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description Publicationkeyboard_double_arrow_right Article 2022 NorwayPublisher:Oxford University Press (OUP) Laake, Ida; Skodvin, Siri Nærland; Blix, Kristine; Caspersen, Ida Henriette; Gjessing, Håkon K.; Juvet, Lene Kristine; Magnus, Per Minor; Mjaaland, Siri; Robertson, Anna Hayman; Starrfelt, Jostein; Trogstad, Lill; Feiring, Berit;Abstract Background Understanding how booster vaccination can prevent moderate and severe illness without hospitalization is crucial to evaluate the full advantage of mRNA boosters. Methods We followed 85 801 participants (aged 31–81 years) in 2 large population-based cohorts during the Omicron BA.1/2 wave. Information on home testing, PCR testing, and symptoms of coronavirus disease 2019 (COVID-19) was extracted from biweekly questionnaires covering the period 12 January 2022 to 7 April 2022. Vaccination status and data on previous SARS-CoV-2 infection were obtained from national registries. Cox regression was used to estimate the effectiveness of booster vaccination compared to receipt of 2-dose primary series >130 days previously. Results The effectiveness of booster vaccination increased with increasing severity of COVID-19 and decreased with time since booster vaccination. The effectiveness against severe COVID-19 was reduced from 80.9% shortly after booster vaccination to 63.4% in the period >90 days after vaccination. There was hardly any effect against mild COVID-19. The effectiveness tended to be lower among subjects aged ≥60 years than those aged <50 years. Conclusions This is the first population-based study to evaluate booster effectiveness against self-reported mild, moderate, and severe COVID-19. Our findings contribute valuable information on duration of protection and thus timing of additional booster vaccinations.
Bergen Open Research... arrow_drop_down Bergen Open Research Archive - UiB; Norwegian Open Research ArchivesArticle . 2022 . Peer-reviewedNorwegian Institute of Public Health Open RepositoryArticle . 2022Data sources: Norwegian Institute of Public Health Open RepositoryThe Journal of Infectious DiseasesArticle . 2022 . Peer-reviewedLicense: CC BY NC NDData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Bergen Open Research... arrow_drop_down Bergen Open Research Archive - UiB; Norwegian Open Research ArchivesArticle . 2022 . Peer-reviewedNorwegian Institute of Public Health Open RepositoryArticle . 2022Data sources: Norwegian Institute of Public Health Open RepositoryThe Journal of Infectious DiseasesArticle . 2022 . Peer-reviewedLicense: CC BY NC NDData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 NorwayPublisher:Oxford University Press (OUP) Funded by:EC | EVA-GLOBALEC| EVA-GLOBALAnders Tveita; Sarah Louise Murphy; Jan Cato Holter; Anders Benjamin Kildal; Annika E Michelsen; Tøri Vigeland Lerum; Mari Kaarbø; Lars Heggelund; Aleksander Rygh Holten; Ane-Kristine Finbråten; Karl Erik Müller; Alexander Mathiessen; Simen Bøe; Børre Fevang; Beathe Kiland Granerud; Kristian Tonby; Andreas Lind; Susanne Gjeruldsen Dudman; Katerina Nezvalova Henriksen; Fredrik Müller; Ole Henning Skjønsberg; Marius Trøseid; Andreas Barratt-Due; Anne Ma Dyrhol-Riise; Pål Aukrust; Bente Halvorsen; Tuva Børresdatter Dahl; Thor Ueland; Cathrine Austad; Mette Bogen; Anne Hermann; Hanne Opsand; Trude Steinsvik; Bjørn Martin Woll; Erik Egeland Christensen; Kristin Eftestøl; Liv Hesstvedt; Synne Jenum; Marthe Jøntvedt Jørgensen; Elisabeth Toverud Landaas; Sarah Nur; Vidar Ormaasen; Frank Olav Pettersen; Else Quist-Paulsen; Dag Henrik Reikvam; Kjerstin Røstad; Linda Skeie; Anne Katrine Steffensen; Birgitte Stiksrud; Berit Gravrok; Vegard Skogen; Garth Daryl Tylden; Jan Terje Andersen; Anette Kolderup; Trine Kåsine; Fridtjof Lund-Johansen; Inge Christoffer Olsen; Karoline Hansen Skåra; Trung Tran; Cathrine Fladeby; Liv Hesstvedt; Mona Holberg-Petersen; Synne Jenum; Simreen Kaur Johal; Dag Henrik Reikvam; Kjerstin Røstad; Anne Katrine Steffensen; Birgitte Stiksrud; Eline Brenno Vaage; Erik Egeland Christensen; Marthe Jøntvedt Jørgensen; Sarah Nur; Vidar Ormaasen; Frank Olav Pettersen; Saad Aballi; Jorunn Brynhildsen; Waleed Ghanima; Anne Marie