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19 research outcomes, page 1 of 2
  • publication . Article . 2021
    Open Access
    Authors:
    Raoul De Gasparo; Mattia Pedotti; Luca Simonelli; Petr Nickl; Frauke Muecksch; Irene Cassaniti; Elena Percivalle; Julio C. C. Lorenzi; Federica Mazzola; Davide Magrì; ...
    Persistent Identifiers
    Publisher: Springer Science and Business Media LLC
    Project: EC | ATAC (101003650)

    Neutralizing antibodies that target the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein are among the most promising approaches against COVID-19. A bispecific IgG1-like molecule (CoV-X2) has been developed on the basis of C121 and C135, two antibodies deri...

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  • publication . Article . Other literature type . 2021
    Open Access English
    Authors:
    Gaebler, Christian; Wang, Zijun; Lorenzi, Julio C. C.; Muecksch, Frauke; Finkin, Shlomo; Tokuyama, Minami; Cho, Alice; Jankovic, Mila; Schaefer-Babajew, Dennis; Oliveira, Thiago Y.; ...
    Persistent Identifiers
    Publisher: Nature Publishing Group
    Project: EC | ATAC (101003650)

    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected 78 million individuals and is responsible for over 1.7 million deaths to date. Infection is associated with the development of variable levels of antibodies with neutralizing activity, which can p...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Sanchez-Felipe, Lorena; Vercruysse, Thomas; Sharma, Sapna; Ma, Ji; Lemmens, Viktor; Van Looveren, Dominique; Arkalagud Javarappa, Mahadesh Prasad; Boudewijns, Robbert; Malengier-Devlies, Bert; Liesenborghs, Laurens; ...
    Publisher: Springer Science and Business Media LLC
    Project: EC | SCORE (101003627)

    The expanding pandemic of coronavirus disease 2019 (COVID-19) requires the development of safe, efficacious and fast-acting vaccines. Several vaccine platforms are being leveraged for a rapid emergency response1. Here we describe the development of a candidate vaccine (...

  • publication . Article . Other literature type . 2020
    Open Access English
    Authors:
    Barnes, Christopher O.; Jette, Claudia A.; Abernathy, Morgan E.; Dam, Kim-Marie A.; Esswein, Shannon R.; Gristick, Harry B.; Malyutin, Andrey G.; Sharaf, Naima G.; Huey-Tubman, Kathryn E.; Lee, Yu E.; ...
    Persistent Identifiers
    Publisher: Springer Science and Business Media LLC
    Project: EC | ATAC (101003650)

    The coronavirus disease 2019 (COVID-19) pandemic presents an urgent health crisis. Human neutralizing antibodies that target the host ACE2 receptor-binding domain (RBD) of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike protein show promise therap...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Litviňuková, Monika; Talavera-López, Carlos; Maatz, Henrike; Reichart, Daniel; Worth, Catherine L.; Lindberg, Eric L.; Kanda, Masatoshi; Polanski, Krzysztof; Heinig, Matthias; Lee, Michael; ...
    Publisher: Nature
    Project: EC | CodingHeart (788970)

    Single-cell and single-nucleus RNA sequencing are used to construct a cellular atlas of the human heart that will aid further research into cardiac physiology and disease.

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  • publication . Article . 2020
    Open Access English
    Authors:
    Maisonnasse, Pauline; Guedj, Jérémie; Contreras, Vanessa; Behillil, Sylvie; Solas, Caroline; Marlin, Romain; Naninck, Thibaut; Pizzorno, Andres; Lemaitre, Julien; Gonçalves, Antonio; ...
    Publisher: HAL CCSD
    Project: ANR | IDMIT (ANR-11-INBS-0008), EC | Fight-nCoV (101003555), EC | EVAg (653316), EC | TRANSVAC2 (730964)

    International audience; Coronavirus disease 2019 (COVID-19) has rapidly become a global pandemic and no antiviral drug or vaccine is yet available for the treatment of this disease1-3. Several clinical studies are ongoing to evaluate the efficacy of repurposed drugs tha...

  • publication . Article . Other literature type . 2020
    Open Access English
    Authors:
    Zunlong Ke; Joaquín Otón; Kun Qu; Mirko Cortese; Vojtech Zila; Lesley McKeane; Takanori Nakane; Jasenko Zivanov; Christopher J. Neufeldt; Berati Cerikan; ...
    Persistent Identifiers
    Project: EC | MEMBRANEFUSION (648432)

    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virions are surrounded by a lipid bilayer from which spike (S) protein trimers protrude1. Heavily glycosylated S trimers bind to the angiotensin-converting enzyme 2 receptor and mediate entry of virions into t...

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  • publication . Article . 2020
    Open Access
    Authors:
    Julien Carvelli; Olivier Demaria; Frédéric Vély; Luciana Batista; Nassima Chouaki Benmansour; Joanna Fares; Sabrina Carpentier; Marie-Laure Thibult; Ariane Morel; Romain Remark; ...
    Persistent Identifiers
    Publisher: Springer Science and Business Media LLC
    Project: EC | EVA-GLOBAL (871029)

    Coronavirus disease 2019 (COVID-19) is a disease caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in a pandemic1. The C5a complement factor and its receptor C5aR1 (also known as CD88) have a key role in the initiatio...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Shin, Donghyuk; Mukherjee, Rukmini; Grewe, Diana; Bojkova, Denisa; Baek, Kheewoong; Bhattacharya, Anshu; Schulz, Laura; Widera, Marek; Mehdipour, Ahmad Reza; Tascher, Georg; ...
    Project: EC | Nedd8Activate (789016)

    Biochemical, structural and functional studies on the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) papain-like protease PLpro reveal that it regulates host antiviral responses by preferentially cleaving the ubiquitin-like interferon-stimulated gene 15 pr...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Robbiani, Davide F.; Gaebler, Christian; Muecksch, Frauke; Lorenzi, Julio C. C.; Wang, Zijun; Cho, Alice; Agudelo, Marianna; Barnes, Christopher O.; Gazumyan, Anna; Finkin, Shlomo; ...
    Persistent Identifiers
    Publisher: Springer Science and Business Media LLC
    Project: EC | ATAC (101003650)

    During the COVID-19 pandemic, SARS-CoV-2 infected millions of people and claimed hundreds of thousands of lives. Virus entry into cells depends on the receptor binding domain (RBD) of the SARS-CoV-2 spike protein (S). Although there is no vaccine, it is likely that anti...

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19 research outcomes, page 1 of 2