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12 research outcomes, page 1 of 2
  • publication . Article . 2020
    Open Access English
    Authors:
    Marcel A. Behr; Maziar Divangahi; Erwin Schurr;
    Persistent Identifiers
    Publisher: Oxford University Press
    Project: CIHR

    <jats:title>Abstract</jats:title> <jats:p>Developers of severe acute respiratory syndrome coronavirus 2 vaccines should consider some of the lessons from a “new” vaccine introduced in 1921, namely bacille Calmette-Guérin.</jats:p>

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  • publication . Article . Preprint . 2020
    Open Access English
    Authors:
    Kinloch, Natalie N.; Ritchie, Gordon; Brumme, Chanson J.; Dong, Winnie; Dong, Weiyan; Lawson, Tanya; Jones, R. Brad; Montaner, Julio S.G.; Leung, Victor; Romney, Marc G.; ...
    Persistent Identifiers
    Publisher: Oxford University Press
    Project: CIHR

    Abstract False-negative SARS-CoV-2 test results can negatively impact the clinical and public health response to COVID-19. We used droplet digital PCR (ddPCR) to demonstrate that human DNA levels, a stable molecular marker of sampling quality, were significantly lower i...

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  • publication . Other literature type . Article . 2017
    Open Access English
    Authors:
    Makeda Semret; Ian Schiller; Barbara Ann Jardin; Charles Frenette; Vivian G. Loo; Jesse Papenburg; Shelly A. McNeil; Nandini Dendukuri;
    Persistent Identifiers
    Publisher: Oxford University Press
    Project: CIHR

    Background Respiratory tract infections are frequent causes of hospitalization and initiation of empirical antimicrobial therapy. Testing for a broad panel of respiratory viruses has been advocated as a useful tool for antibiotic stewardship. We conducted a prospective ...

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  • publication . Other literature type . Article . 2016
    Open Access English
    Authors:
    Chad E. Mire; Joan B. Geisbert; Krystle N. Agans; Emily P. Thi; Amy C. H. Lee; Karla A. Fenton; Thomas W. Geisbert;
    Persistent Identifiers
    Publisher: Oxford University Press
    Project: NIH | BSL4 Evaluation Core (1U19AI109711-01), NIH | National Biocontainment L... (5UC7AI094660-03)

    Background Convalescent serum and blood were used to treat patients during outbreaks of Zaire ebolavirus (ZEBOV) infection in 1976 and 1995, with inconclusive results. During the recent 2013-2016 West African epidemic, serum/plasma from survivors of ZEBOV infection was ...

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  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Katherine V. Houser; Lisa M. Gretebeck; Tianlei Ying; Yanping Wang; Leatrice Vogel; Elaine W. Lamirande; Kevin W. Bock; Ian N. Moore; Dimiter S. Dimitrov; Kanta Subbarao;
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)

    With >1600 documented human infections with Middle East respiratory syndrome coronavirus (MERS-CoV) and a case fatality rate of approximately 36%, medical countermeasures are needed to prevent and limit the disease. We examined the in vivo efficacy of the human monoclon...

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  • publication . Article . 2015
    Open Access
    Authors:
    Karen L. Laurie; Teagan Guarnaccia; Louise A. Carolan; Ada W. C. Yan; Malet Aban; Stephen Petrie; Pengxing Cao; Jane M. Heffernan; Jodie McVernon; Jennifer Mosse; ...
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)

    (See the editorial commentary by Schultz-Cherry on pages 1690–1.) Viral interference, whereby infection with one virus limits infection and replication of a second virus, has been described in humans [1–7]. Within populations, different respiratory viruses reach their e...

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  • publication . Article . 2014
    Open Access English
    Authors:
    Ziad A. Memish; Abdullah M. Assiri; Malak Almasri; Rafat F. Alhakeem; Abdulhafeez Turkestani; Abdullah A. Al Rabeeah; Jaffar A. Al-Tawfiq; Abdullah Alzahrani; Essam Azhar; Hatem Q. Makhdoom; ...
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    Publisher: Oxford University Press

    Abstract Background. Annually, Saudi Arabia is the host of the Hajj mass gathering. We aimed to determine the Middle East respiratory syndrome coronavirus (MERS-CoV) nasal carriage rate among pilgrims performing the 2013 Hajj and to describe the compliance with the Saud...

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  • publication . Article . 2014
    Open Access English
    Authors:
    Ann R. Falsey; Janet E. McElhaney; Jiri Beran; Gerrit A van Essen; Xavier Duval; Meral Esen; Florence Galtier; Pierre Gervais; Shinn-Jang Hwang; Peter G. Kremsner; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: CIHR

    International audience; Background. Few studies have prospectively assessed viral etiologies of acute respiratory infections in community-based elderly individuals. We assessed viral respiratory pathogens in individuals ≥65 years with influenza-like illness (ILI).Method...

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  • publication . Article . 2014
    Open Access English
    Authors:
    Ziad A. Memish; Jaffar A. Al-Tawfiq; Hatem Q. Makhdoom; Abdullah M. Assiri; Raafat F. Alhakeem; Ali Albarrak; Sarah Alsubaie; Abdullah A Al-Rabeeah; Waleed H. Hajomar; Raheela Hussain; ...
    Persistent Identifiers
    Publisher: Oxford University Press
    Project: EC | EMPERIE (223498), EC | ANTIGONE (278976), WT

    Abstract Background. Analysis of clinical samples from patients with new viral infections is critical to confirm the diagnosis, to specify the viral load, and to sequence data necessary for characterizing the viral kinetics, transmission, and evolution. We analyzed samp...

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  • publication . Article . Other literature type . 2011
    Open Access
    Authors:
    Mike Bray; James V. Lawler; Jason Paragas; Peter B. Jahrling; Daniel J. Mollura;
    Persistent Identifiers
    Publisher: Oxford University Press (OUP)

    Research on the pathogenesis and therapy of influenza and other emerging respiratory viral infections would be aided by methods that directly visualize pathophysiologic processes in patients and laboratory animals. At present, imaging of diseases, such as swine-origin H...

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12 research outcomes, page 1 of 2