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description Publicationkeyboard_double_arrow_right Article 2024 ItalyPublisher:Elsevier BV Authors: Myftiu, Jurgena; Gigliarano, Chiara; Maggi, Elena; Scagni, Andrea;Myftiu, Jurgena; Gigliarano, Chiara; Maggi, Elena; Scagni, Andrea;handle: 2318/1950751
Archivio Istituziona... arrow_drop_down Research in Transportation Business & ManagementArticle . 2024 . Peer-reviewedLicense: CC BY NC NDData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.rtbm.2023.101091&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Archivio Istituziona... arrow_drop_down Research in Transportation Business & ManagementArticle . 2024 . Peer-reviewedLicense: CC BY NC NDData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.rtbm.2023.101091&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024 ItalyPublisher:Elsevier BV Authors: Bruno Casella; Walter Riviera; Marco Aldinucci; Gloria Menegaz;Bruno Casella; Walter Riviera; Marco Aldinucci; Gloria Menegaz;handle: 2318/1950975
Summary: Federated learning is a cooperative learning approach that has emerged as an effective way to address privacy concerns. Here, we present a protocol for training MERGE: a federated multi-input neural network (NN) for COVID-19 prognosis. We describe steps for collecting and preprocessing datasets. We then detail the process of training a multi-input NN. This protocol can be adapted for use with datasets containing both image- and table-based input sources.For complete details on the use and execution of this protocol, please refer to Casella et al.1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.
Archivio Istituziona... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.xpro.2023.102812&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Archivio Istituziona... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.xpro.2023.102812&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024 ItalyPublisher:Frontiers Media SA Babak Moazen; Babak Moazen; Nasrul Ismail; Nisreen Agbaria; Nisreen Agbaria; Sara Mazzilli; Davide Petri; Arianna Amaya; Jemima D’Arcy; Emma Plugge; Emma Plugge; Lara Tavoschi; Heino Stöver;handle: 11568/1226367
BackgroundDespite the elevated risks of infection transmission, people in prisons frequently encounter significant barriers in accessing essential healthcare services in many countries. The present scoping review aimed to evaluate the state of availability and model of delivery of vaccination services within correctional facilities across the globe.MethodsFollowing the methodological framework for scoping reviews and adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) extension for scoping reviews criteria, we conducted a systematic search across four peer-reviewed literature databases (Medline via PubMed, Web of Science, the Cochrane Library, Science Direct, and EBSCO), as well as 14 sources of grey literature. Two researchers meticulously examined the identified papers independently to extract pertinent data published between 2012 and 2022. The quality of the selected publications was assessed using established quality assessment tools.ResultsOf the 11,281 identified papers 52 met the inclusion criteria. With the exception of one, all the included publications presented data from high-income countries, predominantly originating from the United States. Across the world, the most prevalent vaccines available in prison settings were COVID-19 and HBV vaccines, typically distributed in response to health crises such as pandemics, epidemics, and local outbreaks. Vaccine coverage and uptake rates within correctional facilities displayed noteworthy disparities among various countries and regions. Besides, individual and organizational barriers and facilitating factors of vaccination in prison settings emerged and discussed in the text.DiscussionThe lack of vaccination services combined with low rates of vaccination coverage and uptake among people living and working in correctional facilities represents a cause for concern. Prisons are not isolated from the broader community, therefore, efforts to increase vaccine uptake among people who live and work in prisons will yield broader public health benefits.
Frontiers in Public ... arrow_drop_down Frontiers in Public Health; Archivio della Ricerca - Università di PisaArticle . 2024 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Frontiers in Public ... arrow_drop_down Frontiers in Public Health; Archivio della Ricerca - Università di PisaArticle . 2024 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fpubh.2024.1323195&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024 ItalyPublisher:MDPI AG Authors: Lucrezia Greta Armando; Raffaella Baroetto Parisi; Cristina Rolando; Mariangela Esiliato; +5 AuthorsLucrezia Greta Armando; Raffaella Baroetto Parisi; Cristina Rolando; Mariangela Esiliato; Valeria Vinciguerra; Cecilia Bertiond; Abdoulaye Diarassouba; Clara Cena; Gianluca Miglio;handle: 2318/1952930
