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The following results are related to COVID-19. Are you interested to view more results? Visit OpenAIRE - Explore.
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2,264 research outcomes, page 1 of 227
  • publication . Article . 2022
    Closed Access
    Authors:
    Rachid Essalmani; Jaspreet Jain; Delia Susan-Resiga; Ursula Andréo; Alexandra Evagelidis; Rabeb Mouna Derbali; David N. Huynh; Frédéric Dallaire; Mélanie Laporte; Adrien Delpal; ...
    Persistent Identifiers
    Publisher: American Society for Microbiology
    Project: CIHR

    SARS-CoV-2, the etiological agent of COVID-19, has so far resulted in >6.1 million deaths worldwide. The spike protein (S) of the virus directs infection of the lungs and other tissues by binding the angiotensin-converting enzyme 2 (ACE2) receptor.

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  • publication . Article . 2022
    Closed Access
    Authors:
    Mei-Qin Liu; Ren-Di Jiang; Jing Guo; Ying Chen; Dong-Sheng Yang; Xi Wang; Hao-Feng Lin; Ang Li; Bei Li; Ben Hu; ...
    Persistent Identifiers
    Publisher: American Society for Microbiology

    The genetic diversity of SARSr-CoVs in wildlife and their potential risk of cross-species infection highlight the necessity of developing wide-spectrum vaccines against infection of various SARSr-CoVs. In this study, we tested the protective efficacy of the SARS-CoV-2 i...

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  • publication . Article . 2022
    Closed Access
    Authors:
    Qibin Geng; Ke Shi; Gang Ye; Wei Zhang; Hideki Aihara; Fang Li;
    Persistent Identifiers
    Publisher: American Society for Microbiology

    Despite the scarcity of the SARS-CoV-2 receptor—human angiotensin-converting enzyme 2 (ACE2)—in the respiratory tract, the omicron variant efficiently infects the respiratory tract, causing rapid and widespread infections of COVID-19. The omicron variant contains extens...

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  • publication . Article . 2022
    Closed Access
    Authors:
    Jiyao Chen; Zhuang Li; Jiahui Guo; Shangen Xu; Junwei Zhou; Qian Chen; Xue Tong; Dang Wang; Guiqing Peng; Liurong Fang; ...
    Persistent Identifiers
    Publisher: American Society for Microbiology

    The nsp5-encoded 3C-like protease is the main coronavirus protease, playing a vital role in viral replication and immune evasion by cleaving viral polyproteins and host immune-related molecules. We showed that both SARS-CoV-2 nsp5 and SARS-CoV nsp5 cleave the NEMO at mu...

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  • publication . Article . 2022
    Closed Access
    Authors:
    Jian Li; Cheng Lin; Xuelan Zhou; Fanglin Zhong; Pei Zeng; Yang Yang; Yuting Zhang; Bo Yu; Xiaona Fan; Peter J. McCormick; ...
    Persistent Identifiers
    Publisher: American Society for Microbiology

    The current pandemic of multiple variants has created an urgent need for effective inhibitors of SARS-CoV-2 to complement vaccine strategies. PF-07321332, developed by Pfizer, is the first orally administered coronavirus-specific main protease inhibitor approved by the ...

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  • publication . Article . 2022
    Closed Access
    Authors:
    Jessica Pires Farias; Patrícia de Souza da Silva; Mayanna Moreira Costa Fogaça; Itana Vivian Rocha Santana; Wilson Barros Luiz; Alexander Birbrair; Jaime Henrique Amorim;
    Persistent Identifiers
    Publisher: American Society for Microbiology

    COVID-19 continues to spread around the world despite significant progress in vaccine distribution and population immunity. The dynamics of the antiviral antibody response postvaccination is critical to evaluate vaccine effectiveness across different vaccine platforms a...

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  • publication . Article . 2022
    Open Access
    Authors:
    Trevor J. Hancock; Peyton Hickman; Niloo Kazerooni; Melissa Kennedy; Stephen A. Kania; Michelle Dennis; Nicole Szafranski; Richard Gerhold; Chunlei Su; Tom Masi; ...
    Persistent Identifiers
    Publisher: American Society for Microbiology

    We report cross-reactive antibodies from prepandemic cats and postpandemic South Carolina white-tailed deer that are specific for that SARS-CoV RBD. There are several potential explanations for this cross-reactivity, each with important implications to coronavirus disea...

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  • publication . Article . 2022
    Open Access
    Authors:
    Xiao-Shuang Zheng; Qi Wang; Juan Min; Xu-Rui Shen; Qian Li; Qiu-Chen Zhao; Xi Wang; Ren-Di Jiang; Rong Geng; Ying Chen; ...
    Persistent Identifiers
    Publisher: American Society for Microbiology

    We demonstrated the single-cell landscape in lung and spleen upon SARS-CoV-2 infection in an acute severe disease mouse model that replicated human symptoms, including severe lung pathology and lymphopenia. Our comprehensive study revealed the key role of neutrophil-med...

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  • publication . Article . 2022
    Closed Access
    Authors:
    Jie Gao; Yan-Dong Tang; Wei Hu; Chunfu Zheng;
    Persistent Identifiers
    Publisher: American Society for Microbiology

    Viruses have evolved diverse strategies to hijack the cellular gene expression system for their replication. The poly(A) binding proteins (PABPs), a family of critical gene expression factors, are viruses’ common targets.

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  • publication . Article . 2022
    Closed Access
    Authors:
    Camila Metz-Zumaran; Carmon Kee; Patricio Doldan; Cuncai Guo; Megan L. Stanifer; Steeve Boulant;
    Persistent Identifiers
    Publisher: American Society for Microbiology

    SARS-CoV-2 infection is not restricted to the respiratory tract and a large number of COVID-19 patients experience gastrointestinal distress. Interferons are key molecules produced by the cell to combat virus infection.

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2,264 research outcomes, page 1 of 227