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12 research outcomes, page 1 of 2
  • publication . Article . 2021
    Open Access English
    Authors:
    de Nooijer, Aline H; Grondman, Inge; Janssen, Nico A F; Netea, Mihai G; Willems, Loek; van de Veerdonk, Frank L; Giamarellos-Bourboulis, Evangelos J; Toonen, Erik J M; Joosten, Leo A B; Jaeger, Martin; ...
    Publisher: Oxford University Press (OUP)

    Background: Excessive activation of immune responses in coronavirus disease 2019 (COVID-19) is considered to be related to disease severity, complications, and mortality rate. The complement system is an important component of innate immunity and can stimulate inflammat...

  • publication . Article . Other literature type . 2020
    Open Access
    Authors:
    Gerco den Hartog; Rutger M. Schepp; Marjan Kuijer; Corine H. GeurtsvanKessel; Josine van Beek; Nynke Y. Rots; Marion Koopmans; Fiona R. M. van der Klis; Robert S. van Binnendijk;
    Publisher: Oxford University Press (OUP)

    Detection of SARS-CoV-2–specific antibodies is instrumental to study seroprevalence and immune protection to the virus. We validated a multiplex assay to detect antibodies to SARS-CoV-2 N, S1, and RBD, and provide a framework to perform accurate serosurveys for COVID-19...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Li, Pengfei; Liu, Jiaye; Ma, Zhongren; Bramer, Wichor M; Peppelenbosch, Maikel P; Pan, Qiuwei;
    Persistent Identifiers
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  • publication . Article . 2018
    Open Access English
    Authors:
    Patience K. Kiyuka; Charles N. Agoti; Patrick K. Munywoki; Regina Njeru; Anne Bett; James R. Otieno; Grieven P Otieno; Everlyn Kamau; Taane G. Clark; László van den Hoek; ...
    Persistent Identifiers
    Project: UKRI | Geographic genetic profil... (MR/M01360X/1), UKRI | Zika: Zika virus surveill... (MC_PC_15103), WT | Defining pathways of resp... (102975), UKRI | Understanding the transmi... (MR/N010469/1), UKRI | The interactions between ... (MR/K000551/1)

    Infections with human coronavirus NL63 are common and reinfections occur repeatedly throughout life. A subset of repeat infections show enhanced virus replication with no evidence of genotype switching, indicating that initial exposure is insufficient to elicit a protec...

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  • publication . Article . 2017
    Open Access
    Authors:
    Reina S. Sikkema; Elmoubasher Farag; Sayed Himatt; Adel K Ibrahim; Hamad Al-Romaihi; Salih A. Al-Marri; Mohamed Al-Thani; Ahmed M. El-Sayed; Mohammed Al-Hajri; Bart L. Haagmans; ...
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)
    Project: EC | COMPARE (643476), EC | PREPARE (602525)

    Abstract The transmission routes and risk factors for zoonotic Middle East respiratory syndrome coronavirus (MERS-CoV) infections are still unknown. We used the World Health Organization questionnaire for MERS-CoV case-control studies to assess risk factors for human ME...

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  • publication . Article . Other literature type . 2015
    Open Access English
    Authors:
    Viktoriya Borisevich; Benhur Lee; Andrew C. Hickey; Blair L. DeBuysscher; Christopher C. Broder; Heinz Feldmann; Barry Rockx;
    Persistent Identifiers
    Project: NIH | Nipah Virus and Hendra Vi... (5R01AI054715-03)

    textabstractHenipaviruses are zoonotic viruses that can cause severe and acute respiratory diseases and encephalitis in humans. To date, no vaccine or treatments are approved for human use. The presence of neutralizing antibodies is a strong correlate of protection agai...

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  • publication . Article . 2014
    Open Access English
    Authors:
    Ann R. Falsey; Janet E. McElhaney; Jiri Beran; Gerrit A van Essen; Xavier Duval; Meral Esen; Florence Galtier; Pierre Gervais; Shinn-Jang Hwang; Peter G. Kremsner; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: CIHR

    International audience; Background. Few studies have prospectively assessed viral etiologies of acute respiratory infections in community-based elderly individuals. We assessed viral respiratory pathogens in individuals ≥65 years with influenza-like illness (ILI).Method...

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  • publication . Other literature type . Article . 2011
    Open Access English
    Authors:
    Dennis K. M. Ip; Martin Schutten; Vicky J. Fang; Rita O. P. Fung; Regina Dutkowski; Kwok-Hung Chan; Gabriel M. Leung; J. S. Malik Peiris; Benjamin J. Cowling;
    Persistent Identifiers
    Publisher: Oxford University Press
    Project: NIH | Peer-Driven Intervention ... (5R01AI070005-02), NIH | MIDAS Center for Communic... (1U54GM088558-01), NIH | A Controlled Trial of Mas... (5U01CI000439-02)

    Few studies have investigated the validity of self-collected nose and throat swabs for influenza confirmation in community settings. We followed outpatients with confirmed influenza with sequential measurement of viral loads and applied log-linear regression models to t...

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  • publication . Other literature type . Article . 2010
    Open Access English
    Authors:
    Barry Rockx; Eric F. Donaldson; Matthew B. Frieman; Timothy P. Sheahan; Davide Corti; Antonio Lanzavecchia; Ralph S. Baric;
    Project: NIH | SARS Reverse Genetics (5R01AI059136-03), NIH | Developing Vaccine Candid... (3P01AI059443-03S1)

    markdownabstractBackground. Severe acute respiratory syndrome (SARS) emerged as a human disease in 2002. Detailed phylogenetic analysis and epidemiologic studies have suggested that the SARS Coronavirus (SARS-CoV) originated from animals. The spike (S) glycoprotein has ...

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  • publication . Article . 2006
    Open Access English
    Authors:
    Luan-Yin Chang; Bor-Luen Chiang; Chuan-Liang Kao; Mei-Hwan Wu; Pei-Jer Chen; Ben Berkhout; Hui-Ching Yang; Li-Min Huang;
    Persistent Identifiers

    Abstract We investigated whether infection with a novel human coronavirus (HCoV), called “New Haven coronavirus” (HCoV-NH)—which is similar to and likely represents the same species as another novel HCoV, HCoV-NL63—is associated with Kawasaki disease (KD) in Taiwan. Fif...

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12 research outcomes, page 1 of 2