The association between younger age and poorer mental health during the COVID-19 pandemic has been documented. Whether these changes were associated with a change in antidepressant (AD) use is not well understood. This study aimed to estimate the impact of the COVID-19 pandemic on AD use by young adults in the ASL TO4 Regione Piemonte (Italy). The impact of the pandemic on the weekly prevalence of AD users was assessed using interrupted time-series analysis with autoregressive integrated moving average models. A total of 1071 subjects (18–22 years with ≥1 AD dispensation) were included in the study. The observed prevalence was lower than the predicted value for several weeks after the introduction of the lockdown. However, it was consistently higher than the predicted values from week 134. The maximum difference between observed and predicted values (25 subjects per 10,000 young adults) was found at week 170. Changes in AD use were observed in both genders and were more pronounced for selective serotonin reuptake inhibitors. In conclusion, the impact of the COVID-19 pandemic on the mental health of young adults is likely to be significant in the coming years, which may place a future burden on pharmaceutical public health and community health.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/pharmacy12010021&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/pharmacy12010021&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024 ItalyPublisher:Elsevier BV Authors: Bongiovanni, Alessio; Fiandrino, Simona;Bongiovanni, Alessio; Fiandrino, Simona;handle: 2318/1947927
Research in Internat... arrow_drop_down Research in International Business and Finance; Archivio Istituzionale (AperTO)Article . 2024 . 2023 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.ribaf.2023.102193&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!more_vert Research in Internat... arrow_drop_down Research in International Business and Finance; Archivio Istituzionale (AperTO)Article . 2024 . 2023 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.ribaf.2023.102193&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024 ItalyPublisher:Institute of Electrical and Electronics Engineers (IEEE) Authors: Nicola Farronato; Veronica Scuotto; Marco Pironti; Manlio Del Giudice;Nicola Farronato; Veronica Scuotto; Marco Pironti; Manlio Del Giudice;handle: 2318/1949105
IEEE Transactions on... arrow_drop_down IEEE Transactions on Engineering ManagementArticle . 2024 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/tem.2022.3200945&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert IEEE Transactions on... arrow_drop_down IEEE Transactions on Engineering ManagementArticle . 2024 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/tem.2022.3200945&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 ItalyPublisher:Springer Science and Business Media LLC Martina Amanzio; Giuseppina Elena Cipriani; Nicola Canessa; Francesca Borghesi; Alice Chirico; Pietro Cipresso;handle: 2318/1952220
AbstractThe response of older people to the COVID-19 pandemic has attracted much attention as they are at increased risk of adverse outcomes. A longitudinal study has shown that improvement in global cognitive, executive and language functioning in healthy older adults enrolled at the University of the Third Age appears to play a protective role against emotional dysregulation and mood changes during the pandemic. To date, no study has examined emotional dysregulation through COVID-19-related images using facial electromyographic recordings in healthy older adults. Therefore, we aimed to analyze the relationships between zygomaticus and corrugator reactivity, neuropsychological measures, and the affective dimensions of arousal, dominance, and valence. The results showed an unexpected association between higher zygomaticus activity and higher levels of apathy, depression, and anxiety. In contrast, increased contracture of the corrugator was associated with poorer performance on cognitive tests (global cognition, memory, executive functions) and physical status, i.e., walking speed. These results are consistent with the reappraisal of emotional stimuli in response to the challenges of the pandemic. Interestingly, COVID-19-related stimuli triggered the activation of bottom-up affectivity strategies associated with higher mood levels and interacted with top-down factors that play an important role in the dysregulation of cognitive control.
Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO); Scientific ReportsArticle . 2023 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41598-023-50310-1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO); Scientific ReportsArticle . 2023 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41598-023-50310-1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 Italy, United Kingdom, Italy, Netherlands, ItalyPublisher:American Medical Association (AMA) Publicly fundedAuthors: Camirand-Lemyre, Félix; Merson, Laura; Tirupakuzhi Vijayaraghavan, Bharath Kumar; Burrell, Aidan J C; +213 AuthorsCamirand-Lemyre, Félix; Merson, Laura; Tirupakuzhi Vijayaraghavan, Bharath Kumar; Burrell, Aidan J C; Citarella, Barbara Wanjiru; Domingue, Marie-Pier; Lévesque, Simon; Usuf, Effua; Wils, Evert-Jan; Ohshimo, Shinichiro; Martin-Loeches, Ignacio; Sandulescu, Oana; Laake, Jon Henrik; Lamontagne, François; ISARIC Clinical Characterisation Group: Sheryl Ann Abdukahil; Nurul Najmee Abdulkadir; Ryuzo Abe; Laurent Abel; Amal Abrous; Lara Absil; Kamal Abu Jabal; Nashat Abu Salah; Andrew Acker; Elisabeth Adam; Diana Adrião; Saleh Al Ageel; Shakeel Ahmed; Kate Ainscough; Eka Airlangga; Tharwat Aisa; Ali Ait Hssain; Younes Ait Tamlihat; Takako Akimoto; Ernita Akmal; Chika Akwani; Eman Al Qasim; Razi Alalqam; Aliya Mohammed Alameen; Angela Alberti; Tala Al-Dabbous; Senthilkumar Alegesan; Marta Alessi; Beatrice Alex; Kévin Alexandre; Abdulrahman Al-Fares; Huda Alfoudri; Imran Ali; Adam Ali; Kazali Enagnon Alidjnou; Qabas Alkhafajee; Clotilde Allavena; Nathalie Allou; João Alves; Rita Alves; João Melo Alves; Joana Alves Cabrita; Maria Amaral; Nur Amira; Roberto Andini; Claire Andréjak; Andrea