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description Publicationkeyboard_double_arrow_right Article 2022 France, Belgium, Italy, Former Yugoslav Republic of Macedonia, Brazil, France, France, Netherlands, Switzerland, Turkey, Spain, Turkey, France, France, Denmark, Italy, France, BelgiumPublisher:Proceedings of the National Academy of Sciences Funded by:EC | ATAC, ANR | AABIFNCOV, EC | EASI-Genomics +12 projectsEC| ATAC ,ANR| AABIFNCOV ,EC| EASI-Genomics ,NIH| Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success ,ANR| CNSVIRGEN ,NIH| Yale Center for Mendelian Genomics ,NIH| Monogenic basis of resistance to SARS-CoV2 and predisposition to severe COVID-19 ,NIH| Characterization of host immune responses to SARS-CoV-2 ,NIH| NHGRI Genome Sequencing Program Coordinating Center ,NIH| Inborn errors of immunity in patients with life-threatening COVID-19 ,NIH| Host factors contributing to susceptibility to COVID-19 disease ,EC| MORE2ADA2 ,NIH| Type I interferon-stimulated genes and the antiviral immune response ,NIH| Modulation of Human Dendritic Cell Development by Adjuvants and Vaccines ,NIH| High Performance Computing Instrumentation for the Yale Center for Genome AnalysiJérémy Manry; Paul Bastard; Adrian Gervais; Tom Le Voyer; Jérémie Rosain; Quentin Philippot; Eleftherios Michailidis; Hans-Heinrich Hoffmann; Shohei Eto; Marina Garcia-Prat; Lucy Bizien; Alba Parra-Martínez; Rui Yang; Liis Haljasmägi; Mélanie Migaud; Karita Särekannu; Julia Maslovskaja; Nicolas de Prost; Yacine Tandjaoui-Lambiotte; Charles-Edouard Luyt; Blanca Amador-Borrero; Alexandre Gaudet; Julien Poissy; Pascal Morel; Pascale Richard; Fabrice Cognasse; Jesús Troya; Sophie Trouillet-Assant; Alexandre Belot; Kahina Saker; Pierre Garçon; Jacques G. Rivière; Jean-Christophe Lagier; Stéphanie Gentile; Lindsey B. Rosen; Elana Shaw; Tomohiro Morio; Junko Tanaka; David Dalmau; Pierre-Louis Tharaux; Damien Sene; Alain Stepanian; Bruno Mégarbane; Vasiliki Triantafyllia; Arnaud Fekkar; James R. Heath; José Luis Franco; Juan-Manuel Anaya; Jordi Solé-Violán; Luisa Imberti; Andrea Biondi; Paolo Bonfanti; Riccardo Castagnoli; Ottavia M. Delmonte; Yu Zhang; Andrew L. Snow; Steven M. Holland; Catherine M. Biggs; Marcela Moncada-Vélez; Andrés Augusto Arias; Lazaro Lorenzo; Soraya Boucherit; Dany Anglicheau; Anna M. Planas; Filomeen Haerynck; Sotirija Duvlis; Tayfun Ozcelik; Sevgi Keles; Ahmed A. Bousfiha; Jalila El Bakkouri; Carolina Ramirez-Santana; Stéphane Paul; Qiang Pan-Hammarström; Lennart Hammarström; Annabelle Dupont; Alina Kurolap; Christine N. Metz; Alessandro Aiuti; Giorgio Casari; Vito Lampasona; Fabio Ciceri; Lucila A. Barreiros; Elena Dominguez-Garrido; Mateus Vidigal; Mayana Zatz; Diederik van de Beek; Sabina Sahanic; Ivan Tancevski; Yurii Stepanovskyy; Oksana Boyarchuk; Yoko Nukui; Miyuki Tsumura; Loreto Vidaur; Stuart G. Tangye; Sonia Burrel; Darragh Duffy; Lluis Quintana-Murci; Adam Klocperk; Nelli Y. Kann; Anna Shcherbina; Yu-Lung Lau; Daniel Leung; Matthieu Coulongeat; Julien Marlet; Rutger Koning; Luis Felipe Reyes; Angélique Chauvineau-Grenier; Fabienne Venet; Guillaume Monneret; Michel C. Nussenzweig; Romain Arrestier; Idris Boudhabhay; Hagit Baris-Feldman; David Hagin; Joost Wauters; Isabelle Meyts; Adam H. Dyer; Sean P. Kennelly; Nollaig M. Bourke; Rabih Halwani; Fatemeh Saheb Sharif-Askari; Karim Dorgham; Jérôme Sallette; Souad Mehlal Sedkaoui; Suzan AlKhater; Raúl Rigo-Bonnin; Francisco Morandeira; Lucie Roussel; Donald C. Vinh; Christian Erikstrup; Antonio Condino-Neto; Carolina Prando; Anastasiia Bondarenko; András N. Spaan; Laurent Gilardin; Jacques Fellay; Stanislas Lyonnet; Kaya Bilguvar; Richard P. Lifton; Shrikant Mane; Mark S. Anderson; Bertrand Boisson; Vivien Béziat; Shen-Ying Zhang; Evangelos Andreakos; Olivier Hermine; Aurora Pujol; Pärt Peterson; Trine H. Mogensen; Lee Rowen; James Mond; Stéphanie Debette; Xavier de Lamballerie; Charles Burdet; Lila Bouadma; Marie Zins; Pere Soler-Palacin; Roger Colobran; Guy Gorochov; Xavier Solanich; Sophie Susen; Javier Martinez-Picado; Didier Raoult; Marc Vasse; Peter K. Gregersen; Lorenzo Piemonti; Carlos Rodríguez-Gallego; Luigi D. Notarangelo; Helen C. Su; Kai Kisand; Satoshi Okada; Anne Puel; Emmanuelle Jouanguy; Charles M. Rice; Pierre Tiberghien; Qian Zhang; Jean-Laurent Casanova; Laurent Abel; Aurélie Cobat; Peng Zhang; Yoann Seeleuthner; Estelle Talouarn; Astrid Marchal; Daniela Matuozzo; Aliénor de la Chapelle; Jie Chen; Maya Chrabieh; Dana Liu; Yelena Nemirowskaya; Inés Marín Cruz; Marie Materna; Sophie Pelet; Chloé Thibault; Zhiyong Liu; Jorge Abad; Giulia Accordino; Cristian Achille; Sergio Aguilera-Albesa; Aina Aguiló-Cucurull; Alessandro Aiuti; Teresa Auguet; Mateus V. Castro; Cyril Cyrus; Olov Ekwall; Jan Gunst; Mikko Seppänen; Ali Sobh; Guillaume Voiriot; Virginia Quaresima; Olivier Terrier; Laurent Renia;pmid: 36179016
pmc: PMC9173764
handle: 10261/279776 , 20.500.11768/129015 , 11693/111766 , 1854/LU-8767983 , 11443/2890 , 10281/376820
pmid: 36179016
pmc: PMC9173764
handle: 10261/279776 , 20.500.11768/129015 , 11693/111766 , 1854/LU-8767983 , 11443/2890 , 10281/376820
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing IFN-α, IFN-ω, and/or IFN-β are found in ∼20% of deceased patients across age groups, and in ∼1% of individuals aged 4% of those >70 y old in the general population. With a sample of 1,261 unvaccinated deceased patients and 34,159 individuals of the general population sampled before the pandemic, we estimated both IFR and relative risk of death (RRD) across age groups for individuals carrying autoantibodies neutralizing type I IFNs, relative to noncarriers. The RRD associated with any combination of autoantibodies was higher in subjects under 70 y old. For autoantibodies neutralizing IFN-α2 or IFN-ω, the RRDs were 17.0 (95% CI: 11.7 to 24.7) and 5.8 (4.5 to 7.4) for individuals <70 y and ≥70 y old, respectively, whereas, for autoantibodies neutralizing both molecules, the RRDs were 188.3 (44.8 to 774.4) and 7.2 (5.0 to 10.3), respectively. In contrast, IFRs increased with age, ranging from 0.17% (0.12 to 0.31) for individuals <40 y old to 26.7% (20.3 to 35.2) for those ≥80 y old for autoantibodies neutralizing IFN-α2 or IFN-ω, and from 0.84% (0.31 to 8.28) to 40.5% (27.82 to 61.20) for autoantibodies neutralizing both. Autoantibodies against type I IFNs increase IFRs, and are associated with high RRDs, especially when neutralizing both IFN-α2 and IFN-ω. Remarkably, IFRs increase with age, whereas RRDs decrease with age. Autoimmunity to type I IFNs is a strong and common predictor of COVID-19 death. ispartof: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA vol:119 issue:21 ispartof: location:United States status: published
UGD Academic Reposit... arrow_drop_down Ghent University Academic BibliographyArticle . 2022Data sources: Ghent University Academic BibliographyRecolector de Ciencia Abierta, RECOLECTAArticleData sources: Recolector de Ciencia Abierta, RECOLECTABilkent University Institutional RepositoryArticle . 2022Data sources: Bilkent University Institutional RepositoryRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2022 . Peer-reviewedRecolector de Ciencia Abierta, RECOLECTAArticle . 2022Data sources: Recolector de Ciencia Abierta, RECOLECTAInfoscience - EPFL scientific publicationsArticleData sources: Infoscience - EPFL scientific publicationsHAL Descartes; HAL-PasteurArticle . 2022License: CC BYFull-Text: https://hal.science/hal-03856619/documentAcibadem University Open Access RepositoryArticle . 2022Data sources: Acibadem University Open Access Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu98 citations 98 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert UGD Academic Reposit... arrow_drop_down Ghent University Academic BibliographyArticle . 2022Data sources: Ghent University Academic BibliographyRecolector de Ciencia Abierta, RECOLECTAArticleData sources: Recolector de Ciencia Abierta, RECOLECTABilkent University Institutional RepositoryArticle . 2022Data sources: Bilkent University Institutional RepositoryRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2022 . Peer-reviewedRecolector de Ciencia Abierta, RECOLECTAArticle . 2022Data sources: Recolector de Ciencia Abierta, RECOLECTAInfoscience - EPFL scientific publicationsArticleData sources: Infoscience - EPFL scientific publicationsHAL Descartes; HAL-PasteurArticle . 2022License: CC BYFull-Text: https://hal.science/hal-03856619/documentAcibadem University Open Access RepositoryArticle . 2022Data sources: Acibadem University Open Access Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2022 France, Spain, France, Netherlands, France, France, FrancePublisher:Research Square Platform LLC Publicly fundedFunded by:EC | ATAC, NIH | Yale Center for Mendelian..., ANR | AABIFNCOV +14 projectsEC| ATAC ,NIH| Yale Center for Mendelian Genomics ,ANR| AABIFNCOV ,EC| EASI-Genomics ,ANR| CNSVIRGEN ,NIH| Inborn errors of immunity in patients with life-threatening COVID-19 ,EC| RECoVER ,NIH| Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success ,NIH| High Performance Computing Instrumentation for the Yale Center for Genome Analysi ,NIH| Monogenic basis of resistance to SARS-CoV2 and predisposition to severe COVID-19 ,NIH| Characterization of host immune responses to SARS-CoV-2 ,NIH| NHGRI Genome Sequencing Program Coordinating Center ,NIH| Modulation of Human Dendritic Cell Development by Adjuvants and Vaccines ,EC| MORE2ADA2 ,ANR| GenMIS-C ,NIH| Type I interferon-stimulated genes and the antiviral immune response ,NIH| Host factors contributing to susceptibility to COVID-19 diseaseManry, Jeremy; Bastard, Paul; Gervais, Adrian; Voyer, Tom Le; Rosain, Jérémie; Philippot, Quentin; Michailidis, Eleftherios; Hoffmann, Hans-Heinrich; Eto, Shohei; Garcia-Prat, Marina; Bizien, Lucy; Parra-Martínez, Alba; Yang, Rui; Haljasmägi, Liis; Migaud, Mélanie; Särekannu, Karita; Maslovskaja, Julia; de Prost, Nicolas; Tandjaoui-Lambiotte, Yacine; Luyt, Charles-Edouard; Amador-Borrero, Blanca; Gaudet, Alexandre; Poissy, Julien; Morel, Pascal; Richard, Pascale; Cognasse, Fabrice; Troya, Jesus; Trouillet-Assant, Sophie; Belot, Alexandre; Saker, Kahina; Garçon, Pierre; Rivière, Jacques G.; Lagier, Jean-Christophe; Gentile, Stéphanie; Rosen, Lindsey; Shaw, Elana; Morio, Tomohiro; Tanaka, Junko; Dalmau, David; Tharaux, Pierre-Louis; Sene, Damien; Stepanian, Alain; Mégarbane, Bruno; Triantafyllia, Vasiliki; Fekkar, Arnaud; Heath, James; Franco, Jose; Anaya, Juan-Manuel; Solé-Violán, Jordi; Imberti, Luisa; Biondi, Andrea; Bonfanti, Paolo; Castagnoli, Riccardo; Delmonte, Ottavia; Zhang, Yu; Snow, Andrew; Holland, Steve; Biggs, Catherine; Moncada-Vélez, Marcela; Arias, Andrés; Lorenzo, Lazaro; Boucherit, Soraya; Anglicheau, Dany; Planas, Anna; Haerynck, Filomeen; Duvlis, Sotirija; Nussbaum, Robert; Ozcelik, Tayfun; Keles, Sevgi; Bousfiha, Aziz; Bakkouri, Jalila El; Ramirez-Santana, Carolina; Paul, Stéphane; Pan-Hammarstrom, Qiang; Hammarstrom, Lennart; Dupont, Annabelle; Kurolap, Alina; Metz, Christine; Aiuti, Alessandro; Casari, Giorgio; Lampasona, Vito; Ciceri, Fabio; Barreiros, Lucila; Dominguez-Garrido, Elena; Vidigal, Mateus; Zatz, Mayana; de Beek, Diederik van; Sahanic, Sabina; Tancevski, Ivan; Stepanovskyy, Yurii; Boyarchuk, Oksana; Nukui, Yoko; Tsumura, Miyuki; Vidaur, Loreto; Tangye, Stuart; Burrel, Sonia; Duffy, Darragh; Quintana-Murci, Lluis; Klocperk, Adam; Kann, Nelli; Shcherbina, Anna; Lau, Yu-Lung; Leung, Daniel; Coulongeat, Matthieu; Marlet, Julien; Koning, Rutger; Reyes, Luis; Chauvineau-Grenier, Angélique; Venet, Fabienne; monneret, guillaume; Nussenzweig, Michel; Arrestier, Romain; Boudhabhay, Idris; Baris-Feldman, Hagit; Hagin, David; Wauters, Joost; Meyts, Isabelle; Dyer, Adam; Kennelly, Sean; Bourke, Nollaig; Halwani, Rabih; Sharif-Askari, Fatemeh; Dorgham, Karim; Sallette, Jérôme; Mehlal-Sedkaoui, Souad; AlKhater, Suzan; Rigo-Bonnin, Raúl; Morandeira, Francisco; Roussel, Lucie; Vinh, Donald; Erikstrup, Christian; Condino-Neto, Antonio; Prando, Carolina; Bondarenko, Anastasiia; Spaan, András; Gilardin, Laurent; Fellay, Jacques; Lyonnet, Stanislas; Bilguvar, Kaya; Lifton, Richard; Mane, Shrikant; Anderson, Mark; Boisson, Bertrand; Béziat, Vivien; Zhang, Shen-Ying; Andreakos, Evangelos; Hermine, Olivier; Pujol, Aurora; Peterson, Pärt; Mogensen, Trine