- home
- Advanced Search
- EU-CONEXUS
- Publications
- Other literature type
- HAL-Pasteur
- EU-CONEXUS
- Publications
- Other literature type
- HAL-Pasteur
Loading
description Publicationkeyboard_double_arrow_right Article 2023 Spain, NetherlandsPublisher:Proceedings of the National Academy of Sciences Funded by:NWO | Enhancing biodiversity-ba..., EC | SHOWCASENWO| Enhancing biodiversity-based ecosystem services to crops through optimized densities of green infrastructure in agricultural landscapes ,EC| SHOWCASEAuthors: Scheper, Jeroen; Badenhausser, Isabelle; Kantelhardt, Jochen; Kirchweger, Stefan; +8 AuthorsScheper, Jeroen; Badenhausser, Isabelle; Kantelhardt, Jochen; Kirchweger, Stefan; Bartomeus, Ignasi; Bretagnolle, Vincent; Clough, Yann; Gross, Nicolas; Raemakers, Ivo; Vilà, Montserrat; Zaragoza-Trello, Carlos; Kleijn, David;Agricultural expansion and intensification have boosted global food production but have come at the cost of environmental degradation and biodiversity loss. Biodiversity-friendly farming that boosts ecosystem services, such as pollination and natural pest control, is widely being advocated to maintain and improve agricultural productivity while safeguarding biodiversity. A vast body of evidence showing the agronomic benefits of enhanced ecosystem service delivery represent important incentives to adopt practices enhancing biodiversity. However, the costs of biodiversity-friendly management are rarely taken into account and may represent a major barrier impeding uptake by farmers. Whether and how biodiversity conservation, ecosystem service delivery, and farm profit can go hand in hand is unknown. Here, we quantify the ecological, agronomic, and net economic benefits of biodiversity-friendly farming in an intensive grassland–sunflower system in Southwest France. We found that reducing land-use intensity on agricultural grasslands drastically enhances flower availability and wild bee diversity, including rare species. Biodiversity-friendly management on grasslands furthermore resulted in an up to 17% higher revenue on neighboring sunflower fields through positive effects on pollination service delivery. However, the opportunity costs of reduced grassland forage yields consistently exceeded the economic benefits of enhanced sunflower pollination. Our results highlight that profitability is often a key constraint hampering adoption of biodiversity-based farming and uptake critically depends on society’s willingness to pay for associated delivery of public goods such as biodiversity. European Union 862480
Proceedings of the N... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; idUS. Depósito de Investigación de la Universidad de Sevilla.Article . 2023License: CC BY NC NDFull-Text: https://doi.org/10.1073/pnas.2212124120Mémoires en Sciences de l'Information et de la CommunicationArticle . 2023Full-Text: https://hal.science/hal-04167122/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2212124120&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Proceedings of the N... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; idUS. Depósito de Investigación de la Universidad de Sevilla.Article . 2023License: CC BY NC NDFull-Text: https://doi.org/10.1073/pnas.2212124120Mémoires en Sciences de l'Information et de la CommunicationArticle . 2023Full-Text: https://hal.science/hal-04167122/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2212124120&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2022 FrancePublisher:Proceedings of the National Academy of Sciences Funded by:EC | ECOFEED, NSF | Collaborative Research: Q..., ANR | AQUATHERM +1 projectsEC| ECOFEED ,NSF| Collaborative Research: Quantifying Climate-forced Extinction Risks for Lizards, Amphibians, Fishes, and Plants ,ANR| AQUATHERM ,NSF| OPUS: CRS Conceptual and Analytical Synthesis of Ecomorphological insights into diversification and adaptationDupoué, Andréaz; Blaimont, Pauline; Angelier, Frédéric; Ribout, Cécile; Rozen-Rechels, David; Richard, Murielle; Miles, Donald; de Villemereuil, Pierre; Rutschmann, Alexis; Badiane, Arnaud; Aubret, Fabien; Lourdais, Olivier; Meylan, Sandrine; Cote, Julien; Clobert, Jean; Le Galliard, Jean-François;Aging is the price to pay for acquiring and processing energy through cellular activity and life history productivity. Climate warming can exacerbate the inherent pace of aging, as illustrated by a faster erosion of protective telomere DNA sequences. This biomarker integrates individual pace of life and parental effects through the germline, but whether intra- and intergenerational telomere dynamics underlies population trends remains an open question. Here, we investigated the covariation between life history, telomere length (TL), and extinction risk among three age classes in a cold-adapted ectotherm ( Zootoca vivipara ) facing warming-induced extirpations in its distribution limits. TL followed the same threshold relationships with population extinction risk at birth, maturity, and adulthood, suggesting intergenerational accumulation of accelerated aging rate in declining populations. In dwindling populations, most neonates inherited already short telomeres, suggesting they were born physiologically old and unlikely to reach recruitment. At adulthood, TL further explained females’ reproductive performance, switching from an index of individual quality in stable populations to a biomarker of reproductive costs in those close to extirpation. We compiled these results to propose the aging loop hypothesis and conceptualize how climate-driven telomere shortening in ectotherms may accumulate across generations and generate tipping points before local extirpation.
Proceedings of the N... arrow_drop_down ArchiMer - Institutional Archive of IfremerOther literature type . 2022Data sources: ArchiMer - Institutional Archive of IfremerHAL - UPEC / UPEM; HAL-InsermArticle . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2201371119&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 19 citations 19 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert Proceedings of the N... arrow_drop_down ArchiMer - Institutional Archive of IfremerOther literature type . 2022Data sources: ArchiMer - Institutional Archive of IfremerHAL - UPEC / UPEM; HAL-InsermArticle . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2201371119&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 France, Netherlands, Denmark, Denmark, France, France, France, FrancePublisher:F1000 Research Ltd Funded by:EC | BioExcel-2, EC | EOSC-LifeEC| BioExcel-2 ,EC| EOSC-LifeAnna-Lena Lamprecht; Magnus Palmblad; Jon Ison; Veit Schwämmle; Mohammad Sadnan Al Manir; Ilkay Altintas; Christopher J. O. Baker; A. Amor; Salvador Capella-Gutierrez; Paulos Charonyktakis; Michael R. Crusoe; Yolanda Gil; Carole Goble; Timothy J. Griffin; Paul Groth; Hans Ienasescu; Pratik D. Jagtap; Matúš Kalaš; Vedran Kasalica; Alireza Khanteymoori; Tobias Kuhn; Hailiang Mei; Hervé Ménager; Steffen Möller; Robin A. Richardson; Vincent Robert; Stian Soiland-Reyes; Robert Stevens; Szoke Szaniszlo; Suzan Verberne; Aswin Verhoeven; Katherine Wolstencroft;pmid: 34804501
pmc: PMC8573700
Scientific data analyses often combine several computational tools in automated pipelines, or workflows. Thousands of such workflows have been used in the life sciences, though their composition has remained a cumbersome manual process due to a lack of standards for annotation, assembly, and implementation. Recent technological advances have returned the long-standing vision of automated workflow composition into focus. This article summarizes a recent Lorentz Center workshop dedicated to automated composition of workflows in the life sciences. We survey previous initiatives to automate the composition process, and discuss the current state of the art and future perspectives. We start by drawing the “big picture” of the scientific workflow development life cycle, before surveying and discussing current methods, technologies and practices for semantic domain modelling, automation in workflow development, and workflow assessment. Finally, we derive a roadmap of individual and community-based actions to work toward the vision of automated workflow development in the forthcoming years. A central outcome of the workshop is a general description of the workflow life cycle in six stages: 1) scientific question or hypothesis, 2) conceptual workflow, 3) abstract workflow, 4) concrete workflow, 5) production workflow, and 6) scientific results. The transitions between stages are facilitated by diverse tools and methods, usually incorporating domain knowledge in some form. Formal semantic domain modelling is hard and often a bottleneck for the application of semantic technologies. However, life science communities have made considerable progress here in recent years and are continuously improving, renewing interest in the application of semantic technologies for workflow exploration, composition and instantiation. Combined with systematic benchmarking with reference data and large-scale deployment of production-stage workflows, such technologies enable a more systematic process of workflow development than we know today. We believe that this can lead to more robust, reusable, and sustainable workflows in the future.