Angheben; François Angoulvant; Séverine Ansart; Sivanesen Anthonidass; Massimo Antonelli; Carlos Alexandre Antunes de Brito; Ardiyan Apriyana; Yaseen Arabi; Irene Aragao; Francisco Arancibia; Carolline Araujo; Antonio Arcadipane; Patrick Archambault; Lukas Arenz; Jean-Benoît Arlet; Christel Arnold-Day; Lovkesh Arora; Rakesh Arora; Elise Artaud-Macari; Angel Asensio; Elizabeth A Ashley; Muhammad Ashraf; Jean Baptiste Assie; Amirul Asyraf; Minahel Atif; Anika Atique; Am Udara Lakshan Attanyake; Johann Auchabie; Hugues Aumaitre; Adrien Auvet; Eyvind W Axelsen; Laurène Azemar; Cecile Azoulay; Hakeem Babatunde; Benjamin Bach; Delphine Bachelet; Claudine Badr; Roar Bævre-Jensen; Nadia Baig; John Kenneth Baillie; J Kevin Baird; Erica Bak; Agamemnon Bakakos; Nazreen Abu Bakar; Andriy Bal; Mohanaprasanth Balakrishnan; Firouzé Bani-Sadr; Renata Barbalho; Nicholas Yuri Barbosa; Wendy S Barclay; Saef Umar Barnett; Michaela Barnikel; Helena Barrasa; Cleide Barrigoto; Marie Bartoli; Joaquín Baruch; Romain Basmaci; Muhammad Fadhli Hassin Basri; Denise Battaglini; Jules Bauer; Diego Fernando Bautista Rincon; Denisse Bazan Dow; Abigail Beane; Alexandra Bedossa; Ker Hong Bee; Husna Begum; Sylvie Behilill; Albertus Beishuizen; Aleksandr Beljantsev; David Bellemare; Anna Beltrame; Beatriz Amorim Beltrão; Marine Beluze; Nicolas Benech; Lionel Eric Benjiman; Suzanne Bennett; Luís Bento; Jan-Erik Berdal; Delphine Bergeaud; Hazel Bergin; José Luis Bernal Sobrino; Giulia Bertoli; Lorenzo Bertolino; Simon Bessis; Sybille Bevilcaqua; Karine Bezulier; Amar Bhatt; Krishna Bhavsar; Claudia Bianco; Farah Nadiah Bidin; Felwa Bin Humaid; Mohd Nazlin Bin Kamarudin; Zeno Bisoffi; Patrick Biston; Laurent Bitker; Mustapha Bittaye; Jonathan Bitton; Pablo Blanco-Schweizer; Catherine Blier; Frank Bloos; Mathieu Blot; Filomena Boccia; Laetitia Bodenes; Debby Bogaert; Anne-Hélène Boivin; Isabela Bolaños; Pierre-Adrien Bolze; François Bompart; Aurelius Bonfasius; Diogo Borges; Raphaël Borie; Hans Martin Bosse; Elisabeth Botelho-Nevers; Lila Bouadma; Olivier Bouchaud; Sabelline Bouchez; Dounia Bouhmani; Damien Bouhour; Kévin Bouiller; Laurence Bouillet; Camile Bouisse; Latsaniphone Bountthasavong; Anne-Sophie Boureau; John Bourke; Maude Bouscambert; Aurore Bousquet; Jason Bouziotis; Marielle Boyer-Besseyre; Maria Boylan; Fernando Augusto Bozza; Axelle Braconnier; Cynthia Braga; Timo Brandenburger; Filipa Brás Monteiro; Luca Brazzi; Patrick Breen; Dorothy Breen; David Brewster; Kathy Brickell; Tessa Broadley; Sofia Cardoso; Adrian Ceccato; José Miguel Cisneros Herreros; Sara Clohisey; Andrea Cortegiani; Wim Dieperink; Susanne Dudman; Patricia Fontela; Louis Gerbaud Morlaes; Victoria Janes; Antonio Loforte; Alejandro Martín-Quiros; Jamel Ortoleva; Jolanta Popielska; Cornelius Rau; Malcolm G Semple; Gabriel Suen;ImportanceResearch diversity and representativeness are paramount in building trust, generating valid biomedical knowledge, and possibly in implementing clinical guidelines.ObjectivesTo compare variations over time and across World Health Organization (WHO) geographic regions of corticosteroid use for treatment of severe COVID-19; secondary objectives were to evaluate the association between the timing of publication of the RECOVERY (Randomised Evaluation of COVID-19 Therapy) trial (June 2020) and the WHO guidelines for corticosteroids (September 2020) and the temporal trends observed in corticosteroid use by region and to describe the geographic distribution of the recruitment in clinical trials that informed the WHO recommendation.Design, Setting, and ParticipantsThis prospective cohort study of 434 851 patients was conducted between January 31, 2020, and September 2, 2022, in 63 countries worldwide. The data were collected under the auspices of the International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC)–WHO Clinical Characterisation Protocol for Severe Emerging Infections. Analyses were restricted to patients hospitalized for severe COVID-19 (a subset of the ISARIC data set).ExposureCorticosteroid use as reported to the ISARIC-WHO Clinical Characterisation Protocol for Severe Emerging Infections.Main Outcomes and MeasuresNumber and percentage of patients hospitalized with severe COVID-19 who received corticosteroids by time period and by WHO geographic region.ResultsAmong 434 851 patients with confirmed severe or critical COVID-19 for whom receipt of corticosteroids could be ascertained (median [IQR] age, 61.0 [48.0-74.0] years; 53.0% male), 174 307 (40.1%) received corticosteroids during the study period. Of the participants in clinical trials that informed the guideline, 91.6% were recruited from the United Kingdom. In all regions, corticosteroid use for severe COVID-19 increased, but this increase corresponded to the timing of the RECOVERY trial (time-interruption coefficient 1.0 [95% CI, 0.9-1.2]) and WHO guideline (time-interruption coefficient 1.9 [95% CI, 1.7-2.0]) publications only in Europe. At the end of the study period, corticosteroid use for treatment of severe COVID-19 was highest in the Americas (5421 of 6095 [88.9%]; 95% CI, 87.7-90.2) and lowest in Africa (31 588 of 185 191 [17.1%]; 95% CI, 16.8-17.3).Conclusions and RelevanceThe results of this cohort study showed that implementation of the guidelines for use of corticosteroids in the treatment of severe COVID-19 varied geographically. Uptake of corticosteroid treatment was lower in regions with limited clinical trial involvement. Improving research diversity and representativeness may facilitate timely knowledge uptake and guideline implementation.