Hyrup; Rowen, Lee; Mond, James; Debette, Stéphanie; deLamballerie, Xavier; Burdet, Charles; Bouadma, Lila; Zins, Marie; Soler-Palacin, Pere; Colobran, Roger; Gorochov, Guy; Solanich, Xavier; Susen, Sophie; Martinez-Picado, Javier; Raoult, Didier; Vasse, Marc; Gregersen, Peter; Rodríguez-Gallego, Carlos; Piemonti, Lorenzo; Notarangelo, Luigi; Su, Helen; Kisand, Kai; Okada, Satoshi; Puel, Anne; Jouanguy, Emmanuelle; Rice, Charles; Tiberghien, Pierre; Zhang, Qian; Casanova, Jean-Laurent; Abel, Laurent; Cobat, Aurélie;There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing IFN-α, IFN-ω, and/or IFN-β are found in ∼20% of deceased patients across age groups, and in ∼1% of individuals aged 4% of those >70 y old in the general population. With a sample of 1,261 unvaccinated deceased patients and 34,159 individuals of the general population sampled before the pandemic, we estimated both IFR and relative risk of death (RRD) across age groups for individuals carrying autoantibodies neutralizing type I IFNs, relative to noncarriers. The RRD associated with any combination of autoantibodies was higher in subjects under 70 y old. For autoantibodies neutralizing IFN-α2 or IFN-ω, the RRDs were 17.0 (95% CI: 11.7 to 24.7) and 5.8 (4.5 to 7.4) for individuals <70 y and ≥70 y old, respectively, whereas, for autoantibodies neutralizing both molecules, the RRDs were 188.3 (44.8 to 774.4) and 7.2 (5.0 to 10.3), respectively. In contrast, IFRs increased with age, ranging from 0.17% (0.12 to 0.31) for individuals <40 y old to 26.7% (20.3 to 35.2) for those ≥80 y old for autoantibodies neutralizing IFN-α2 or IFN-ω, and from 0.84% (0.31 to 8.28) to 40.5% (27.82 to 61.20) for autoantibodies neutralizing both. Autoantibodies against type I IFNs increase IFRs, and are associated with high RRDs, especially when neutralizing both IFN-α2 and IFN-ω. Remarkably, IFRs increase with age, whereas RRDs decrease with age. Autoimmunity to type I IFNs is a strong and common predictor of COVID-19 death.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2022Full-Text: http://europepmc.org/articles/PMC8764723Data sources: PubMed CentralDipòsit Digital de Documents de la UABArticle . 2022Data sources: Dipòsit Digital de Documents de la UABHAL-ENS-LYON; HAL-Pasteur; HAL - Université de Lille; HAL-Inserm; HAL AMUPreprint . 2022License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!visibility 40visibility views 40 download downloads 137 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2022Full-Text: http://europepmc.org/articles/PMC8764723Data sources: PubMed CentralDipòsit Digital de Documents de la UABArticle . 2022Data sources: Dipòsit Digital de Documents de la UABHAL-ENS-LYON; HAL-Pasteur; HAL - Université de Lille; HAL-Inserm; HAL AMUPreprint . 2022License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.21203/rs.3.rs-1225906/v1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 FrancePublisher:Informa UK Limited Funded by:ANR | ACROBATANR| ACROBATValentin Sencio; Arnaud Machelart; Cyril Robil; Nicolas Benech; Eik Hoffmann; Chloé Galbert; Lucie Deryuter; Séverine Heumel; Aline Hantute-Ghesquier; Anne Flourens; Priscille Brodin; Fabrice Infanti; Virgile Richard; Jean Dubuisson; Corinne Grangette; Thierry Sulpice; Isabelle Wolowczuk; Florence Pinet; Vincent Prévot; Sandrine Belouzard; François Briand; Martine Duterque-Coquillaud; Harry Sokol; François Trottein;Mounting evidence suggests that the gut-to-lung axis is critical during respiratory viral infections. We herein hypothesized that disruption of gut homeostasis during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may associate with early disease outcomes. To address this question, we took advantage of the Syrian hamster model. Our data confirmed that this model recapitulates some hallmark features of the human disease in the lungs. We further showed that SARS-CoV-2 infection associated with mild intestinal inflammation, relative alteration in intestinal barrier property and liver inflammation and altered lipid metabolism. These changes occurred concomitantly with an alteration of the gut microbiota composition over the course of infection, notably characterized by a higher relative abundance of deleterious bacterial taxa such as Enterobacteriaceae and Desulfovibrionaceae. Conversely, several members of the Ruminococcaceae and Lachnospiraceae families, including bacteria known to produce the fermentative products short-chain fatty acids (SCFAs), had a reduced relative proportion compared to non-infected controls. Accordingly, infection led to a transient decrease in systemic SCFA amounts. SCFA supplementation during infection had no effect on clinical and inflammatory parameters. Lastly, a strong correlation between some gut microbiota taxa and clinical and inflammation indices of SARS-CoV-2 infection severity was evidenced. Collectively, alteration of the gut microbiota correlates with disease severity in hamsters making this experimental model valuable for the design of interventional, gut microbiota-targeted, approaches for the control of COVID-19. International audience
HAL-Inserm; HAL - Un... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8726722Data sources: PubMed CentralHAL - Université de Lille; HAL-InsermArticle . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 42 citations 42 popularity Top 1% influence Average impulse Top 1% Powered by BIP!more_vert HAL-Inserm; HAL - Un... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8726722Data sources: PubMed CentralHAL - Université de Lille; HAL-InsermArticle . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 France, Italy, France, Denmark, France, Belgium, Turkey, France, Former Yugoslav Republic of Macedonia, Netherlands, Italy, Spain, United Kingdom, Brazil, Spain, Italy, France, Finland, France, Spain, France, France, Italy, Italy, France, FrancePublisher:American Association for the Advancement of Science (AAAS) Publicly fundedFunded by:ANR | AABIFNCOV, EC | EASI-Genomics, EC | MORE2ADA2 +12 projectsANR| AABIFNCOV ,EC| EASI-Genomics ,EC| MORE2ADA2 ,EC| RECoVER ,NIH| Modulation of Human Dendritic Cell Development by Adjuvants and Vaccines ,NIH| Monogenic basis of resistance to SARS-CoV2 and predisposition to severe COVID-19 ,NIH| Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success ,ANR| GENCOVID ,NIH| Yale Center for Mendelian Genomics ,NIH| Characterization of host immune responses to SARS-CoV-2 ,NIH| NHGRI Genome Sequencing Program Coordinating Center ,EC| ATAC ,NIH| Type I interferon-stimulated genes and the antiviral immune response ,NIH| Host factors contributing to susceptibility to COVID-19 disease ,NIH| High Performance Computing Instrumentation for the Yale Center for Genome AnalysiBastard, Paul; Gervais, Adrian; Le Voyer, Tom; Rosain, Jérémie; Philippot, Quentin; Manry, Jérémy; Michailidis, Eleftherios; Hoffmann, Hans-Heinrich; Eto, Shohei; Garcia-Prat, Marina; Bizien, Lucy; Parra-Martínez, Alba; Yang, Rui; Haljasmägi, Liis; Migaud, Mélanie; Särekannu, Karita; Maslovskaja, Julia; de Prost, Nicolas; Tandjaoui-Lambiotte, Yacine; Luyt, Charles-Edouard; Amador-Borrero, Blanca; Gaudet, Alexandre; Poissy, Julien; Morel, Pascal; Richard, Pascale; Cognasse, Fabrice; Troya, Jesus; Trouillet-Assant, Sophie; Belot, Alexandre; Saker, Kahina; Garçon, Pierre; Rivière, Jacques G.; Lagier, Jean-Christophe; Gentile, Stéphanie; Rosen, Lindsey B.; Shaw, Elana; Morio, Tomohiro; Tanaka, Junko; Dalmau, David; Tharaux, Pierre-Louis; Sene, Damien; Stepanian, Alain; Megarbane, Bruno; Triantafyllia, Vasiliki; Fekkar, Arnaud; Heath, James R.; Franco, José Luis; Anaya, Juan-Manuel; Solé-Violán, Jordi; Imberti, Luisa; Biondi, Andrea; Bonfanti, Paolo; Castagnoli, Riccardo; Delmonte, Ottavia M.; Zhang, Yu; Snow, Andrew L.; Holland, Steven M.; Biggs, Catherine M.; Moncada-Vélez, Marcela; Arias, Andrés Augusto; Lorenzo, Lazaro; Boucherit, Soraya; Coulibaly, Boubacar; Anglicheau, Dany; Planas, Anna M.; Haerynck, Filomeen; Duvlis, Sotirija; Nussbaum, Robert L.; Ozcelik, Tayfun; Keles, Sevgi; Bousfiha, Ahmed A.; El Bakkouri, Jalila; Ramirez-Santana, Carolina; Paul, Stéphane; Pan-Hammarström, Qiang; Hammarström, Lennart; Dupont, Annabelle; Kurolap, Alina; Metz, Christine N.; Aiuti, Alessandro; Casari, Giorgio; Lampasona, Vito; Ciceri, Fabio; Barreiros, Lucila A.; Dominguez-Garrido, Elena; Vidigal, Mateus; Zatz, Mayana; van de Beek, Diederik; Sahanic, Sabina; Tancevski, Ivan; Stepanovskyy, Yurii; Boyarchuk, Oksana; Nukui, Yoko; Tsumura, Miyuki; Vidaur, Loreto; Tangye, Stuart G.; Burrel, Sonia; Duffy, Darragh; Quintana-Murci, Lluis; Klocperk, Adam; Kann, Nelli Y.; Shcherbina, Anna; Lau, Yu-Lung; Leung, Daniel; Coulongeat, Matthieu; Marlet, Julien; Koning, Rutger; Reyes, Luis Felipe; Chauvineau-Grenier, Angélique; Venet, Fabienne; Monneret, Guillaume; Nussenzweig, Michel C.; Arrestier, Romain; Boudhabhay, Idris; Baris-Feldman, Hagit; Hagin, David; Wauters, Joost; Meyts, Isabelle; Dyer, Adam H.; Kennelly, Sean P.; Bourke, Nollaig M.; Halwani, Rabih; Sharif-Askari, Narjes Saheb; Dorgham, Karim; Sallette, Jérome; Mehlal Sedkaoui, Souad; AlKhater, Suzan; Rigo-Bonnin, Raúl; Morandeira, Francisco; Roussel, Lucie; Vinh, Donald C.; Ostrowski, Sisse Rye; Condino-Neto, Antonio; Prando, Carolina; Bondarenko, Anastasiia; Spaan, András N.; Gilardin, Laurent; Fellay, Jacques; Lyonnet, Stanislas; Bilguvar, Kaya; Lifton, Richard P.; Mane, Shrikant; Anderson, Mark S.; Boisson, Bertrand; Béziat, Vivien; Zhang, Shen-Ying; Andreakos, Evangelos; Hermine, Olivier; Pujol, Aurora; Peterson, Pärt; Mogensen, Trine H.; Rowen, Lee; Mond, James; Debette, Stéphanie; de Lamballerie, Xavier; Duval, Xavier; Mentré, France; Zins, Marie; Soler-Palacin, Pere; Colobran, Roger; Gorochov, Guy; Solanich, Xavier; Susen, Sophie; Martinez-Picado, Javier; Raoult, Didier; Vasse, Marc; Gregersen, Peter K.; Piemonti, Lorenzo; Rodríguez-Gallego, Carlos; Notarangelo, Luigi D.; Su, Helen C.; Kisand, Kai; Okada, Satoshi; Puel, Anne; Jouanguy, Emmanuelle; Rice, Charles M.; Tiberghien, Pierre; Zhang, Qian; Cobat, Aurélie; Abel, Laurent; Casanova, Jean-Laurent; Bigio, Benedetta; Boucherit, Soraya; de la Chapelle, Aliénor; Chen, Jie; Chrabieh, Maya; Coulibaly, Boubacar; Liu, Dana; Nemirowskaya, Yelena; Cruz, Inés Marín; Materna, Marie; Pelet, Sophie; Seeleuthner, Yoann; Thibault, Chloé; Liu, Zhiyong; Abad, Jorge; Accordino, Giulia; Achille, Cristian; Aguilera-Albesa, Sergio; Aguiló-Cucurull, Aina; Alonso-Arias, Rebeca; Alsina, Laia; Antolí, Arnau; Bahram, Seiamak; Baldanti, Fausto; Blanchard-Rohner, Geraldine; Blanco, Ignacio; Blázquez-Gamero, Daniel; Bleibtreu, Alexandre; Borghesi, Alessandro; Bruno, Raffaele; Carapito, Raphael; Cassaniti, Irene; Castro, Mateus V; Charbit, Bruno; Cyrus, Cyril; Danion, François; Darley, David Ross; Dauby, Nicolas; Ekwall, Olov; Elnagdy, Marwa H; Emiroglu, Melike; Ferrer, Ricard; Gonzalez-Granado, Luis I; Hanitsch, Leif Gunnar; Gunst, Jan; Hariyan, Tetyana; Humbert, Linda; Kido, Yasutoshi; Kılıç, Ahmet Osman; Lévy, Romain; Lye, David C; Marjani, Majid; Mathian, Alexis; Million, Matthieu; Papadaki, Maria; Parizot, Christophe; Parola, Philippe; Pérez-Fernández, Xosé Luis; de Chambrun, Marc Pineton; Ploin, Dominique; Resmini, Léa; Romero, Carolina Soledad; Ruch, Yvon; Ruiz-Rodriguez, Juan Carlos; Salagianni, Maria; Sánchez-Ramón, Silvia; Schluter, Agatha; Scolari, Francesco; Seppänen, Mikko; Siouti, Eleni; Sobh, Ali; Tipu, Imran; Tolstrup, Martin; Troya, Jesús; Uzunhan, Yurdagul; Vabres, Pierre; Voiriot, Guillaume; Young, Barnaby E; Levi, Hoste; Citerio, Giuseppe; Dalgard, Clifton L.; Sottini, Alessandra; Quaresima, Virginia; Licari, Amelia; Marseglia, Gian Luigi; Batten, Isabella; Reddy, Conor; Connolly, Emma; Storgaard, Merete; Erikstrup, Christian; Pedersen, Ole Birger; Mikkelsen, Susan; Dinh, Khoa Manh; Townsend, Liam; Couffignal, Camille; Deplanque, Dominique; Diallo, Alpha; Etienne, Manuel; Gaymard, Alexandre; Hulot, Jean-Sébastien; Rosa-Calatrava, Manuel; Terrier, Olivier; Gribouval, Olivier; Bruhns, Pierre; Kenny, Rose Anne; Touvier, Mathilde; Burdet, Charles; Thy, Michael; Maillot, Adrien; Beudel, Martijn; Bogaard, Harm Jan; Bos, Lieuwe; Hemke, Robert; Sigaloff, Kim; van der Valk, Marc; Brouwer, Matthijs C.; Bryceson, Yenan; Cooper, Megan A.; Karamitros, Timokratis; Ling, Yun; Novelli, Antonio; Renia, Laurent; Ramaswamy, Sathishkumar; Turvey, Stuart E; Uddin, K M Furkan; Nadif, Rachel;handle: 2445/180396 , 20.500.11768/118484 , 1854/LU-8720604 , 10230/54189 , 10261/250618 , 11693/76825 , 10138/340517 , 2108/294678 , 10281/324305 , 11379/552041