NARCIS arrow_drop_down Europe PubMed CentralArticle . 2021 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC8573700Data sources: PubMed CentralLeiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2021License: CC BYUniversity of Southern Denmark Research Output; F1000ResearchOther literature type . Article . 2021Data sources: University of Southern Denmark Research OutputF1000ResearchArticle . 2021Online Research Database In TechnologyArticle . 2021 . Peer-reviewedData sources: Online Research Database In Technologyadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.12688/f1000research.54159.1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 7 citations 7 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert NARCIS arrow_drop_down Europe PubMed CentralArticle . 2021 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC8573700Data sources: PubMed CentralLeiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2021License: CC BYUniversity of Southern Denmark Research Output; F1000ResearchOther literature type . Article . 2021Data sources: University of Southern Denmark Research OutputF1000ResearchArticle . 2021Online Research Database In TechnologyArticle . 2021 . Peer-reviewedData sources: Online Research Database In Technologyadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.12688/f1000research.54159.1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 Italy, Croatia, ItalyPublisher:Proceedings of the National Academy of Sciences Funded by:EC | HIDDEN FOODSEC| HIDDEN FOODSClaudio Ottoni; Dusan Boric; Olivia Cheronet; Vitale Sparacello; Irene Dori; Alfredo Coppa; Dragana Antonović; Dario Vujević; T. Douglas Price; Ron Pinhasi; Emanuela Cristiani;Archaeological dental calculus, or mineralized plaque, is a key tool to track the evolution of oral microbiota across time in response to processes that impacted our culture and biology, such as the rise of farming during the Neolithic. However, the extent to which the human oral flora changed from prehistory until present has remained elusive due to the scarcity of data on the microbiomes of prehistoric humans. Here, we present our reconstruction of oral microbiomes via shotgun metagenomics of dental calculus in 44 ancient foragers and farmers from two regions playing a pivotal role in the spread of farming across Europe—the Balkans and the Italian Peninsula. We show that the introduction of farming in Southern Europe did not alter significantly the oral microbiomes of local forager groups, and it was in particular associated with a higher abundance of the species Olsenella sp. oral taxon 807. The human oral environment in prehistory was dominated by a microbial species, Anaerolineaceae bacterium oral taxon 439, that diversified geographically. A Near Eastern lineage of this bacterial commensal dispersed with Neolithic farmers and replaced the variant present in the local foragers. Our findings also illustrate that major taxonomic shifts in human oral microbiome composition occurred after the Neolithic and that the functional profile of modern humans evolved in recent times to develop peculiar mechanisms of antibiotic resistance that were previously absent. Significance The oral microbial community living in symbiosis with humans is a rich and diverse driver of health and disease that is strongly influenced by our ecology and lifestyle. However, its evolution across human prehistory remains elusive. By analyzing the DNA entrapped in archaeological dental calculus, we characterize the oral microbiomes of 44 prehistoric foragers and farmers from Southern Europe. We demonstrate that the genome of an oral bacteria diversified geographically and recorded one of the most dramatic changes in our biological and cultural history, the spread of farming. The transition to agriculture did not alter significantly the oral microbiome of ancient humans, whereas more significant changes occurred later in history, including the development of peculiar antibiotic resistance pathways.
Archivio della ricer... arrow_drop_down Archivio della ricerca- Università di Roma La Sapienza; Archivio della Ricerca - Università di Roma Tor vergata; Proceedings of the National Academy of Sciences; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2021 . Peer-reviewedLicense: CC BY NC NDEurope PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8364157Data sources: PubMed CentralArchivio della ricerca- Università di Roma La SapienzaArticle . 2021Data sources: Archivio della ricerca- Università di Roma La SapienzaArchivio della Ricerca - Università di Roma Tor vergataArticle . 2021Data sources: Archivio della Ricerca - Università di Roma Tor vergataadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2102116118&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 26 citations 26 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Archivio della ricer... arrow_drop_down Archivio della ricerca- Università di Roma La Sapienza; Archivio della Ricerca - Università di Roma Tor vergata; Proceedings of the National Academy of Sciences; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2021 . Peer-reviewedLicense: CC BY NC NDEurope PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8364157Data sources: PubMed CentralArchivio della ricerca- Università di Roma La SapienzaArticle . 2021Data sources: Archivio della ricerca- Università di Roma La SapienzaArchivio della Ricerca - Università di Roma Tor vergataArticle . 2021Data sources: Archivio della Ricerca - Università di Roma Tor vergataadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2102116118&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 Italy, Switzerland, Italy, Italy, Lithuania, Bulgaria, Spain, Germany, Italy, Czech Republic, France, Italy, Italy, NetherlandsPublisher:Proceedings of the National Academy of Sciences Funded by:FWF | The Global Naturalized Al...FWF| The Global Naturalized Alien Flora (GloNAF) databaseTrevor S. Fristoe; Milan Chytrý; Wayne Dawson; Franz Essl; Rubén H. Heleno; Holger Kreft; Noëlie Maurel; Jan Pergl; Petr Pyšek; Hanno Seebens; Patrick Weigelt; Pablo Vargas; Qiang Yang; Fabio Attorre; Erwin Bergmeier; Markus Bernhardt-Römermann; Idoia Biurrun; Steffen Boch; Gianmaria Bonari; Zoltán Botta-Dukát; Hans Henrik Bruun; Chaeho Byun; Andraž Čarni; Maria Laura Carranza; Jane A. Catford; Bruno Enrico Leone Cerabolini; Eduardo Chacón-Madrigal; Daniela Ciccarelli; Renata Ćušterevska; Iris de Ronde; Jürgen Dengler; Valentin Golub; Rense Haveman; Nate Hough-Snee; Ute Jandt; Florian Jansen; Anna Kuzemko; Filip Küzmič; Jonathan Lenoir; Armin Macanović; Corrado Marcenò; Adam R. Martin; Sean T. Michaletz; Akira Mori; Ülo Niinemets; Tomáš Peterka; Remigiusz Pielech; Valerijus Rašomavičius; Solvita Rūsiņa; Arildo S. Dias; Mária Šibíková; Urban Šilc; Angela Stanisci; Steven Jansen; Jens-Christian Svenning; Grzegorz Swacha; Fons van der Plas; Kiril Vassilev; Mark van Kleunen;pmc: PMC8179145
pmid: 34050023
handle: 11695/99627 , 11391/1505754 , 10261/262510 , 11365/1248645 , 11573/1661226 , 11104/0324950
pmc: PMC8179145
pmid: 34050023
handle: 11695/99627 , 11391/1505754 , 10261/262510 , 11365/1248645 , 11573/1661226 , 11104/0324950