Archivio Istituziona... arrow_drop_down Oxford University Research ArchiveArticle . 2024License: CC BYData sources: Oxford University Research ArchiveJAMA Network OpenArticle . 2023add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1001/jamanetworkopen.2023.46502&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Archivio Istituziona... arrow_drop_down Oxford University Research ArchiveArticle . 2024License: CC BYData sources: Oxford University Research ArchiveJAMA Network OpenArticle . 2023add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1001/jamanetworkopen.2023.46502&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 ItalyPublisher:MDPI AG Andrea Bovero; Sarah Balzani; Gabriela Tormen; Francesca Malandrone; Sara Carletto;doi: 10.3390/jcm13010095
handle: 2318/1949312
The COVID-19 pandemic was an unprecedented event that further stimulated the debate on the concept of trauma. To increase knowledge about the traumatic potential of the pandemic, the main objective of this study was to identify, through a systematic literature review, the main factors associated with the adaptive outcome of post-traumatic growth caused by COVID-19. Studies were selected from the PsychInfo, Embase, and PubMed databases, and 29 articles were included at the end of the screening process. The identified factors are of different natures, including personal variables such as personality traits, coping, and cognitive strategies used to face adversity, and interpersonal variables, one of the most important of which is the level of social support. In addition, several results confirmed a relationship between post-traumatic growth and post-traumatic stress symptoms, as well as indices related to psychological well-being. Finally, the results are discussed by comparing them with those already present in the literature, as well as with some of the main explanatory models of post-traumatic growth. In this regard, some of the factors identified, such as maladaptive coping, avoidance symptoms, optimism, and low-stress tolerance, suggest the possibility that the process of post-traumatic growth may also be characterized by an illusory dimension.
Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO); Journal of Clinical MedicineArticle . 2023 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO); Journal of Clinical MedicineArticle . 2023 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 ItalyPublisher:Frontiers Media SA Teresa Fasciana; Alberto Antonelli; Alberto Antonelli; Gabriele Bianco; Donatella Lombardo; Giulia Codda; Emanuela Roscetto; Marianna Perez; Dario Lipari; Ignazio Arrigo; Elena Galia; Maria Rita Tricoli; Maddalena Calvo; Claudia Niccolai; Claudia Niccolai; Fabio Morecchiato; Giulia Errico; Stefania Stefani; Rossana Cavallo; Anna Marchese; Anna Marchese; Maria Rosaria Catania; Simone Ambretti; Gian Maria Rossolini; Gian Maria Rossolini; Annalisa Pantosti; Anna Teresa Palamara; Anna Teresa Palamara; Michela Sabbatucci; Michela Sabbatucci; Nicola Serra; Anna Giammanco;handle: 11585/964131
BackgroundAmong multidrug-resistant (MDR) bacteria able to threaten human health, carbapenem-resistant Enterobacterales (CRE) have become a major public health threat globally. National and international guidelines point out the importance of active routine surveillance policies to prevent CRE transmission. Therefore, defining lines of intervention and strategies capable of containing and controlling the spread of CRE is considered determinant. CRE screening is one of the main actions to curb transmission and control outbreaks, outlining the presence and also the prevalence and types of carbapenemase enzymes circulating locally.ObjectiveThe purpose of this study was to outline the epidemiology of CRE colonization in Italy, detecting CRE-colonized patients at admission and during hospitalization, before and during the first year of COVID-19.Materials and methodsA total of 11,063 patients admitted to seven different hospitals (Bologna, Catania, Florence, Genoa, Naples, Palermo, and Turin) in Intensive Care Units (ICU) and other wards (non-ICU) located in the North, Center, and South of Italy were enrolled and screened for CRE carriage at admission (T0) and during the first 3 weeks of hospitalization (T1-T3). The study spanned two periods, before (September 2018-Septemeber 2019, I observational period) and during the COVID-19 pandemic (October 2019–September 2020, II observational period).ResultsOverall, the prevalence of CRE-colonized patients at admission in ICU or in other ward, ranged from 3.9 to 11.5%, while a percentage from 5.1 to 15.5% of patients acquired CRE during hospital stay. There were large differences between the I and II period of study according to the different geographical areas and enrolling centers. Overall, comparison of prevalence of CRE-positive patients showed a significant increased trend between I and II observational periods both in ICU and non-ICU wards, mostly in the Southern participating centers. KPC-producing Klebsiella pneumoniae was the most frequent CRE species-carbapenemase combination reported in this study. In particular, the presence of KPC-producing K. pneumoniae was reported in period I during hospitalization in all the CRE-positive patients enrolled in ICU in Turin (North Italy), while in period II at admission in all the CRE-positive patients enrolled in ICU in Catania and in 58.3% of non-ICU CRE-positive patients in Naples (both centers in South Italy).ConclusionThe prevalence of CRE in Italy highly increased during the COVID-19 pandemic, mostly in the Southern hospital centers. KPC-producing K. pneumoniae was the most frequent colonizing CRE species reported. The results of our study confirmed the crucial value of active surveillance as well as the importance of multicenter studies representing diverse geographical areas even in endemic countries. Differences in CRE colonization prevalence among centers suggest the need for diversified and center-specific interventions as well as for strengthening efforts in infection prevention and control practices and policies.
