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description Publicationkeyboard_double_arrow_right Article 2023 NetherlandsPublisher:Springer Science and Business Media LLC Authors: Atmowihardjo, Leila N.; Schippers, Job R.; Duijvelaar, Erik; Bartelink, Imke H.; +18 AuthorsAtmowihardjo, Leila N.; Schippers, Job R.; Duijvelaar, Erik; Bartelink, Imke H.; Bet, Pierre M.; Swart, Noortje E.L.; van Rein, Nienke; Purdy, Keith; Cavalla, David; McElroy, Andrew; Fritchley, Sarah; Vonk Noordegraaf, Anton; Endeman, Henrik; van Velzen, Patricia; Koopmans, Matty; Bogaard, Harm Jan; Heunks, Leo; Juffermans, Nicole; Schultz, Marcus J.; Tuinman, Pieter R.; Bos, Lieuwe D.J.; Aman, Jurjan;Abstract Purpose A hallmark of acute respiratory distress syndrome (ARDS) is hypoxaemic respiratory failure due to pulmonary vascular hyperpermeability. The tyrosine kinase inhibitor imatinib reversed pulmonary capillary leak in preclinical studies and improved clinical outcomes in hospitalized COVID-19 patients. We investigated the effect of intravenous (IV) imatinib on pulmonary edema in COVID-19 ARDS. Methods This was a multicenter, randomized, double-blind, placebo-controlled trial. Invasively ventilated patients with moderate-to-severe COVID-19 ARDS were randomized to 200 mg IV imatinib or placebo twice daily for a maximum of seven days. The primary outcome was the change in extravascular lung water index (∆EVLWi) between days 1 and 4. Secondary outcomes included safety, duration of invasive ventilation, ventilator-free days (VFD) and 28-day mortality. Posthoc analyses were performed in previously identified biological subphenotypes. Results 66 patients were randomized to imatinib (n = 33) or placebo (n = 33). There was no difference in ∆EVLWi between the groups (0.19 ml/kg, 95% CI − 3.16 to 2.77, p = 0.89). Imatinib treatment did not affect duration of invasive ventilation (p = 0.29), VFD (p = 0.29) or 28-day mortality (p = 0.79). IV imatinib was well-tolerated and appeared safe. In a subgroup of patients characterized by high IL-6, TNFR1 and SP-D levels (n = 20), imatinib significantly decreased EVLWi per treatment day (− 1.17 ml/kg, 95% CI − 1.87 to − 0.44). Conclusions IV imatinib did not reduce pulmonary edema or improve clinical outcomes in invasively ventilated COVID-19 patients. While this trial does not support the use of imatinib in the general COVID-19 ARDS population, imatinib reduced pulmonary edema in a subgroup of patients, underscoring the potential value of predictive enrichment in ARDS trials. Trial registrationNCT04794088, registered 11 March 2021. European Clinical Trials Database (EudraCT number: 2020-005447-23).
NARCIS arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert NARCIS arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13054-023-04516-4&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2023Publisher:Research Square Platform LLC de Beaufort, Eloïse; Carteaux, Guillaume; Morin, François; Lesimple, Arnaud; Haudebourg, Anne-Fleur; Fresnel, Emeline; Duval, Damien; Broc, Alexandre; Mercat, Alain; Brochard, Laurent; Savary, Dominique; Beloncle, François; Mekontso Dessap, Armand; Richard, Jean-Christophe;Abstract Background Several noninvasive ventilatory supports rely in their design on high oxygen consumption which may precipitate oxygen shortage, as experienced during the COVID-19 pandemic. In this bench-to-bedside study, we assessed the performance of a new continuous positive airway pressure (CPAP) device integrating a large reservoir (“Bag-CPAP”) designed to minimize oxygen consumption, and compared it with other CPAP devices. Methods First, a bench study compared the performances of Bag-CPAP and four CPAP devices with an intensive care unit ventilator. Two FiO2 targets (40–60% and 80–100%) at a predefined positive end expiratory pressure (PEEP) level between 5 and 10 cm H2O were tested and fraction of inspired oxygen (FiO2) and oxygen consumption were measured. Device-imposed work of breathing (WOB) was also evaluated. Second, an observational clinical study evaluated the new CPAP in 20 adult patients with acute respiratory failure in two hospitals in France. Actual FiO2, PEEP, peripheral oxygen saturation, respiratory rate, and dyspnea score were assessed. Results All six systems tested in the bench study reached the minimal FiO2 target of 40% and four reached at least 80% FiO2 while maintaining PEEP in the predefined range. Device-delivered FiO2/consumed oxygen ratio was the highest with the new reservoir-based CPAP irrespective of FiO2 target. WOB induced by the device was higher with Bag-CPAP. In the clinical study, Bag-CPAP was well tolerated and could reach high (> 90%) and moderate (> 50%) FiO2 with an oxygen flow rate of 15 [15–16] and 8 [7–9] L/min, respectively. Dyspnea score improved significantly after introduction of Bag-CPAP, and SpO2 increased. Conclusions In vitro, Bag-CPAP exhibited the highest oxygen saving properties albeit had increased WOB. It was well accepted clinically and reduced dyspnea. Bag-CPAP may be useful to treat patients with acute respiratory failure in the field, especially when facing constraints in oxygen delivery.