Halstensen; Åse Berg; Bjørn Blomberg; Reidar Kvåle; Nina Langeland; Kristin Greve Isdahl Mohn; Olav Dalgard; Ragnhild Eiken; Richard Alexander Molvik; Carl Magnus Ystrøm; Gernot Ernst; Lars Thoresen; Lise Tuset Gustad; Lars Mølgaard Saxhaug; Nina Vibeche Skei; Raisa Hannula; Mette Haugli; Roy Bjørkholt Olsen; Hedda Hoel; Dag Arne Lihaug Hoff; Asgeir Johannessen; Bjørn Åsheim-Hansen; Bård Reikvam Kittang; Lan Ai Kieu Le; Ravinea Manotheepan; Lena Bugge Nordberg; Hans Schmidt Rasmussen; Grethe-Elisabeth Stenvik; Ruth Foseide Thorkildsen; Leif Erik Vinge; Pawel Mielnik; Vegard Skogen; Hilde Skudal; Birgitte Tholin;Abstract Background Immune dysregulation is a major factor in the development of severe coronavirus disease 2019 (COVID-19). The homeostatic chemokines CCL19 and CCL21 have been implicated as mediators of tissue inflammation, but data on their regulation in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is limited. We thus investigated the levels of these chemokines in COVID-19 patients. Methods Serial blood samples were obtained from patients hospitalized with COVID-19 (n = 414). Circulating CCL19 and CCL21 levels during hospitalization and 3-month follow-up were analyzed. In vitro assays and analysis of RNAseq data from public repositories were performed to further explore possible regulatory mechanisms. Results A consistent increase in circulating levels of CCL19 and CCL21 was observed, with high levels correlating with disease severity measures, including respiratory failure, need for intensive care, and 60-day all-cause mortality. High levels of CCL21 at admission were associated with persisting impairment of pulmonary function at the 3-month follow-up. Conclusions Our findings highlight CCL19 and CCL21 as markers of immune dysregulation in COVID-19. This may reflect aberrant regulation triggered by tissue inflammation, as observed in other chronic inflammatory and autoimmune conditions. Determination of the source and regulation of these chemokines and their effects on lung tissue is warranted to further clarify their role in COVID-19. Clinical Trials Registration NCT04321616 and NCT04381819.
The Journal of Infec... arrow_drop_down Bergen Open Research Archive - UiB; Norwegian Open Research ArchivesArticle . 2022 . Peer-reviewedMunin - Open Research Archive; Norwegian Open Research ArchivesArticle . 2022 . Peer-reviewedLicense: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 10 citations 10 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert The Journal of Infec... arrow_drop_down Bergen Open Research Archive - UiB; Norwegian Open Research ArchivesArticle . 2022 . Peer-reviewedMunin - Open Research Archive; Norwegian Open Research ArchivesArticle . 2022 . Peer-reviewedLicense: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 NorwayPublisher:Oxford University Press (OUP) Funded by:EC | FLUCOP, EC | INCENTIVEEC| FLUCOP ,EC| INCENTIVETrieu, Mai-Chi; Bansal, Amit; Madsen, Anders; Zhou, Fan; Sævik, Marianne; Vahokoski, Juha; Brokstad, Karl Albert; Krammer, Florian; Tøndel, Camilla; Mohn, Kristin G I; Blomberg, Bjørn; Langeland, Nina; Cox, Rebecca J; Kittang, Bård; Linchausen, Dagrunn Waag; Amdam, Håkon; Onyango, Therese Bredholt; Bredholt, Geir; Ertesvåg, Nina; Lartey, Sarah; Sandnes, Helene Heitmann; Grøvan, Fredrik; Bartsch, Hauke; Syre, Heidi; Real, Francisco; Berg, Åse Garløv;pmc: PMC7798943
handle: 11250/2725625 , 11250/2755253
Abstract Background During the coronavirus disease 2019 (COVID-19) pandemic, many countries experienced infection in health care workers (HCW) due to overburdened health care systems. Whether infected HCW acquire protective immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unclear. Methods In a Norwegian prospective cohort study, we enrolled 607 HCW before and after the first COVID-19 wave. Exposure history, COVID-19–like symptoms, and serum samples were collected. SARS-CoV-2–specific antibodies were characterized by spike-protein IgG/IgM/IgA enzyme-linked immunosorbent and live-virus neutralization assays. Results Spike-specific IgG/IgM/IgA antibodies increased after the first wave in HCW with, but not in HCW without, COVID-19 patient exposure. Thirty-two HCW (5.3%) had spike-specific