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description Publicationkeyboard_double_arrow_right Article 2024 ItalyPublisher:Elsevier BV Authors: Myftiu, Jurgena; Gigliarano, Chiara; Maggi, Elena; Scagni, Andrea;Myftiu, Jurgena; Gigliarano, Chiara; Maggi, Elena; Scagni, Andrea;handle: 2318/1950751
Archivio Istituziona... arrow_drop_down Research in Transportation Business & ManagementArticle . 2024 . Peer-reviewedLicense: CC BY NC NDData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Archivio Istituziona... arrow_drop_down Research in Transportation Business & ManagementArticle . 2024 . Peer-reviewedLicense: CC BY NC NDData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024 ItalyPublisher:Elsevier BV Authors: Bruno Casella; Walter Riviera; Marco Aldinucci; Gloria Menegaz;Bruno Casella; Walter Riviera; Marco Aldinucci; Gloria Menegaz;handle: 2318/1950975
Summary: Federated learning is a cooperative learning approach that has emerged as an effective way to address privacy concerns. Here, we present a protocol for training MERGE: a federated multi-input neural network (NN) for COVID-19 prognosis. We describe steps for collecting and preprocessing datasets. We then detail the process of training a multi-input NN. This protocol can be adapted for use with datasets containing both image- and table-based input sources.For complete details on the use and execution of this protocol, please refer to Casella et al.1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.
Archivio Istituziona... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Archivio Istituziona... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024 ItalyPublisher:Frontiers Media SA Babak Moazen; Babak Moazen; Nasrul Ismail; Nisreen Agbaria; Nisreen Agbaria; Sara Mazzilli; Davide Petri; Arianna Amaya; Jemima D’Arcy; Emma Plugge; Emma Plugge; Lara Tavoschi; Heino Stöver;handle: 11568/1226367
BackgroundDespite the elevated risks of infection transmission, people in prisons frequently encounter significant barriers in accessing essential healthcare services in many countries. The present scoping review aimed to evaluate the state of availability and model of delivery of vaccination services within correctional facilities across the globe.MethodsFollowing the methodological framework for scoping reviews and adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) extension for scoping reviews criteria, we conducted a systematic search across four peer-reviewed literature databases (Medline via PubMed, Web of Science, the Cochrane Library, Science Direct, and EBSCO), as well as 14 sources of grey literature. Two researchers meticulously examined the identified papers independently to extract pertinent data published between 2012 and 2022. The quality of the selected publications was assessed using established quality assessment tools.ResultsOf the 11,281 identified papers 52 met the inclusion criteria. With the exception of one, all the included publications presented data from high-income countries, predominantly originating from the United States. Across the world, the most prevalent vaccines available in prison settings were COVID-19 and HBV vaccines, typically distributed in response to health crises such as pandemics, epidemics, and local outbreaks. Vaccine coverage and uptake rates within correctional facilities displayed noteworthy disparities among various countries and regions. Besides, individual and organizational barriers and facilitating factors of vaccination in prison settings emerged and discussed in the text.DiscussionThe lack of vaccination services combined with low rates of vaccination coverage and uptake among people living and working in correctional facilities represents a cause for concern. Prisons are not isolated from the broader community, therefore, efforts to increase vaccine uptake among people who live and work in prisons will yield broader public health benefits.
Frontiers in Public ... arrow_drop_down Frontiers in Public Health; Archivio della Ricerca - Università di PisaArticle . 2024 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Frontiers in Public ... arrow_drop_down Frontiers in Public Health; Archivio della Ricerca - Università di PisaArticle . 2024 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024 ItalyPublisher:MDPI AG Authors: Lucrezia Greta Armando; Raffaella Baroetto Parisi; Cristina Rolando; Mariangela Esiliato; +5 AuthorsLucrezia Greta Armando; Raffaella Baroetto Parisi; Cristina Rolando; Mariangela Esiliato; Valeria Vinciguerra; Cecilia Bertiond; Abdoulaye Diarassouba; Clara Cena; Gianluca Miglio;handle: 2318/1952930