handle: 2445/180396 , 20.500.11768/118484 , 1854/LU-8720604 , 10230/54189 , 10261/250618 , 11693/76825 , 10138/340517 , 2108/294678 , 10281/324305 , 11379/552041
The Laboratory of Human Genetics of Infectious Diseases is supported by the Howard Hughes Medical Institute, the Rockefeller University, the St. Giles Foundation, the National Institutes of Health (NIH) (R01AI088364), the National Center for Advancing Translational Sciences (NCATS), NIH Clinical and Translational Science Awards (CTSA) program (UL1 TR001866), a Fast Grant from Emergent Ventures, Mercatus Center at George Mason University, the Yale Center for Mendelian Genomics and the GSP Coordinating Center funded by the National Human Genome Research Institute (NHGRI) (UM1HG006504 and U24HG008956), the Yale High Performance Computing Center (S10OD018521), the Fisher Center for Alzheimer’s Research Foundation, the Meyer Foundation, the JPB Foundation, the French National Research Agency (ANR) under the “Investments for the Future” program (ANR-10-IAHU-01), the Integrative Biology of Emerging Infectious Diseases Laboratory of Excellence (ANR-10-LABX-62-IBEID), the French Foundation for Medical Research (FRM) (EQU201903007798), the FRM and ANR GENCOVID project (ANR-20-COVI-0003), ANRS Nord-Sud (ANRS-COV05), ANR GENVIR (ANR-20-CE93-003) and ANR AABIFNCOV (ANR-20-CO11-0001) projects, the European Union’s Horizon 2020 research and innovation programme under grant agreement no. 824110 (EASI-Genomics), the Square Foundation, Grandir–Fonds de solidarité pour l’Enfance, the Fondation du Souffle, the SCOR Corporate Foundation for Science, Institut National de la Santé et de la Recherche Médicale (INSERM), REACTing-INSERM; and the University of Paris. P.B. was supported by the FRM (EA20170638020). P.B., J.R., and T.L.V. were supported by the MD-PhD program of the Imagine Institute (with the support of the Fondation Bettencourt Schueller). Work in the Laboratory of Virology and Infectious Disease was supported by the NIH (P01AI138398-S1, 2U19AI111825, and R01AI091707-10S1), a George Mason University Fast Grant, and the G. Harold and Leila Y. Mathers Charitable Foundation. The French COVID Cohort study group was sponsored by INSERM and supported by the REACTing consortium and by a grant from the French Ministry of Health (PHRC 20-0424). The Cov-Contact Cohort was supported by the REACTing consortium, the French Ministry of Health, and the European Commission (RECOVER WP 6). This work was also partly supported by the Intramural Research Program of the NIAID and NIDCR, NIH (grants ZIA AI001270 to L.D.N. and 1ZIAAI001265 to H.C.S.). This program is supported by the Agence Nationale de la Recherche (reference ANR-10-LABX-69-01). K.K.’s group was supported by the Estonian Research Council grants PRG117 and PRG377. R.H. was supported by an Al Jalila Foundation Seed Grant (AJF202019), Dubai, UAE, and a COVID-19 research grant (CoV19-0307) from the University of Sharjah, UAE. S.G.T. is supported by Investigator and Program Grants awarded by the National Health and Medical Research Council of Australia and a UNSW Sydney COVID Rapid Response Initiative Grant. L.I. reported funding from Regione Lombardia, Italy (project “Risposta immune in pazienti con COVID-19 e co-morbidità”). L.I. and G. L. Marseglia reported funding from Regione Lombardia, Italy (project Risposta immune in pazienti con COVID-19 e co-morbidità). This research was partially supported by the Instituto de Salud Carlos III (COV20/0968). J.R.H. reported funding from Biomedical Advanced Research and Development Authority HHSO10201600031C. S.O. reports funding Research Program on Emerging and Re-emerging Infectious Diseases from Japan Agency for Medical Research and Development, AMED (grant number JP20fk0108531). G.G. was supported by ANR Flash COVID-19 program and SARS-CoV-2 Program of the Faculty of Medicine from Sorbonne University iCOVID programs. The Three-City (3C) Study was conducted under a partnership agreement among the INSERM, the Victor Segalen Bordeaux 2 University, and Sanofi-Aventis. The Fondation pour la Recherche Médicale funded the preparation and initiation of the study. The 3C Study was also supported by the Caisse Nationale d’Assurance Maladie des Travailleurs Salariés, Direction générale de la Santé, Mutuelle Générale de l’Education Nationale (MGEN), Institut de la Longévité, Conseils Régionaux of Aquitaine and Bourgogne, Fondation de France, and Ministry of Research–INSERM Programme “Cohortes et collections de données biologiques”. S. Debette was supported by the University of Bordeaux Initiative of Excellence. P.K.G. reports funding from the National Cancer Institute, NIH, under contract no. 75N91019D00024, task order no. 75N91021F00001. J.W. is supported by an FWO Fundamental Clinical Mandate (1833317N). Sample processing at IrsiCaixa was possible thanks to the crowdfunding initiative YoMeCorono. Work at Vall d’Hebron was also partly supported by research funding from Instituto de Salud Carlos III grant PI17/00660 cofinanced by the European Regional Development Fund (ERDF). C.R.-G. and colleagues of the Canarian Health System Sequencing Hub were supported by the Instituto de Salud Carlos III (COV20_01333 and COV20_01334, Spanish Ministry for Science and Innovation RTC-2017-6471-1; AEI/FEDER, UE), Fundación DISA (OA18/017 and OA20/024), and Cabildo Insular de Tenerife (CGIEU0000219140 and “Apuestas científicas del ITER para colaborar en la lucha contra la COVID-19”). C.M.B. is supported by a MSFHR Health Professional-Investigator Award. P.Q.H. and L.H. were funded by the European Union’s Horizon 2020 research and innovation program (ATAC, 101003650). Work at Y.-L.L.’s laboratory in the University of Hong Kong (HKU) was supported by the Society for the Relief of Disabled Children. MBBS/PhD study of D.L. in HKU was supported by the Croucher Foundation. J.L.F. was supported in part by the Coopération Scientifique France-Colciencias (ECOS-Nord/COLCIENCIAS/MEN/ICETEX (806-2018) and Colciencias contract 713-2016 (code 111574455633)]. A.K. was in part supported by grants NU20-05-00282 and NV18-05-00162 issued by the Czech Health Research Council and Ministry of Health, Czech Republic. L.P. was funded by Program Project COVID-19 OSR-UniSR and Ministero della Salute (COVID-2020-12371617). I.M. is a Senior Clinical Investigator at the Research Foundation–Flanders and is supported by the CSL Behring Chair of Primary Immunodeficiencies; by the KU Leuven C1 grant C16/18/007; by a VIB-GC PID grant; by the FWO frants G0C8517N, G0B5120N, and G0E8420N; and by the Jeffrey Modell Foundation. I.M. has received funding under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 948959). E.A. received funding from the Hellenic Foundation for Research and Innovation (INTERFLU, no. 1574). M.Vi received funding from the São Paulo Research Foundation (FAPESP) (grant number 2020/09702-1) and JBS SA (grant number 69004). The NH-COVAIR study group consortium was supported by a grant from the Meath Foundation Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma diluted 1:10) of IFN-α and/or IFN-ω are found in about 10% of patients with critical COVID-19 (coronavirus disease 2019) pneumonia but not in individuals with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-α and/or IFN-ω (100 pg/ml; in 1:10 dilutions of plasma) in 13.6% of 3595 patients with critical COVID-19, including 21% of 374 patients >80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1124 deceased patients (aged 20 days to 99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-β. We also show, in a sample of 34,159 uninfected individuals from the general population, that auto-Abs neutralizing high concentrations of IFN-α and/or IFN-ω are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of individuals carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals 80 years. By contrast, auto-Abs neutralizing IFN-β do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over 80s and total fatal COVID-19 cases. Peer reviewed
Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2021License: CC BYFull-Text: https://doi.org/10.1126/sciimmunol.abl4340BOA - Bicocca Open Archive; Oxford University Research Archive; UPF Digital Repository; Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele; Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) - Universidade de São Paulo (USP); Archivio della Ricerca - Università di Roma Tor vergata; Science Immunology; PURE Aarhus UniversityOther literature type . Article . 2021 . 2022 . Peer-reviewedLicense: CC BYData sources: BOA - Bicocca Open Archive; European Union Open Data Portal; Oxford University Research Archive; Sygma; Crossref; UPF Digital Repository; Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele; LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; NARCIS; Archivio della Ricerca - Università di Roma Tor vergata; PURE Aarhus UniversityServeur académique lausannoisArticle . 2021License: CC BYData sources: Serveur académique lausannoisCopenhagen University Research Information SystemArticle . 2021Data sources: Copenhagen University Research Information SystemGhent University Academic BibliographyArticle . 2021Data sources: Ghent University Academic BibliographyHELDA - Digital Repository of the University of HelsinkiArticle . 2021 . Peer-reviewedData sources: HELDA - Digital Repository of the University of HelsinkiRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2021 . Peer-reviewedBilkent University Institutional RepositoryArticle . 2021Data sources: Bilkent University Institutional RepositoryArchivio della Ricerca - Università di Roma Tor vergataArticle . 2021Data sources: Archivio della Ricerca - Università di Roma Tor vergataHAL-ENS-LYON; HAL - Université de LilleArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 319 citations 319 popularity Top 0.1% influence Top 1% impulse Top 0.1% Powered by BIP!visibility 438visibility views 438 download downloads 2,518 Powered bymore_vert Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2021License: CC BYFull-Text: https://doi.org/10.1126/sciimmunol.abl4340BOA - Bicocca Open Archive; Oxford University Research Archive; UPF Digital Repository; Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele; Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) - Universidade de São Paulo (USP); Archivio della Ricerca - Università di Roma Tor vergata; Science Immunology; PURE Aarhus UniversityOther literature type . Article . 2021 . 2022 . Peer-reviewedLicense: CC BYData sources: BOA - Bicocca Open Archive; European Union Open Data Portal; Oxford University Research Archive; Sygma; Crossref; UPF Digital Repository; Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele; LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; NARCIS; Archivio della Ricerca - Università di Roma Tor vergata; PURE Aarhus UniversityServeur académique lausannoisArticle . 2021License: CC BYData sources: Serveur académique lausannoisCopenhagen University Research Information SystemArticle . 2021Data sources: Copenhagen University Research Information SystemGhent University Academic BibliographyArticle . 2021Data sources: Ghent University Academic BibliographyHELDA - Digital Repository of the University of HelsinkiArticle . 2021 . Peer-reviewedData sources: HELDA - Digital Repository of the University of HelsinkiRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2021 . Peer-reviewedBilkent University Institutional RepositoryArticle . 2021Data sources: Bilkent University Institutional RepositoryArchivio della Ricerca - Università di Roma Tor vergataArticle . 