Understanding drivers of success for alien species can inform on potential future invasions. Recent conceptual advances highlight that species may achieve invasiveness via performance along at least three distinct dimensions: 1) local abundance, 2) geographic range size, and 3) habitat breadth in naturalized distributions. Associations among these dimensions and the factors that determine success in each have yet to be assessed at large geographic scales. Here, we combine data from over one million vegetation plots covering the extent of Europe and its habitat diversity with databases on species' distributions, traits, and historical origins to provide a comprehensive assessment of invasiveness dimensions for the European alien seed plant flora. Invasiveness dimensions are linked in alien distributions, leading to a continuum from overall poor invaders to super invaders - abundant, widespread aliens that invade diverse habitats. This pattern echoes relationships among analogous dimensions measured for native European species. Success along invasiveness dimensions was associated with details of alien species' introduction histories: earlier introduction dates were positively associated with all three dimensions, and consistent with theory-based expectations, species originating from other continents, particularly acquisitive growth strategists, were among the most successful invaders in Europe. Despite general correlations among invasiveness dimensions, we identified habitats and traits associated with atypical patterns of success in only one or two dimensions - for example, the role of disturbed habitats in facilitating widespread specialists. We conclude that considering invasiveness within a multidimensional framework can provide insights into invasion processes while also informing general understanding of the dynamics of species distributions. Deutsche Forschungsgemeinschaft (264740629) Grantová Agentura České Republiky (19-28491X) Grantová Agentura České Republiky (19-28807X) Grantová Agentura České Republiky (RVO 67985939) Austrian Science Fund (I 2086 - B29) Bundesministerium für Bildung und Forschung (01LC1807A) Eusko Jaurlaritza (IT299-10) National Research Foundation of Korea (2018R1C1B6005351) University of Latvia (AAp2016/B041//Zd2016/AZ03) Villum Fonden (16549)
Research@WUR; Archiv... arrow_drop_down Research@WUR; Archivio della ricerca- Università di Roma La Sapienza; PURE Aarhus University; Proceedings of the National Academy of SciencesOther literature type . Article . 2021 . Peer-reviewedArchivio della ricerca- Università di Roma La SapienzaArticle . 2021Data sources: Archivio della ricerca- Università di Roma La SapienzaInstitutional Repository of Nature Research CentreOther literature type . 2021License: CC BYData sources: Institutional Repository of Nature Research CentreRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2021 . 2022Repository of the Czech Academy of SciencesArticle . 2021Data sources: Repository of the Czech Academy of SciencesRepository of the Czech Academy of SciencesArticle . 2021Data sources: Repository of the Czech Academy of SciencesMémoires en Sciences de l'Information et de la CommunicationArticle . 2021Full-Text: https://hal.science/hal-03362885/documentArchivio della Ricerca - Università di PisaArticle . 2021Data sources: Archivio della Ricerca - Università di Pisaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2021173118&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 41 citations 41 popularity Top 1% influence Average impulse Top 1% Powered by BIP!visibility 159visibility views 159 download downloads 92 Powered bymore_vert Research@WUR; Archiv... arrow_drop_down Research@WUR; Archivio della ricerca- Università di Roma La Sapienza; PURE Aarhus University; Proceedings of the National Academy of SciencesOther literature type . Article . 2021 . Peer-reviewedArchivio della ricerca- Università di Roma La SapienzaArticle . 2021Data sources: Archivio della ricerca- Università di Roma La SapienzaInstitutional Repository of Nature Research CentreOther literature type . 2021License: CC BYData sources: Institutional Repository of Nature Research CentreRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2021 . 2022Repository of the Czech Academy of SciencesArticle . 2021Data sources: Repository of the Czech Academy of SciencesRepository of the Czech Academy of SciencesArticle . 2021Data sources: Repository of the Czech Academy of SciencesMémoires en Sciences de l'Information et de la CommunicationArticle . 2021Full-Text: https://hal.science/hal-03362885/documentArchivio della Ricerca - Università di PisaArticle . 2021Data sources: Archivio della Ricerca - Università di Pisaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2021173118&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 United Kingdom, Spain, Canada, ItalyPublisher:Proceedings of the National Academy of Sciences Funded by:UKRI | Genomic imprinting and th..., WTUKRI| Genomic imprinting and the epigenetic control of developmental processes ,WTRaquel Montalbán-Loro; Glenda Lassi; Anna Lozano-Ureña; Ana Perez-Villalba; Esteban Jiménez-Villalba; Marika Charalambous; Giorgio Vallortigara; Alexa E. Horner; Lisa M. Saksida; Timothy J. Bussey; José Luis Trejo; Valter Tucci; Anne C. Ferguson-Smith; Sacri R. Ferrón;Neurogenesis in the adult brain gives rise to functional neurons, which integrate into neuronal circuits and modulate neural plasticity. Sustained neurogenesis throughout life occurs in the subgranular zone (SGZ) of the dentate gyrus in the hippocampus and is hypothesized to be involved in behavioral/cognitive processes such as memory and in diseases. Genomic imprinting is of critical importance to brain development and normal behavior, and exemplifies how epigenetic states regulate genome function and gene dosage. While most genes are expressed from both alleles, imprinted genes are usually expressed from either the maternally or the paternally inherited chromosome. Here, we show that in contrast to its canonical imprinting in nonneurogenic regions, Delta-like homolog 1 (Dlk1) is expressed biallelically in the SGZ, and both parental alleles are required for stem cell behavior and normal adult neurogenesis in the hippocampus. To evaluate the effects of maternally, paternally, and biallelically inherited mutations within the Dlk1 gene in specific behavioral domains, we subjected Dlk1-mutant mice to a battery of tests that dissociate and evaluate the effects of Dlk1 dosage on spatial learning ability and on anxiety traits. Importantly, reduction in Dlk1 levels triggers specific cognitive abnormalities that affect aspects of discriminating differences in environmental stimuli, emphasizing the importance of selective absence of imprinting in this neurogenic niche. This work was supported by grants from Ministerio de Economía y Competitividad (SAF2016-78845-R and PID2019-110045GB-I00), Fundación Banco Bilbao Vizcaya Argentaria, and Generalitat Valenciana (AICO/2020/367) to S.R.F. and grants from the Medical Research Council (MR/R009791/1), Wellcome Trust (21757/Z/18/Z), and European Union FP7 Ingenium Training Network to A.C.F.-S. R.M.-L. was funded by a Spanish Researchers Formation program, and A.L.-U. was fundedby the Generalitat Valenciana fellowship program.