antibodies (11 seroconverted with ≥4-fold increase, 21 were seropositive at baseline). Neutralizing antibodies were found in 11 HCW that seroconverted, of whom 4 (36.4%) were asymptomatic. Ninety-seven HCW were tested by reverse transcriptase polymerase chain reaction (RT-PCR) during follow-up; 8 were positive (7 seroconverted, 1 had undetectable antibodies). Conclusions We found increases in SARS-CoV-2 neutralizing antibodies in infected HCW, especially after COVID-19 patient exposure. Our data show a low number of SARS-CoV-2–seropositive HCW in a low-prevalence setting; however, the proportion of seropositivity was higher than RT-PCR positivity, highlighting the importance of antibody testing. Low numbers of SARS-CoV-2–seropositive HCW were found in Norway and 1.8% of HCW seroconverted with neutralizing antibodies. Seropositivity was higher than RT-PCR positivity in HCW with 36% asymptomatic, representing a risk of infection within the health care setting.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7798943Data sources: PubMed CentralBergen Open Research Archive - UiB; Norwegian Open Research ArchivesArticle . 2021 . 2020 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/infdis/jiaa737&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 39 citations 39 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7798943Data sources: PubMed CentralBergen Open Research Archive - UiB; Norwegian Open Research ArchivesArticle . 2021 . 2020 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/infdis/jiaa737&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018Publisher:Oxford University Press (OUP) Inger Heimdal; Nina Moe; Sidsel Krokstad; Andreas Christensen; Lars Høsøien Skanke; Svein Arne Nordbø; Henrik Døllner;Abstract Background The burden of human coronavirus (HCoV)-associated respiratory tract infections (RTIs) in hospitalized children is poorly defined. We studied the occurrence and hospitalization rates of HCoV over 9 years. Methods Children from Sør-Trøndelag County, Norway, hospitalized with RTIs and asymptomatic controls, were prospectively enrolled from 2006 to 2015. Nasopharyngeal aspirates were analyzed with semiquantitative polymerase chain reaction (PCR) tests for HCoV subtypes OC43, 229E, NL63, and HKU1, and 13 other respiratory pathogens. Results HCoV was present in 9.1% (313/3458) of all RTI episodes: 46.6% OC43, 32.3% NL63, 16.0% HKU1, and 5.8% 229E. Hospitalization rates for HCoV-positive children with lower RTIs were 1.5 and 2.8 per 1000 <5 and <1 years of age, respectively. The detection rate among controls was 10.2% (38/373). Codetections occurred in 68.1% of the patients and 68.4% of the controls. In a logistic regression analysis, high HCoV genomic loads (cycle threshold <28 in PCR analysis) were associated with RTIs (odds ratio = 3.12, P = .016) adjusted for relevant factors. Conclusions HCoVs occurred in 1 of 10 hospitalized children with RTIs and asymptomatic controls. A high HCoV genomic load was associated with RTI. HCoVs are associated with a substantial burden of RTIs in need of hospitalization. During a 9-year period, human coronaviruses OC43, NL63, HKU1, and 229E occurred at similar rates in hospitalized children with respiratory tract infections and asymptomatic controls, but infected children had higher genomic loads, supporting a causal role in infection.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2018Full-Text: http://europepmc.org/articles/PMC7107437Data sources: PubMed CentralThe Journal of Infectious DiseasesArticle . 2018 . Peer-reviewedLicense: OUP Standard Publication ReuseData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 120 citations 120 popularity Top 1% influence Top 1% impulse Top 1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2018Full-Text: http://europepmc.org/articles/PMC7107437Data sources: PubMed CentralThe Journal of Infectious DiseasesArticle . 