2021Data sources: Archivio della Ricerca - Università di Roma Tor vergataHAL-ENS-LYON; HAL - Université de LilleArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint 2020 FrancePublisher:Cold Spring Harbor Laboratory Funded by:ANR | INCEPTIONANR| INCEPTIONFontanet, Arnaud; Tondeur, Laura; Madec, Yoann; Grant, Rebecca; Besombes, Camille; Jolly, Nathalie; Fernandes Pellerin, Sandrine; Ungeheuer, Marie-Noelle; Cailleau, Isabelle; Kuhmel, Lucie; Temmam, Sarah; Huon, Christele; Chen, Kuang-Yu; Crescenzo, Bernadette; Munier, Sandie; Demeret, Caroline; Grzelak, Ludivine; Staropoli, Isabelle; Bruel, Timothee; Gallian, Pierre; Cauchemez, Simon; van der Werf, Sylvie; Schwartz, Olivier; Eloit, Marc; Hoen, Bruno;Background: The Oise department in France has been heavily affected by COVID-19 in early 2020.Methods: Between 30 March and 4 April 2020, we conducted a retrospective closed cohort study amongpupils, their parents and siblings, as well as teachers and non-teaching staff of a high-school located inOise. Participants completed a questionnaire that covered history of fever and/or respiratory symptomssince 13 January 2020 and had blood tested for the presence of anti-SARS-CoV-2 antibodies. Theinfection attack rate (IAR) was defined as the proportion of participants with confirmed SARS-CoV-2infection based on antibody detection. Blood samples from two blood donor centres collected between23 and 27 March 2020 in the Oise department were also tested for presence of anti-SARS-CoV-2antibodies.Findings: Of the 661 participants (median age: 37 years), 171 participants had anti-SARS-CoV-2antibodies. The overall IAR was 25.9% (95% confidence interval (CI) = 22.6-29.4), and the infectionfatality rate was 0% (one-sided 97.5% CI = 0 - 2.1). Nine of the ten participants hospitalised since midJanuary were in the infected group, giving a hospitalisation rate of 5.3% (95% CI = 2.4 –9.8). Anosmia and ageusia had high positive predictive values for SARS-CoV-2 infection (84.7% and 88.1%,respectively). Smokers had a lower IAR compared to non-smokers (7.2% versus 28.0%, P <0.001). Theproportion of infected individuals who had no symptoms during the study period was 17.0% (95% CI =11.2 – 23.4). The proportion of donors with anti-SARS-CoV-2 antibodies in two nearby blood banksof the Oise department was 3.0% (95% CI = 1.1 - 6.4).Interpretation: The relatively low IAR observed in an area where SARS-CoV-2 actively circulatedweeks before confinement measures indicates that establishing herd immunity will take time, and thatlifting these measures in France will be long and complex. Posté sur MedRxiv le 23 avril 2020
medRxiv arrow_drop_down medRxivPreprint . 2020 . Peer-reviewedHAL Descartes; HAL-Pasteur; HAL AMU; Mémoires en Sciences de l'Information et de la Communication; HAL-IRDPreprint . 2021License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu127 citations 127 popularity Top 1% influence Top 1% impulse Top 0.1% Powered by BIP!more_vert medRxiv arrow_drop_down medRxivPreprint . 2020 . Peer-reviewedHAL Descartes; HAL-Pasteur; HAL AMU; Mémoires en Sciences de l'Information et de la Communication; HAL-IRDPreprint . 2021License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 France Funded by:ANR | Viro-DUBANR| Viro-DUBJupin, Isabelle; Ayach, Maya; Jomat, Lucile; Fieulaine, Sonia; Bressanelli, Stéphane;The positive-strand RNA virus Turnip yellow mosaic virus (TYMV) encodes an ovarian tumor (OTU)-like protease/deubiquitinase (PRO/DUB) protein domain involved both in proteolytic processing of the viral polyprotein through its PRO activity, and in removal of ubiquitin chains from ubiquitylated substrates through its DUB activity. Here, the crystal structures of TYMV PRO/DUB mutants and molecular dynamics simulations reveal that an idiosyncratic mobile loop participates in reversibly constricting its unusual catalytic site by adopting "open", "intermediate" or "closed" conformations. The two cis-prolines of the loop form a rigid flap that in the most closed conformation zips up against the other side of the catalytic cleft. The intermediate and closed conformations also correlate with a reordering of the TYMV PRO/DUB catalytic dyad, that then assumes a classical, yet still unusually mobile, OTU DUB alignment. Further structure-based mutants designed to interfere with the loop's mobility were assessed for enzymatic activity in vitro and in vivo, and were shown to display reduced DUB activity while retaining PRO activity. This indicates that control of the switching between the dual PRO/DUB activities resides prominently within this loop next to the active site. Introduction of mutations into the viral genome revealed that the DUB activity contributes to the extent of viral RNA accumulation both in single cells and in whole plants. In addition, the conformation of the mobile flap was also found to influence symptoms severity in planta. Such mutants now provide powerful tools with which to study the specific roles of reversible ubiquitylation in viral infection. Author summary Viruses have much smaller genomes than their hosts. Consequently, they often encode proteins which are multifunctional. For instance, some viral proteases have a dual function, being also deubiquitinases, i.e. enzymes capable of removing ubiquitin tags grafted onto proteins and that often target them for destruction. The protease and deubiquitinase activities share a single active site that is used alternately for one function or the other, but how this switch between activities may be regulated is presently unknown. To answer this question, we studied a simple plant virus that is a useful model system for these complex molecular biology phenomena, and that encodes a simplified protease/deubiquitinase. Here, thanks to a combination of structural and functional analyses, we managed to decouple the two activities, killing the deubiquitinase activity while preserving the protease one. This successful decoupling relies on our discovery that a loop inserted next to the active site is mobile, and can thus act as a switch between the two activities. This result allowed us to demonstrate the importance of the specific deubiquinase activity in viral multiplication. In addition, viral symptoms were also severely affected by mutations affecting the loop mobility. Our data provide powerful tools for further studies, that may also be relevant for more complex or medically relevant viruses.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5695851Data sources: PubMed CentralPLoS Pathogens; OpenAPC Global InitiativeArticle . Conference object . 2017 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 18 citations 18 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5695851Data sources: PubMed CentralPLoS Pathogens; OpenAPC Global InitiativeArticle . Conference object . 2017 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2016 Italy, Italy, France Funded by:ANR | Amidex, ANR | HarMS-flu, EC | PREDEMICS +1 projectsANR| Amidex ,ANR| HarMS-flu ,EC| PREDEMICS ,EC| MULTIPLEXBioglio L.; Genois M.; Vestergaard C. L.; Poletto C.; Barrat A.; Colizza V.;AbstractBackgroundThe homogeneous mixing assumption is widely adopted in epidemic modelling for its parsimony and represents the building block of more complex approaches, including very detailed agent-based models. The latter assume homogeneous mixing within schools, workplaces and households, mostly for the lack of detailed information on human contact behaviour within these settings. The recent data availability on high-resolution face-to-face interactions makes it now possible to assess the goodness of this simplified scheme in reproducing relevant aspects of the infection dynamics.MethodsWe consider empirical contact networks gathered in different contexts, as well as synthetic data obtained through realistic models of contacts in structured populations. We perform stochastic spreading simulations on these contact networks and in populations of the same size under a homogeneous mixing hypothesis. We adjust the epidemiological parameters of the latter in order to fit the prevalence curve of the contact epidemic model. We quantify the agreement by comparing epidemic peak times, peak values, and epidemic sizes.ResultsGood approximations of the peak times and peak values are obtained with the homogeneous mixing approach, with a median relative difference smaller than 20 % in all cases investigated. Accuracy in reproducing the peak time depends on the setting under study, while for the peak value it is independent of the setting. Recalibration is found to be linear in the epidemic parameters used in the contact data simulations, showing changes across empirical settings but robustness across groups and population sizes.ConclusionsAn adequate rescaling of the epidemiological parameters can yield a good agreement between the epidemic curves obtained with a real contact network and a homogeneous mixing approach in a population of the same size. The use of such recalibrated homogeneous mixing approximations would enhance the accuracy and realism of agent-based simulations and limit the intrinsic biases of the homogeneous mixing. International audience
HAL AMU; Mémoires en... arrow_drop_down Europe PubMed CentralArticle . 2016Full-Text: http://europepmc.org/articles/PMC5109722Data sources: PubMed CentralZENODO; OpenAPC Global Initiative; BMC Infectious DiseasesOther literature type . Article . Conference object . 2016 . Peer-reviewedLicense: Springer TDMHAL-Inserm; Hal-DiderotArticle . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s12879-016-2003-3&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 10 citations 10 popularity Top 10% influence Average impulse Average Powered by BIP!visibility 24visibility views 24 download downloads 55 Powered bymore_vert HAL AMU; Mémoires en... arrow_drop_down Europe PubMed CentralArticle . 2016Full-Text: http://europepmc.org/articles/PMC5109722Data sources: PubMed CentralZENODO; OpenAPC Global Initiative; BMC Infectious DiseasesOther literature type . Article . Conference object . 2016 . Peer-reviewedLicense: Springer TDMHAL-Inserm; Hal-DiderotArticle . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s12879-016-2003-3&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2015 France Funded by:ANR | PandoravirusANR| PandoravirusPriet, Stéphane; Lartigue, Audrey; Debart, Françoise; Claverie, Jean-Michel; Abergel, Chantal;AbstractGiant viruses from the Mimiviridae family replicate entirely in their host cytoplasm where their genes are transcribed by a viral transcription apparatus. mRNA polyadenylation uniquely occurs at hairpin-forming palindromic sequences terminating viral transcripts. Here we show that a conserved gene cluster both encode the enzyme responsible for the hairpin cleavage and the viral polyA polymerases (vPAP). Unexpectedly, the vPAPs are homodimeric and uniquely self-processive. The vPAP backbone structures exhibit a symmetrical architecture with two subdomains sharing a nucleotidyltransferase topology, suggesting that vPAPs originate from an ancestral duplication. A Poxvirus processivity factor homologue encoded by Megavirus chilensis displays a conserved 5′-GpppA 2′O methyltransferase activity but is also able to internally methylate the mRNAs’ polyA tails. These findings elucidate how the arm wrestling between hosts and their viruses to access the translation machinery is taking place in Mimiviridae.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2015Full-Text: http://europepmc.org/articles/PMC4402537Data sources: PubMed CentralNucleic Acids Research; OpenAPC Global InitiativeArticle . Conference object . 2015 . Peer-reviewedLicense: CC BYHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2015add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/nar/gkv224&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 16 citations 16 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2015Full-Text: http://europepmc.org/articles/PMC4402537Data sources: PubMed CentralNucleic Acids Research; OpenAPC Global InitiativeArticle . Conference object . 2015 . Peer-reviewedLicense: CC BYHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2015add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/nar/gkv224&type=result"></script>'); --> </script>