IRIS - Institutional... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2021Full-Text: http://europepmc.org/articles/PMC7980393Data sources: PubMed CentralProceedings of the National Academy of SciencesArticle . 2021 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2021Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2021 . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2015505118&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 14 citations 14 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 32visibility views 32 download downloads 119 Powered bymore_vert IRIS - Institutional... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2021Full-Text: http://europepmc.org/articles/PMC7980393Data sources: PubMed CentralProceedings of the National Academy of SciencesArticle . 2021 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2021Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2021 . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2015505118&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 BelgiumPublisher:Proceedings of the National Academy of Sciences Funded by:EC | POLYADAPTEC| POLYADAPTVlogiannitis, Spyridon; Mavridis, Konstantinos; Dermauw, Wannes; Snoeck, Simon; Katsavou, Evangelia; Morou, Evangelia; Harizanis, Paschalis; Swevers, Luc; Hemingway, Janet; Feyereisen, René; Van Leeuwen, Thomas; Vontas, John;Varroa destructor is one of the main problems in modern beekeeping. Highly selective acaricides with low toxicity to bees are used internationally to control this mite. One of the key acaricides is the organophosphorus (OP) proinsecticide coumaphos, that becomes toxic after enzymatic activation inside Varroa. We show here that mites from the island Andros (AN-CR) exhibit high levels of coumaphos resistance. Resistance is not mediated by decreased coumaphos uptake, target-site resistance, or increased detoxification. Reduced proinsecticide activation by a cytochrome P450 enzyme was the main resistance mechanism, a powerful and rarely encountered evolutionary solution to insecticide selection pressure. After treatment with sublethal doses of [(14)C] coumaphos, susceptible mite extracts had substantial amounts of coroxon, the activated metabolite of coumaphos, while resistant mites had only trace amounts. This indicates a suppression of the P450 (CYP)-mediated activation step in the AN-CR mites. Bioassays with coroxon to bypass the activation step showed that resistance was dramatically reduced. There are 26 CYPs present in the V. destructor genome. Transcriptome analysis revealed overexpression in resistant mites of CYP4DP24 and underexpression of CYP3012A6 and CYP4EP4. RNA interference of CYP4EP4 in the susceptible population, to mimic underexpression seen in the resistant mites, prevented coumaphos activation and decreased coumaphos toxicity.
Proceedings of the N... arrow_drop_down Proceedings of the National Academy of SciencesOther literature type . Article . 2021 . Peer-reviewedGhent University Academic BibliographyArticle . 2021Data sources: Ghent University Academic BibliographyGhent University Academic BibliographyArticle . 2021Data sources: Ghent University Academic Bibliographyadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2020380118&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 40 citations 40 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 4visibility views 4 download downloads 13 Powered bymore_vert Proceedings of the N... arrow_drop_down Proceedings of the National Academy of SciencesOther literature type . Article . 2021 . Peer-reviewedGhent University Academic BibliographyArticle . 2021Data sources: Ghent University Academic BibliographyGhent University Academic BibliographyArticle . 2021Data sources: Ghent University Academic Bibliographyadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2020380118&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021Publisher:Proceedings of the National Academy of Sciences Kevin M. Huang; Megan E. Zavorka Thomas; Tarek Magdy; Eric D. Eisenmann; Muhammad Erfan Uddin; Duncan DiGiacomo; Alexander Pan; Markus Keiser; Marcus Otter; Sherry H. Xia; Yang Li; Yan Jin; Qiang Fu; Alice A. Gibson; Ingrid M. Bonilla; Cynthia A. Carnes; Kara N. Corps; Vincenzo Coppola; Sakima A. Smith; Daniel Addison; Anne T. Nies; Ralf Bundschuh; Taosheng Chen; Maryam B. Lustberg; Joanne Wang; Stefan Oswald; Moray J. Campbell; Pearlly S. Yan; Sharyn D. Baker; Shuiying Hu; Paul W. Burridge; Alex Sparreboom;Doxorubicin is a commonly used anticancer agent that can cause debilitating and irreversible cardiac injury. The initiating mechanisms contributing to this side effect remain unknown, and current preventative strategies offer only modest protection. Using stem-cell-derived cardiomyocytes from patients receiving doxorubicin, we probed the transcriptomic landscape of solute carriers and identified organic cation transporter 3 (OCT3) (SLC22A3) as a critical transporter regulating the cardiac accumulation of doxorubicin. Functional validation studies in heterologous overexpression models confirmed that doxorubicin is transported into cardiomyocytes by OCT3 and that deficiency of OCT3 protected mice from acute and chronic doxorubicin-related changes in cardiovascular function and genetic pathways associated with cardiac damage. To provide proof-of-principle and demonstrate translational relevance of this transport mechanism, we identified several pharmacological inhibitors of OCT3, including nilotinib, and found that pharmacological targeting of OCT3 can also preserve cardiovascular function following treatment with doxorubicin without affecting its plasma levels or antitumor effects in multiple models of leukemia and breast cancer. Finally, we identified a previously unrecognized, OCT3-dependent pathway of doxorubicin-induced cardiotoxicity that results in a downstream signaling cascade involving the calcium-binding proteins S100A8 and S100A9. These collective findings not only shed light on the etiology of doxorubicin-induced cardiotoxicity, but also are of potential translational relevance and provide a rationale for the implementation of a targeted intervention strategy to prevent this debilitating side effect.
