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21 research outcomes, page 1 of 3
  • publication . Article . 2021
    Open Access
    Authors:
    Werner J. D. Ouwendijk; Matthijs P. Raadsen; Jeroen J. A. van Kampen; Robert M. Verdijk; Jan H. von der Thüsen; Lihui Guo; Rogier A.S. Hoek; Johannes P.C. van den Akker; Henrik Endeman; Thomas Langerak; ...
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)

    SARS-CoV-2 induced lower respiratory tract (LRT) disease can deteriorate to acute respiratory distress syndrome (ARDS). Because the release of neutrophil extracellular traps (NETs) is implicated in ARDS pathogenesis, we investigated the presence of NETs and correlates o...

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  • publication . Article . 2021
    Open Access
    Authors:
    José Luis Piñana; Aliénor Xhaard; Gloria Tridello; Jakob Passweg; Anne E. Kozijn; Nicola Polverelli; Inmaculada Heras; Ariadna Pérez; Jaime Sanz; Dagmar Berghuis; ...

    <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Little is known about characteristics of seasonal human coronaviruses (HCoVs) (NL63, 229E, OC43, and HKU1) after allogeneic stem cell transplantation (allo-HSCT).</jats:p> </jats:se...

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  • publication . Article . 2021
    Open Access
    Authors:
    Nico A. F. Janssen; Inge Grondman; Aline H. de Nooijer; Collins K Boahen; Valerie A C M Koeken; Vasiliki Matzaraki; Vinod Kumar; Xuehui He; Matthijs Kox; Hans J. P. M. Koenen; ...
    Project: EC | TRAIN-OLD (833247)

    <jats:title>Abstract</jats:title> <jats:p>The clinical spectrum of COVID-19 varies and the differences in host response characterizing this variation have not been fully elucidated. COVID-19 disease severity correlates with an excessive proinflammatory immune response a...

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  • publication . Article . 2020
    Open Access
    Authors:
    de Nooijer, Aline H; Grondman, Inge; Janssen, Nico A F; Netea, Mihai G; Willems, Loek; van de Veerdonk, Frank L; Giamarellos-Bourboulis, Evangelos J; Toonen, Erik J M; Joosten, Leo A B; Jaeger, Martin; ...
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)

    Abstract Background Excessive activation of immune responses in coronavirus disease 2019 (COVID-19) is considered to be related to disease severity, complications, and mortality rate. The complement system is an important component of innate immunity and can stimulate i...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Eelke Brandsma; Han J.M.P. Verhagen; Thijs J.W. van de Laar; Eric C. J. Claas; Marion Cornelissen; Emile van den Akker;
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)

    <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Recent advances in CRISPR-based diagnostics suggest that DETECTR, a combination of reverse-transcriptase loop-mediated isothermal amplification (RT-LAMP) and subsequent Cas12 bystan...

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  • publication . Preprint . Article . 2020
    Open Access
    Authors:
    Gerco den Hartog; Rutger M. Schepp; Marjan Kuijer; Corine H. GeurtsvanKessel; Josine van Beek; Nynke Y. Rots; Marion Koopmans; Fiona R. M. van der Klis; Robert S. van Binnendijk;
    Publisher: Cold Spring Harbor Laboratory

    Detection of SARS-CoV-2–specific antibodies is instrumental to study seroprevalence and immune protection to the virus. We validated a multiplex assay to detect antibodies to SARS-CoV-2 N, S1, and RBD, and provide a framework to perform accurate serosurveys for COVID-19...

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  • publication . Article . Preprint . 2020
    Open Access English
    Authors:
    Eelke Brandsma; Han J.M.P. Verhagen; Thijs J.W. van de Laar; Eric C. J. Claas; Marion Cornelissen; Emile van den Akker;
    Persistent Identifiers
    Publisher: Oxford University Press

    <jats:title>Abstract</jats:title><jats:p>Recent advances in CRISPR-based diagnostics suggest that DETECTR, a combination of isothermal reverse transcriptase loop mediated amplification (RT-LAMP) and subsequent Cas12 bystander nuclease activation by amplicon targeting ri...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Pengfei Li; Jiaye Liu; Zhongren Ma; Wichor M. Bramer; Maikel P. Peppelenbosch; Qiuwei Pan;
    Persistent Identifiers
    Publisher: Oxford University Press
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  • publication . Article . 2018
    Open Access English
    Authors:
    Patience K. Kiyuka; Charles N. Agoti; Patrick K. Munywoki; Regina Njeru; Anne Bett; James R. Otieno; Grieven P Otieno; Everlyn Kamau; Taane G. Clark; László van den Hoek; ...
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)
    Project: UKRI | The interactions between ... (MR/K000551/1), UKRI | Understanding the transmi... (MR/N010469/1), UKRI | Zika: Zika virus surveill... (MC_PC_15103), UKRI | Geographic genetic profil... (MR/M01360X/1), WT | Defining pathways of resp... (102975)

    Infections with human coronavirus NL63 are common and reinfections occur repeatedly throughout life. A subset of repeat infections show enhanced virus replication with no evidence of genotype switching, indicating that initial exposure is insufficient to elicit a protec...

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  • publication . Article . 2017
    Open Access
    Authors:
    Reina S. Sikkema; Elmoubasher Farag; Sayed Himatt; Adel K Ibrahim; Hamad Al-Romaihi; Salih A. Al-Marri; Mohamed Al-Thani; Ahmed M. El-Sayed; Mohammed Al-Hajri; Bart L. Haagmans; ...
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)
    Project: EC | COMPARE (643476), EC | PREPARE (602525)

    Abstract The transmission routes and risk factors for zoonotic Middle East respiratory syndrome coronavirus (MERS-CoV) infections are still unknown. We used the World Health Organization questionnaire for MERS-CoV case-control studies to assess risk factors for human ME...

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21 research outcomes, page 1 of 3