The association between younger age and poorer mental health during the COVID-19 pandemic has been documented. Whether these changes were associated with a change in antidepressant (AD) use is not well understood. This study aimed to estimate the impact of the COVID-19 pandemic on AD use by young adults in the ASL TO4 Regione Piemonte (Italy). The impact of the pandemic on the weekly prevalence of AD users was assessed using interrupted time-series analysis with autoregressive integrated moving average models. A total of 1071 subjects (18–22 years with ≥1 AD dispensation) were included in the study. The observed prevalence was lower than the predicted value for several weeks after the introduction of the lockdown. However, it was consistently higher than the predicted values from week 134. The maximum difference between observed and predicted values (25 subjects per 10,000 young adults) was found at week 170. Changes in AD use were observed in both genders and were more pronounced for selective serotonin reuptake inhibitors. In conclusion, the impact of the COVID-19 pandemic on the mental health of young adults is likely to be significant in the coming years, which may place a future burden on pharmaceutical public health and community health.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/pharmacy12010021&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/pharmacy12010021&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024 ItalyPublisher:Elsevier BV Authors: Bongiovanni, Alessio; Fiandrino, Simona;Bongiovanni, Alessio; Fiandrino, Simona;handle: 2318/1947927
Research in Internat... arrow_drop_down Research in International Business and Finance; Archivio Istituzionale (AperTO)Article . 2024 . 2023 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routeshybrid 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!more_vert Research in Internat... arrow_drop_down Research in International Business and Finance; Archivio Istituzionale (AperTO)Article . 2024 . 2023 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024 ItalyPublisher:Institute of Electrical and Electronics Engineers (IEEE) Authors: Nicola Farronato; Veronica Scuotto; Marco Pironti; Manlio Del Giudice;Nicola Farronato; Veronica Scuotto; Marco Pironti; Manlio Del Giudice;handle: 2318/1949105
IEEE Transactions on... arrow_drop_down IEEE Transactions on Engineering ManagementArticle . 2024 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routeshybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert IEEE Transactions on... arrow_drop_down IEEE Transactions on Engineering ManagementArticle . 2024 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/tem.2022.3200945&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 ItalyPublisher:Springer Science and Business Media LLC Martina Amanzio; Giuseppina Elena Cipriani; Nicola Canessa; Francesca Borghesi; Alice Chirico; Pietro Cipresso;handle: 2318/1952220
AbstractThe response of older people to the COVID-19 pandemic has attracted much attention as they are at increased risk of adverse outcomes. A longitudinal study has shown that improvement in global cognitive, executive and language functioning in healthy older adults enrolled at the University of the Third Age appears to play a protective role against emotional dysregulation and mood changes during the pandemic. To date, no study has examined emotional dysregulation through COVID-19-related images using facial electromyographic recordings in healthy older adults. Therefore, we aimed to analyze the relationships between zygomaticus and corrugator reactivity, neuropsychological measures, and the affective dimensions of arousal, dominance, and valence. The results showed an unexpected association between higher zygomaticus activity and higher levels of apathy, depression, and anxiety. In contrast, increased contracture of the corrugator was associated with poorer performance on cognitive tests (global cognition, memory, executive functions) and physical status, i.e., walking speed. These results are consistent with the reappraisal of emotional stimuli in response to the challenges of the pandemic. Interestingly, COVID-19-related stimuli triggered the activation of bottom-up affectivity strategies associated with higher mood levels and interacted with top-down factors that play an important role in the dysregulation of cognitive control.
Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO); Scientific ReportsArticle . 2023 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO); Scientific ReportsArticle . 2023 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 Italy, United Kingdom, Italy, Netherlands, ItalyPublisher:American Medical Association (AMA) Publicly fundedAuthors: Camirand-Lemyre, Félix; Merson, Laura; Tirupakuzhi Vijayaraghavan, Bharath Kumar; Burrell, Aidan J C; +213 AuthorsCamirand-Lemyre, Félix; Merson, Laura; Tirupakuzhi Vijayaraghavan, Bharath Kumar; Burrell, Aidan J C; Citarella, Barbara Wanjiru; Domingue, Marie-Pier; Lévesque, Simon; Usuf, Effua; Wils, Evert-Jan; Ohshimo, Shinichiro; Martin-Loeches, Ignacio; Sandulescu, Oana; Laake, Jon Henrik; Lamontagne, François; ISARIC Clinical Characterisation Group: Sheryl Ann Abdukahil; Nurul Najmee Abdulkadir; Ryuzo Abe; Laurent Abel; Amal Abrous; Lara Absil; Kamal Abu Jabal; Nashat Abu Salah; Andrew Acker; Elisabeth Adam; Diana Adrião; Saleh Al Ageel; Shakeel Ahmed; Kate Ainscough; Eka Airlangga; Tharwat Aisa; Ali Ait Hssain; Younes Ait Tamlihat; Takako Akimoto; Ernita Akmal; Chika Akwani; Eman Al Qasim; Razi Alalqam; Aliya Mohammed Alameen; Angela Alberti; Tala Al-Dabbous; Senthilkumar Alegesan; Marta Alessi; Beatrice Alex; Kévin Alexandre; Abdulrahman Al-Fares; Huda Alfoudri; Imran Ali; Adam Ali; Kazali Enagnon Alidjnou; Qabas Alkhafajee; Clotilde Allavena; Nathalie Allou; João Alves; Rita Alves; João Melo Alves; Joana Alves Cabrita; Maria Amaral; Nur Amira; Roberto Andini; Claire Andréjak; Andrea Angheben; François Angoulvant; Séverine Ansart; Sivanesen Anthonidass; Massimo Antonelli; Carlos Alexandre Antunes de Brito; Ardiyan Apriyana; Yaseen Arabi; Irene Aragao; Francisco Arancibia; Carolline