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4 research outcomes, page 1 of 1
  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Kathrin Pieper; Joshua Tan; Luca Piccoli; Mathilde Foglierini; Sonia Barbieri; Yiwei Chen; Chiara Silacci-Fregni; Tobias Wolf; David Jarrossay; Marica Anderle; ...
    Publisher: Springer Science and Business Media LLC
    Project: EC | BROADimmune (670955), WT

    In two previously described donors, the extracellular domain of LAIR1, a collagen-binding inhibitory receptor encoded on chromosome 19 (ref. 1), was inserted between the V and DJ segments of an antibody. This insertion generated, through somatic mutations, broadly react...

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  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Manjunatha, Ujjini H.; Vinayak, Sumiti; Zambriski, Jennifer A.; Chao, Alexander T.; Sy, Tracy; Noble, Christian G.; Bonamy, Ghislain M. C.; Kondreddi, Ravinder R.; Zou, Bin; Gedeck, Peter; ...
    Persistent Identifiers
    Project: WT | Enabling phenotypic scree... (107678), NIH | Genetic analysis of Crypt... (1R01AI112427-01A1), NIH | Exploring TrpB in the pat... (1F32AI124518-01)

    Diarrhoeal disease is responsible for 8.6% of global child mortality. Recent epidemiological studies found the protozoan parasite Cryptosporidium to be a leading cause of paediatric diarrhoea, with particularly grave impact on infants and immunocompromised individuals. ...

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  • publication . Article . 2015
    Open Access
    Authors:
    Tan, Joshua; Pieper, Kathrin; Piccoli, Luca; Abdi, Abdirahman; Foglierini, Mathilde; Geiger, Roger; Maria Tully, Claire; Jarrossay, David; Maina Ndungu, Francis; Wambua, Juliana; ...
    Persistent Identifiers
    Project: WT | Developing research capac... (084538), SNSF | Human B cells and plasma ... (310030_141254), EC | BROADimmune (670955), SNSF | Analytic vaccinology (310030B_160279), WT | Director's discretionary ... (077092), WT | Immunology, Infection & T... (099811), WT | Measuring the impact of n... (084535), WT | Integrated studies of the... (092741), WT | Non-var-Encoded Variant A... (084378), EC | IMMUNEXPLORE (250348),...

    None: Plasmodium falciparum antigens expressed on the surface of infected erythrocytes are important targets of naturally acquired immunity against malaria, but their high number and variability provide the pathogen with a powerful means of escape from host antibodies. ...

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  • publication . Article . 2006
    Open Access English
    Authors:
    Olivier Namy; Stephen J. Moran; David I. Stuart; Robert J. C. Gilbert; Ian Brierley;
    Persistent Identifiers
    Publisher: Nature Publishing Group UK
    Project: WT

    Tying the pseudoknot Ribosomal frameshifting is a translational mechanism involved in protein synthesis during the replication of many viral pathogens and in cellular genes more generally. A new set of images of an 80S ribosome stalled at an mRNA pseudoknot shows how th...

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4 research outcomes, page 1 of 1