Proceedings of the N... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2021 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2020168118&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 34 citations 34 popularity Top 1% influence Average impulse Top 10% Powered by BIP!more_vert Proceedings of the N... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2021 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2020168118&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2020 FrancePublisher:Proceedings of the National Academy of Sciences Funded by:NSERCNSERCMatthew P. Duda; Sylvie Allen-Mahé; Christophe Barbraud; Jules M. Blais; Amaël Boudreau; Rachel Bryant; Karine Delord; Christopher Grooms; Linda E. Kimpe; Bruno Letournel; Joeline E Lim; Hervé Lormée; Neal Michelutti; Gregory J. Robertson; Frank Urtizbéréa; Sabina I. Wilhelm; John P. Smol;International audience; Recent estimates indicate that ∼70% of the world’s seabird populations have declined since the 1950s due to human activities. However, for almost all bird populations, there is insufficient long-term monitoring to understand baseline (i.e., preindustrial) conditions, which are required to distinguish natural versus anthropogenically driven changes. Here, we address this lack of long-term monitoring data with multiproxy paleolimnological approaches to examine the long-term population dynamics of a major colony of Leach’s Storm-petrel (Hydrobates leucorhous) on Grand Colombier Island in the St. Pierre and Miquelon archipelago—an overseas French territory in the northwest Atlantic Ocean. By reconstructing the last ∼5,800 y of storm-petrel dynamics, we demonstrate that this colony underwent substantial natural fluctuations until the start of the 19th century, when population cycles were disrupted, coinciding with the establishment and expansion of a European settlement. Our paleoenvironmental data, coupled with on-the-ground population surveys, indicate that the current colony is only ∼16% of the potential carrying capacity, reinforcing concerning trends of globally declining seabird populations. As seabirds are sentinel species of marine ecosystem health, such declines provide a call to action for global conservation. In response, we emphasize the need for enlarged protected areas and the rehabilitation of disturbed islands to protect ecologically critical seabird populations. Furthermore, long-term data, such as those provided by paleoecological approaches, are required to better understand shifting baselines in conservation to truly recognize current rates of ecological loss.
Europe PubMed Centra... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2020 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2016811117&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 12 citations 12 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2020 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2016811117&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2020 Italy, Brazil, United States, United Kingdom, Spain, FrancePublisher:Proceedings of the National Academy of Sciences Publicly fundedMatthew A. Whalen; Ross Whippo; John J. Stachowicz; Paul H. York; Erin Aiello; Teresa Alcoverro; Andrew H. Altieri; Lisandro Benedetti-Cecchi; Camilla Bertolini; Midoli Bresch; Fabio Bulleri; Paul E. Carnell; Stéphanie Cimon; Rod M. Connolly; Mathieu Cusson; Meredith S. Diskin; Elrika D’Souza; Augusto A. V. Flores; F. Joel Fodrie; Aaron W. E. Galloway; Lindsay C. Gaskins; Olivia J. Graham; Torrance C. Hanley; Christopher J. Henderson; Clara M. Hereu; Margot Hessing-Lewis; Kevin A. Hovel; Brent B. Hughes; A. Randall Hughes; Kristin M. Hultgren; Holger Jänes; Dean S. Janiak; Lane N. Johnston; Pablo Jorgensen; Brendan P. Kelaher; Claudia Kruschel; Brendan S. Lanham; Kun-Seop Lee; Jonathan S. Lefcheck; Enrique Lozano-Álvarez; Peter I. Macreadie; Zachary L. Monteith; Nessa E. O'Connor; Andrew D. Olds; Jennifer K. O'Leary; Christopher J. Patrick; Oscar Pino; Alistair G. B. Poore; Michael Rasheed; Wendel W. Raymond; Katrin Reiss; O. Kennedy Rhoades; Max T. Robinson; Paige G. Ross; Francesca Rossi; Thomas A. Schlacher; Janina Seemann; Brian R. Silliman; Delbert L. Smee; Martin Thiel; Richard K. F. Unsworth; Brigitta I. van Tussenbroek; Adriana Vergés; Mallarie E. Yeager; Bree K. Yednock; Shelby L. Ziegler; J. Emmett Duffy;The global distribution of primary production and consumption by humans (fisheries) is well-documented, but we have no map linking the central ecological process of consumption within food webs to temperature and other ecological drivers. Using standardized assays that span 105° of latitude on four continents, we show that rates of bait consumption by generalist predators in shallow marine ecosystems are tightly linked to both temperature and the composition of consumer assemblages. Unexpectedly, rates of consumption peaked at midlatitudes (25 to 35°) in both Northern and Southern Hemispheres across both seagrass and unvegetated sediment habitats. This pattern contrasts with terrestrial systems, where biotic interactions reportedly weaken away from the equator, but it parallels an emerging pattern of a subtropical peak in marine biodiversity. The higher consumption at midlatitudes was closely related to the type of consumers present, which explained rates of consumption better than consumer density, biomass, species diversity, or habitat. Indeed, the apparent effect of temperature on consumption was mostly driven by temperature-associated turnover in consumer community composition. Our findings reinforce the key influence of climate warming on altered species composition and highlight its implications for the functioning of Earth’s ecosystems. We acknowledge funding from the Smithsonian Institution and the Tula Foundation. Este artículo contiene 7 páginas, 3 figuras, 1 tabla. Peer reviewed
Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2020 . Peer-reviewedeScholarship - University of CaliforniaArticle . 2020Data sources: eScholarship - University of CaliforniaArchivio della Ricerca - Università di PisaArticle . 2020Data sources: Archivio della Ricerca - Università di Pisaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2005255117&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 28 citations 28 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 52visibility views 52 download downloads 183 Powered bymore_vert Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2020 . Peer-reviewedeScholarship - University of CaliforniaArticle . 2020Data sources: eScholarship - University of CaliforniaArchivio della Ricerca - Università di PisaArticle . 2020Data sources: Archivio della Ricerca - Università di Pisaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2005255117&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu
Loading