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 2 citations 2 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023Publisher:Springer Science and Business Media LLC Funded by:WTWTLucia Gandini; Gabriele Fior; Andreas Schibler; Nchafatso G. Obonyo; Gianluigi Li Bassi; Jacky Y. Suen; John F. Fraser;add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13054-023-04394-w&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13054-023-04394-w&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023Publisher:Springer Science and Business Media LLC Funded by:NIH | Viral adaptation to CD4 T..., NIH | Neutrophil Exosomes: New ..., NIH | Sex Differences in the Ro... +1 projectsNIH| Viral adaptation to CD4 T cell responses and the impact on HIV immunity ,NIH| Neutrophil Exosomes: New Pathogenic Entities in COPD ,NIH| Sex Differences in the Role of Hydrogen Sulfide in Alzheimer's Disease ,NIH| Mechanisms driving endothelial angiopoietin-2 expression and vascular dysfunction during pediatric sepsisAuthors: Michael John Patton; Carlos J. Orihuela; Kevin S. Harrod; Mohammad A. N. Bhuiyan; +12 AuthorsMichael John Patton; Carlos J. Orihuela; Kevin S. Harrod; Mohammad A. N. Bhuiyan; Paari Dominic; Christopher G. Kevil; Daniel Fort; Vincent X. Liu; Maha Farhat; Jonathan L. Koff; Charitharth V. Lal; Anuj Gaggar; Robert P. Richter; Nathaniel Erdmann; Matthew Might; Amit Gaggar;Abstract Background Recent single-center reports have suggested that community-acquired bacteremic co-infection in the context of Coronavirus disease 2019 (COVID-19) may be an important driver of mortality; however, these reports have not been validated with a multicenter, demographically diverse, cohort study with data spanning the pandemic. Methods In this multicenter, retrospective cohort study, inpatient encounters were assessed for COVID-19 with community-acquired bacteremic co-infection using 48-h post-admission blood cultures and grouped by: (1) confirmed co-infection [recovery of bacterial pathogen], (2) suspected co-infection [negative culture with ≥ 2 antimicrobials administered], and (3) no evidence of co-infection [no culture]. The primary outcomes were in-hospital mortality, ICU admission, and mechanical ventilation. COVID-19 bacterial co-infection risk factors and impact on primary outcomes were determined using multivariate logistic regressions and expressed as adjusted odds ratios with 95% confidence intervals (Cohort, OR 95% CI, Wald test p value). Results The studied cohorts included 13,781 COVID-19 inpatient encounters from 2020 to 2022 in the University of Alabama at Birmingham (UAB, n = 4075) and Ochsner Louisiana State University Health—Shreveport (OLHS, n = 9706) cohorts with confirmed (2.5%), suspected (46%), or no community-acquired bacterial co-infection (51.5%) and a comparison cohort consisting of 99,170 inpatient encounters from 2010 to 2019 (UAB pre-COVID-19 pandemic cohort). Significantly increased likelihood of COVID-19 bacterial co-infection was observed in patients with elevated ≥ 15 neutrophil-to-lymphocyte ratio (UAB: 1.95 [1.21–3.07]; OLHS: 3.65 [2.66–5.05], p < 0.001 for both) within 48-h of hospital admission. Bacterial co-infection was found to confer the greatest increased risk for in-hospital mortality (UAB: 3.07 [2.42–5.46]; OLHS: 4.05 [2.29–6.97], p < 0.001 for both), ICU admission (UAB: 4.47 [2.87–7.09], OLHS: 2.65 [2.00–3.48], p < 0.001 for both), and mechanical ventilation (UAB: 3.84 [2.21–6.12]; OLHS: 2.75 [1.87–3.92], p < 0.001 for both) across both cohorts, as compared to other risk factors for severe disease. Observed mortality in COVID-19 bacterial co-infection (24%) dramatically exceeds the mortality rate associated with community-acquired bacteremia in pre-COVID-19 pandemic inpatients (5.9%) and was consistent across alpha, delta, and omicron SARS-CoV-2 variants. Conclusions Elevated neutrophil-to-lymphocyte ratio is a prognostic indicator of COVID-19 bacterial co-infection within 48-h of admission. Community-acquired bacterial co-infection, as defined by blood culture-positive results, confers greater increased risk of in-hospital mortality, ICU admission, and mechanical ventilation than previously described risk factors (advanced age, select comorbidities, male sex) for COVID-19 mortality, and is independent of SARS-CoV-2 variant.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 27 citations 27 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13054-023-04312-0&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 United Kingdom, NetherlandsPublisher:Springer Science and Business Media LLC Filippini, DFL; Di Gennaro, E; van Amstel, RBE; Beenen, LFM; Grasso, S; Pisani, L; Bos, LDJ; Smit, MR;Abstract Background Patients with COVID-19-related acute respiratory distress syndrome (ARDS) require respiratory support with invasive mechanical ventilation and show varying responses to recruitment manoeuvres. In patients with ARDS not related to COVID-19, two pulmonary subphenotypes that differed in recruitability were identified using latent class analysis (LCA) of imaging and clinical respiratory parameters. We aimed to evaluate if similar subphenotypes are present in patients with COVID-19-related ARDS. Methods This is the retrospective analysis of mechanically ventilated patients with COVID-19-related ARDS who underwent CT scans at positive end-expiratory pressure of 10 cmH2O and after a recruitment manoeuvre at 20 cmH2O. LCA was applied to quantitative CT-derived parameters, clinical respiratory parameters, blood gas analysis and routine laboratory values before recruitment to identify subphenotypes. Results 99 patients were included. Using 12 variables, a two-class LCA model was identified as best fitting. Subphenotype 2 (recruitable) was characterized by a lower PaO2/FiO2, lower normally aerated lung volume and lower compliance as opposed to a higher non-aerated lung mass and higher mechanical power when compared to subphenotype 1 (non-recruitable). Patients with subphenotype 2 had more decrease in non-aerated lung mass in response to a standardized recruitment manoeuvre (p = 0.024) and were mechanically ventilated longer until successful extubation (adjusted SHR 0.46, 95% CI 0.23–0.91, p = 0.026), while no difference in survival was found (p = 0.814). Conclusions A recruitable and non-recruitable subphenotype were identified in patients with COVID-19-related ARDS. These findings are in line with previous studies in non-COVID-19-related ARDS and suggest that a combination of imaging and clinical respiratory parameters could facilitate the identification of recruitable lungs before the manoeuvre.
