mechanism is unknown, but it is thought to involve thi...

As COVID-19 vaccinations became available and were proven effective in preventing serious infection, uptake amongst individuals varied, including in medically vulnerable populations. This cross-sectional multi-site study examined vaccine uptake, hesitancy, and explanato...

PURPOSE: To accommodate the unprecedented number of critically ill patients with pneumonia caused by coronavirus disease 2019 (COVID-19) expansion of the capacity of intensive care unit (ICU) to clinical areas not previously used for critical care was necessary. We desc...

People experiencing homelessness in the UK were unexpectedly and unconditionally offered housing (and support) from the beginning of the first lockdown in March 2020. For many, that meant ‘(re)entering’ the support system and having a chance to ‘move on’ to longer-term ...

Ventilation plays a noteworthy role in maintaining a healthy, comfortable and energy-efficient indoor environment and mitigating the risk of aerosol transmission and disease infection (e.g., SARS-COV-2). In most commercial and office buildings, demand-controlled ventila...

The UK NHS responded to the COVID-19 pandemic from early 2020 by focusing all, bar indispensable services, on pandemic management. There are numerous reports of the adverse impact this diversion of resources has had on various health services, including cancer care. The...

When comparing the risk of a post-infection binary outcome, e.g. hospitalisation, for two variants of an infectious pathogen, it is important to adjust for calendar time of infection. Typically infection time is unknown and positive test time used as a proxy for it. Pos...

In response to disruption to education during the Covid-19 pandemic, mobile phone-based messaging has emerged in some instances as an accessible, low-connectivity way of promoting interactivity. However, no recent reviews have been undertaken in relation to how social m...

OBJECTIVES: To evaluate the persistence of immunogenicity three months after third dose boosters. METHODS: COV-BOOST is a multicentre, randomised, controlled, phase 2 trial of seven COVID-19 vaccines used as a third booster dose. The analysis was conducted using all ran...