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description Publicationkeyboard_double_arrow_right Article 2022 France, Belgium, Italy, Former Yugoslav Republic of Macedonia, Brazil, France, France, Netherlands, Switzerland, Turkey, Spain, Turkey, France, France, Denmark, Italy, France, BelgiumPublisher:Proceedings of the National Academy of Sciences Funded by:EC | ATAC, ANR | AABIFNCOV, EC | EASI-Genomics +12 projectsEC| ATAC ,ANR| AABIFNCOV ,EC| EASI-Genomics ,NIH| Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success ,ANR| CNSVIRGEN ,NIH| Yale Center for Mendelian Genomics ,NIH| Monogenic basis of resistance to SARS-CoV2 and predisposition to severe COVID-19 ,NIH| Characterization of host immune responses to SARS-CoV-2 ,NIH| NHGRI Genome Sequencing Program Coordinating Center ,NIH| Inborn errors of immunity in patients with life-threatening COVID-19 ,NIH| Host factors contributing to susceptibility to COVID-19 disease ,EC| MORE2ADA2 ,NIH| Type I interferon-stimulated genes and the antiviral immune response ,NIH| Modulation of Human Dendritic Cell Development by Adjuvants and Vaccines ,NIH| High Performance Computing Instrumentation for the Yale Center for Genome AnalysiJérémy Manry; Paul Bastard; Adrian Gervais; Tom Le Voyer; Jérémie Rosain; Quentin Philippot; Eleftherios Michailidis; Hans-Heinrich Hoffmann; Shohei Eto; Marina Garcia-Prat; Lucy Bizien; Alba Parra-Martínez; Rui Yang; Liis Haljasmägi; Mélanie Migaud; Karita Särekannu; Julia Maslovskaja; Nicolas de Prost; Yacine Tandjaoui-Lambiotte; Charles-Edouard Luyt; Blanca Amador-Borrero; Alexandre Gaudet; Julien Poissy; Pascal Morel; Pascale Richard; Fabrice Cognasse; Jesús Troya; Sophie Trouillet-Assant; Alexandre Belot; Kahina Saker; Pierre Garçon; Jacques G. Rivière; Jean-Christophe Lagier; Stéphanie Gentile; Lindsey B. Rosen; Elana Shaw; Tomohiro Morio; Junko Tanaka; David Dalmau; Pierre-Louis Tharaux; Damien Sene; Alain Stepanian; Bruno Mégarbane; Vasiliki Triantafyllia; Arnaud Fekkar; James R. Heath; José Luis Franco; Juan-Manuel Anaya; Jordi Solé-Violán; Luisa Imberti; Andrea Biondi; Paolo Bonfanti; Riccardo Castagnoli; Ottavia M. Delmonte; Yu Zhang; Andrew L. Snow; Steven M. Holland; Catherine M. Biggs; Marcela Moncada-Vélez; Andrés Augusto Arias; Lazaro Lorenzo; Soraya Boucherit; Dany Anglicheau; Anna M. Planas; Filomeen Haerynck; Sotirija Duvlis; Tayfun Ozcelik; Sevgi Keles; Ahmed A. Bousfiha; Jalila El Bakkouri; Carolina Ramirez-Santana; Stéphane Paul; Qiang Pan-Hammarström; Lennart Hammarström; Annabelle Dupont; Alina Kurolap; Christine N. Metz; Alessandro Aiuti; Giorgio Casari; Vito Lampasona; Fabio Ciceri; Lucila A. Barreiros; Elena Dominguez-Garrido; Mateus Vidigal; Mayana Zatz; Diederik van de Beek; Sabina Sahanic; Ivan Tancevski; Yurii Stepanovskyy; Oksana Boyarchuk; Yoko Nukui; Miyuki Tsumura; Loreto Vidaur; Stuart G. Tangye; Sonia Burrel; Darragh Duffy; Lluis Quintana-Murci; Adam Klocperk; Nelli Y. Kann; Anna Shcherbina; Yu-Lung Lau; Daniel Leung; Matthieu Coulongeat; Julien Marlet; Rutger Koning; Luis Felipe Reyes; Angélique Chauvineau-Grenier; Fabienne Venet; Guillaume Monneret; Michel C. Nussenzweig; Romain Arrestier; Idris Boudhabhay; Hagit Baris-Feldman; David Hagin; Joost Wauters; Isabelle Meyts; Adam H. Dyer; Sean P. Kennelly; Nollaig M. Bourke; Rabih Halwani; Fatemeh Saheb Sharif-Askari; Karim Dorgham; Jérôme Sallette; Souad Mehlal Sedkaoui; Suzan AlKhater; Raúl Rigo-Bonnin; Francisco Morandeira; Lucie Roussel; Donald C. Vinh; Christian Erikstrup; Antonio Condino-Neto; Carolina Prando; Anastasiia Bondarenko; András N. Spaan; Laurent Gilardin; Jacques Fellay; Stanislas Lyonnet; Kaya Bilguvar; Richard P. Lifton; Shrikant Mane; Mark S. Anderson; Bertrand Boisson; Vivien Béziat; Shen-Ying Zhang; Evangelos Andreakos; Olivier Hermine; Aurora Pujol; Pärt Peterson; Trine H. Mogensen; Lee Rowen; James Mond; Stéphanie Debette; Xavier de Lamballerie; Charles Burdet; Lila Bouadma; Marie Zins; Pere Soler-Palacin; Roger Colobran; Guy Gorochov; Xavier Solanich; Sophie Susen; Javier Martinez-Picado; Didier Raoult; Marc Vasse; Peter K. Gregersen; Lorenzo Piemonti; Carlos Rodríguez-Gallego; Luigi D. Notarangelo; Helen C. Su; Kai Kisand; Satoshi Okada; Anne Puel; Emmanuelle Jouanguy; Charles M. Rice; Pierre Tiberghien; Qian Zhang; Jean-Laurent Casanova; Laurent Abel; Aurélie Cobat; Peng Zhang; Yoann Seeleuthner; Estelle Talouarn; Astrid Marchal; Daniela Matuozzo; Aliénor de la Chapelle; Jie Chen; Maya Chrabieh; Dana Liu; Yelena Nemirowskaya; Inés Marín Cruz; Marie Materna; Sophie Pelet; Chloé Thibault; Zhiyong Liu; Jorge Abad; Giulia Accordino; Cristian Achille; Sergio Aguilera-Albesa; Aina Aguiló-Cucurull; Alessandro Aiuti; Teresa Auguet; Mateus V. Castro; Cyril Cyrus; Olov Ekwall; Jan Gunst; Mikko Seppänen; Ali Sobh; Guillaume Voiriot; Virginia Quaresima; Olivier Terrier; Laurent Renia;pmid: 36179016
pmc: PMC9173764
handle: 10261/279776 , 20.500.11768/129015 , 11693/111766 , 1854/LU-8767983 , 11443/2890 , 10281/376820
pmid: 36179016
pmc: PMC9173764
handle: 10261/279776 , 20.500.11768/129015 , 11693/111766 , 1854/LU-8767983 , 11443/2890 , 10281/376820
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing IFN-α, IFN-ω, and/or IFN-β are found in ∼20% of deceased patients across age groups, and in ∼1% of individuals aged 4% of those >70 y old in the general population. With a sample of 1,261 unvaccinated deceased patients and 34,159 individuals of the general population sampled before the pandemic, we estimated both IFR and relative risk of death (RRD) across age groups for individuals carrying autoantibodies neutralizing type I IFNs, relative to noncarriers. The RRD associated with any combination of autoantibodies was higher in subjects under 70 y old. For autoantibodies neutralizing IFN-α2 or IFN-ω, the RRDs were 17.0 (95% CI: 11.7 to 24.7) and 5.8 (4.5 to 7.4) for individuals <70 y and ≥70 y old, respectively, whereas, for autoantibodies neutralizing both molecules, the RRDs were 188.3 (44.8 to 774.4) and 7.2 (5.0 to 10.3), respectively. In contrast, IFRs increased with age, ranging from 0.17% (0.12 to 0.31) for individuals <40 y old to 26.7% (20.3 to 35.2) for those ≥80 y old for autoantibodies neutralizing IFN-α2 or IFN-ω, and from 0.84% (0.31 to 8.28) to 40.5% (27.82 to 61.20) for autoantibodies neutralizing both. Autoantibodies against type I IFNs increase IFRs, and are associated with high RRDs, especially when neutralizing both IFN-α2 and IFN-ω. Remarkably, IFRs increase with age, whereas RRDs decrease with age. Autoimmunity to type I IFNs is a strong and common predictor of COVID-19 death. ispartof: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA vol:119 issue:21 ispartof: location:United States status: published
UGD Academic Reposit... arrow_drop_down Ghent University Academic BibliographyArticle . 2022Data sources: Ghent University Academic BibliographyRecolector de Ciencia Abierta, RECOLECTAArticleData sources: Recolector de Ciencia Abierta, RECOLECTABilkent University Institutional RepositoryArticle . 2022Data sources: Bilkent University Institutional RepositoryRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2022 . Peer-reviewedRecolector de Ciencia Abierta, RECOLECTAArticle . 2022Data sources: Recolector de Ciencia Abierta, RECOLECTAInfoscience - EPFL scientific publicationsArticleData sources: Infoscience - EPFL scientific publicationsHAL Descartes; HAL-PasteurArticle . 2022License: CC BYFull-Text: https://hal.science/hal-03856619/documentAcibadem University Open Access RepositoryArticle . 2022Data sources: Acibadem University Open Access Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu98 citations 98 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!more_vert UGD Academic Reposit... arrow_drop_down Ghent University Academic BibliographyArticle . 2022Data sources: Ghent University Academic BibliographyRecolector de Ciencia Abierta, RECOLECTAArticleData sources: Recolector de Ciencia Abierta, RECOLECTABilkent University Institutional RepositoryArticle . 2022Data sources: Bilkent University Institutional RepositoryRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2022 . Peer-reviewedRecolector de Ciencia Abierta, RECOLECTAArticle . 2022Data sources: Recolector de Ciencia Abierta, RECOLECTAInfoscience - EPFL scientific publicationsArticleData sources: Infoscience - EPFL scientific publicationsHAL Descartes; HAL-PasteurArticle . 2022License: CC BYFull-Text: https://hal.science/hal-03856619/documentAcibadem University Open Access RepositoryArticle . 2022Data sources: Acibadem University Open Access Repositoryadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint 2022 France, Spain, France, Netherlands, France, France, FrancePublisher:Research Square Platform LLC Publicly fundedFunded by:EC | ATAC, NIH | Yale Center for Mendelian..., ANR | AABIFNCOV +14 projectsEC| ATAC ,NIH| Yale Center for Mendelian Genomics ,ANR| AABIFNCOV ,EC| EASI-Genomics ,ANR| CNSVIRGEN ,NIH| Inborn errors of immunity in patients with life-threatening COVID-19 ,EC| RECoVER ,NIH| Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success ,NIH| High Performance Computing Instrumentation for the Yale Center for Genome Analysi ,NIH| Monogenic basis of resistance to SARS-CoV2 and predisposition to severe COVID-19 ,NIH| Characterization of host immune responses to SARS-CoV-2 ,NIH| NHGRI Genome Sequencing Program Coordinating Center ,NIH| Modulation of Human Dendritic Cell Development by Adjuvants and Vaccines ,EC| MORE2ADA2 ,ANR| GenMIS-C ,NIH| Type I interferon-stimulated genes and the antiviral immune response ,NIH| Host factors contributing to susceptibility to COVID-19 diseaseManry, Jeremy; Bastard, Paul; Gervais, Adrian; Voyer, Tom Le; Rosain, Jérémie; Philippot, Quentin; Michailidis, Eleftherios; Hoffmann, Hans-Heinrich; Eto, Shohei; Garcia-Prat, Marina; Bizien, Lucy; Parra-Martínez, Alba; Yang, Rui; Haljasmägi, Liis; Migaud, Mélanie; Särekannu, Karita; Maslovskaja, Julia; de Prost, Nicolas; Tandjaoui-Lambiotte, Yacine; Luyt, Charles-Edouard; Amador-Borrero, Blanca; Gaudet, Alexandre; Poissy, Julien; Morel, Pascal; Richard, Pascale; Cognasse, Fabrice; Troya, Jesus; Trouillet-Assant, Sophie; Belot, Alexandre; Saker, Kahina; Garçon, Pierre; Rivière, Jacques G.; Lagier, Jean-Christophe; Gentile, Stéphanie; Rosen, Lindsey; Shaw, Elana; Morio, Tomohiro; Tanaka, Junko; Dalmau, David; Tharaux, Pierre-Louis; Sene, Damien; Stepanian, Alain; Mégarbane, Bruno; Triantafyllia, Vasiliki; Fekkar, Arnaud; Heath, James; Franco, Jose; Anaya, Juan-Manuel; Solé-Violán, Jordi; Imberti, Luisa; Biondi, Andrea; Bonfanti, Paolo; Castagnoli, Riccardo; Delmonte, Ottavia; Zhang, Yu; Snow, Andrew; Holland, Steve; Biggs, Catherine; Moncada-Vélez, Marcela; Arias, Andrés; Lorenzo, Lazaro; Boucherit, Soraya; Anglicheau, Dany; Planas, Anna; Haerynck, Filomeen; Duvlis, Sotirija; Nussbaum, Robert; Ozcelik, Tayfun; Keles, Sevgi; Bousfiha, Aziz; Bakkouri, Jalila El; Ramirez-Santana, Carolina; Paul, Stéphane; Pan-Hammarstrom, Qiang; Hammarstrom, Lennart; Dupont, Annabelle; Kurolap, Alina; Metz, Christine; Aiuti, Alessandro; Casari, Giorgio; Lampasona, Vito; Ciceri, Fabio; Barreiros, Lucila; Dominguez-Garrido, Elena; Vidigal, Mateus; Zatz, Mayana; de Beek, Diederik van; Sahanic, Sabina; Tancevski, Ivan; Stepanovskyy, Yurii; Boyarchuk, Oksana; Nukui, Yoko; Tsumura, Miyuki; Vidaur, Loreto; Tangye, Stuart; Burrel, Sonia; Duffy, Darragh; Quintana-Murci, Lluis; Klocperk, Adam; Kann, Nelli; Shcherbina, Anna; Lau, Yu-Lung; Leung, Daniel; Coulongeat, Matthieu; Marlet, Julien; Koning, Rutger; Reyes, Luis; Chauvineau-Grenier, Angélique; Venet, Fabienne; monneret, guillaume; Nussenzweig, Michel; Arrestier, Romain; Boudhabhay, Idris; Baris-Feldman, Hagit; Hagin, David; Wauters, Joost; Meyts, Isabelle; Dyer, Adam; Kennelly, Sean; Bourke, Nollaig; Halwani, Rabih; Sharif-Askari, Fatemeh; Dorgham, Karim; Sallette, Jérôme; Mehlal-Sedkaoui, Souad; AlKhater, Suzan; Rigo-Bonnin, Raúl; Morandeira, Francisco; Roussel, Lucie; Vinh, Donald; Erikstrup, Christian; Condino-Neto, Antonio; Prando, Carolina; Bondarenko, Anastasiia; Spaan, András; Gilardin, Laurent; Fellay, Jacques; Lyonnet, Stanislas; Bilguvar, Kaya; Lifton, Richard; Mane, Shrikant; Anderson, Mark; Boisson, Bertrand; Béziat, Vivien; Zhang, Shen-Ying; Andreakos, Evangelos; Hermine, Olivier; Pujol, Aurora; Peterson, Pärt; Mogensen, Trine