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The following results are related to COVID-19. Are you interested to view more results? Visit OpenAIRE - Explore.
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28 research outcomes, page 1 of 3
  • publication . Article . 2021
    Open Access
    Authors:
    Raoul De Gasparo; Mattia Pedotti; Luca Simonelli; Petr Nickl; Frauke Muecksch; Irene Cassaniti; Elena Percivalle; Julio C. C. Lorenzi; Federica Mazzola; Davide Magrì; ...
    Persistent Identifiers
    Publisher: Springer Science and Business Media LLC
    Project: EC | ATAC (101003650)

    Neutralizing antibodies that target the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein are among the most promising approaches against COVID-19. A bispecific IgG1-like molecule (CoV-X2) has been developed on the basis of C121 and C135, two antibodies deri...

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  • publication . Other literature type . Article . 2021
    Open Access English
    Authors:
    Wang, Zijun; Schmidt, Fabian; Weisblum, Yiska; Muecksch, Frauke; Barnes, Christopher O.; Finkin, Shlomo; Schaefer-Babajew, Dennis; Cipolla, Melissa; Gaebler, Christian; Lieberman, Jenna A.; ...
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory

    To date severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected over 100 million individuals resulting in over two million deaths. Many vaccines are being deployed to prevent coronavirus disease 2019 (COVID-19) including two novel mRNA-based vaccines (...

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  • publication . Article . Other literature type . 2021
    Open Access English
    Authors:
    Gaebler, Christian; Wang, Zijun; Lorenzi, Julio C. C.; Muecksch, Frauke; Finkin, Shlomo; Tokuyama, Minami; Cho, Alice; Jankovic, Mila; Schaefer-Babajew, Dennis; Oliveira, Thiago Y.; ...
    Persistent Identifiers
    Publisher: Nature Publishing Group
    Project: EC | ATAC (101003650)

    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected 78 million individuals and is responsible for over 1.7 million deaths to date. Infection is associated with the development of variable levels of antibodies with neutralizing activity, which can p...

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  • publication . Article . Other literature type . 2020
    Open Access English
    Authors:
    Barnes, Christopher O.; Jette, Claudia A.; Abernathy, Morgan E.; Dam, Kim-Marie A.; Esswein, Shannon R.; Gristick, Harry B.; Malyutin, Andrey G.; Sharaf, Naima G.; Huey-Tubman, Kathryn E.; Lee, Yu E.; ...
    Persistent Identifiers
    Publisher: Springer Science and Business Media LLC
    Project: EC | ATAC (101003650)

    The coronavirus disease 2019 (COVID-19) pandemic presents an urgent health crisis. Human neutralizing antibodies that target the host ACE2 receptor-binding domain (RBD) of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike protein show promise therap...

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  • The p53 tumour-suppressor protein is a cell's principal guardian against cancer. Most cancers eliminate p53 — but it seems that its pathway remains intact, so resurrecting it might provide a cancer therapy. The p53 tumour suppressor is either mutated or inactivated by o...

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  • publication . Preprint . Article . Other literature type . 2020
    Open Access English
    Authors:
    Brandi N. Williamson; Friederike Feldmann; Benjamin Schwarz; Kimberly Meade-White; Danielle P. Porter; Jonathan Schulz; Neeltje van Doremalen; Ian Leighton; Claude Kwe Yinda; Lizzette Pérez-Pérez; ...
    Publisher: Cold Spring Harbor Laboratory

    <jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Effective therapeutics to treat COVID-19 are urgently needed. Remdesivir is a nucleotide prodrug with in vitro and in vivo efficacy against coronaviruses. Here, we tested the efficacy ...

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  • publication . Other literature type . Article . 2018
    Open Access English
    Authors:
    Kim, Yoon Seok; Kato, Hideaki E.; Yamashita, Keitaro; Ito, Shota; Inoue, Keiichi; Ramakrishnan, Charu; Fenno, Lief E.; Evans, Kathryn E.; Paggi, Joseph M.; Dror, Ron O.; ...
    Persistent Identifiers
    Project: NIH | Channel structure-based t... (4R01MH075957-09)

    The naturally occurring channelrhodopsin variant anion channelrhodopsin-1 (ACR1), discovered in the cryptophyte algae Guillardia theta, exhibits large light-gated anion conductance and high anion selectivity when expressed in heterologous settings, properties that suppo...

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  • publication . Other literature type . Article . 2018
    Open Access
    Authors:
    Zhang, Rong; Kim, Arthur S.; Fox, Julie M.; Nair, Sharmila; Basore, Katherine; Klimstra, William B.; Rimkunas, Rebecca; Fong, Rachel H.; Lin, Hueylie; Poddar, Subhajit; ...
    Persistent Identifiers
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Structural and functional... (5R01AI114816-05), NIH | Molecular Mechanisms of E... (4R01AI095436-05), NIH | Chikungunya Virus Replica... (5R01AI123348-05)

    Arthritogenic alphaviruses comprise a group of enveloped RNA viruses that are transmitted to humans by mosquitoes and cause debilitating acute and chronic musculoskeletal disease 1 . The host factors required for alphavirus entry remain poorly characterized 2 . Here we ...

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  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Zhou, Peng; Fan, Hang; Lan, Tian; Yang, Xing-Lou; Shi, Wei-Feng; Zhang, Wei; Zhu, Yan; Zhang, Ya-Wei; Xie, Qing-Mei; Mani, Shailendra; ...
    Persistent Identifiers
    Publisher: Springer Nature
    Project: NIH | Understanding the Risk of... (5R01AI110964-05)

    Analysis of viral samples from deceased piglets shows that a bat coronavirus was responsible for an outbreak of fatal disease in China and highlights the importance of the identification of coronavirus diversity and distribution in bats in order to mitigate future outbr...

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  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Kathrin Pieper; Joshua Tan; Luca Piccoli; Mathilde Foglierini; Sonia Barbieri; Yiwei Chen; Chiara Silacci-Fregni; Tobias Wolf; David Jarrossay; Marica Anderle; ...
    Publisher: Springer Science and Business Media LLC
    Project: EC | BROADimmune (670955), WT

    In two previously described donors, the extracellular domain of LAIR1, a collagen-binding inhibitory receptor encoded on chromosome 19 (ref. 1), was inserted between the V and DJ segments of an antibody. This insertion generated, through somatic mutations, broadly react...

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28 research outcomes, page 1 of 3