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11 research outcomes, page 1 of 2
  • publication . Other literature type . Article . 2018
    Open Access English
    Authors:
    Kim, Yoon Seok; Kato, Hideaki E.; Yamashita, Keitaro; Ito, Shota; Inoue, Keiichi; Ramakrishnan, Charu; Fenno, Lief E.; Evans, Kathryn E.; Paggi, Joseph M.; Dror, Ron O.; ...
    Persistent Identifiers
    Project: NIH | Channel structure-based t... (4R01MH075957-09)

    The naturally occurring channelrhodopsin variant anion channelrhodopsin-1 (ACR1), discovered in the cryptophyte algae Guillardia theta, exhibits large light-gated anion conductance and high anion selectivity when expressed in heterologous settings, properties that suppo...

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  • publication . Other literature type . Article . 2018
    Open Access
    Authors:
    Zhang, Rong; Kim, Arthur S.; Fox, Julie M.; Nair, Sharmila; Basore, Katherine; Klimstra, William B.; Rimkunas, Rebecca; Fong, Rachel H.; Lin, Hueylie; Poddar, Subhajit; ...
    Persistent Identifiers
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Structural and functional... (5R01AI114816-05), NIH | Molecular Mechanisms of E... (4R01AI095436-05), NIH | Chikungunya Virus Replica... (5R01AI123348-05)

    Arthritogenic alphaviruses comprise a group of enveloped RNA viruses that are transmitted to humans by mosquitoes and cause debilitating acute and chronic musculoskeletal disease 1 . The host factors required for alphavirus entry remain poorly characterized 2 . Here we ...

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  • publication . Article . Other literature type . 2018
    Open Access
    Authors:
    Zhou, Peng; Fan, Hang; Lan, Tian; Yang, Xing-Lou; Shi, Wei-Feng; Zhang, Wei; Zhu, Yan; Zhang, Ya-Wei; Xie, Qing-Mei; Mani, Shailendra; ...
    Persistent Identifiers
    Publisher: Springer Nature
    Project: NIH | Understanding the Risk of... (5R01AI110964-05)

    Analysis of viral samples from deceased piglets shows that a bat coronavirus was responsible for an outbreak of fatal disease in China and highlights the importance of the identification of coronavirus diversity and distribution in bats in order to mitigate future outbr...

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  • publication . Other literature type . Article . 2017
    Open Access
    Authors:
    Ozorowski, Gabriel; Pallesen, Jesper; de Val, Natalia; Lyumkis, Dmitry; Cottrell, Christopher A.; Torres, Jonathan L.; Copps, Jeffrey; Stanfield, Robyn L.; Cupo, Albert; Pugach, Pavel; ...
    Persistent Identifiers
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Project 2 (5P50GM103368-03), NIH | Center for HIV/AIDS Vacci... (3UM1AI100663-04S1), NIH | Production of native-like... (1P01AI110657-01A1)

    SUMMARY For many enveloped viruses, binding to a receptor(s) on a host cell acts as a first step in a series of events culminating in fusion with the host cell membrane and transfer of genetic material for replication [for review see1,2]. The envelope glycoprotein (Env)...

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  • publication . Article . 2017
    Open Access
    Authors:
    Kevin J. Olival; Parviez R. Hosseini; Carlos Zambrana-Torrelio; Noam Ross; Tiffany L. Bogich; Peter Daszak;
    Persistent Identifiers
    Publisher: Springer Science and Business Media LLC
    Project: NIH | Risk of Viral Emergence f... (5R01AI079231-03), NIH | Understanding the Risk of... (5R01AI110964-05)

    The majority of human emerging infectious diseases (EIDs) are zoonotic, with viruses originating in wild mammals of particular concern (e.g. HIV, Ebola, SARS)1–3. Understanding patterns of viral diversity in wildlife and determinants of successful cross-species transmis...

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  • publication . Article . Other literature type . 2017
    Open Access English
    Authors:
    Manjunatha, Ujjini H.; Vinayak, Sumiti; Zambriski, Jennifer A.; Chao, Alexander T.; Sy, Tracy; Noble, Christian G.; Bonamy, Ghislain M. C.; Kondreddi, Ravinder R.; Zou, Bin; Gedeck, Peter; ...
    Persistent Identifiers
    Project: WT | Enabling phenotypic scree... (107678), NIH | Genetic analysis of Crypt... (1R01AI112427-01A1), NIH | Exploring TrpB in the pat... (1F32AI124518-01)

    Diarrhoeal disease is responsible for 8.6% of global child mortality. Recent epidemiological studies found the protozoan parasite Cryptosporidium to be a leading cause of paediatric diarrhoea, with particularly grave impact on infants and immunocompromised individuals. ...

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  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Walls, Alexandra C.; Tortorici, M.Alejandra; Bosch, Berend-Jan; Frenz, Brandon; Rottier, Peter J.M.; DiMaio, Frank; Rey, Félix A.; Veesler, David;
    Persistent Identifiers
    Publisher: Springer Science and Business Media LLC
    Project: NIH | TRAINING IN MOLECULAR BIO... (5T32GM008268-09)

    International audience; The tremendous pandemic potential of coronaviruses was demonstrated twice in the past few decades by two global outbreaks of deadly pneumonia. Entry of coronaviruses into cells is mediated by the transmembrane spike glycoprotein S, which forms a ...

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  • publication . Article . Other literature type . 2016
    Open Access
    Authors:
    Warren, Travis K.; Jordan, Robert; Lo, Michael K.; Ray, Adrian S.; Mackman, Richard L.; Soloveva, Veronica; Siegel, Dustin; Perron, Michel; Bannister, Roy; Hui, Hon C.; ...
    Persistent Identifiers
    Project: NIH | Initiation and regulation... (5R01AI113321-03)

    The most recent Ebola virus outbreak in West Africa, which was unprecedented in the number of cases and fatalities, geographic distribution, and number of nations affected, highlights the need for safe, effective, and readily available antiviral agents for treatment and...

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  • publication . Article . Other literature type . 2013
    Open Access English
    Authors:
    Ge, Xing-Yi; Li, Jia-Lu; Yang, Xing-Lou; Chmura, Aleksei A.; Zhu, Guangjian; Epstein, Jonathan H.; Mazet, Jonna K.; Hu, Ben; Zhang, Wei; Peng, Cheng; ...
    Persistent Identifiers
    Project: NIH | Risk of Viral Emergence f... (5R01AI079231-03), NIH | The Ecology, Emergence an... (5R01TW005869-09), NIH | Comparative Spillover Dyn... (1R56TW009502-01)

    The 2002–3 pandemic caused by severe acute respiratory syndrome coronavirus (SARS-CoV) was one of the most significant public health events in recent history1. An ongoing outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV)2 suggests that this group of vi...

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  • publication . Article . 2013
    Open Access
    Authors:
    Jessica A. Belser; Kortney M. Gustin; Melissa B. Pearce; Taronna R. Maines; Hui Zeng; Claudia Pappas; Xiangjie Sun; Paul J. Carney; Julie Villanueva; James Stevens; ...
    Persistent Identifiers
    Publisher: Springer Science and Business Media LLC
    Project: NIH | PILOT--ANTIGENS AND T CEL... (1U54GM062116-01A1)

    The new H7N9 influenza virus, recently emerged in China, can replicate in human airway cells and in the respiratory tract of ferrets to a higher level than can seasonal H3N2 virus and shows higher lethality in mice than genetically related H7N9 and H9N2 viruses, but sho...

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11 research outcomes, page 1 of 2