Critical Care arrow_drop_down Oxford University Research ArchiveArticle . 2023License: CC BYData sources: Oxford University Research Archiveadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13054-022-04251-2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 6 citations 6 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 4visibility views 4 Powered bymore_vert Critical Care arrow_drop_down Oxford University Research ArchiveArticle . 2023License: CC BYData sources: Oxford University Research Archiveadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13054-022-04251-2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2022 United Kingdom, BelgiumPublisher:Research Square Platform LLC Joanne McPeake; Nancy Kentish-Barnes; Emilie Banse; Lynne Anderson; Cecilia Cuzco; Elie Azoulay; Tara Quasim; Pedro Castro; Kathryn Puxty;PURPOSE: To guarantee the safety of the public, clinicians and patients during the COVID-19 pandemic, hospital visits were severely restricted internationally. There are limited data on the precise impact of these visiting restrictions on Intensive Care Unit clinicians. Our objectives therefore were to explore the impact of family visitation restrictions on clinicians and care delivery and describe innovation alongside areas for potential improvement. METHODS: A qualitative approach using focus groups was employed. We recruited members of the multi-disciplinary team from Spain, France and the UK. Framework analysis was used to synthesize and interpret data. RESULTS: In total, 28 staff from multiple international sites contributed to data across six focus groups: 12 from the UK, 9 from France and 7 from Spain. In relation to the key aims, we derived four themes: the emergence of new technologies, relationships and rapport establishment, communication challenges and end-of-life care provision. Across each theme, the overarching concepts of clinician emotional exhaustion and emotional distress emerged alongside the negative impact on job satisfaction. CONCLUSION: The impact of COVID-19 family visitation restrictions is far reaching. Future research should examine the wider impact of family presence in the ICU. Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.21203/rs.3.rs-2222776/v1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 6visibility views 6 download downloads 5 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.21203/rs.3.rs-2222776/v1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Italy, Italy, Belgium, Italy, United Kingdom, TurkeyPublisher:Springer Science and Business Media LLC Funded by:SNSF | Epidemiology and determin..., UKRI | 'Mechanisms of impaired n...SNSF| Epidemiology and determinants of catheter-related and hospital-acquired bloodstream infections: from a large university hospital to a global picture ,UKRI| 'Mechanisms of impaired neutrophil phagosome maturation and its impact on invasive bacterial infectionsBuetti, Niccolò; Tabah, Alexis; Loiodice, Ambre; Ruckly, Stéphane; Aslan, Abdullah Tarik; Montrucchio, Giorgia; Cortegiani, Andrea; Saltoglu, Nese; Kayaaslan, Bircan; Aksoy, Firdevs; Murat, Akova; Akdoğan, Özlem; Saracoglu, Kemal Tolga; Erdogan, Cem; Leone, Marc; Ferrer, Ricard; Paiva, José-Artur; Hayashi, Yoshiro; Ramanan, Mahesh; Conway Morris, Andrew; Barbier, François; Timsit, Jean-François; Jeffrey, Lipman; Edward, Litton; Anna Maria, Palermo; Timothy, Yap; Ege Eroglu; Koji Hosokawa; Hideki Yoshida; Shigeki Fujitani; Farid Zand; Ata Mahmoodpoor; Seyed Mohammad Nasirodin Tabatabaei; Omar Elrabi; Ghaleb A Almekhlafi; Gabriela Vidal; Marta Aparicio; Irene Alonzo; Silvio A Namendys-Silva; Mariana Hermosillo; Roberto Alejandro Castillo; Liesbet De Bus; Jan De Waele; Isabelle Hollevoet; Nicolas De Schryver; Nicolas Serck; Pedja Kovacevic; Biljana Zlojutro; Etienne Ruppe; Philippe Montravers; Thierry Dulac; Jérémy Castanera; Alexandre Massri; Charlotte Guesdon; Pierre Garcon; Matthieu Duprey; François Philippart; Marc Tran; Cédric Bruel; Pierre Kalfon; Gaëtan Badre; Sophie Demeret; Loïc Le Guennec; Matteo Bassetti; Daniele Giacobbe; Gabriele Sales; Ivan Daroui; Giovanni Lodi; Mariachiara Ippolito; Davide Bellina; Andrea Di Guardo; Monica Rocco; Silvia Fiorelli; Adam Mikstacki; Mariusz Peichota; Iwona Pietraszek-Grzywaczewska; Pedro Póvoa; Andriy Krystopchuk; Ana Teresa; António Manuel Pereira de Figueiredo; Isabel Botelho; Vasco Costa; Rui Pedro Cunha; Alexey Gritsan; Vladislav Belskiy; Mikhail Furman; Maria Martinez; Vanessa Casares; Maria Pilar Gracia Arnillas; Rosana Munoz Bermudez; Alejandro Ubeda; Maria Salgado; Emilio Maseda; Alejandro Suarez De La Rica; Miguel Angel Blasco-Navalpotro; Alberto Orejas Gallego; Josef Prazak; J L Pagani; S Abed-Maillard; Arzu Topeli Iskit; Selcuk Mehtap; Solakoğlu Ceyhun; Ayşe Kaya Kalem; Ibrahim Kurt; Murat Telli; Barcin Ozturk; Nurcan Baykam; Ridvan Karaali; Iftihar Koksal; Yeliz Bilir; Seda Guzeldag; Gulden Ersoz; Guliz Evik; Yasar Bayindir; Yasemin Ersoy; Ari Ercole; Ashok Raj; Artemis Zormpa; George Tinaslanidis; Reena Khade; Ashraf Roshdy; Santhana Kannan; Supriya Antrolikar; Nicholas Marsden; Ben Attwood; Jamie Patel; Mohan Gurjar; Carol Dsilva; Jagadish Chandran; Bashir El Sanousi; Elfayadh Saidahmed; Hytham K S Hamid;pmid: 36258239
pmc: PMC9578203
Abstract Background The study aimed to describe the epidemiology and outcomes of hospital-acquired bloodstream infections (HABSIs) between COVID-19 and non-COVID-19 critically ill patients. Methods We used data from the Eurobact II study, a prospective observational multicontinental cohort study on HABSI treated in ICU. For the current analysis, we selected centers that included both COVID-19 and non-COVID-19 critically ill patients. We performed descriptive statistics between COVID-19 and non-COVID-19 in terms of patients’ characteristics, source of infection and microorganism distribution. We studied the association between COVID-19 status and mortality using multivariable fragility Cox models. Results A total of 53 centers from 19 countries over the 5 continents were eligible. Overall, 829 patients (median age 65 years [IQR 55; 74]; male, n = 538 [64.9%]) were treated for a HABSI. Included patients comprised 252 (30.4%) COVID-19 and 577 (69.6%) non-COVID-19 patients. The time interval between hospital admission and HABSI was similar between both groups. Respiratory sources (40.1 vs. 26.0%, p < 0.0001) and primary HABSI (25.4% vs. 17.2%, p = 0.006) were more frequent in COVID-19 patients. COVID-19 patients had more often enterococcal (20.5% vs. 9%) and Acinetobacter spp. (18.8% vs. 13.6%) HABSIs. Bacteremic COVID-19 patients had an increased mortality hazard ratio (HR) versus non-COVID-19 patients (HR 1.91, 95% CI 1.49–2.45). Conclusions We showed that the epidemiology of HABSI differed between COVID-19 and non-COVID-19 patients. Enterococcal HABSI predominated in COVID-19 patients. COVID-19 patients with HABSI had elevated risk of mortality. Trial registration ClinicalTrials.org number NCT03937245. Registered 3 May 2019. Funder: Norva Dahlia foundation and the Redcliffe Hospital Private Practice Trust Fund Funder: European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Funder: European society of Intensive Care Medicine
