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12 research outcomes, page 1 of 2
  • publication . Article . Other literature type . 2020
    Open Access
    Authors:
    Y Peng; Alexander J. Mentzer; G Liu; X Yao; Z Yin; D Dong; Wanwisa Dejnirattisai; T Rostron; P Supasa; C Liu; ...
    Persistent Identifiers
    Publisher: Springer Science and Business Media LLC
    Project: UKRI | ISARIC - Coronavirus Clin... (MC_PC_19059), WT

    The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines and therapeutics will depend on understanding viral immunity. We studied T cell memory in 42 patients following recovery from COVID-19 (28 with mild disease and 14 with severe disea...

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  • publication . Preprint . Article . 2020
    Open Access
    Authors:
    Mark Hamer; Mika Kivimäki; Catharine R. Gale; G. David Batty;
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Healthy transitions from ... (1R56AG052519-01), AKA | Midlife predictors of dem... (311492), UKRI | Biomedical follow-up of 1... (MR/P023444/1), NIH | Education, socioeconomic ... (1R01AG056477-01A1)

    Aims: It is important to identify characteristics of people who may be most at risk of COVID19 to inform policy and intervention. Little is known about the impact of unhealthy lifestyles including smoking, physical inactivity, obesity, and excessive alcohol intake. We c...

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  • publication . Preprint . Article . Other literature type . 2020
    Open Access
    Authors:
    Rajith K. R. Rajoli; Henry Pertinez; Usman Arshad; Helen Box; Lee Tatham; Paul Curley; Megan Neary; Joanne Sharp; Neill J. Liptrott; Anthony Valentijn; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Long acting NRTI therapie... (1R01AI134091-01), EC | REFINE (761104), UKRI | An Injectable Implant Pro... (EP/S012265/1), UKRI | MICA: New combination the... (MR/S00467X/1), NIH | Long-Acting/Extended Rele... (3R24AI118397-02S1)

    AbstractBackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been declared a global pandemic by the World Health Organisation and urgent treatment and prevention strategies are needed. Many clinical trials have been initiated with existing medicati...

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  • publication . Preprint . Article . 2020
    Open Access
    Authors:
    Long H. Nguyen; David A. Drew; Amit D. Joshi; Chuan-Guo Guo; Wenjie Ma; Raaj S. Mehta; Daniel Sikavi; Chun-Han Lo; Sohee Kwon; Mingyang Song; ...
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory
    Project: NIH | Nurses Health Study 3: A ... (1R24ES028521-01A1), WT | TwinsUK (2019-2023) - An ... (212904), NIH | Life Course Cancer Epidem... (2U01CA176726-06), WT | King's College London Med... (203148), WT | Programme for High Dimens... (213038), NIH | Cancer Epidemiology Cohor... (2U01CA167552-06), NIH | Long Term Multidisciplina... (5UM1CA186107-05), NIH | OCCUPATIONAL HEALTH (5P30ES000002-36), UKRI | MICA: Ancestry and biolog... (MR/M016560/1)

    BackgroundData for frontline healthcare workers (HCWs) and risk of SARS-CoV-2 infection are limited and whether personal protective equipment (PPE) mitigates this risk is unknown. We evaluated risk for COVID-19 among frontline HCWs compared to the general community and ...

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  • publication . Preprint . Article . 2020
    Open Access
    Authors:
    Maria Jose Lista; Pedro M. Matos; Thomas J. A. Maguire; Kate Poulton; Elena Ortiz-Zapater; Robert Page; Helin Sertkaya; Ana M. Ortega-Prieto; Aoife M. O’Byrne; Clement Bouton; ...
    Persistent Identifiers
    Publisher: Cold Spring Harbor Laboratory
    Project: UKRI | Regulation of HIV-1 and E... (MR/S000844/1), WT | Interferon and MX2 Mediat... (106223), WT | Strategic endgames – modu... (218537), UKRI | Defining the role of CAR ... (MR/S009191/1)

    Abstract There is a worldwide shortage of reagents to perform detection of SARS-CoV-2. Many clinical diagnostic laboratories rely on commercial platforms that provide integrated end-to-end solutions. While this provides established robust pipelines, there is a clear bot...

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  • publication . Preprint . Other literature type . Article . 2020
    Open Access English
    Authors:
    Jombart, Thibaut; van Zandvoort, Kevin; Russell, Timothy W.; Jarvis, Christopher I.; Gimma, Amy; Abbott, Sam; Clifford, Sam; Funk, Sebastian; Gibbs, Hamish; Liu, Yang; ...
    Publisher: Cold Spring Harbor Laboratory
    Project: WT | Immunity dynamics and epi... (206250), WT | Real-time modelling for f... (210758), UKRI | GCRF: RECAP - Research ca... (ES/P010873/1), WT , WT | Using mathematical modell... (208812)

    ABSTRACTWe estimate the number of COVID-19 cases from newly reported deaths in a population without previous reports. Our results suggest that by the time a single death occurs, hundreds to thousands of cases are likely to be present in that population. This suggests co...

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  • publication . Article . 2018
    Open Access
    Authors:
    Dey, Tapan; Kalita, Jatin; Weldon, Sinéad; Taggart, Clifford;
    Persistent Identifiers
    Publisher: MDPI AG
    Project: UKRI | The role of Cathepsin S i... (MR/P022847/1)

    In the context of respiratory disease, chronic obstructive pulmonary disease (COPD) is the leading cause of mortality worldwide. Despite much development in the area of drug development, currently there are no effective medicines available for the treatment of this dise...

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  • publication . Article . Other literature type . 2016
    Open Access English
    Authors:
    Alexander Borodavka; Surendra W. Singaram; Peter G. Stockley; William M. Gelbart; Avinoam Ben-Shaul; Roman Tuma;
    Persistent Identifiers
    Publisher: Biophysical Society.
    Project: WT | Dissecting molecular mech... (103068), WT | The molecular basis of bi... (089310), UKRI | Single-molecule assays of... (BB/J00667X/1)

    Long RNA molecules are at the core of gene regulation across all kingdoms of life, whilst also serving as genomes in RNA viruses. Few studies have addressed the basic physical properties of long single-stranded RNAs. Long RNAs with non-repeating sequences usually adopt ...

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  • publication . Other literature type . Article . 2016
    Open Access English
    Authors:
    Chowell, Gerardo; Cleaton, Julie M.; Viboud, Cecile;
    Persistent Identifiers
    Publisher: Oxford University Press
    Project: NSF | US-UK Collab: Risks of An... (1414374), UKRI | US-UK EEID Collab: Risks ... (BB/M008894/1)

    The paucity of traditional epidemiological data during epidemic emergencies calls for alternative data streams to characterize the key features of an outbreak, including the nature of risky exposures, the reproduction number, and transmission heterogeneities. We illustr...

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  • publication . Other literature type . Article . 2014
    Open Access English
    Authors:
    Charlotte Harrison; K. Ravi Acharya;
    Persistent Identifiers
    Publisher: Springer Netherlands
    Project: UKRI | Structural studies on hum... (G1001685)

    Angiotensin-I converting enzyme (ACE, EC 3.4.15.1) is a zinc dependent dipeptidyl carboxypeptidase with an essential role in mammalian blood pressure regulation as part of the renin-angiotensin aldosterone system (RAAS). As such, it has long been targeted in the treatme...

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12 research outcomes, page 1 of 2