description Publicationkeyboard_double_arrow_right Article 2023 Spain, NetherlandsPublisher:Proceedings of the National Academy of Sciences Funded by:NWO | Enhancing biodiversity-ba..., EC | SHOWCASENWO| Enhancing biodiversity-based ecosystem services to crops through optimized densities of green infrastructure in agricultural landscapes ,EC| SHOWCASEAuthors: Scheper, Jeroen; Badenhausser, Isabelle; Kantelhardt, Jochen; Kirchweger, Stefan; +8 AuthorsScheper, Jeroen; Badenhausser, Isabelle; Kantelhardt, Jochen; Kirchweger, Stefan; Bartomeus, Ignasi; Bretagnolle, Vincent; Clough, Yann; Gross, Nicolas; Raemakers, Ivo; Vilà, Montserrat; Zaragoza-Trello, Carlos; Kleijn, David;Agricultural expansion and intensification have boosted global food production but have come at the cost of environmental degradation and biodiversity loss. Biodiversity-friendly farming that boosts ecosystem services, such as pollination and natural pest control, is widely being advocated to maintain and improve agricultural productivity while safeguarding biodiversity. A vast body of evidence showing the agronomic benefits of enhanced ecosystem service delivery represent important incentives to adopt practices enhancing biodiversity. However, the costs of biodiversity-friendly management are rarely taken into account and may represent a major barrier impeding uptake by farmers. Whether and how biodiversity conservation, ecosystem service delivery, and farm profit can go hand in hand is unknown. Here, we quantify the ecological, agronomic, and net economic benefits of biodiversity-friendly farming in an intensive grassland–sunflower system in Southwest France. We found that reducing land-use intensity on agricultural grasslands drastically enhances flower availability and wild bee diversity, including rare species. Biodiversity-friendly management on grasslands furthermore resulted in an up to 17% higher revenue on neighboring sunflower fields through positive effects on pollination service delivery. However, the opportunity costs of reduced grassland forage yields consistently exceeded the economic benefits of enhanced sunflower pollination. Our results highlight that profitability is often a key constraint hampering adoption of biodiversity-based farming and uptake critically depends on society’s willingness to pay for associated delivery of public goods such as biodiversity. European Union 862480
Proceedings of the N... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; idUS. Depósito de Investigación de la Universidad de Sevilla.Article . 2023License: CC BY NC NDFull-Text: https://doi.org/10.1073/pnas.2212124120Mémoires en Sciences de l'Information et de la CommunicationArticle . 2023Full-Text: https://hal.science/hal-04167122/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2212124120&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 4 citations 4 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Proceedings of the N... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; idUS. Depósito de Investigación de la Universidad de Sevilla.Article . 2023License: CC BY NC NDFull-Text: https://doi.org/10.1073/pnas.2212124120Mémoires en Sciences de l'Information et de la CommunicationArticle . 2023Full-Text: https://hal.science/hal-04167122/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2212124120&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2022 FrancePublisher:Proceedings of the National Academy of Sciences Funded by:EC | ECOFEED, NSF | Collaborative Research: Q..., ANR | AQUATHERM +1 projectsEC| ECOFEED ,NSF| Collaborative Research: Quantifying Climate-forced Extinction Risks for Lizards, Amphibians, Fishes, and Plants ,ANR| AQUATHERM ,NSF| OPUS: CRS Conceptual and Analytical Synthesis of Ecomorphological insights into diversification and adaptationDupoué, Andréaz; Blaimont, Pauline; Angelier, Frédéric; Ribout, Cécile; Rozen-Rechels, David; Richard, Murielle; Miles, Donald; de Villemereuil, Pierre; Rutschmann, Alexis; Badiane, Arnaud; Aubret, Fabien; Lourdais, Olivier; Meylan, Sandrine; Cote, Julien; Clobert, Jean; Le Galliard, Jean-François;Aging is the price to pay for acquiring and processing energy through cellular activity and life history productivity. Climate warming can exacerbate the inherent pace of aging, as illustrated by a faster erosion of protective telomere DNA sequences. This biomarker integrates individual pace of life and parental effects through the germline, but whether intra- and intergenerational telomere dynamics underlies population trends remains an open question. Here, we investigated the covariation between life history, telomere length (TL), and extinction risk among three age classes in a cold-adapted ectotherm ( Zootoca vivipara ) facing warming-induced extirpations in its distribution limits. TL followed the same threshold relationships with population extinction risk at birth, maturity, and adulthood, suggesting intergenerational accumulation of accelerated aging rate in declining populations. In dwindling populations, most neonates inherited already short telomeres, suggesting they were born physiologically old and unlikely to reach recruitment. At adulthood, TL further explained females’ reproductive performance, switching from an index of individual quality in stable populations to a biomarker of reproductive costs in those close to extirpation. We compiled these results to propose the aging loop hypothesis and conceptualize how climate-driven telomere shortening in ectotherms may accumulate across generations and generate tipping points before local extirpation.
Proceedings of the N... arrow_drop_down ArchiMer - Institutional Archive of IfremerOther literature type . 2022Data sources: ArchiMer - Institutional Archive of IfremerHAL - UPEC / UPEM; HAL-InsermArticle . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2201371119&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 19 citations 19 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert Proceedings of the N... arrow_drop_down ArchiMer - Institutional Archive of IfremerOther literature type . 2022Data sources: ArchiMer - Institutional Archive of IfremerHAL - UPEC / UPEM; HAL-InsermArticle . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2201371119&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 France, Netherlands, Denmark, Denmark, France, France, France, FrancePublisher:F1000 Research Ltd Funded by:EC | BioExcel-2, EC | EOSC-LifeEC| BioExcel-2 ,EC| EOSC-LifeAnna-Lena Lamprecht; Magnus Palmblad; Jon Ison; Veit Schwämmle; Mohammad Sadnan Al Manir; Ilkay Altintas; Christopher J. O. Baker; A. Amor; Salvador Capella-Gutierrez; Paulos Charonyktakis; Michael R. Crusoe; Yolanda Gil; Carole Goble; Timothy J. Griffin; Paul Groth; Hans Ienasescu; Pratik D. Jagtap; Matúš Kalaš; Vedran Kasalica; Alireza Khanteymoori; Tobias Kuhn; Hailiang Mei; Hervé Ménager; Steffen Möller; Robin A. Richardson; Vincent Robert; Stian Soiland-Reyes; Robert Stevens; Szoke Szaniszlo; Suzan Verberne; Aswin Verhoeven; Katherine Wolstencroft;pmid: 34804501
pmc: PMC8573700
Scientific data analyses often combine several computational tools in automated pipelines, or workflows. Thousands of such workflows have been used in the life sciences, though their composition has remained a cumbersome manual process due to a lack of standards for annotation, assembly, and implementation. Recent technological advances have returned the long-standing vision of automated workflow composition into focus. This article summarizes a recent Lorentz Center workshop dedicated to automated composition of workflows in the life sciences. We survey previous initiatives to automate the composition process, and discuss the current state of the art and future perspectives. We start by drawing the “big picture” of the scientific workflow development life cycle, before surveying and discussing current methods, technologies and practices for semantic domain modelling, automation in workflow development, and workflow assessment. Finally, we derive a roadmap of individual and community-based actions to work toward the vision of automated workflow development in the forthcoming years. A central outcome of the workshop is a general description of the workflow life cycle in six stages: 1) scientific question or hypothesis, 2) conceptual workflow, 3) abstract workflow, 4) concrete workflow, 5) production workflow, and 6) scientific results. The transitions between stages are facilitated by diverse tools and methods, usually incorporating domain knowledge in some form. Formal semantic domain modelling is hard and often a bottleneck for the application of semantic technologies. However, life science communities have made considerable progress here in recent years and are continuously improving, renewing interest in the application of semantic technologies for workflow exploration, composition and instantiation. Combined with systematic benchmarking with reference data and large-scale deployment of production-stage workflows, such technologies enable a more systematic process of workflow development than we know today. We believe that this can lead to more robust, reusable, and sustainable workflows in the future.