Apollo arrow_drop_down Archivio della ricerca- Università di Roma La Sapienza; Critical Care; Ghent University Academic BibliographyArticle . 2022 . Peer-reviewedLicense: CC BYİstanbul Medipol University Institutional RepositoryArticle . 2022Data sources: İstanbul Medipol University Institutional RepositoryGhent University Academic BibliographyArticle . 2022Data sources: Ghent University Academic BibliographyArchivio Istituzionale (AperTO); Archivio IstituzionaleArticle . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13054-022-04166-y&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 18 citations 18 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 150visibility views 150 download downloads 70 Powered bymore_vert Apollo arrow_drop_down Archivio della ricerca- Università di Roma La Sapienza; Critical Care; Ghent University Academic BibliographyArticle . 2022 . Peer-reviewedLicense: CC BYİstanbul Medipol University Institutional RepositoryArticle . 2022Data sources: İstanbul Medipol University Institutional RepositoryGhent University Academic BibliographyArticle . 2022Data sources: Ghent University Academic BibliographyArchivio Istituzionale (AperTO); Archivio IstituzionaleArticle . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13054-022-04166-y&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 NetherlandsPublisher:Springer Science and Business Media LLC Jean-Louis, Vincent; Carole, Boulanger; Margo M C, van Mol; Laura, Hawryluck; Elie, Azoulay;AbstractShortage of nurses on the ICU is not a new phenomenon, but has been exacerbated by the COVID-19 pandemic. The underlying reasons are relatively well-recognized, and include excessive workload, moral distress, and perception of inappropriate care, leading to burnout and increased intent to leave, setting up a vicious circle whereby fewer nurses result in increased pressure and stress on those remaining. Nursing shortages impact patient care and quality-of-work life for all ICU staff and efforts should be made by management, nurse leaders, and ICU clinicians to understand and ameliorate the factors that lead nurses to leave. Here, we highlight 10 broad areas that ICU clinicians should be aware of that may improve quality of work-life and thus potentially help with critical care nurse retention.
NARCIS arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13054-022-04182-y&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert NARCIS arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 United KingdomPublisher:Springer Science and Business Media LLC Authors: Al Sulaiman, Khalid; Korayem, Ghazwa B.; Altebainawi, Ali F.; Al Harbi, Shmeylan; +25 AuthorsAl Sulaiman, Khalid; Korayem, Ghazwa B.; Altebainawi, Ali F.; Al Harbi, Shmeylan; Alissa, Abdulrahman; Alharthi, Abdullah; Kensara, Raed; Alfahed, Amjaad; Vishwakarma, Ramesh; Al Haji, Hussain; Almohaimid, Naif; Al Zumai, Omar; Alrubayan, Fahad; Asiri, Abdulmajid; Alkahtani, Nasser; Alolayan, Abdulaziz; Alsohimi, Samiah; Melibari, Nawal; Almagthali, Alaa; Aljahdali, Seba; Alenazi, Abeer A.; Alsaeedi, Alawi S.; Al Ghamdi, Ghassan; Al Faris, Omar; Alqahtani, Joud; Al Qahtani, Jalal; Alshammari, Khalid A.; Alshammari, Khalil I.; Aljuhani, Ohoud;Abstract Background Inhaled nitric oxide (iNO) is used as rescue therapy in patients with refractory hypoxemia due to severe COVID-19 acute respiratory distress syndrome (ARDS) despite the recommendation against the use of this treatment. To date, the effect of iNO on the clinical outcomes of critically ill COVID-19 patients with moderate-to-severe ARDS remains arguable. Therefore, this study aimed to evaluate the use of iNO in critically ill COVID-19 patients with moderate-to-severe ARDS. Methods This multicenter, retrospective cohort study included critically ill adult patients with confirmed COVID-19 treated from March 01, 2020, until July 31, 2021. Eligible patients with moderate-to-severe ARDS were subsequently categorized into two groups based on inhaled nitric oxide (iNO) use throughout their ICU stay. The primary endpoint was the improvement in oxygenation parameters 24 h after iNO use. Other outcomes were considered secondary. Propensity score matching (1:2) was used based on the predefined criteria. Results A total of 1598 patients were screened, and 815 were included based on the eligibility criteria. Among them, 210 patients were matched based on predefined criteria. Oxygenation parameters (PaO2, FiO2 requirement, P/F ratio, oxygenation index) were significantly improved 24 h after iNO administration within a median of six days of ICU admission. However, the risk of 30-day and in-hospital mortality were found to be similar between the two groups (HR: 1.18; 95% CI: 0.77, 1.82; p = 0.45 and HR: 1.40; 95% CI: 0.94, 2.11; p= 0.10, respectively). On the other hand, ventilator-free days (VFDs) were significantly fewer, and ICU and hospital LOS were significantly longer in the iNO group. In addition, patients who received iNO had higher odds of acute kidney injury (AKI) (OR (95% CI): 2.35 (1.30, 4.26), p value = 0.005) and hospital/ventilator-acquired pneumonia (OR (95% CI): 3.2 (1.76, 5.83), p value = 0.001). Conclusion In critically ill COVID-19 patients with moderate-to-severe ARDS, iNO rescue therapy is associated with improved oxygenation parameters but no mortality benefits. Moreover, iNO use is associated with higher odds of AKI, pneumonia, longer LOS, and fewer VFDs.
