Quick search
Advanced search in
Research outcomes
Field to searchTerm
Add rule
The following results are related to COVID-19. Are you interested to view more results? Visit OpenAIRE - Explore.
Download Results
25 research outcomes, page 1 of 3
  • publication . Article . Other literature type . 2020
    Open Access
    Authors:
    Yu, Ping; Zhu, Jiang; Zhang, Zhengdong; Han, Yingjun;
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)

    Abstract An ongoing outbreak of pneumonia associated with 2019 novel coronavirus was reported in China. It is unclear whether the virus is infective exists during the incubation period, although person-to-person transmission has been reported elsewhere. We report the ep...

    Add to ORCID
  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Lau, Susanna K P; Zhang, Libiao; Luk, Hayes K H; Xiong, Lifeng; Peng, Xingwen; Li, Kenneth S M; He, Xiangyang; Zhao, Pyrear Su-Hui; Fan, Rachel Y Y; Wong, Antonio C P; ...
    Persistent Identifiers

    The discovery of Hp-BatCoV HKU25 bridges the evolutionary gap between MERS-CoV and existing bat viruses, and suggests that bat viruses may have evolved to generate MERS-CoV through modulation of the spike protein for binding to hDPP4.

    Add to ORCID
  • publication . Article . 2018
    Open Access English
    Authors:
    Peihua Niu; Senyan Zhang; Panpan Zhou; Baoying Huang; Yao Deng; Kun Qin; Pengfei Wang; Wenling Wang; Xinquan Wang; Jianfang Zhou; ...
    Persistent Identifiers
    Publisher: Oxford University Press

    We describe the MERS-CoV-neutralizing antibody repertoires from a survivor and characterized 13 ultrapotent mAbs. The mAbs, MERS-GD27 and MERS-GD33, exhibited the strongest neutralizing activities. Both targeted receptor-binding domain via different contacts. The epitop...

    Add to ORCID
  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Chen, Zhe; Bao, Linlin; Chen, Cong; Zou, Tingting; Xue, Ying; Li, Fengdi; Lv, Qi; Gu, Songzhi; Gao, Xiaopan; Cui, Sheng; ...
    Persistent Identifiers
    Publisher: Oxford University Press

    Summary A human monoclonal antibody, MCA1, directly targeting the receptor-binding domain of Middle East respiratory syndrome coronavirus (MERS-CoV) S glycoprotein, was isolated from a human survivor. MCA1 highly neutralized MERS-CoV in vitro and completely inhibited vi...

    Add to ORCID
  • publication . Other literature type . Article . 2016
    Open Access
    Authors:
    Chu, Hin; Zhou, Jie; Wong, Bosco Ho-Yin; Li, Cun; Chan, Jasper Fuk-Woo; Cheng, Zhong-Shan; Yang, Dong; Wang, Dong; Lee, Andrew Chak-Yiu; Li, Chuangen; ...
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)

    Abstract Middle East respiratory syndrome (MERS) is associated with a mortality rate of >35%. We previously showed that MERS coronavirus (MERS-CoV) could infect human macrophages and dendritic cells and induce cytokine dysregulation. Here, we further investigated the in...

    Add to ORCID
  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Katherine V. Houser; Lisa M. Gretebeck; Tianlei Ying; Yanping Wang; Leatrice Vogel; Elaine W. Lamirande; Kevin W. Bock; Ian N. Moore; Dimiter S. Dimitrov; Kanta Subbarao;
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)

    With >1600 documented human infections with Middle East respiratory syndrome coronavirus (MERS-CoV) and a case fatality rate of approximately 36%, medical countermeasures are needed to prevent and limit the disease. We examined the in vivo efficacy of the human monoclon...

    Add to ORCID
  • publication . Article . 2016
    Open Access English
    Authors:
    Zhiqiang Wu; Li Yang; Xianwen Ren; Junpeng Zhang; Fan Yang; Shuyi Zhang; Qi Jin;
    Persistent Identifiers
    Publisher: Oxford University Press

    Abstract Several lineage B betacoronaviruses termed severe acute respiratory syndrome (SARS)–like CoVs (SL-CoVs) were identified from Rhinolophus bats in China. These viruses are characterized by a set of unique accessory open reading frames (ORFs) that are located betw...

    Add to ORCID
  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Chan, Jasper Fuk-Woo; Yao, Yanfeng; Yeung, Man-Lung; Deng, Wei; Bao, Linlin; Jia, Lilong; Li, Fengdi; Xiao, Chong; Gao, Hong; Yu, Pin; ...
    Persistent Identifiers

    Abstract Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe disease in human with an overall case-fatality rate of >35%. Effective antivirals are crucial for improving the clinical outcome of MERS. Although a number of repurposed drugs, convalescent-p...

    Add to ORCID
  • publication . Other literature type . Article . 2015
    Open Access English
    Authors:
    Channappanavar, Rudragouda; Lu, Lu; Xia, Shuai; Du, Lanying; Meyerholz, David K.; Perlman, Stanley; Jiang, Shibo;
    Persistent Identifiers
    Publisher: Oxford University Press
    Project: NIH | Animal Core (5P01AI060699-10), NIH | Role of anti-SARS-CoV T c... (5R01AI091322-04)

    To gain entry into the target cell, Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) uses its spike (S) protein S2 subunit to fuse with the plasma or endosomal membrane. Previous work identified a peptide derived from the heptad repeat (HR) 2 domain in S2 ...

    Add to ORCID
  • publication . Article . Other literature type . 2015
    Open Access
    Authors:
    Tianlei Ying; Wei Li; Dimiter S. Dimitrov;
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)
    Add to ORCID
25 research outcomes, page 1 of 3