Araujo; Antonio Arcadipane; Patrick Archambault; Lukas Arenz; Jean-Benoît Arlet; Christel Arnold-Day; Lovkesh Arora; Rakesh Arora; Elise Artaud-Macari; Angel Asensio; Elizabeth A Ashley; Muhammad Ashraf; Jean Baptiste Assie; Amirul Asyraf; Minahel Atif; Anika Atique; Am Udara Lakshan Attanyake; Johann Auchabie; Hugues Aumaitre; Adrien Auvet; Eyvind W Axelsen; Laurène Azemar; Cecile Azoulay; Hakeem Babatunde; Benjamin Bach; Delphine Bachelet; Claudine Badr; Roar Bævre-Jensen; Nadia Baig; John Kenneth Baillie; J Kevin Baird; Erica Bak; Agamemnon Bakakos; Nazreen Abu Bakar; Andriy Bal; Mohanaprasanth Balakrishnan; Firouzé Bani-Sadr; Renata Barbalho; Nicholas Yuri Barbosa; Wendy S Barclay; Saef Umar Barnett; Michaela Barnikel; Helena Barrasa; Cleide Barrigoto; Marie Bartoli; Joaquín Baruch; Romain Basmaci; Muhammad Fadhli Hassin Basri; Denise Battaglini; Jules Bauer; Diego Fernando Bautista Rincon; Denisse Bazan Dow; Abigail Beane; Alexandra Bedossa; Ker Hong Bee; Husna Begum; Sylvie Behilill; Albertus Beishuizen; Aleksandr Beljantsev; David Bellemare; Anna Beltrame; Beatriz Amorim Beltrão; Marine Beluze; Nicolas Benech; Lionel Eric Benjiman; Suzanne Bennett; Luís Bento; Jan-Erik Berdal; Delphine Bergeaud; Hazel Bergin; José Luis Bernal Sobrino; Giulia Bertoli; Lorenzo Bertolino; Simon Bessis; Sybille Bevilcaqua; Karine Bezulier; Amar Bhatt; Krishna Bhavsar; Claudia Bianco; Farah Nadiah Bidin; Felwa Bin Humaid; Mohd Nazlin Bin Kamarudin; Zeno Bisoffi; Patrick Biston; Laurent Bitker; Mustapha Bittaye; Jonathan Bitton; Pablo Blanco-Schweizer; Catherine Blier; Frank Bloos; Mathieu Blot; Filomena Boccia; Laetitia Bodenes; Debby Bogaert; Anne-Hélène Boivin; Isabela Bolaños; Pierre-Adrien Bolze; François Bompart; Aurelius Bonfasius; Diogo Borges; Raphaël Borie; Hans Martin Bosse; Elisabeth Botelho-Nevers; Lila Bouadma; Olivier Bouchaud; Sabelline Bouchez; Dounia Bouhmani; Damien Bouhour; Kévin Bouiller; Laurence Bouillet; Camile Bouisse; Latsaniphone Bountthasavong; Anne-Sophie Boureau; John Bourke; Maude Bouscambert; Aurore Bousquet; Jason Bouziotis; Marielle Boyer-Besseyre; Maria Boylan; Fernando Augusto Bozza; Axelle Braconnier; Cynthia Braga; Timo Brandenburger; Filipa Brás Monteiro; Luca Brazzi; Patrick Breen; Dorothy Breen; David Brewster; Kathy Brickell; Tessa Broadley; Sofia Cardoso; Adrian Ceccato; José Miguel Cisneros Herreros; Sara Clohisey; Andrea Cortegiani; Wim Dieperink; Susanne Dudman; Patricia Fontela; Louis Gerbaud Morlaes; Victoria Janes; Antonio Loforte; Alejandro Martín-Quiros; Jamel Ortoleva; Jolanta Popielska; Cornelius Rau; Malcolm G Semple; Gabriel Suen;ImportanceResearch diversity and representativeness are paramount in building trust, generating valid biomedical knowledge, and possibly in implementing clinical guidelines.ObjectivesTo compare variations over time and across World Health Organization (WHO) geographic regions of corticosteroid use for treatment of severe COVID-19; secondary objectives were to evaluate the association between the timing of publication of the RECOVERY (Randomised Evaluation of COVID-19 Therapy) trial (June 2020) and the WHO guidelines for corticosteroids (September 2020) and the temporal trends observed in corticosteroid use by region and to describe the geographic distribution of the recruitment in clinical trials that informed the WHO recommendation.Design, Setting, and ParticipantsThis prospective cohort study of 434 851 patients was conducted between January 31, 2020, and September 2, 2022, in 63 countries worldwide. The data were collected under the auspices of the International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC)–WHO Clinical Characterisation Protocol for Severe Emerging Infections. Analyses were restricted to patients hospitalized for severe COVID-19 (a subset of the ISARIC data set).ExposureCorticosteroid use as reported to the ISARIC-WHO Clinical Characterisation Protocol for Severe Emerging Infections.Main Outcomes and MeasuresNumber and percentage of patients hospitalized with severe COVID-19 who received corticosteroids by time period and by WHO geographic region.ResultsAmong 434 851 patients with confirmed severe or critical COVID-19 for whom receipt of corticosteroids could be ascertained (median [IQR] age, 61.0 [48.0-74.0] years; 53.0% male), 174 307 (40.1%) received corticosteroids during the study period. Of the participants in clinical trials that informed the guideline, 91.6% were recruited from the United Kingdom. In all regions, corticosteroid use for severe COVID-19 increased, but this increase corresponded to the timing of the RECOVERY trial (time-interruption coefficient 1.0 [95% CI, 0.9-1.2]) and WHO guideline (time-interruption coefficient 1.9 [95% CI, 1.7-2.0]) publications only in Europe. At the end of the study period, corticosteroid use for treatment of severe COVID-19 was highest in the Americas (5421 of 6095 [88.9%]; 95% CI, 87.7-90.2) and lowest in Africa (31 588 of 185 191 [17.1%]; 95% CI, 16.8-17.3).Conclusions and RelevanceThe results of this cohort study showed that implementation of the guidelines for use of corticosteroids in the treatment of severe COVID-19 varied geographically. Uptake of corticosteroid treatment was lower in regions with limited clinical trial involvement. Improving research diversity and representativeness may facilitate timely knowledge uptake and guideline implementation.
