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657 research outcomes, page 1 of 66
  • publication . Article . 2021
    Open Access English
    Authors:
    Qin, Pan; Luo, Wen-Ting; Su, Quan; Zhao, Pengwei; Zhang, Yuqi; Wang, Bin; Yang, Yong-Le; Huang, Yao-Wei;
    Persistent Identifiers
    Publisher: Elsevier BV

    Highlights • PDCoV accessory protein NS6 is expressed during infection in vivo. • A 13-KDa NS6 protein is detected in purified PDCoV virions. • NS6 is incorporated into PDCoV particles by immunogold labeling with anti-NS6. • Anti-NS6 does not exhibit neutralizing activi...

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  • publication . Article . 2021
    Open Access English
    Authors:
    Detsika, Maria G.; Ampelakiotou, Kleio; Grigoriou, Eirini; Psarra, Katherina; Jahaj, Edison; Roussos, Charis; Dimopoulou, Ioanna; Orfanos, Stylianos E.; Tsirogianni, Alexandra; Kotanidou, Anastasia;
    Persistent Identifiers
    Publisher: Elsevier BV

    Infection with SARS-COV-2 may result in severe pneumonia potentially leading to mechanical ventilation and intensive care treatment. The aim of the present study was to analyze the immune responses in critically ill coronavirus 2019 (COVID-19) patients requiring mechani...

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  • publication . Article . 2021
    Open Access English
    Authors:
    Ratcliff, Jeremy; Simmonds, Peter;
    Persistent Identifiers
    Publisher: The Authors. Published by Elsevier Inc.

    Highlights - SARS-CoV-2 sequence variants contain an overabundance of C- > U transitions - C- > U transitions are the hallmark of the activity of APOBEC cytosine deaminases - Further work is needed to determine APOBEC's role in coronavirus evolution

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  • publication . Article . 2021
    Open Access English
    Authors:
    Stauft, Charles B.; Lien, Christopher Z.; Selvaraj, Prabhuanand; Liu, Shufeng; Wang, Tony T.;
    Persistent Identifiers
    Publisher: Published by Elsevier Inc.

    Dynamic tracking of variant frequencies among viruses circulating in the global pandemic has revealed the emergence and dominance of a D614G mutation in the SARS-CoV-2 spike protein. To address whether pandemic SARS-CoV-2 G614 variant has evolved to become more pathogen...

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  • publication . Article . 2021
    Open Access English
    Authors:
    OBrien, Amornrat; Chen, Da-Yuan; Hackbart, Matthew; Close, Brianna J.; OBrien, Timothy E.; Saeed, Mohsan; Baker, Susan C.;
    Persistent Identifiers
    Publisher: Elsevier Inc.

    The need to stem the current outbreak of SARS-CoV-2 responsible for COVID-19 is driving the search for inhibitors that will block coronavirus replication and pathogenesis. The coronavirus 3C-like protease (3CLpro) encoded in the replicase polyprotein is an attractive ta...

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  • publication . Article . 2021
    Open Access English
    Authors:
    Mihelc, Elaine M.; Baker, Susan C.; Lanman, Jason K.;
    Persistent Identifiers
    Publisher: Elsevier BV

    Highlights • Large volume electron tomography provides a broad view of coronavirus membrane rearrangements. • Double membrane vesicles form by budding from the ER. • Double membrane vesicles are trafficked to lysosomes for degradation. • The reticulovesicular network br...

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  • publication . Article . 2021
    Open Access English
    Authors:
    Lu, Kristina T.; Yamamoto, Takuya; McDonald, David; Li, Wei; Tan, Marissa; Moi, Meng Ling; Park, Eun-Chung; Yoshimatsu, Kumiko; Ricciardone, Marie; Hildesheim, Allan; ...
    Persistent Identifiers
    Publisher: Elsevier BV
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  • publication . Article . 2021
    Open Access English
    Authors:
    Freire-Paspuel, Byron; Vega-Marino, Patricio; Velez, Alberto; Cruz, Marilyn; Perez, Franklin; Garcia-Bereguiain, Miguel Angel;
    Persistent Identifiers
    Publisher: Elsevier BV
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  • publication . Article . 2021
    Open Access English
    Authors:
    Takeshita, Masaru; Nishina, Naoshi; Moriyama, Saya; Takahashi, Yoshimasa; Uwamino, Yoshifumi; Nagata, Mika; Aoki, Wataru; Masaki, Katsunori; Ishii, Makoto; Saya, Hideyuki; ...
    Persistent Identifiers
    Publisher: The Authors. Published by Elsevier Inc.

    Highlights • Antibodies against viral antigens of each isotype are mutually correlated. • Antibodies against Spike antigens were correlated with neutralizing titer. • Low Ct value, pneumonia, and high CRP level were associated with neutralizing titer. • 87.5% of asympto...

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  • publication . Article . 2021
    Open Access English
    Authors:
    Terry, James S.; Anderson, Loran BR.; Scherman, Michael S.; McAlister, Carley E.; Perera, Rushika; Schountz, Tony; Geiss, Brian J.;
    Persistent Identifiers
    Publisher: Elsevier BV

    To help fight COVID-19, new molecular tools specifically targeting critical components of the causative agent of COVID-19, SARS-Coronavirus-2 (SARS-CoV-2), are desperately needed. The SARS-CoV-2 nucleocapsid protein is critical for viral replication, integral to viral p...

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657 research outcomes, page 1 of 66