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30 research outcomes, page 1 of 3
  • publication . Article . 2020
    Open Access English
    Authors:
    Gordon, David,; Hiatt, Joseph; Bouhaddou, Mehdi; Rezelj, Veronica,; Ulferts, Svenja; Braberg, Hannes; Jureka, Alexander,; Obernier, Kirsten; Guo, Jeffrey,; Batra, Jyoti; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: NIH | MEDICAL SCIENTIIST TRAINI... (5T32GM007618-27), NIH | Structural Basis of Vesic... (1R01NS089713-01A1), NIH | Cytoscape: A Modeling Pla... (5R01HG009979-15), NIH | STRUCTURE AND FUNCTION OF... (5R01GM024485-12), NIH | Discovery of novel, ubiqu... (5R01AI120694-02), UKRI | Elucidating the role of S... (BB/S009566/1), UKRI | Understanding signalling ... (MC_UU_12016/2), NIH | Development and Testing o... (5R35GM122481-02), NIH | Gene Expression Profiling... (5P01AI063302-03), NIH | Protein secretion in bact... (1R01AI128214-01A1)

    <jats:p>The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a grave threat to public health and the global economy. SARS-CoV-2 is closely related to the more lethal but less transmissible coronaviruses SARS-CoV-1 and Middle ...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Paul Bastard; Lindsey B. Rosen; Qian Zhang; Eleftherios Michailidis; Hans-Heinrich Hoffmann; Yu Zhang; Karim Dorgham; Quentin Philippot; Jérémie Rosain; Vivien Béziat; ...
    Publisher: HAL CCSD
    Project: ANR | IFN-COVID19 (ANR-20-COVI-0064), NIH | Developing, Demonstrating... (5UL1TR001866-03), NIH | NHGRI Genome Sequencing P... (5U24HG008956-02), NIH | Inborn errors of immunity... (5R01AI088364-07), NIH | Yale Center for Mendelian... (5UM1HG006504-07), NIH | Modulation of Human Dendr... (5U19AI111825-02), NIH | Type I interferon-stimula... (5R01AI091707-05)

    In a large immunological and genomics study of COVID-19 patients, autoantibodies to type 1 interferons correlated with outcomes.

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  • publication . Article . Other literature type . 2020
    Open Access English
    Authors:
    Mavian, Carla; Pond, Sergei Kosakovsky; Marini, Simone; Magalis, Brittany Rife; Vandamme, Anne-Mieke; Dellicour, Simon; Scarpino, Samuel V; Houldcroft, Charlotte; Villabona-Arenas, Julian; Paisie, Taylor K; ...
    Publisher: National Academy of Sciences
    Project: NIH | HIV Dynamic Modelling for... (1R21AI138815-01)

    NA

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  • publication . Article . Other literature type . 2020
    Open Access
    Authors:
    Sophie Vichier-Guerre; Therese C. Ku; Sylvie Pochet; Katherine L. Seley-Radtke;
    Publisher: Wiley
    Project: NIH | A Flexible Approach to In... (5R21AI118470-02)

    Abstract The structurally unique “fleximer” nucleosides were originally designed to investigate how flexibility in a nucleobase could potentially affect receptor–ligand recognition and function. Recently they have been shown to have low‐to‐sub‐micromolar levels of activ...

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  • publication . Article . Preprint . 2020
    Open Access English
    Authors:
    Crawford, Katharine H.D.; Eguia, Rachel; Dingens, Adam S.; Loes, Andrea N.; Malone, Keara D.; Wolf, Caitlin R.; Chu, Helen Y.; Tortorici, M. Alejandra; Veesler, David; Murphy, Michael; ...
    Persistent Identifiers
    Publisher: MDPI
    Project: NIH | Prospectively characteriz... (1R01AI141707-01), NIH | Engineering Humoral Immun... (1DP2DA040254-01), NIH | Structural Studies of Cor... (5R01GM120553-03)

    International audience; SARS-CoV-2 enters cells using its Spike protein, which is also the main target of neutralizing antibodies. Therefore, assays to measure how antibodies and sera affect Spike-mediated viral infection are important for studying immunity. Because SAR...

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  • publication . Article . Preprint . Other literature type . 2020
    Open Access English
    Authors:
    Andrea Di Gioacchino; Petr Šulc; Anastassia V. Komarova; Benjamin D Greenbaum; Rémi Monasson; Simona Cocco;
    Publisher: HAL CCSD
    Project: NIH | Modulating anti-HIV immun... (7R01AI081848-04)

    SARS-CoV-2 infection can lead to acute respiratory syndrome in patients, which can be due in part to dysregulated immune signalling. We analyze here the occurrences of CpG dinucleotides, which are putative pathogen-associated molecular patterns, along the viral sequence...

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  • publication . Article . Preprint . Other literature type . 2020
    Open Access English
    Authors:
    Alexandra C. Walls; Young-Jun Park; M. Alejandra Tortorici; Abigail Wall; Andrew T. McGuire; David Veesler;
    Publisher: Elsevier BV
    Project: NIH | Structural Studies of Cor... (5R01GM120553-03)

    <jats:title>SUMMARY</jats:title><jats:p>The recent emergence of a novel coronavirus associated with an ongoing outbreak of pneumonia (Covid-2019) resulted in infections of more than 72,000 people and claimed over 1,800 lives. Coronavirus spike (S) glycoprotein trimers p...

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  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Park, Young-Jun; Walls, Alexandra C.; Wang, Zhaoqian; Sauer, Maximillian M.; Li, Wentao; Tortorici, M. Alejandra; Bosch, Berend-Jan; DiMaio, Frank; Veesler, David;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: NIH | Structural Studies of Cor... (5R01GM120553-03)

    The Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe and often lethal respiratory illness in humans, and no vaccines or specific treatments are available. Infections are initiated via binding of the MERS-CoV spike (S) glycoprotein to sialosides and ...

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  • publication . Part of book or chapter of book . Other literature type . Article . 2019
    Open Access English
    Authors:
    Tortorici, M. Alejandra; Veesler, David;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: NIH | Structural Studies of Cor... (5R01GM120553-03)

    International audience; Coronaviruses (CoVs) have caused outbreaks of deadly pneumonia in humans since the beginning of the 21st century. The severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2002 and was responsible for an epidemic that spread to five...

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  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Tortorici, M. Alejandra; Walls, Alexandra C.; Lang, Yifei; Wang, Chunyan; Li, Zeshi; Koerhuis, Danielle; Boons, Geert-Jan; Bosch, Berend-Jan; Rey, Félix A.; de Groot, Raoul J.; ...
    Persistent Identifiers
    Project: NIH | Direct Detection Device f... (1S10OD018111-01), NIH | Structural Studies of Cor... (5R01GM120553-03), NSF | MRI: Acquisition of a dir... (1338135), NIH | West/Midwest Consortium f... (5U24GM116792-03), NIH | High-End CryoEM Instrumen... (1S10RR023057-01)

    International audience; Coronaviruses cause respiratory tract infections in humans and outbreaks of deadly pneumonia worldwide. Infections are initiated by the transmembrane spike (S) glycoprotein, which binds to host receptors and fuses the viral and cellular membranes...

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30 research outcomes, page 1 of 3