University of East A... arrow_drop_down University of East Anglia digital repositoryArticle . 2022 . Peer-reviewedData sources: University of East Anglia digital repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 17 citations 17 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 9visibility views 9 download downloads 1 Powered bymore_vert University of East A... arrow_drop_down University of East Anglia digital repositoryArticle . 2022 . Peer-reviewedData sources: University of East Anglia digital repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 United KingdomPublisher:Springer Science and Business Media LLC Victoria, Stokes; Kwee Yen, Goh; Graham, Whiting; Sebastian, Bates; Hannah, Greenlee; Anthony, Wilson; Alexander J, Parker;Critical Care arrow_drop_down The University of Manchester - Institutional Repository; Critical CareArticle . 2022 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13054-022-04144-4&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Critical Care arrow_drop_down The University of Manchester - Institutional Repository; Critical CareArticle . 2022 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article 2023 NetherlandsPublisher:Springer Science and Business Media LLC Authors: Atmowihardjo, Leila N.; Schippers, Job R.; Duijvelaar, Erik; Bartelink, Imke H.; +18 AuthorsAtmowihardjo, Leila N.; Schippers, Job R.; Duijvelaar, Erik; Bartelink, Imke H.; Bet, Pierre M.; Swart, Noortje E.L.; van Rein, Nienke; Purdy, Keith; Cavalla, David; McElroy, Andrew; Fritchley, Sarah; Vonk Noordegraaf, Anton; Endeman, Henrik; van Velzen, Patricia; Koopmans, Matty; Bogaard, Harm Jan; Heunks, Leo; Juffermans, Nicole; Schultz, Marcus J.; Tuinman, Pieter R.; Bos, Lieuwe D.J.; Aman, Jurjan;Abstract Purpose A hallmark of acute respiratory distress syndrome (ARDS) is hypoxaemic respiratory failure due to pulmonary vascular hyperpermeability. The tyrosine kinase inhibitor imatinib reversed pulmonary capillary leak in preclinical studies and improved clinical outcomes in hospitalized COVID-19 patients. We investigated the effect of intravenous (IV) imatinib on pulmonary edema in COVID-19 ARDS. Methods This was a multicenter, randomized, double-blind, placebo-controlled trial. Invasively ventilated patients with moderate-to-severe COVID-19 ARDS were randomized to 200 mg IV imatinib or placebo twice daily for a maximum of seven days. The primary outcome was the change in extravascular lung water index (∆EVLWi) between days 1 and 4. Secondary outcomes included safety, duration of invasive ventilation, ventilator-free days (VFD) and 28-day mortality. Posthoc analyses were performed in previously identified biological subphenotypes. Results 66 patients were randomized to imatinib (n = 33) or placebo (n = 33). There was no difference in ∆EVLWi between the groups (0.19 ml/kg, 95% CI − 3.16 to 2.77, p = 0.89). Imatinib treatment did not affect duration of invasive ventilation (p = 0.29), VFD (p = 0.29) or 28-day mortality (p = 0.79). IV imatinib was well-tolerated and appeared safe. In a subgroup of patients characterized by high IL-6, TNFR1 and SP-D levels (n = 20), imatinib significantly decreased EVLWi per treatment day (− 1.17 ml/kg, 95% CI − 1.87 to − 0.44). Conclusions IV imatinib did not reduce pulmonary edema or improve clinical outcomes in invasively ventilated COVID-19 patients. While this trial does not support the use of imatinib in the general COVID-19 ARDS population, imatinib reduced pulmonary edema in a subgroup of patients, underscoring the potential value of predictive enrichment in ARDS trials. Trial registrationNCT04794088, registered 11 March 2021. European Clinical Trials Database (EudraCT number: 2020-005447-23).
NARCIS arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert NARCIS arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13054-023-04516-4&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2023Publisher:Research Square Platform LLC de Beaufort, Eloïse; Carteaux, Guillaume; Morin, François; Lesimple, Arnaud; Haudebourg, Anne-Fleur; Fresnel, Emeline; Duval, Damien; Broc, Alexandre; Mercat, Alain; Brochard, Laurent; Savary, Dominique; Beloncle, François; Mekontso Dessap, Armand; Richard, Jean-Christophe;Abstract Background Several noninvasive ventilatory supports rely in their design on high oxygen consumption which may precipitate oxygen shortage, as experienced during the COVID-19 pandemic. In this bench-to-bedside study, we assessed the performance of a new continuous positive airway pressure (CPAP) device integrating a large reservoir (“Bag-CPAP”) designed to minimize oxygen consumption, and compared it with other CPAP devices. Methods First, a bench study compared the performances of Bag-CPAP and four CPAP devices with an intensive care unit ventilator. Two FiO2 targets (40–60% and 80–100%) at a predefined positive end expiratory pressure (PEEP) level between 5 and 10 cm H2O were tested and fraction of inspired oxygen (FiO2) and oxygen consumption were measured. Device-imposed work of breathing (WOB) was also evaluated. Second, an observational clinical study evaluated the new CPAP in 20 adult patients with acute respiratory failure in two hospitals in France. Actual FiO2, PEEP, peripheral oxygen saturation, respiratory rate, and dyspnea score were assessed. Results All six systems tested in the bench study reached the minimal FiO2 target of 40% and four reached at least 80% FiO2 while maintaining PEEP in the predefined range. Device-delivered FiO2/consumed oxygen ratio was the highest with the new reservoir-based CPAP irrespective of FiO2 target. WOB induced by the device was higher with Bag-CPAP. In the clinical study, Bag-CPAP was well tolerated and could reach high (> 90%) and moderate (> 50%) FiO2 with an oxygen flow rate of 15 [15–16] and 8 [7–9] L/min, respectively. Dyspnea score improved significantly after introduction of Bag-CPAP, and SpO2 increased. Conclusions In vitro, Bag-CPAP exhibited the highest oxygen saving properties albeit had increased WOB. It was well accepted clinically and reduced dyspnea. Bag-CPAP may be useful to treat patients with acute respiratory failure in the field, especially when facing constraints in oxygen delivery.