Hyrup; Rowen, Lee; Mond, James; Debette, Stéphanie; deLamballerie, Xavier; Burdet, Charles; Bouadma, Lila; Zins, Marie; Soler-Palacin, Pere; Colobran, Roger; Gorochov, Guy; Solanich, Xavier; Susen, Sophie; Martinez-Picado, Javier; Raoult, Didier; Vasse, Marc; Gregersen, Peter; Rodríguez-Gallego, Carlos; Piemonti, Lorenzo; Notarangelo, Luigi; Su, Helen; Kisand, Kai; Okada, Satoshi; Puel, Anne; Jouanguy, Emmanuelle; Rice, Charles; Tiberghien, Pierre; Zhang, Qian; Casanova, Jean-Laurent; Abel, Laurent; Cobat, Aurélie;There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing IFN-α, IFN-ω, and/or IFN-β are found in ∼20% of deceased patients across age groups, and in ∼1% of individuals aged 4% of those >70 y old in the general population. With a sample of 1,261 unvaccinated deceased patients and 34,159 individuals of the general population sampled before the pandemic, we estimated both IFR and relative risk of death (RRD) across age groups for individuals carrying autoantibodies neutralizing type I IFNs, relative to noncarriers. The RRD associated with any combination of autoantibodies was higher in subjects under 70 y old. For autoantibodies neutralizing IFN-α2 or IFN-ω, the RRDs were 17.0 (95% CI: 11.7 to 24.7) and 5.8 (4.5 to 7.4) for individuals <70 y and ≥70 y old, respectively, whereas, for autoantibodies neutralizing both molecules, the RRDs were 188.3 (44.8 to 774.4) and 7.2 (5.0 to 10.3), respectively. In contrast, IFRs increased with age, ranging from 0.17% (0.12 to 0.31) for individuals <40 y old to 26.7% (20.3 to 35.2) for those ≥80 y old for autoantibodies neutralizing IFN-α2 or IFN-ω, and from 0.84% (0.31 to 8.28) to 40.5% (27.82 to 61.20) for autoantibodies neutralizing both. Autoantibodies against type I IFNs increase IFRs, and are associated with high RRDs, especially when neutralizing both IFN-α2 and IFN-ω. Remarkably, IFRs increase with age, whereas RRDs decrease with age. Autoimmunity to type I IFNs is a strong and common predictor of COVID-19 death.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2022Full-Text: http://europepmc.org/articles/PMC8764723Data sources: PubMed CentralDipòsit Digital de Documents de la UABArticle . 2022Data sources: Dipòsit Digital de Documents de la UABHAL-ENS-LYON; HAL-Pasteur; HAL - Université de Lille; HAL-Inserm; HAL AMUPreprint . 2022License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!visibility 40visibility views 40 download downloads 137 Powered bymore_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2022Full-Text: http://europepmc.org/articles/PMC8764723Data sources: PubMed CentralDipòsit Digital de Documents de la UABArticle . 2022Data sources: Dipòsit Digital de Documents de la UABHAL-ENS-LYON; HAL-Pasteur; HAL - Université de Lille; HAL-Inserm; HAL AMUPreprint . 2022License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 FrancePublisher:Informa UK Limited Funded by:ANR | ACROBATANR| ACROBATValentin Sencio; Arnaud Machelart; Cyril Robil; Nicolas Benech; Eik Hoffmann; Chloé Galbert; Lucie Deryuter; Séverine Heumel; Aline Hantute-Ghesquier; Anne Flourens; Priscille Brodin; Fabrice Infanti; Virgile Richard; Jean Dubuisson; Corinne Grangette; Thierry Sulpice; Isabelle Wolowczuk; Florence Pinet; Vincent Prévot; Sandrine Belouzard; François Briand; Martine Duterque-Coquillaud; Harry Sokol; François Trottein;Mounting evidence suggests that the gut-to-lung axis is critical during respiratory viral infections. We herein hypothesized that disruption of gut homeostasis during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may associate with early disease outcomes. To address this question, we took advantage of the Syrian hamster model. Our data confirmed that this model recapitulates some hallmark features of the human disease in the lungs. We further showed that SARS-CoV-2 infection associated with mild intestinal inflammation, relative alteration in intestinal barrier property and liver inflammation and altered lipid metabolism. These changes occurred concomitantly with an alteration of the gut microbiota composition over the course of infection, notably characterized by a higher relative abundance of deleterious bacterial taxa such as Enterobacteriaceae and Desulfovibrionaceae. Conversely, several members of the Ruminococcaceae and Lachnospiraceae families, including bacteria known to produce the fermentative products short-chain fatty acids (SCFAs), had a reduced relative proportion compared to non-infected controls. Accordingly, infection led to a transient decrease in systemic SCFA amounts. SCFA supplementation during infection had no effect on clinical and inflammatory parameters. Lastly, a strong correlation between some gut microbiota taxa and clinical and inflammation indices of SARS-CoV-2 infection severity was evidenced. Collectively, alteration of the gut microbiota correlates with disease severity in hamsters making this experimental model valuable for the design of interventional, gut microbiota-targeted, approaches for the control of COVID-19. International audience
HAL-Inserm; HAL - Un... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8726722Data sources: PubMed CentralHAL - Université de Lille; HAL-InsermArticle . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 42 citations 42 popularity Top 1% influence Average impulse Top 1% Powered by BIP!more_vert HAL-Inserm; HAL - Un... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8726722Data sources: PubMed CentralHAL - Université de Lille; HAL-InsermArticle . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 France, Italy, France, Denmark, France, Belgium, Turkey, France, Former Yugoslav Republic of Macedonia, Netherlands, Italy, Spain, United Kingdom, Brazil, Spain, Italy, France, Finland, France, Spain, France, France, Italy, Italy, France, FrancePublisher:American Association for the Advancement of Science (AAAS) Publicly fundedFunded by:ANR | AABIFNCOV, EC | EASI-Genomics, EC | MORE2ADA2 +12 projectsANR| AABIFNCOV ,EC| EASI-Genomics ,EC| MORE2ADA2 ,EC| RECoVER ,NIH| Modulation of Human Dendritic Cell Development by Adjuvants and Vaccines ,NIH| Monogenic basis of resistance to SARS-CoV2 and predisposition to severe COVID-19 ,NIH| Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success ,ANR| GENCOVID ,NIH| Yale Center for Mendelian Genomics ,NIH| Characterization of host immune responses to SARS-CoV-2 ,NIH| NHGRI Genome Sequencing Program Coordinating Center ,EC| ATAC ,NIH| Type I interferon-stimulated genes and the antiviral immune response ,NIH| Host factors contributing to susceptibility to COVID-19 disease ,NIH| High Performance Computing Instrumentation for the Yale Center for Genome AnalysiBastard, Paul; Gervais, Adrian; Le Voyer, Tom; Rosain, Jérémie; Philippot, Quentin; Manry, Jérémy; Michailidis, Eleftherios; Hoffmann, Hans-Heinrich; Eto, Shohei; Garcia-Prat, Marina; Bizien, Lucy; Parra-Martínez, Alba; Yang, Rui; Haljasmägi, Liis; Migaud, Mélanie; Särekannu, Karita; Maslovskaja, Julia; de Prost, Nicolas; Tandjaoui-Lambiotte, Yacine; Luyt, Charles-Edouard; Amador-Borrero, Blanca; Gaudet, Alexandre; Poissy, Julien; Morel, Pascal; Richard, Pascale; Cognasse, Fabrice; Troya, Jesus; Trouillet-Assant, Sophie; Belot, Alexandre; Saker, Kahina; Garçon, Pierre; Rivière, Jacques G.; Lagier, Jean-Christophe; Gentile, Stéphanie; Rosen, Lindsey B.; Shaw, Elana; Morio, Tomohiro; Tanaka, Junko; Dalmau, David; Tharaux, Pierre-Louis; Sene, Damien; Stepanian, Alain; Megarbane, Bruno; Triantafyllia, Vasiliki; Fekkar, Arnaud; Heath, James R.; Franco, José Luis; Anaya, Juan-Manuel; Solé-Violán, Jordi; Imberti, Luisa; Biondi, Andrea; Bonfanti, Paolo; Castagnoli, Riccardo; Delmonte, Ottavia M.; Zhang, Yu; Snow, Andrew L.; Holland, Steven M.; Biggs, Catherine M.; Moncada-Vélez, Marcela; Arias, Andrés Augusto; Lorenzo, Lazaro; Boucherit, Soraya; Coulibaly, Boubacar; Anglicheau, Dany; Planas, Anna M.; Haerynck, Filomeen; Duvlis, Sotirija; Nussbaum, Robert L.; Ozcelik, Tayfun; Keles, Sevgi; Bousfiha, Ahmed A.; El Bakkouri, Jalila; Ramirez-Santana, Carolina; Paul, Stéphane; Pan-Hammarström, Qiang; Hammarström, Lennart; Dupont, Annabelle; Kurolap, Alina; Metz, Christine N.; Aiuti, Alessandro; Casari, Giorgio; Lampasona, Vito; Ciceri, Fabio; Barreiros, Lucila A.; Dominguez-Garrido, Elena; Vidigal, Mateus; Zatz, Mayana; van de Beek, Diederik; Sahanic, Sabina; Tancevski, Ivan; Stepanovskyy, Yurii; Boyarchuk, Oksana; Nukui, Yoko; Tsumura, Miyuki; Vidaur, Loreto; Tangye, Stuart G.; Burrel, Sonia; Duffy, Darragh; Quintana-Murci, Lluis; Klocperk, Adam; Kann, Nelli Y.; Shcherbina, Anna; Lau, Yu-Lung; Leung, Daniel; Coulongeat, Matthieu; Marlet, Julien; Koning, Rutger; Reyes, Luis Felipe; Chauvineau-Grenier, Angélique; Venet, Fabienne; Monneret, Guillaume; Nussenzweig, Michel C.; Arrestier, Romain; Boudhabhay, Idris; Baris-Feldman, Hagit; Hagin, David; Wauters, Joost; Meyts, Isabelle; Dyer, Adam H.; Kennelly, Sean P.; Bourke, Nollaig M.; Halwani, Rabih; Sharif-Askari, Narjes Saheb; Dorgham, Karim; Sallette, Jérome; Mehlal Sedkaoui, Souad; AlKhater, Suzan; Rigo-Bonnin, Raúl; Morandeira, Francisco; Roussel, Lucie; Vinh, Donald C.; Ostrowski, Sisse Rye; Condino-Neto, Antonio; Prando, Carolina; Bondarenko, Anastasiia; Spaan, András N.; Gilardin, Laurent; Fellay, Jacques; Lyonnet, Stanislas; Bilguvar, Kaya; Lifton, Richard P.; Mane, Shrikant; Anderson, Mark S.; Boisson, Bertrand; Béziat, Vivien; Zhang, Shen-Ying; Andreakos, Evangelos; Hermine, Olivier; Pujol, Aurora; Peterson, Pärt; Mogensen, Trine H.; Rowen, Lee; Mond, James; Debette, Stéphanie; de Lamballerie, Xavier; Duval, Xavier; Mentré, France; Zins, Marie; Soler-Palacin, Pere; Colobran, Roger; Gorochov, Guy; Solanich, Xavier; Susen, Sophie; Martinez-Picado, Javier; Raoult, Didier; Vasse, Marc; Gregersen, Peter K.; Piemonti, Lorenzo; Rodríguez-Gallego, Carlos; Notarangelo, Luigi D.; Su, Helen C.; Kisand, Kai; Okada, Satoshi; Puel, Anne; Jouanguy, Emmanuelle; Rice, Charles M.; Tiberghien, Pierre; Zhang, Qian; Cobat, Aurélie; Abel, Laurent; Casanova, Jean-Laurent; Bigio, Benedetta; Boucherit, Soraya; de la Chapelle, Aliénor; Chen, Jie; Chrabieh, Maya; Coulibaly, Boubacar; Liu, Dana; Nemirowskaya, Yelena; Cruz, Inés Marín; Materna, Marie; Pelet, Sophie; Seeleuthner, Yoann; Thibault, Chloé; Liu, Zhiyong; Abad, Jorge; Accordino, Giulia; Achille, Cristian; Aguilera-Albesa, Sergio; Aguiló-Cucurull, Aina; Alonso-Arias, Rebeca; Alsina, Laia; Antolí, Arnau; Bahram, Seiamak; Baldanti, Fausto; Blanchard-Rohner, Geraldine; Blanco, Ignacio; Blázquez-Gamero, Daniel; Bleibtreu, Alexandre; Borghesi, Alessandro; Bruno, Raffaele; Carapito, Raphael; Cassaniti, Irene; Castro, Mateus V; Charbit, Bruno; Cyrus, Cyril; Danion, François; Darley, David Ross; Dauby, Nicolas; Ekwall, Olov; Elnagdy, Marwa H; Emiroglu, Melike; Ferrer, Ricard; Gonzalez-Granado, Luis I; Hanitsch, Leif Gunnar; Gunst, Jan; Hariyan, Tetyana; Humbert, Linda; Kido, Yasutoshi; Kılıç, Ahmet Osman; Lévy, Romain; Lye, David C; Marjani, Majid; Mathian, Alexis; Million, Matthieu; Papadaki, Maria; Parizot, Christophe; Parola, Philippe; Pérez-Fernández, Xosé Luis; de Chambrun, Marc Pineton; Ploin, Dominique; Resmini, Léa; Romero, Carolina Soledad; Ruch, Yvon; Ruiz-Rodriguez, Juan Carlos; Salagianni, Maria; Sánchez-Ramón, Silvia; Schluter, Agatha; Scolari, Francesco; Seppänen, Mikko; Siouti, Eleni; Sobh, Ali; Tipu, Imran; Tolstrup, Martin; Troya, Jesús; Uzunhan, Yurdagul; Vabres, Pierre; Voiriot, Guillaume; Young, Barnaby E; Levi, Hoste; Citerio, Giuseppe; Dalgard, Clifton L.; Sottini, Alessandra; Quaresima, Virginia; Licari, Amelia; Marseglia, Gian Luigi; Batten, Isabella; Reddy, Conor; Connolly, Emma; Storgaard, Merete; Erikstrup, Christian; Pedersen, Ole Birger; Mikkelsen, Susan; Dinh, Khoa Manh; Townsend, Liam; Couffignal, Camille; Deplanque, Dominique; Diallo, Alpha; Etienne, Manuel; Gaymard, Alexandre; Hulot, Jean-Sébastien; Rosa-Calatrava, Manuel; Terrier, Olivier; Gribouval, Olivier; Bruhns, Pierre; Kenny, Rose Anne; Touvier, Mathilde; Burdet, Charles; Thy, Michael; Maillot, Adrien; Beudel, Martijn; Bogaard, Harm Jan; Bos, Lieuwe; Hemke, Robert; Sigaloff, Kim; van der Valk, Marc; Brouwer, Matthijs C.; Bryceson, Yenan; Cooper, Megan A.; Karamitros, Timokratis; Ling, Yun; Novelli, Antonio; Renia, Laurent; Ramaswamy, Sathishkumar; Turvey, Stuart E; Uddin, K M Furkan; Nadif, Rachel;handle: 2445/180396 , 20.500.11768/118484 , 1854/LU-8720604 , 10230/54189 , 10261/250618 , 11693/76825 , 10138/340517 , 2108/294678 , 10281/324305 , 11379/552041