NARCIS arrow_drop_down Europe PubMed CentralArticle . 2021 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC8573700Data sources: PubMed CentralLeiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2021License: CC BYUniversity of Southern Denmark Research Output; F1000ResearchOther literature type . Article . 2021Data sources: University of Southern Denmark Research OutputF1000ResearchArticle . 2021Online Research Database In TechnologyArticle . 2021 . Peer-reviewedData sources: Online Research Database In Technologyadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.12688/f1000research.54159.1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 7 citations 7 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert NARCIS arrow_drop_down Europe PubMed CentralArticle . 2021 . Peer-reviewedFull-Text: http://europepmc.org/articles/PMC8573700Data sources: PubMed CentralLeiden University Scholarly Publications Repository; NARCISOther literature type . Article . 2021License: CC BYUniversity of Southern Denmark Research Output; F1000ResearchOther literature type . Article . 2021Data sources: University of Southern Denmark Research OutputF1000ResearchArticle . 2021Online Research Database In TechnologyArticle . 2021 . Peer-reviewedData sources: Online Research Database In Technologyadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.12688/f1000research.54159.1&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2021 Italy, Croatia, ItalyPublisher:Proceedings of the National Academy of Sciences Funded by:EC | HIDDEN FOODSEC| HIDDEN FOODSClaudio Ottoni; Dusan Boric; Olivia Cheronet; Vitale Sparacello; Irene Dori; Alfredo Coppa; Dragana Antonović; Dario Vujević; T. Douglas Price; Ron Pinhasi; Emanuela Cristiani;Archaeological dental calculus, or mineralized plaque, is a key tool to track the evolution of oral microbiota across time in response to processes that impacted our culture and biology, such as the rise of farming during the Neolithic. However, the extent to which the human oral flora changed from prehistory until present has remained elusive due to the scarcity of data on the microbiomes of prehistoric humans. Here, we present our reconstruction of oral microbiomes via shotgun metagenomics of dental calculus in 44 ancient foragers and farmers from two regions playing a pivotal role in the spread of farming across Europe—the Balkans and the Italian Peninsula. We show that the introduction of farming in Southern Europe did not alter significantly the oral microbiomes of local forager groups, and it was in particular associated with a higher abundance of the species Olsenella sp. oral taxon 807. The human oral environment in prehistory was dominated by a microbial species, Anaerolineaceae bacterium oral taxon 439, that diversified geographically. A Near Eastern lineage of this bacterial commensal dispersed with Neolithic farmers and replaced the variant present in the local foragers. Our findings also illustrate that major taxonomic shifts in human oral microbiome composition occurred after the Neolithic and that the functional profile of modern humans evolved in recent times to develop peculiar mechanisms of antibiotic resistance that were previously absent. Significance The oral microbial community living in symbiosis with humans is a rich and diverse driver of health and disease that is strongly influenced by our ecology and lifestyle. However, its evolution across human prehistory remains elusive. By analyzing the DNA entrapped in archaeological dental calculus, we characterize the oral microbiomes of 44 prehistoric foragers and farmers from Southern Europe. We demonstrate that the genome of an oral bacteria diversified geographically and recorded one of the most dramatic changes in our biological and cultural history, the spread of farming. The transition to agriculture did not alter significantly the oral microbiome of ancient humans, whereas more significant changes occurred later in history, including the development of peculiar antibiotic resistance pathways.
Archivio della ricer... arrow_drop_down Archivio della ricerca- Università di Roma La Sapienza; Archivio della Ricerca - Università di Roma Tor vergata; Proceedings of the National Academy of Sciences; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2021 . Peer-reviewedLicense: CC BY NC NDEurope PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8364157Data sources: PubMed CentralArchivio della ricerca- Università di Roma La SapienzaArticle . 2021Data sources: Archivio della ricerca- Università di Roma La SapienzaArchivio della Ricerca - Università di Roma Tor vergataArticle . 2021Data sources: Archivio della Ricerca - Università di Roma Tor vergataadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2102116118&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 26 citations 26 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Archivio della ricer... arrow_drop_down Archivio della ricerca- Università di Roma La Sapienza; Archivio della Ricerca - Università di Roma Tor vergata; Proceedings of the National Academy of Sciences; Croatian Scientific Bibliography - CROSBIOther literature type . Article . 2021 . Peer-reviewedLicense: CC BY NC NDEurope PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8364157Data sources: PubMed CentralArchivio della ricerca- Università di Roma La SapienzaArticle . 2021Data sources: Archivio della ricerca- Università di Roma La SapienzaArchivio della Ricerca - Università di Roma Tor vergataArticle . 2021Data sources: Archivio della Ricerca - Università di Roma Tor vergataadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2102116118&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 Italy, Switzerland, Italy, Italy, Lithuania, Bulgaria, Spain, Germany, Italy, Czech Republic, France, Italy, Italy, NetherlandsPublisher:Proceedings of the National Academy of Sciences Funded by:FWF | The Global Naturalized Al...FWF| The Global Naturalized Alien Flora (GloNAF) databaseTrevor S. Fristoe; Milan Chytrý; Wayne Dawson; Franz Essl; Rubén H. Heleno; Holger Kreft; Noëlie Maurel; Jan Pergl; Petr Pyšek; Hanno Seebens; Patrick Weigelt; Pablo Vargas; Qiang Yang; Fabio Attorre; Erwin Bergmeier; Markus Bernhardt-Römermann; Idoia Biurrun; Steffen Boch; Gianmaria Bonari; Zoltán Botta-Dukát; Hans Henrik Bruun; Chaeho Byun; Andraž Čarni; Maria Laura Carranza; Jane A. Catford; Bruno Enrico Leone Cerabolini; Eduardo Chacón-Madrigal; Daniela Ciccarelli; Renata Ćušterevska; Iris de Ronde; Jürgen Dengler; Valentin Golub; Rense Haveman; Nate Hough-Snee; Ute Jandt; Florian Jansen; Anna Kuzemko; Filip Küzmič; Jonathan Lenoir; Armin Macanović; Corrado Marcenò; Adam R. Martin; Sean T. Michaletz; Akira Mori; Ülo Niinemets; Tomáš Peterka; Remigiusz Pielech; Valerijus Rašomavičius; Solvita Rūsiņa; Arildo S. Dias; Mária Šibíková; Urban Šilc; Angela Stanisci; Steven Jansen; Jens-Christian Svenning; Grzegorz Swacha; Fons van der Plas; Kiril Vassilev; Mark van Kleunen;pmc: PMC8179145
pmid: 34050023
handle: 11695/99627 , 11391/1505754 , 10261/262510 , 11365/1248645 , 11573/1661226 , 11104/0324950
pmc: PMC8179145
pmid: 34050023
handle: 11695/99627 , 11391/1505754 , 10261/262510 , 11365/1248645 , 11573/1661226 , 11104/0324950