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.21203/rs.3.rs-2790211/v1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 2 citations 2 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.21203/rs.3.rs-2790211/v1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023Publisher:Springer Science and Business Media LLC Funded by:WTWTLucia Gandini; Gabriele Fior; Andreas Schibler; Nchafatso G. Obonyo; Gianluigi Li Bassi; Jacky Y. Suen; John F. Fraser;add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13054-023-04394-w&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13054-023-04394-w&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023Publisher:Springer Science and Business Media LLC Funded by:NIH | Viral adaptation to CD4 T..., NIH | Neutrophil Exosomes: New ..., NIH | Sex Differences in the Ro... +1 projectsNIH| Viral adaptation to CD4 T cell responses and the impact on HIV immunity ,NIH| Neutrophil Exosomes: New Pathogenic Entities in COPD ,NIH| Sex Differences in the Role of Hydrogen Sulfide in Alzheimer's Disease ,NIH| Mechanisms driving endothelial angiopoietin-2 expression and vascular dysfunction during pediatric sepsisAuthors: Michael John Patton; Carlos J. Orihuela; Kevin S. Harrod; Mohammad A. N. Bhuiyan; +12 AuthorsMichael John Patton; Carlos J. Orihuela; Kevin S. Harrod; Mohammad A. N. Bhuiyan; Paari Dominic; Christopher G. Kevil; Daniel Fort; Vincent X. Liu; Maha Farhat; Jonathan L. Koff; Charitharth V. Lal; Anuj Gaggar; Robert P. Richter; Nathaniel Erdmann; Matthew Might; Amit Gaggar;Abstract Background Recent single-center reports have suggested that community-acquired bacteremic co-infection in the context of Coronavirus disease 2019 (COVID-19) may be an important driver of mortality; however, these reports have not been validated with a multicenter, demographically diverse, cohort study with data spanning the pandemic. Methods In this multicenter, retrospective cohort study, inpatient encounters were assessed for COVID-19 with community-acquired bacteremic co-infection using 48-h post-admission blood cultures and grouped by: (1) confirmed co-infection [recovery of bacterial pathogen], (2) suspected co-infection [negative culture with ≥ 2 antimicrobials administered], and (3) no evidence of co-infection [no culture]. The primary outcomes were in-hospital mortality, ICU admission, and mechanical ventilation. COVID-19 bacterial co-infection risk factors and impact on primary outcomes were determined using multivariate logistic regressions and expressed as adjusted odds ratios with 95% confidence intervals (Cohort, OR 95% CI, Wald test p value). Results The studied cohorts included 13,781 COVID-19 inpatient encounters from 2020 to 2022 in the University of Alabama at Birmingham (UAB, n = 4075) and Ochsner Louisiana State University Health—Shreveport (OLHS, n = 9706) cohorts with confirmed (2.5%), suspected (46%), or no community-acquired bacterial co-infection (51.5%) and a comparison cohort consisting of 99,170 inpatient encounters from 2010 to 2019 (UAB pre-COVID-19 pandemic cohort). Significantly increased likelihood of COVID-19 bacterial co-infection was observed in patients with elevated ≥ 15 neutrophil-to-lymphocyte ratio (UAB: 1.95 [1.21–3.07]; OLHS: 3.65 [2.66–5.05], p < 0.001 for both) within 48-h of hospital admission. Bacterial co-infection was found to confer the greatest increased risk for in-hospital mortality (UAB: 3.07 [2.42–5.46]; OLHS: 4.05 [2.29–6.97], p < 0.001 for both), ICU admission (UAB: 4.47 [2.87–7.09], OLHS: 2.65 [2.00–3.48], p < 0.001 for both), and mechanical ventilation (UAB: 3.84 [2.21–6.12]; OLHS: 2.75 [1.87–3.92], p < 0.001 for both) across both cohorts, as compared to other risk factors for severe disease. Observed mortality in COVID-19 bacterial co-infection (24%) dramatically exceeds the mortality rate associated with community-acquired bacteremia in pre-COVID-19 pandemic inpatients (5.9%) and was consistent across alpha, delta, and omicron SARS-CoV-2 variants. Conclusions Elevated neutrophil-to-lymphocyte ratio is a prognostic indicator of COVID-19 bacterial co-infection within 48-h of admission. Community-acquired bacterial co-infection, as defined by blood culture-positive results, confers greater increased risk of in-hospital mortality, ICU admission, and mechanical ventilation than previously described risk factors (advanced age, select comorbidities, male sex) for COVID-19 mortality, and is independent of SARS-CoV-2 variant.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13054-023-04312-0&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 27 citations 27 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13054-023-04312-0&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 United Kingdom, NetherlandsPublisher:Springer Science and Business Media LLC Filippini, DFL; Di Gennaro, E; van Amstel, RBE; Beenen, LFM; Grasso, S; Pisani, L; Bos, LDJ; Smit, MR;Abstract Background Patients with COVID-19-related acute respiratory distress syndrome (ARDS) require respiratory support with invasive mechanical ventilation and show varying responses to recruitment manoeuvres. In patients with ARDS not related to COVID-19, two pulmonary subphenotypes that differed in recruitability were identified using latent class analysis (LCA) of imaging and clinical respiratory parameters. We aimed to evaluate if similar subphenotypes are present in patients with COVID-19-related ARDS. Methods This is the retrospective analysis of mechanically ventilated patients with COVID-19-related ARDS who underwent CT scans at positive end-expiratory pressure of 10 cmH2O and after a recruitment manoeuvre at 20 cmH2O. LCA was applied to quantitative CT-derived parameters, clinical respiratory parameters, blood gas analysis and routine laboratory values before recruitment to identify subphenotypes. Results 99 patients were included. Using 12 variables, a two-class LCA model was identified as best fitting. Subphenotype 2 (recruitable) was characterized by a lower PaO2/FiO2, lower normally aerated lung volume and lower compliance as opposed to a higher non-aerated lung mass and higher mechanical power when compared to subphenotype 1 (non-recruitable). Patients with subphenotype 2 had more decrease in non-aerated lung mass in response to a standardized recruitment manoeuvre (p = 0.024) and were mechanically ventilated longer until successful extubation (adjusted SHR 0.46, 95% CI 0.23–0.91, p = 0.026), while no difference in survival was found (p = 0.814). Conclusions A recruitable and non-recruitable subphenotype were identified in patients with COVID-19-related ARDS. These findings are in line with previous studies in non-COVID-19-related ARDS and suggest that a combination of imaging and clinical respiratory parameters could facilitate the identification of recruitable lungs before the manoeuvre.