2018 . Peer-reviewedLicense: OUP Standard Publication ReuseData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article 2022 NorwayPublisher:Oxford University Press (OUP) Laake, Ida; Skodvin, Siri Nærland; Blix, Kristine; Caspersen, Ida Henriette; Gjessing, Håkon K.; Juvet, Lene Kristine; Magnus, Per Minor; Mjaaland, Siri; Robertson, Anna Hayman; Starrfelt, Jostein; Trogstad, Lill; Feiring, Berit;Abstract Background Understanding how booster vaccination can prevent moderate and severe illness without hospitalization is crucial to evaluate the full advantage of mRNA boosters. Methods We followed 85 801 participants (aged 31–81 years) in 2 large population-based cohorts during the Omicron BA.1/2 wave. Information on home testing, PCR testing, and symptoms of coronavirus disease 2019 (COVID-19) was extracted from biweekly questionnaires covering the period 12 January 2022 to 7 April 2022. Vaccination status and data on previous SARS-CoV-2 infection were obtained from national registries. Cox regression was used to estimate the effectiveness of booster vaccination compared to receipt of 2-dose primary series >130 days previously. Results The effectiveness of booster vaccination increased with increasing severity of COVID-19 and decreased with time since booster vaccination. The effectiveness against severe COVID-19 was reduced from 80.9% shortly after booster vaccination to 63.4% in the period >90 days after vaccination. There was hardly any effect against mild COVID-19. The effectiveness tended to be lower among subjects aged ≥60 years than those aged <50 years. Conclusions This is the first population-based study to evaluate booster effectiveness against self-reported mild, moderate, and severe COVID-19. Our findings contribute valuable information on duration of protection and thus timing of additional booster vaccinations.
Bergen Open Research... arrow_drop_down Bergen Open Research Archive - UiB; Norwegian Open Research ArchivesArticle . 2022 . Peer-reviewedNorwegian Institute of Public Health Open RepositoryArticle . 2022Data sources: Norwegian Institute of Public Health Open RepositoryThe Journal of Infectious DiseasesArticle . 2022 . Peer-reviewedLicense: CC BY NC NDData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/infdis/jiac419&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 8 citations 8 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Bergen Open Research... arrow_drop_down Bergen Open Research Archive - UiB; Norwegian Open Research ArchivesArticle . 2022 . Peer-reviewedNorwegian Institute of Public Health Open RepositoryArticle . 2022Data sources: Norwegian Institute of Public Health Open RepositoryThe Journal of Infectious DiseasesArticle . 2022 . Peer-reviewedLicense: CC BY NC NDData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/infdis/jiac419&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 NorwayPublisher:Oxford University Press (OUP) Funded by:EC | EVA-GLOBALEC| EVA-GLOBALAnders Tveita; Sarah Louise Murphy; Jan Cato Holter; Anders Benjamin Kildal; Annika E Michelsen; Tøri Vigeland Lerum; Mari Kaarbø; Lars Heggelund; Aleksander Rygh Holten; Ane-Kristine Finbråten; Karl Erik Müller; Alexander Mathiessen; Simen Bøe; Børre Fevang; Beathe Kiland Granerud; Kristian Tonby; Andreas Lind; Susanne Gjeruldsen Dudman; Katerina Nezvalova Henriksen; Fredrik Müller; Ole Henning Skjønsberg; Marius Trøseid; Andreas Barratt-Due; Anne Ma Dyrhol-Riise; Pål Aukrust; Bente Halvorsen; Tuva Børresdatter Dahl; Thor Ueland; Cathrine Austad; Mette Bogen; Anne Hermann; Hanne Opsand; Trude Steinsvik; Bjørn Martin Woll; Erik Egeland Christensen; Kristin Eftestøl; Liv Hesstvedt; Synne Jenum; Marthe Jøntvedt Jørgensen; Elisabeth Toverud Landaas; Sarah Nur; Vidar Ormaasen; Frank Olav Pettersen; Else Quist-Paulsen; Dag Henrik Reikvam; Kjerstin Røstad; Linda Skeie; Anne Katrine Steffensen; Birgitte Stiksrud; Berit Gravrok; Vegard Skogen; Garth Daryl Tylden; Jan Terje Andersen; Anette Kolderup; Trine Kåsine; Fridtjof Lund-Johansen; Inge Christoffer Olsen; Karoline Hansen Skåra; Trung Tran; Cathrine Fladeby; Liv Hesstvedt; Mona Holberg-Petersen; Synne Jenum; Simreen Kaur Johal; Dag Henrik Reikvam; Kjerstin Røstad; Anne Katrine Steffensen; Birgitte Stiksrud; Eline Brenno Vaage; Erik Egeland Christensen; Marthe Jøntvedt Jørgensen; Sarah Nur; Vidar Ormaasen; Frank Olav Pettersen; Saad Aballi; Jorunn Brynhildsen; Waleed Ghanima; Anne Marie Halstensen; Åse Berg; Bjørn Blomberg; Reidar Kvåle; Nina Langeland; Kristin Greve Isdahl Mohn; Olav