handle: 2445/180396 , 20.500.11768/118484 , 1854/LU-8720604 , 10230/54189 , 10261/250618 , 11693/76825 , 10138/340517 , 2108/294678 , 10281/324305 , 11379/552041
The Laboratory of Human Genetics of Infectious Diseases is supported by the Howard Hughes Medical Institute, the Rockefeller University, the St. Giles Foundation, the National Institutes of Health (NIH) (R01AI088364), the National Center for Advancing Translational Sciences (NCATS), NIH Clinical and Translational Science Awards (CTSA) program (UL1 TR001866), a Fast Grant from Emergent Ventures, Mercatus Center at George Mason University, the Yale Center for Mendelian Genomics and the GSP Coordinating Center funded by the National Human Genome Research Institute (NHGRI) (UM1HG006504 and U24HG008956), the Yale High Performance Computing Center (S10OD018521), the Fisher Center for Alzheimer’s Research Foundation, the Meyer Foundation, the JPB Foundation, the French National Research Agency (ANR) under the “Investments for the Future” program (ANR-10-IAHU-01), the Integrative Biology of Emerging Infectious Diseases Laboratory of Excellence (ANR-10-LABX-62-IBEID), the French Foundation for Medical Research (FRM) (EQU201903007798), the FRM and ANR GENCOVID project (ANR-20-COVI-0003), ANRS Nord-Sud (ANRS-COV05), ANR GENVIR (ANR-20-CE93-003) and ANR AABIFNCOV (ANR-20-CO11-0001) projects, the European Union’s Horizon 2020 research and innovation programme under grant agreement no. 824110 (EASI-Genomics), the Square Foundation, Grandir–Fonds de solidarité pour l’Enfance, the Fondation du Souffle, the SCOR Corporate Foundation for Science, Institut National de la Santé et de la Recherche Médicale (INSERM), REACTing-INSERM; and the University of Paris. P.B. was supported by the FRM (EA20170638020). P.B., J.R., and T.L.V. were supported by the MD-PhD program of the Imagine Institute (with the support of the Fondation Bettencourt Schueller). Work in the Laboratory of Virology and Infectious Disease was supported by the NIH (P01AI138398-S1, 2U19AI111825, and R01AI091707-10S1), a George Mason University Fast Grant, and the G. Harold and Leila Y. Mathers Charitable Foundation. The French COVID Cohort study group was sponsored by INSERM and supported by the REACTing consortium and by a grant from the French Ministry of Health (PHRC 20-0424). The Cov-Contact Cohort was supported by the REACTing consortium, the French Ministry of Health, and the European Commission (RECOVER WP 6). This work was also partly supported by the Intramural Research Program of the NIAID and NIDCR, NIH (grants ZIA AI001270 to L.D.N. and 1ZIAAI001265 to H.C.S.). This program is supported by the Agence Nationale de la Recherche (reference ANR-10-LABX-69-01). K.K.’s group was supported by the Estonian Research Council grants PRG117 and PRG377. R.H. was supported by an Al Jalila Foundation Seed Grant (AJF202019), Dubai, UAE, and a COVID-19 research grant (CoV19-0307) from the University of Sharjah, UAE. S.G.T. is supported by Investigator and Program Grants awarded by the National Health and Medical Research Council of Australia and a UNSW Sydney COVID Rapid Response Initiative Grant. L.I. reported funding from Regione Lombardia, Italy (project “Risposta immune in pazienti con COVID-19 e co-morbidità”). L.I. and G. L. Marseglia reported funding from Regione Lombardia, Italy (project Risposta immune in pazienti con COVID-19 e co-morbidità). This research was partially supported by the Instituto de Salud Carlos III (COV20/0968). J.R.H. reported funding from Biomedical Advanced Research and Development Authority HHSO10201600031C. S.O. reports funding Research Program on Emerging and Re-emerging Infectious Diseases from Japan Agency for Medical Research and Development, AMED (grant number JP20fk0108531). G.G. was supported by ANR Flash COVID-19 program and SARS-CoV-2 Program of the Faculty of Medicine from Sorbonne University iCOVID programs. The Three-City (3C) Study was conducted under a partnership agreement among the INSERM, the Victor Segalen Bordeaux 2 University, and Sanofi-Aventis. The Fondation pour la Recherche Médicale funded the preparation and initiation of the study. The 3C Study was also supported by the Caisse Nationale d’Assurance Maladie des Travailleurs Salariés, Direction générale de la Santé, Mutuelle Générale de l’Education Nationale (MGEN), Institut de la Longévité, Conseils Régionaux of Aquitaine and Bourgogne, Fondation de France, and Ministry of Research–INSERM Programme “Cohortes et collections de données biologiques”. S. Debette was supported by the University of Bordeaux Initiative of Excellence. P.K.G. reports funding from the National Cancer Institute, NIH, under contract no. 75N91019D00024, task order no. 75N91021F00001. J.W. is supported by an FWO Fundamental Clinical Mandate (1833317N). Sample processing at IrsiCaixa was possible thanks to the crowdfunding initiative YoMeCorono. Work at Vall d’Hebron was also partly supported by research funding from Instituto de Salud Carlos III grant PI17/00660 cofinanced by the European Regional Development Fund (ERDF). C.R.-G. and colleagues of the Canarian Health System Sequencing Hub were supported by the Instituto de Salud Carlos III (COV20_01333 and COV20_01334, Spanish Ministry for Science and Innovation RTC-2017-6471-1; AEI/FEDER, UE), Fundación DISA (OA18/017 and OA20/024), and Cabildo Insular de Tenerife (CGIEU0000219140 and “Apuestas científicas del ITER para colaborar en la lucha contra la COVID-19”). C.M.B. is supported by a MSFHR Health Professional-Investigator Award. P.Q.H. and L.H. were funded by the European Union’s Horizon 2020 research and innovation program (ATAC, 101003650). Work at Y.-L.L.’s laboratory in the University of Hong Kong (HKU) was supported by the Society for the Relief of Disabled Children. MBBS/PhD study of D.L. in HKU was supported by the Croucher Foundation. J.L.F. was supported in part by the Coopération Scientifique France-Colciencias (ECOS-Nord/COLCIENCIAS/MEN/ICETEX (806-2018) and Colciencias contract 713-2016 (code 111574455633)]. A.K. was in part supported by grants NU20-05-00282 and NV18-05-00162 issued by the Czech Health Research Council and Ministry of Health, Czech Republic. L.P. was funded by Program Project COVID-19 OSR-UniSR and Ministero della Salute (COVID-2020-12371617). I.M. is a Senior Clinical Investigator at the Research Foundation–Flanders and is supported by the CSL Behring Chair of Primary Immunodeficiencies; by the KU Leuven C1 grant C16/18/007; by a VIB-GC PID grant; by the FWO frants G0C8517N, G0B5120N, and G0E8420N; and by the Jeffrey Modell Foundation. I.M. has received funding under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 948959). E.A. received funding from the Hellenic Foundation for Research and Innovation (INTERFLU, no. 1574). M.Vi received funding from the São Paulo Research Foundation (FAPESP) (grant number 2020/09702-1) and JBS SA (grant number 69004). The NH-COVAIR study group consortium was supported by a grant from the Meath Foundation Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma diluted 1:10) of IFN-α and/or IFN-ω are found in about 10% of patients with critical COVID-19 (coronavirus disease 2019) pneumonia but not in individuals with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-α and/or IFN-ω (100 pg/ml; in 1:10 dilutions of plasma) in 13.6% of 3595 patients with critical COVID-19, including 21% of 374 patients >80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1124 deceased patients (aged 20 days to 99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-β. We also show, in a sample of 34,159 uninfected individuals from the general population, that auto-Abs neutralizing high concentrations of IFN-α and/or IFN-ω are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of individuals carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals 80 years. By contrast, auto-Abs neutralizing IFN-β do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over 80s and total fatal COVID-19 cases. Peer reviewed
Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2021License: CC BYFull-Text: https://doi.org/10.1126/sciimmunol.abl4340BOA - Bicocca Open Archive; Oxford University Research Archive; UPF Digital Repository; Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele; Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) - Universidade de São Paulo (USP); Archivio della Ricerca - Università di Roma Tor vergata; Science Immunology; PURE Aarhus UniversityOther literature type . Article . 2021 . 2022 . Peer-reviewedLicense: CC BYData sources: BOA - Bicocca Open Archive; European Union Open Data Portal; Oxford University Research Archive; Sygma; Crossref; UPF Digital Repository; Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele; LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; NARCIS; Archivio della Ricerca - Università di Roma Tor vergata; PURE Aarhus UniversityServeur académique lausannoisArticle . 2021License: CC BYData sources: Serveur académique lausannoisCopenhagen University Research Information SystemArticle . 2021Data sources: Copenhagen University Research Information SystemGhent University Academic BibliographyArticle . 2021Data sources: Ghent University Academic BibliographyHELDA - Digital Repository of the University of HelsinkiArticle . 2021 . Peer-reviewedData sources: HELDA - Digital Repository of the University of HelsinkiRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2021 . Peer-reviewedBilkent University Institutional RepositoryArticle . 2021Data sources: Bilkent University Institutional RepositoryArchivio della Ricerca - Università di Roma Tor vergataArticle . 2021Data sources: Archivio della Ricerca - Università di Roma Tor vergataHAL-ENS-LYON; HAL - Université de LilleArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 319 citations 319 popularity Top 0.1% influence Top 1% impulse Top 0.1% Powered by BIP!visibility 438visibility views 438 download downloads 2,518 Powered bymore_vert Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2021License: CC BYFull-Text: https://doi.org/10.1126/sciimmunol.abl4340BOA - Bicocca Open Archive; Oxford University Research Archive; UPF Digital Repository; Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele; Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) - Universidade de São Paulo (USP); Archivio della Ricerca - Università di Roma Tor vergata; Science Immunology; PURE Aarhus UniversityOther literature type . Article . 2021 . 2022 . Peer-reviewedLicense: CC BYData sources: BOA - Bicocca Open Archive; European Union Open Data Portal; Oxford University Research Archive; Sygma; Crossref; UPF Digital Repository; Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele; LAReferencia - Red Federada de Repositorios Institucionales de Publicaciones Científicas Latinoamericanas; NARCIS; Archivio della Ricerca - Università di Roma Tor vergata; PURE Aarhus UniversityServeur académique lausannoisArticle . 2021License: CC BYData sources: Serveur académique lausannoisCopenhagen University Research Information SystemArticle . 2021Data sources: Copenhagen University Research Information SystemGhent University Academic BibliographyArticle . 2021Data sources: Ghent University Academic BibliographyHELDA - Digital Repository of the University of HelsinkiArticle . 2021 . Peer-reviewedData sources: HELDA - Digital Repository of the University of HelsinkiRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2021 . Peer-reviewedBilkent University Institutional RepositoryArticle . 2021Data sources: Bilkent University Institutional RepositoryArchivio della Ricerca - Università di Roma Tor vergataArticle . 