Critical Care arrow_drop_down Oxford University Research ArchiveArticle . 2023License: CC BYData sources: Oxford University Research Archiveadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13054-022-04251-2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 6 citations 6 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 4visibility views 4 Powered bymore_vert Critical Care arrow_drop_down Oxford University Research ArchiveArticle . 2023License: CC BYData sources: Oxford University Research Archiveadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13054-022-04251-2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2022 United Kingdom, BelgiumPublisher:Research Square Platform LLC Joanne McPeake; Nancy Kentish-Barnes; Emilie Banse; Lynne Anderson; Cecilia Cuzco; Elie Azoulay; Tara Quasim; Pedro Castro; Kathryn Puxty;PURPOSE: To guarantee the safety of the public, clinicians and patients during the COVID-19 pandemic, hospital visits were severely restricted internationally. There are limited data on the precise impact of these visiting restrictions on Intensive Care Unit clinicians. Our objectives therefore were to explore the impact of family visitation restrictions on clinicians and care delivery and describe innovation alongside areas for potential improvement. METHODS: A qualitative approach using focus groups was employed. We recruited members of the multi-disciplinary team from Spain, France and the UK. Framework analysis was used to synthesize and interpret data. RESULTS: In total, 28 staff from multiple international sites contributed to data across six focus groups: 12 from the UK, 9 from France and 7 from Spain. In relation to the key aims, we derived four themes: the emergence of new technologies, relationships and rapport establishment, communication challenges and end-of-life care provision. Across each theme, the overarching concepts of clinician emotional exhaustion and emotional distress emerged alongside the negative impact on job satisfaction. CONCLUSION: The impact of COVID-19 family visitation restrictions is far reaching. Future research should examine the wider impact of family presence in the ICU. Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 6visibility views 6 download downloads 5 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 Italy, Italy, Belgium, Italy, United Kingdom, TurkeyPublisher:Springer Science and Business Media LLC Funded by:SNSF | Epidemiology and determin..., UKRI | 'Mechanisms of impaired n...SNSF| Epidemiology and determinants of catheter-related and hospital-acquired bloodstream infections: from a large university hospital to a global picture ,UKRI| 'Mechanisms of impaired neutrophil phagosome maturation and its impact on invasive bacterial infectionsBuetti, Niccolò; Tabah, Alexis; Loiodice, Ambre; Ruckly, Stéphane; Aslan, Abdullah Tarik; Montrucchio, Giorgia; Cortegiani, Andrea; Saltoglu, Nese; Kayaaslan, Bircan; Aksoy, Firdevs; Murat, Akova; Akdoğan, Özlem; Saracoglu, Kemal Tolga; Erdogan, Cem; Leone, Marc; Ferrer, Ricard; Paiva, José-Artur; Hayashi, Yoshiro; Ramanan, Mahesh; Conway Morris, Andrew; Barbier, François; Timsit, Jean-François; Jeffrey, Lipman; Edward, Litton; Anna Maria, Palermo; Timothy, Yap; Ege Eroglu; Koji Hosokawa; Hideki Yoshida; Shigeki Fujitani; Farid Zand; Ata Mahmoodpoor; Seyed Mohammad Nasirodin Tabatabaei; Omar Elrabi; Ghaleb A Almekhlafi; Gabriela Vidal; Marta Aparicio; Irene Alonzo; Silvio A Namendys-Silva; Mariana Hermosillo; Roberto Alejandro Castillo; Liesbet De Bus; Jan De Waele; Isabelle Hollevoet; Nicolas De Schryver; Nicolas Serck; Pedja Kovacevic; Biljana Zlojutro; Etienne Ruppe; Philippe Montravers; Thierry Dulac; Jérémy Castanera; Alexandre Massri; Charlotte Guesdon; Pierre Garcon; Matthieu Duprey; François Philippart; Marc Tran; Cédric Bruel; Pierre Kalfon; Gaëtan Badre; Sophie Demeret; Loïc Le Guennec; Matteo Bassetti; Daniele Giacobbe; Gabriele Sales; Ivan Daroui; Giovanni Lodi; Mariachiara Ippolito; Davide Bellina; Andrea Di Guardo; Monica Rocco; Silvia Fiorelli; Adam Mikstacki; Mariusz Peichota; Iwona Pietraszek-Grzywaczewska; Pedro Póvoa; Andriy Krystopchuk; Ana Teresa; António Manuel Pereira de Figueiredo; Isabel Botelho; Vasco Costa; Rui Pedro Cunha; Alexey Gritsan; Vladislav Belskiy; Mikhail Furman; Maria Martinez; Vanessa Casares; Maria Pilar Gracia Arnillas; Rosana Munoz Bermudez; Alejandro Ubeda; Maria Salgado; Emilio Maseda; Alejandro Suarez De La Rica; Miguel Angel Blasco-Navalpotro; Alberto Orejas Gallego; Josef Prazak; J L Pagani; S Abed-Maillard; Arzu Topeli Iskit; Selcuk Mehtap; Solakoğlu Ceyhun; Ayşe Kaya Kalem; Ibrahim Kurt; Murat Telli; Barcin Ozturk; Nurcan Baykam; Ridvan Karaali; Iftihar Koksal; Yeliz Bilir; Seda Guzeldag; Gulden Ersoz; Guliz Evik; Yasar Bayindir; Yasemin Ersoy; Ari Ercole; Ashok Raj; Artemis Zormpa; George Tinaslanidis; Reena Khade; Ashraf Roshdy; Santhana Kannan; Supriya Antrolikar; Nicholas Marsden; Ben Attwood; Jamie Patel; Mohan Gurjar; Carol Dsilva; Jagadish Chandran; Bashir El Sanousi; Elfayadh Saidahmed; Hytham K S Hamid;pmid: 36258239
pmc: PMC9578203
Abstract Background The study aimed to describe the epidemiology and outcomes of hospital-acquired bloodstream infections (HABSIs) between COVID-19 and non-COVID-19 critically ill patients. Methods We used data from the Eurobact II study, a prospective observational multicontinental cohort study on HABSI treated in ICU. For the current analysis, we selected centers that included both COVID-19 and non-COVID-19 critically ill patients. We performed descriptive statistics between COVID-19 and non-COVID-19 in terms of patients’ characteristics, source of infection and microorganism distribution. We studied the association between COVID-19 status and mortality using multivariable fragility Cox models. Results A total of 53 centers from 19 countries over the 5 continents were eligible. Overall, 829 patients (median age 65 years [IQR 55; 74]; male, n = 538 [64.9%]) were treated for a HABSI. Included patients comprised 252 (30.4%) COVID-19 and 577 (69.6%) non-COVID-19 patients. The time interval between hospital admission and HABSI was similar between both groups. Respiratory sources (40.1 vs. 26.0%, p < 0.0001) and primary HABSI (25.4% vs. 17.2%, p = 0.006) were more frequent in COVID-19 patients. COVID-19 patients had more often enterococcal (20.5% vs. 9%) and Acinetobacter spp. (18.8% vs. 13.6%) HABSIs. Bacteremic COVID-19 patients had an increased mortality hazard ratio (HR) versus non-COVID-19 patients (HR 1.91, 95% CI 1.49–2.45). Conclusions We showed that the epidemiology of HABSI differed between COVID-19 and non-COVID-19 patients. Enterococcal HABSI predominated in COVID-19 patients. COVID-19 patients with HABSI had elevated risk of mortality. Trial registration ClinicalTrials.org number NCT03937245. Registered 3 May 2019. Funder: Norva Dahlia foundation and the Redcliffe Hospital Private Practice Trust Fund Funder: European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Funder: European society of Intensive Care Medicine