Dalgard; Ragnhild Eiken; Richard Alexander Molvik; Carl Magnus Ystrøm; Gernot Ernst; Lars Thoresen; Lise Tuset Gustad; Lars Mølgaard Saxhaug; Nina Vibeche Skei; Raisa Hannula; Mette Haugli; Roy Bjørkholt Olsen; Hedda Hoel; Dag Arne Lihaug Hoff; Asgeir Johannessen; Bjørn Åsheim-Hansen; Bård Reikvam Kittang; Lan Ai Kieu Le; Ravinea Manotheepan; Lena Bugge Nordberg; Hans Schmidt Rasmussen; Grethe-Elisabeth Stenvik; Ruth Foseide Thorkildsen; Leif Erik Vinge; Pawel Mielnik; Vegard Skogen; Hilde Skudal; Birgitte Tholin;Abstract Background Immune dysregulation is a major factor in the development of severe coronavirus disease 2019 (COVID-19). The homeostatic chemokines CCL19 and CCL21 have been implicated as mediators of tissue inflammation, but data on their regulation in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is limited. We thus investigated the levels of these chemokines in COVID-19 patients. Methods Serial blood samples were obtained from patients hospitalized with COVID-19 (n = 414). Circulating CCL19 and CCL21 levels during hospitalization and 3-month follow-up were analyzed. In vitro assays and analysis of RNAseq data from public repositories were performed to further explore possible regulatory mechanisms. Results A consistent increase in circulating levels of CCL19 and CCL21 was observed, with high levels correlating with disease severity measures, including respiratory failure, need for intensive care, and 60-day all-cause mortality. High levels of CCL21 at admission were associated with persisting impairment of pulmonary function at the 3-month follow-up. Conclusions Our findings highlight CCL19 and CCL21 as markers of immune dysregulation in COVID-19. This may reflect aberrant regulation triggered by tissue inflammation, as observed in other chronic inflammatory and autoimmune conditions. Determination of the source and regulation of these chemokines and their effects on lung tissue is warranted to further clarify their role in COVID-19. Clinical Trials Registration NCT04321616 and NCT04381819.
The Journal of Infec... arrow_drop_down Bergen Open Research Archive - UiB; Norwegian Open Research ArchivesArticle . 2022 . Peer-reviewedMunin - Open Research Archive; Norwegian Open Research ArchivesArticle . 2022 . Peer-reviewedLicense: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/infdis/jiac313&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 10 citations 10 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert The Journal of Infec... arrow_drop_down Bergen Open Research Archive - UiB; Norwegian Open Research ArchivesArticle . 2022 . Peer-reviewedMunin - Open Research Archive; Norwegian Open Research ArchivesArticle . 2022 . Peer-reviewedLicense: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/infdis/jiac313&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2020 NorwayPublisher:Oxford University Press (OUP) Funded by:EC | FLUCOP, EC | INCENTIVEEC| FLUCOP ,EC| INCENTIVETrieu, Mai-Chi; Bansal, Amit; Madsen, Anders; Zhou, Fan; Sævik, Marianne; Vahokoski, Juha; Brokstad, Karl Albert; Krammer, Florian; Tøndel, Camilla; Mohn, Kristin G I; Blomberg, Bjørn; Langeland, Nina; Cox, Rebecca J; Kittang, Bård; Linchausen, Dagrunn Waag; Amdam, Håkon; Onyango, Therese Bredholt; Bredholt, Geir; Ertesvåg, Nina; Lartey, Sarah; Sandnes, Helene Heitmann; Grøvan, Fredrik; Bartsch, Hauke; Syre, Heidi; Real, Francisco; Berg, Åse Garløv;pmc: PMC7798943
handle: 11250/2725625 , 11250/2755253
Abstract Background During the coronavirus disease 2019 (COVID-19) pandemic, many countries experienced infection in health care workers (HCW) due to overburdened health care systems. Whether infected HCW acquire protective immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unclear. Methods In a Norwegian prospective cohort study, we enrolled 607 HCW before and after the first COVID-19 wave. Exposure history, COVID-19–like symptoms, and serum samples were collected. SARS-CoV-2–specific antibodies were characterized by spike-protein IgG/IgM/IgA enzyme-linked immunosorbent and live-virus neutralization assays. Results Spike-specific IgG/IgM/IgA antibodies increased after the first wave in HCW with, but not in HCW without, COVID-19 patient