2021Data sources: Archivio della Ricerca - Università di Roma Tor vergataHAL-ENS-LYON; HAL - Université de LilleArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint 2020 FrancePublisher:Cold Spring Harbor Laboratory Funded by:ANR | INCEPTIONANR| INCEPTIONFontanet, Arnaud; Tondeur, Laura; Madec, Yoann; Grant, Rebecca; Besombes, Camille; Jolly, Nathalie; Fernandes Pellerin, Sandrine; Ungeheuer, Marie-Noelle; Cailleau, Isabelle; Kuhmel, Lucie; Temmam, Sarah; Huon, Christele; Chen, Kuang-Yu; Crescenzo, Bernadette; Munier, Sandie; Demeret, Caroline; Grzelak, Ludivine; Staropoli, Isabelle; Bruel, Timothee; Gallian, Pierre; Cauchemez, Simon; van der Werf, Sylvie; Schwartz, Olivier; Eloit, Marc; Hoen, Bruno;Background: The Oise department in France has been heavily affected by COVID-19 in early 2020.Methods: Between 30 March and 4 April 2020, we conducted a retrospective closed cohort study amongpupils, their parents and siblings, as well as teachers and non-teaching staff of a high-school located inOise. Participants completed a questionnaire that covered history of fever and/or respiratory symptomssince 13 January 2020 and had blood tested for the presence of anti-SARS-CoV-2 antibodies. Theinfection attack rate (IAR) was defined as the proportion of participants with confirmed SARS-CoV-2infection based on antibody detection. Blood samples from two blood donor centres collected between23 and 27 March 2020 in the Oise department were also tested for presence of anti-SARS-CoV-2antibodies.Findings: Of the 661 participants (median age: 37 years), 171 participants had anti-SARS-CoV-2antibodies. The overall IAR was 25.9% (95% confidence interval (CI) = 22.6-29.4), and the infectionfatality rate was 0% (one-sided 97.5% CI = 0 - 2.1). Nine of the ten participants hospitalised since midJanuary were in the infected group, giving a hospitalisation rate of 5.3% (95% CI = 2.4 –9.8). Anosmia and ageusia had high positive predictive values for SARS-CoV-2 infection (84.7% and 88.1%,respectively). Smokers had a lower IAR compared to non-smokers (7.2% versus 28.0%, P <0.001). Theproportion of infected individuals who had no symptoms during the study period was 17.0% (95% CI =11.2 – 23.4). The proportion of donors with anti-SARS-CoV-2 antibodies in two nearby blood banksof the Oise department was 3.0% (95% CI = 1.1 - 6.4).Interpretation: The relatively low IAR observed in an area where SARS-CoV-2 actively circulatedweeks before confinement measures indicates that establishing herd immunity will take time, and thatlifting these measures in France will be long and complex. Posté sur MedRxiv le 23 avril 2020
medRxiv arrow_drop_down medRxivPreprint . 2020 . Peer-reviewedHAL Descartes; HAL-Pasteur; HAL AMU; Mémoires en Sciences de l'Information et de la Communication; HAL-IRDPreprint . 2021License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu127 citations 127 popularity Top 1% influence Top 1% impulse Top 0.1% Powered by BIP!more_vert medRxiv arrow_drop_down medRxivPreprint . 2020 . Peer-reviewedHAL Descartes; HAL-Pasteur; HAL AMU; Mémoires en Sciences de l'Information et de la Communication; HAL-IRDPreprint . 2021License: CC BY NC NDadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2017 France Funded by:ANR | Viro-DUBANR| Viro-DUBJupin, Isabelle; Ayach, Maya; Jomat, Lucile; Fieulaine, Sonia; Bressanelli, Stéphane;The positive-strand RNA virus Turnip yellow mosaic virus (TYMV) encodes an ovarian tumor (OTU)-like protease/deubiquitinase (PRO/DUB) protein domain involved both in proteolytic processing of the viral polyprotein through its PRO activity, and in removal of ubiquitin chains from ubiquitylated substrates through its DUB activity. Here, the crystal structures of TYMV PRO/DUB mutants and molecular dynamics simulations reveal that an idiosyncratic mobile loop participates in reversibly constricting its unusual catalytic site by adopting "open", "intermediate" or "closed" conformations. The two cis-prolines of the loop form a rigid flap that in the most closed conformation zips up against the other side of the catalytic cleft. The intermediate and closed conformations also correlate with a reordering of the TYMV PRO/DUB catalytic dyad, that then assumes a classical, yet still unusually mobile, OTU DUB alignment. Further structure-based mutants designed to interfere with the loop's mobility were assessed for enzymatic activity in vitro and in vivo, and were shown to display reduced DUB activity while retaining PRO activity. This indicates that control of the switching between the dual PRO/DUB activities resides prominently within this loop next to the active site. Introduction of mutations into the viral genome revealed that the DUB activity contributes to the extent of viral RNA accumulation both in single cells and in whole plants. In addition, the conformation of the mobile flap was also found to influence symptoms severity in planta. Such mutants now provide powerful tools with which to study the specific roles of reversible ubiquitylation in viral infection. Author summary Viruses have much smaller genomes than their hosts. Consequently, they often encode proteins which are multifunctional. For instance, some viral proteases have a dual function, being also deubiquitinases, i.e. enzymes capable of removing ubiquitin tags grafted onto proteins and that often target them for destruction. The protease and deubiquitinase activities share a single active site that is used alternately for one function or the other, but how this switch between activities may be regulated is presently unknown. To answer this question, we studied a simple plant virus that is a useful model system for these complex molecular biology phenomena, and that encodes a simplified protease/deubiquitinase. Here, thanks to a combination of structural and functional analyses, we managed to decouple the two activities, killing the deubiquitinase activity while preserving the protease one. This successful decoupling relies on our discovery that a loop inserted next to the active site is mobile, and can thus act as a switch between the two activities. This result allowed us to demonstrate the importance of the specific deubiquinase activity in viral multiplication. In addition, viral symptoms were also severely affected by mutations affecting the loop mobility. Our data provide powerful tools for further studies, that may also be relevant for more complex or medically relevant viruses.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5695851Data sources: PubMed CentralPLoS Pathogens; OpenAPC Global InitiativeArticle . Conference object . 2017 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 18 citations 18 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5695851Data sources: PubMed CentralPLoS Pathogens; OpenAPC Global InitiativeArticle . Conference object . 2017 . Peer-reviewedLicense: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2016 Italy, Italy, France Funded by:ANR | Amidex, ANR | HarMS-flu, EC | PREDEMICS +1 projectsANR| Amidex ,ANR| HarMS-flu ,EC| PREDEMICS ,EC| MULTIPLEXBioglio L.; Genois M.; Vestergaard C. L.; Poletto C.; Barrat A.; Colizza V.;AbstractBackgroundThe homogeneous mixing assumption is widely adopted in epidemic modelling for its parsimony and represents the building block of more complex approaches, including very detailed agent-based models. The latter assume homogeneous mixing within schools, workplaces and households, mostly for the lack of detailed information on human contact behaviour within these settings. The recent data availability on high-resolution face-to-face interactions makes it now possible to assess the goodness of this simplified scheme in reproducing relevant aspects of the infection dynamics.MethodsWe consider empirical contact networks gathered in different contexts, as well as synthetic data obtained through realistic models of contacts in structured populations. We perform stochastic spreading simulations on these contact networks and in populations of the same size under a homogeneous mixing hypothesis. We adjust the epidemiological parameters of the latter in order to fit the prevalence curve of the contact epidemic model. We quantify the agreement by comparing epidemic peak times, peak values, and epidemic sizes.ResultsGood approximations of the peak times and peak values are obtained with the homogeneous mixing approach, with a median relative difference smaller than 20 % in all cases investigated. Accuracy in reproducing the peak time depends on the setting under study, while for the peak value it is independent of the setting. Recalibration is found to be linear in the epidemic parameters used in the contact data simulations, showing changes across empirical settings but robustness across groups and population sizes.ConclusionsAn adequate rescaling of the epidemiological parameters can yield a good agreement between the epidemic curves obtained with a real contact network and a homogeneous mixing approach in a population of the same size. The use of such recalibrated homogeneous mixing approximations would enhance the accuracy and realism of agent-based simulations and limit the intrinsic biases of the homogeneous mixing. International audience
HAL AMU; Mémoires en... arrow_drop_down Europe PubMed CentralArticle . 2016Full-Text: http://europepmc.org/articles/PMC5109722Data sources: PubMed CentralZENODO; OpenAPC Global Initiative; BMC Infectious DiseasesOther literature type . Article . Conference object . 2016 . Peer-reviewedLicense: Springer TDMHAL-Inserm; Hal-DiderotArticle . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 10 citations 10 popularity Top 10% influence Average impulse Average Powered by BIP!visibility 24visibility views 24 download downloads 55 Powered bymore_vert HAL AMU; Mémoires en... arrow_drop_down Europe PubMed CentralArticle . 2016Full-Text: http://europepmc.org/articles/PMC5109722Data sources: PubMed CentralZENODO; OpenAPC Global Initiative; BMC Infectious DiseasesOther literature type . Article . Conference object . 2016 . Peer-reviewedLicense: Springer TDMHAL-Inserm; Hal-DiderotArticle . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2015 France Funded by:ANR | PandoravirusANR| PandoravirusPriet, Stéphane; Lartigue, Audrey; Debart, Françoise; Claverie, Jean-Michel; Abergel, Chantal;AbstractGiant viruses from the Mimiviridae family replicate entirely in their host cytoplasm where their genes are transcribed by a viral transcription apparatus. mRNA polyadenylation uniquely occurs at hairpin-forming palindromic sequences terminating viral transcripts. Here we show that a conserved gene cluster both encode the enzyme responsible for the hairpin cleavage and the viral polyA polymerases (vPAP). Unexpectedly, the vPAPs are homodimeric and uniquely self-processive. The vPAP backbone structures exhibit a symmetrical architecture with two subdomains sharing a nucleotidyltransferase topology, suggesting that vPAPs originate from an ancestral duplication. A Poxvirus processivity factor homologue encoded by Megavirus chilensis displays a conserved 5′-GpppA 2′O methyltransferase activity but is also able to internally methylate the mRNAs’ polyA tails. These findings elucidate how the arm wrestling between hosts and their viruses to access the translation machinery is taking place in Mimiviridae.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2015Full-Text: http://europepmc.org/articles/PMC4402537Data sources: PubMed CentralNucleic Acids Research; OpenAPC Global InitiativeArticle . Conference object . 2015 . Peer-reviewedLicense: CC BYHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2015add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 16 citations 16 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2015Full-Text: http://europepmc.org/articles/PMC4402537Data sources: PubMed CentralNucleic Acids Research; OpenAPC Global InitiativeArticle . Conference object . 2015 . Peer-reviewedLicense: CC BYHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2015add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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