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60 research outcomes, page 1 of 6
  • publication . Preprint . Other literature type . Article . 2020
    Open Access English
    Authors:
    Maciej F. Boni; Philippe Lemey; Xiaowei Jiang; Tommy Tsan-Yuk Lam; Blair W. Perry; Todd A. Castoe; Andrew Rambaut; David Robertson;
    Project: EC | ReservoirDOCs (725422), WT , WT | Putting genomic surveilla... (206298)

    <jats:title>Abstract</jats:title><jats:p>There are outstanding evolutionary questions on the recent emergence of coronavirus SARS-CoV-2/hCoV-19 in Hubei province that caused the COVID-19 pandemic, including (1) the relationship of the new virus to the SARS-related coron...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Ping Yu; Jiang Zhu; Zhengdong Zhang; Yingjun Han;
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)

    Abstract An ongoing outbreak of pneumonia associated with 2019 novel coronavirus was reported in China. It is unclear whether the virus is infective exists during the incubation period, although person-to-person transmission has been reported elsewhere. We report the ep...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Yi Fan; Kai Zhao; Zhengli Shi; Peng Zhou;
    Persistent Identifiers
    Publisher: MDPI

    <jats:p>During the past two decades, three zoonotic coronaviruses have been identified as the cause of large-scale disease outbreaks–Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS), and Swine Acute Diarrhea Syndrome (SADS). SARS and MER...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Dan Hu; Zhu Changqiang; Ai Lele; He Ting; Yi Wang; Fuqiang Ye; Yang Lu; Ding Chenxi; Xuhui Zhu; Ruicheng Lv; ...
    Persistent Identifiers
    Publisher: Taylor & Francis Group

    Abstract SARS coronavirus (SARS-CoV), the causative agent of the large SARS outbreak in 2003, originated in bats. Many SARS-like coronaviruses (SL-CoVs) have been detected in bats, particularly those that reside in China, Europe, and Africa. To further understand the ev...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Wang, Liang; Su, Shuo; Bi, Yuhai; Wong, Gary; Gao, George F.;
    Persistent Identifiers

    Infections with bat-origin coronaviruses have caused severe illness in humans by ‘host jump’. Recently, novel bat-origin coronaviruses were found in pigs. The large number of mutations on the receptor-binding domain allowed the viruses to infect the new host, posing a p...

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  • publication . Article . 2018
    Open Access
    Authors:
    Peihua Niu; Senyan Zhang; Panpan Zhou; Baoying Huang; Yao Deng; Kun Qin; Pengfei Wang; Wenling Wang; Xinquan Wang; Jianfang Zhou; ...
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)

    We describe the MERS-CoV-neutralizing antibody repertoires from a survivor and characterized 13 ultrapotent mAbs. The mAbs, MERS-GD27 and MERS-GD33, exhibited the strongest neutralizing activities. Both targeted receptor-binding domain via different contacts. The epitop...

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  • publication . Article . 2018
    Open Access
    Authors:
    Peng Zhou; Hang Fan; Tian Lan; Xing-Lou Yang; Weifeng Shi; Wei Zhang; Yan Zhu; Ya-Wei Zhang; Qingmei Xie; Shailendra Mani; ...
    Persistent Identifiers
    Publisher: Springer Nature
    Project: NIH | Understanding the Risk of... (5R01AI110964-05)

    Analysis of viral samples from deceased piglets shows that a bat coronavirus was responsible for an outbreak of fatal disease in China and highlights the importance of the identification of coronavirus diversity and distribution in bats in order to mitigate future outbr...

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  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Yun Luo; Bei Li; Ren-Di Jiang; Bing-Jie Hu; Dong-Sheng Luo; Guangjian Zhu; Ben Hu; Haizhou Liu; Yun-Zhi Zhang; Xing-Lou Yang; ...
    Persistent Identifiers
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Understanding the Risk of... (5R01AI110964-05)

    Previous studies indicated that fruit bats carry two betacoronaviruses, BatCoV HKU9 and BatCoV GCCDC1. To investigate the epidemiology and genetic diversity of these coronaviruses, we conducted a longitudinal surveillance in fruit bats in Yunnan province, China during 2...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Susanna K. P. Lau; Libiao Zhang; Hayes K.H. Luk; Lifeng Xiong; Xingwen Peng; Kenneth S. M. Li; Xiangyang He; Pyrear S.H. Zhao; Rachel Y. Y. Fan; Antonio C. P. Wong; ...
    Persistent Identifiers
    Publisher: Oxford University Press

    The discovery of Hp-BatCoV HKU25 bridges the evolutionary gap between MERS-CoV and existing bat viruses, and suggests that bat viruses may have evolved to generate MERS-CoV through modulation of the spike protein for binding to hDPP4.

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  • publication . Article . 2017
    Open Access English
    Authors:
    Obameso, Joseph O.; Li, Hong; Jia, Hao; Han, Min; Zhu, Shiyan; Huang, Canping; Zhao, Yuhui; Zhao, Min; Bai, Yu; Yuan, Fei; ...
    Persistent Identifiers
    Publisher: Science China Press

    Bats are connected with the increasing numbers of emerging and re-emerging viruses that may break the species barrier and spread into the human population. Coronaviruses are one of the most common viruses discovered in bats, which were considered as the natural source o...

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60 research outcomes, page 1 of 6