exposure. Thirty-two HCW (5.3%) had spike-specific antibodies (11 seroconverted with ≥4-fold increase, 21 were seropositive at baseline). Neutralizing antibodies were found in 11 HCW that seroconverted, of whom 4 (36.4%) were asymptomatic. Ninety-seven HCW were tested by reverse transcriptase polymerase chain reaction (RT-PCR) during follow-up; 8 were positive (7 seroconverted, 1 had undetectable antibodies). Conclusions We found increases in SARS-CoV-2 neutralizing antibodies in infected HCW, especially after COVID-19 patient exposure. Our data show a low number of SARS-CoV-2–seropositive HCW in a low-prevalence setting; however, the proportion of seropositivity was higher than RT-PCR positivity, highlighting the importance of antibody testing. Low numbers of SARS-CoV-2–seropositive HCW were found in Norway and 1.8% of HCW seroconverted with neutralizing antibodies. Seropositivity was higher than RT-PCR positivity in HCW with 36% asymptomatic, representing a risk of infection within the health care setting.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7798943Data sources: PubMed CentralBergen Open Research Archive - UiB; Norwegian Open Research ArchivesArticle . 2021 . 2020 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/infdis/jiaa737&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 39 citations 39 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2020Full-Text: http://europepmc.org/articles/PMC7798943Data sources: PubMed CentralBergen Open Research Archive - UiB; Norwegian Open Research ArchivesArticle . 2021 . 2020 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018Publisher:Oxford University Press (OUP) Inger Heimdal; Nina Moe; Sidsel Krokstad; Andreas Christensen; Lars Høsøien Skanke; Svein Arne Nordbø; Henrik Døllner;Abstract Background The burden of human coronavirus (HCoV)-associated respiratory tract infections (RTIs) in hospitalized children is poorly defined. We studied the occurrence and hospitalization rates of HCoV over 9 years. Methods Children from Sør-Trøndelag County, Norway, hospitalized with RTIs and asymptomatic controls, were prospectively enrolled from 2006 to 2015. Nasopharyngeal aspirates were analyzed with semiquantitative polymerase chain reaction (PCR) tests for HCoV subtypes OC43, 229E, NL63, and HKU1, and 13 other respiratory pathogens. Results HCoV was present in 9.1% (313/3458) of all RTI episodes: 46.6% OC43, 32.3% NL63, 16.0% HKU1, and 5.8% 229E. Hospitalization rates for HCoV-positive children with lower RTIs were 1.5 and 2.8 per 1000 <5 and <1 years of age, respectively. The detection rate among controls was 10.2% (38/373). Codetections occurred in 68.1% of the patients and 68.4% of the controls. In a logistic regression analysis, high HCoV genomic loads (cycle threshold <28 in PCR analysis) were associated with RTIs (odds ratio = 3.12, P = .016) adjusted for relevant factors. Conclusions HCoVs occurred in 1 of 10 hospitalized children with RTIs and asymptomatic controls. A high HCoV genomic load was associated with RTI. HCoVs are associated with a substantial burden of RTIs in need of hospitalization. During a 9-year period, human coronaviruses OC43, NL63, HKU1, and 229E occurred at similar rates in hospitalized children with respiratory tract infections and asymptomatic controls, but infected children had higher genomic loads, supporting a causal role in infection.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2018Full-Text: http://europepmc.org/articles/PMC7107437Data sources: PubMed CentralThe Journal of Infectious DiseasesArticle . 2018 . Peer-reviewedLicense: OUP Standard Publication ReuseData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/infdis/jiy646&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 120 citations 120 popularity Top 1% influence Top 1% impulse Top 1% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2018Full-Text: http://europepmc.org/articles/PMC7107437Data sources: PubMed CentralThe Journal of Infectious DiseasesArticle . 2018 . Peer-reviewedLicense: OUP Standard Publication ReuseData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/infdis/jiy646&type=result"></script>'); --> </script>
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