Archivio Istituziona... arrow_drop_down Oxford University Research ArchiveArticle . 2024License: CC BYData sources: Oxford University Research ArchiveJAMA Network OpenArticle . 2023add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Archivio Istituziona... arrow_drop_down Oxford University Research ArchiveArticle . 2024License: CC BYData sources: Oxford University Research ArchiveJAMA Network OpenArticle . 2023add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 ItalyPublisher:MDPI AG Andrea Bovero; Sarah Balzani; Gabriela Tormen; Francesca Malandrone; Sara Carletto;doi: 10.3390/jcm13010095
handle: 2318/1949312
The COVID-19 pandemic was an unprecedented event that further stimulated the debate on the concept of trauma. To increase knowledge about the traumatic potential of the pandemic, the main objective of this study was to identify, through a systematic literature review, the main factors associated with the adaptive outcome of post-traumatic growth caused by COVID-19. Studies were selected from the PsychInfo, Embase, and PubMed databases, and 29 articles were included at the end of the screening process. The identified factors are of different natures, including personal variables such as personality traits, coping, and cognitive strategies used to face adversity, and interpersonal variables, one of the most important of which is the level of social support. In addition, several results confirmed a relationship between post-traumatic growth and post-traumatic stress symptoms, as well as indices related to psychological well-being. Finally, the results are discussed by comparing them with those already present in the literature, as well as with some of the main explanatory models of post-traumatic growth. In this regard, some of the factors identified, such as maladaptive coping, avoidance symptoms, optimism, and low-stress tolerance, suggest the possibility that the process of post-traumatic growth may also be characterized by an illusory dimension.
Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO); Journal of Clinical MedicineArticle . 2023 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert Archivio Istituziona... arrow_drop_down Archivio Istituzionale (AperTO); Journal of Clinical MedicineArticle . 2023 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/jcm13010095&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 ItalyPublisher:Frontiers Media SA Teresa Fasciana; Alberto Antonelli; Alberto Antonelli; Gabriele Bianco; Donatella Lombardo; Giulia Codda; Emanuela Roscetto; Marianna Perez; Dario Lipari; Ignazio Arrigo; Elena Galia; Maria Rita Tricoli; Maddalena Calvo; Claudia Niccolai; Claudia Niccolai; Fabio Morecchiato; Giulia Errico; Stefania Stefani; Rossana Cavallo; Anna Marchese; Anna Marchese; Maria Rosaria Catania; Simone Ambretti; Gian Maria Rossolini; Gian Maria Rossolini; Annalisa Pantosti; Anna Teresa Palamara; Anna Teresa Palamara; Michela Sabbatucci; Michela Sabbatucci; Nicola Serra; Anna Giammanco;handle: 11585/964131
BackgroundAmong multidrug-resistant (MDR) bacteria able to threaten human health, carbapenem-resistant Enterobacterales (CRE) have become a major public health threat globally. National and international guidelines point out the importance of active routine surveillance policies to prevent CRE transmission. Therefore, defining lines of intervention and strategies capable of containing and controlling the spread of CRE is considered determinant. CRE screening is one of the main actions to curb transmission and control outbreaks, outlining the presence and also the prevalence and types of carbapenemase enzymes circulating locally.ObjectiveThe purpose of this study was to outline the epidemiology of CRE colonization in Italy, detecting CRE-colonized patients at admission and during hospitalization, before and during the first year of COVID-19.Materials and methodsA total of 11,063 patients admitted to seven different hospitals (Bologna, Catania, Florence, Genoa, Naples, Palermo, and Turin) in Intensive Care Units (ICU) and other wards (non-ICU) located in the North, Center, and South of Italy were enrolled and screened for CRE carriage at admission (T0) and during the first 3 weeks of hospitalization (T1-T3). The study spanned two periods, before (September 2018-Septemeber 2019, I observational period) and during the COVID-19 pandemic (October 2019–September 2020, II observational period).ResultsOverall, the prevalence of CRE-colonized patients at admission in ICU or in other ward, ranged from 3.9 to 11.5%, while a percentage from 5.1 to 15.5% of patients acquired CRE during hospital stay. There were large differences between the I and II period of study according to the different geographical areas and enrolling centers. Overall, comparison of prevalence of CRE-positive patients showed a significant increased trend between I and II observational periods both in ICU and non-ICU wards, mostly in the Southern participating centers. KPC-producing Klebsiella pneumoniae was the most frequent CRE species-carbapenemase combination reported in this study. In particular, the presence of KPC-producing K. pneumoniae was reported in period I during hospitalization in all the CRE-positive patients enrolled in ICU in Turin (North Italy), while in period II at admission in all the CRE-positive patients enrolled in ICU in Catania and in 58.3% of non-ICU CRE-positive patients in Naples (both centers in South Italy).ConclusionThe prevalence of CRE in Italy highly increased during the COVID-19 pandemic, mostly in the Southern hospital centers. KPC-producing K. pneumoniae was the most frequent colonizing CRE species reported. The results of our study confirmed the crucial value of active surveillance as well as the importance of multicenter studies representing diverse geographical areas even in endemic countries. Differences in CRE colonization prevalence among centers suggest the need for diversified and center-specific interventions as well as for strengthening efforts in infection prevention and control practices and policies.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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