Apollo arrow_drop_down Archivio della ricerca- Università di Roma La Sapienza; Critical Care; Ghent University Academic BibliographyArticle . 2022 . Peer-reviewedLicense: CC BYİstanbul Medipol University Institutional RepositoryArticle . 2022Data sources: İstanbul Medipol University Institutional RepositoryGhent University Academic BibliographyArticle . 2022Data sources: Ghent University Academic BibliographyArchivio Istituzionale (AperTO); Archivio IstituzionaleArticle . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13054-022-04166-y&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 18 citations 18 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 150visibility views 150 download downloads 70 Powered bymore_vert Apollo arrow_drop_down Archivio della ricerca- Università di Roma La Sapienza; Critical Care; Ghent University Academic BibliographyArticle . 2022 . Peer-reviewedLicense: CC BYİstanbul Medipol University Institutional RepositoryArticle . 2022Data sources: İstanbul Medipol University Institutional RepositoryGhent University Academic BibliographyArticle . 2022Data sources: Ghent University Academic BibliographyArchivio Istituzionale (AperTO); Archivio IstituzionaleArticle . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13054-022-04166-y&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 NetherlandsPublisher:Springer Science and Business Media LLC Jean-Louis, Vincent; Carole, Boulanger; Margo M C, van Mol; Laura, Hawryluck; Elie, Azoulay;AbstractShortage of nurses on the ICU is not a new phenomenon, but has been exacerbated by the COVID-19 pandemic. The underlying reasons are relatively well-recognized, and include excessive workload, moral distress, and perception of inappropriate care, leading to burnout and increased intent to leave, setting up a vicious circle whereby fewer nurses result in increased pressure and stress on those remaining. Nursing shortages impact patient care and quality-of-work life for all ICU staff and efforts should be made by management, nurse leaders, and ICU clinicians to understand and ameliorate the factors that lead nurses to leave. Here, we highlight 10 broad areas that ICU clinicians should be aware of that may improve quality of work-life and thus potentially help with critical care nurse retention.
NARCIS arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13054-022-04182-y&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert NARCIS arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13054-022-04182-y&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 United KingdomPublisher:Springer Science and Business Media LLC Authors: Al Sulaiman, Khalid; Korayem, Ghazwa B.; Altebainawi, Ali F.; Al Harbi, Shmeylan; +25 AuthorsAl Sulaiman, Khalid; Korayem, Ghazwa B.; Altebainawi, Ali F.; Al Harbi, Shmeylan; Alissa, Abdulrahman; Alharthi, Abdullah; Kensara, Raed; Alfahed, Amjaad; Vishwakarma, Ramesh; Al Haji, Hussain; Almohaimid, Naif; Al Zumai, Omar; Alrubayan, Fahad; Asiri, Abdulmajid; Alkahtani, Nasser; Alolayan, Abdulaziz; Alsohimi, Samiah; Melibari, Nawal; Almagthali, Alaa; Aljahdali, Seba; Alenazi, Abeer A.; Alsaeedi, Alawi S.; Al Ghamdi, Ghassan; Al Faris, Omar; Alqahtani, Joud; Al Qahtani, Jalal; Alshammari, Khalid A.; Alshammari, Khalil I.; Aljuhani, Ohoud;Abstract Background Inhaled nitric oxide (iNO) is used as rescue therapy in patients with refractory hypoxemia due to severe COVID-19 acute respiratory distress syndrome (ARDS) despite the recommendation against the use of this treatment. To date, the effect of iNO on the clinical outcomes of critically ill COVID-19 patients with moderate-to-severe ARDS remains arguable. Therefore, this study aimed to evaluate the use of iNO in critically ill COVID-19 patients with moderate-to-severe ARDS. Methods This multicenter, retrospective cohort study included critically ill adult patients with confirmed COVID-19 treated from March 01, 2020, until July 31, 2021. Eligible patients with moderate-to-severe ARDS were subsequently categorized into two groups based on inhaled nitric oxide (iNO) use throughout their ICU stay. The primary endpoint was the improvement in oxygenation parameters 24 h after iNO use. Other outcomes were considered secondary. Propensity score matching (1:2) was used based on the predefined criteria. Results A total of 1598 patients were screened, and 815 were included based on the eligibility criteria. Among them, 210 patients were matched based on predefined criteria. Oxygenation parameters (PaO2, FiO2 requirement, P/F ratio, oxygenation index) were significantly improved 24 h after iNO administration within a median of six days of ICU admission. However, the risk of 30-day and in-hospital mortality were found to be similar between the two groups (HR: 1.18; 95% CI: 0.77, 1.82; p = 0.45 and HR: 1.40; 95% CI: 0.94, 2.11; p= 0.10, respectively). On the other hand, ventilator-free days (VFDs) were significantly fewer, and ICU and hospital LOS were significantly longer in the iNO group. In addition, patients who received iNO had higher odds of acute kidney injury (AKI) (OR (95% CI): 2.35 (1.30, 4.26), p value = 0.005) and hospital/ventilator-acquired pneumonia (OR (95% CI): 3.2 (1.76, 5.83), p value = 0.001). Conclusion In critically ill COVID-19 patients with moderate-to-severe ARDS, iNO rescue therapy is associated with improved oxygenation parameters but no mortality benefits. Moreover, iNO use is associated with higher odds of AKI, pneumonia, longer LOS, and fewer VFDs.
University of East A... arrow_drop_down University of East Anglia digital repositoryArticle . 2022 . Peer-reviewedData sources: University of East Anglia digital repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 17 citations 17 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 9visibility views 9 download downloads 1 Powered bymore_vert University of East A... arrow_drop_down University of East Anglia digital repositoryArticle . 2022 . Peer-reviewedData sources: University of East Anglia digital repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13054-022-04158-y&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 United KingdomPublisher:Springer Science and Business Media LLC Victoria, Stokes; Kwee Yen, Goh; Graham, Whiting; Sebastian, Bates; Hannah, Greenlee; Anthony, Wilson; Alexander J, Parker;Critical Care arrow_drop_down The University of Manchester - Institutional Repository; Critical CareArticle . 2022 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13054-022-04144-4&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Critical Care arrow_drop_down The University of Manchester - Institutional Repository; Critical CareArticle . 2022 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s13054-022-04144-4&type=result"></script>'); --> </script>
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