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9 research outcomes, page 1 of 1
  • publication . Article . 2018
    Open Access English
    Authors:
    Tapan Dey; Jatin Kalita; Sinéad Weldon; Clifford C. Taggart;
    Persistent Identifiers
    Publisher: MDPI
    Project: UKRI | The role of Cathepsin S i... (MR/P022847/1)

    <jats:p>In the context of respiratory disease, chronic obstructive pulmonary disease (COPD) is the leading cause of mortality worldwide. Despite much development in the area of drug development, currently there are no effective medicines available for the treatment of t...

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  • publication . Article . 2017
    Open Access
    Authors:
    Martin Pelosse; Hannah Crocker; Barbara Gorda; Paul Lemaire; Jens Rauch; Imre Berger;
    Publisher: Springer Science and Business Media LLC
    Project: EC | COMPLEXINC (279039), EC | SYNSIGNAL (613879), UKRI | BrisSynBio: Bristol Centr... (BB/L01386X/1)

    Abstract The MultiBac baculovirus/insect cell expression vector system was conceived as a user-friendly, modular tool-kit for producing multiprotein complexes for structural biology applications. MultiBac has allowed the structure and function of many molecular machines...

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  • publication . Article . 2016
    Open Access
    Authors:
    Sally F. Bloomfield; Graham A. W. Rook; Elizabeth Scott; Fergus Shanahan; Rosalind Stanwell-Smith; Paul Turner;
    Persistent Identifiers
    Publisher: SAGE Publications
    Project: UKRI | Mechanisms underlying the... (MR/K010468/1)

    <jats:sec><jats:title>Aims:</jats:title><jats:p> To review the burden of allergic and infectious diseases and the evidence for a link to microbial exposure, the human microbiome and immune system, and to assess whether we could develop lifestyles which reconnect us with...

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  • publication . Article . 2016
    Open Access
    Authors:
    Ellen B. Fragaszy; Charlotte Warren-Gash; Lili Wang; Andrew Copas; Oliver Dukes; W. John Edmunds; Nilu Goonetilleke; Gabrielle Harvey; Anne M Johnson; Jana Kovar; ...
    Publisher: Oxford University Press (OUP)
    Project: WT , UKRI | FLU PANDEMIC: Study of be... (MC_U122785833), UKRI | Centre for Health service... (MR/K006584/1), UKRI | Flu watch:Community study... (G0600511), UKRI | Flu Watch 2008-09 (G0800767)

    Influenza is a common, highly contagious respiratory virus which infects all age groups, causing a range of outcomes from asymptomatic infection and mild respiratory disease to severe respiratory disease and death.1 If infected, the adaptive immune system produces a hum...

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  • publication . Article . 2015
    Open Access English
    Authors:
    Allan Olspert; Betty Y.-W. Chung; John F. Atkins; John P. Carr; Andrew E. Firth;
    Persistent Identifiers
    Publisher: EMBO Press
    Project: WT | High resolution genome-wi... (096082), WT | Encyclopedia of RNA Virus... (106207), UKRI | Non-canonical gene expres... (BB/J007072/1), WT | Systematic Bioinformatic ... (088789), UKRI | Modelling and manipulatio... (BB/J011762/1), UKRI | Deciphering the enigmatic... (BB/J015652/1)

    The family Potyviridae encompasses ~30% of plant viruses and is responsible for significant economic losses worldwide. Recently, a small overlapping coding sequence, termed pipo, was found to be conserved in the genomes of all potyvirids. PIPO is expressed as part of a ...

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  • publication . Article . 2015
    Open Access
    Authors:
    Leanne K. Finch; Roger Ling; Sawsan Napthine; Allan Olspert; Thomas Michiels; Cécile Lardinois; Susanne Bell; Gary Loughran; Ian Brierley; Andrew E. Firth;
    Persistent Identifiers
    Publisher: American Society for Microbiology
    Project: WT | Encyclopedia of RNA Virus... (106207), WT | Systematic Bioinformatic ... (088789), UKRI | Non-canonical gene expres... (BB/J007072/1)

    <jats:title>ABSTRACT</jats:title><jats:p><jats:italic>Theiler's murine encephalomyelitis virus</jats:italic>(TMEV) is a member of the genus<jats:named-content content-type="genus-species">Cardiovirus</jats:named-content>in the<jats:named-content content-type="genus-spec...

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  • publication . Article . 2013
    Open Access English
    Authors:
    R. Métras; Marc Baguelin; W. John Edmunds; Peter N. Thompson; Alan Kemp; Dirk U. Pfeiffer; Lisa M. Collins; Richard G. White;
    Persistent Identifiers
    Publisher: Centers for Disease Control and Prevention
    Project: UKRI | Respondent-driven samplin... (G0802414)

    A Rift Valley fever (RVF) epidemic affecting animals on domestic livestock farms was reported in South Africa during January–August 2010. The first cases occurred after heavy rainfall, and the virus subsequently spread countrywide. To determine the possible effect of en...

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  • publication . Article . 2012
    Open Access English
    Authors:
    Andrew E. Firth; Brett W. Jagger; Helen M. Wise; Chad C. Nelson; Krishna Parsawar; Norma M. Wills; S. Napthine; Jeffrey Taubenberger; Paul Digard; John F. Atkins;
    Publisher: The Royal Society
    Project: SFI | Altered Genetic Code Read... (08/IN.1/B1889), UKRI | Evolutionary significance... (G0700815), WT | Systematic Bioinformatic ... (088789)

    <jats:p>Programmed ribosomal frameshifting is used in the expression of many virus genes and some cellular genes. In eukaryotic systems, the most well-characterized mechanism involves –1 tandem tRNA slippage on an X_XXY_YYZ motif. By contrast, the mechanisms involved in...

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  • publication . Article . 2011
    Open Access English
    Authors:
    Holger Dinkel; Sushama Michael; Robert J. Weatheritt; Norman E. Davey; Kim Van Roey; Brigitte Altenberg; Grischa Toedt; Bora Uyar; Markus Seiler; Aidan Budd; ...
    Project: UKRI | The BioGRID Database: An ... (BB/F010486/1), EC | SYSCILIA (241955), SNSF | Mechanisms of dynamic +TI... (31003A_122545), EC | SYBOSS (242129), SFI | Towards the druggable int... (08/IN.1/B1864), UKRI | Integrated in silico pred... (BB/I006230/1)

    Linear motifs are short, evolutionarily plastic components of regulatory proteins and provide low-affinity interaction interfaces. These compact modules play central roles in mediating every aspect of the regulatory functionality of the cell. They are particularly promi...

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9 research outcomes, page 1 of 1