Understanding drivers of success for alien species can inform on potential future invasions. Recent conceptual advances highlight that species may achieve invasiveness via performance along at least three distinct dimensions: 1) local abundance, 2) geographic range size, and 3) habitat breadth in naturalized distributions. Associations among these dimensions and the factors that determine success in each have yet to be assessed at large geographic scales. Here, we combine data from over one million vegetation plots covering the extent of Europe and its habitat diversity with databases on species' distributions, traits, and historical origins to provide a comprehensive assessment of invasiveness dimensions for the European alien seed plant flora. Invasiveness dimensions are linked in alien distributions, leading to a continuum from overall poor invaders to super invaders - abundant, widespread aliens that invade diverse habitats. This pattern echoes relationships among analogous dimensions measured for native European species. Success along invasiveness dimensions was associated with details of alien species' introduction histories: earlier introduction dates were positively associated with all three dimensions, and consistent with theory-based expectations, species originating from other continents, particularly acquisitive growth strategists, were among the most successful invaders in Europe. Despite general correlations among invasiveness dimensions, we identified habitats and traits associated with atypical patterns of success in only one or two dimensions - for example, the role of disturbed habitats in facilitating widespread specialists. We conclude that considering invasiveness within a multidimensional framework can provide insights into invasion processes while also informing general understanding of the dynamics of species distributions. Deutsche Forschungsgemeinschaft (264740629) Grantová Agentura České Republiky (19-28491X) Grantová Agentura České Republiky (19-28807X) Grantová Agentura České Republiky (RVO 67985939) Austrian Science Fund (I 2086 - B29) Bundesministerium für Bildung und Forschung (01LC1807A) Eusko Jaurlaritza (IT299-10) National Research Foundation of Korea (2018R1C1B6005351) University of Latvia (AAp2016/B041//Zd2016/AZ03) Villum Fonden (16549)
Research@WUR; Archiv... arrow_drop_down Research@WUR; Archivio della ricerca- Università di Roma La Sapienza; PURE Aarhus University; Proceedings of the National Academy of SciencesOther literature type . Article . 2021 . Peer-reviewedArchivio della ricerca- Università di Roma La SapienzaArticle . 2021Data sources: Archivio della ricerca- Università di Roma La SapienzaInstitutional Repository of Nature Research CentreOther literature type . 2021License: CC BYData sources: Institutional Repository of Nature Research CentreRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2021 . 2022Repository of the Czech Academy of SciencesArticle . 2021Data sources: Repository of the Czech Academy of SciencesRepository of the Czech Academy of SciencesArticle . 2021Data sources: Repository of the Czech Academy of SciencesMémoires en Sciences de l'Information et de la CommunicationArticle . 2021Full-Text: https://hal.science/hal-03362885/documentArchivio della Ricerca - Università di PisaArticle . 2021Data sources: Archivio della Ricerca - Università di Pisaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2021173118&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 41 citations 41 popularity Top 1% influence Average impulse Top 1% Powered by BIP!visibility 159visibility views 159 download downloads 92 Powered bymore_vert Research@WUR; Archiv... arrow_drop_down Research@WUR; Archivio della ricerca- Università di Roma La Sapienza; PURE Aarhus University; Proceedings of the National Academy of SciencesOther literature type . Article . 2021 . Peer-reviewedArchivio della ricerca- Università di Roma La SapienzaArticle . 2021Data sources: Archivio della ricerca- Università di Roma La SapienzaInstitutional Repository of Nature Research CentreOther literature type . 2021License: CC BYData sources: Institutional Repository of Nature Research CentreRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2021 . 2022Repository of the Czech Academy of SciencesArticle . 2021Data sources: Repository of the Czech Academy of SciencesRepository of the Czech Academy of SciencesArticle . 2021Data sources: Repository of the Czech Academy of SciencesMémoires en Sciences de l'Information et de la CommunicationArticle . 2021Full-Text: https://hal.science/hal-03362885/documentArchivio della Ricerca - Università di PisaArticle . 2021Data sources: Archivio della Ricerca - Università di Pisaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2021173118&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 United Kingdom, Spain, Canada, ItalyPublisher:Proceedings of the National Academy of Sciences Funded by:UKRI | Genomic imprinting and th..., WTUKRI| Genomic imprinting and the epigenetic control of developmental processes ,WTRaquel Montalbán-Loro; Glenda Lassi; Anna Lozano-Ureña; Ana Perez-Villalba; Esteban Jiménez-Villalba; Marika Charalambous; Giorgio Vallortigara; Alexa E. Horner; Lisa M. Saksida; Timothy J. Bussey; José Luis Trejo; Valter Tucci; Anne C. Ferguson-Smith; Sacri R. Ferrón;Neurogenesis in the adult brain gives rise to functional neurons, which integrate into neuronal circuits and modulate neural plasticity. Sustained neurogenesis throughout life occurs in the subgranular zone (SGZ) of the dentate gyrus in the hippocampus and is hypothesized to be involved in behavioral/cognitive processes such as memory and in diseases. Genomic imprinting is of critical importance to brain development and normal behavior, and exemplifies how epigenetic states regulate genome function and gene dosage. While most genes are expressed from both alleles, imprinted genes are usually expressed from either the maternally or the paternally inherited chromosome. Here, we show that in contrast to its canonical imprinting in nonneurogenic regions, Delta-like homolog 1 (Dlk1) is expressed biallelically in the SGZ, and both parental alleles are required for stem cell behavior and normal adult neurogenesis in the hippocampus. To evaluate the effects of maternally, paternally, and biallelically inherited mutations within the Dlk1 gene in specific behavioral domains, we subjected Dlk1-mutant mice to a battery of tests that dissociate and evaluate the effects of Dlk1 dosage on spatial learning ability and on anxiety traits. Importantly, reduction in Dlk1 levels triggers specific cognitive abnormalities that affect aspects of discriminating differences in environmental stimuli, emphasizing the importance of selective absence of imprinting in this neurogenic niche. This work was supported by grants from Ministerio de Economía y Competitividad (SAF2016-78845-R and PID2019-110045GB-I00), Fundación Banco Bilbao Vizcaya Argentaria, and Generalitat Valenciana (AICO/2020/367) to S.R.F. and grants from the Medical Research Council (MR/R009791/1), Wellcome Trust (21757/Z/18/Z), and European Union FP7 Ingenium Training Network to A.C.F.-S. R.M.-L. was funded by a Spanish Researchers Formation program, and A.L.-U. was fundedby the Generalitat Valenciana fellowship program.
IRIS - Institutional... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2021Full-Text: http://europepmc.org/articles/PMC7980393Data sources: PubMed CentralProceedings of the National Academy of SciencesArticle . 2021 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2021Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2021 . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2015505118&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 14 citations 14 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 32visibility views 32 download downloads 119 Powered bymore_vert IRIS - Institutional... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2021Full-Text: http://europepmc.org/articles/PMC7980393Data sources: PubMed CentralProceedings of the National Academy of SciencesArticle . 2021 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefRecolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2021Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2021 . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2015505118&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021 BelgiumPublisher:Proceedings of the National Academy of Sciences Funded by:EC | POLYADAPTEC| POLYADAPTVlogiannitis, Spyridon; Mavridis, Konstantinos; Dermauw, Wannes; Snoeck, Simon; Katsavou, Evangelia; Morou, Evangelia; Harizanis, Paschalis; Swevers, Luc; Hemingway, Janet; Feyereisen, René; Van Leeuwen, Thomas; Vontas, John;Varroa destructor is one of the main problems in modern beekeeping. Highly selective acaricides with low toxicity to bees are used internationally to control this mite. One of the key acaricides is the organophosphorus (OP) proinsecticide coumaphos, that becomes toxic after enzymatic activation inside Varroa. We show here that mites from the island Andros (AN-CR) exhibit high levels of coumaphos resistance. Resistance is not mediated by decreased coumaphos uptake, target-site resistance, or increased detoxification. Reduced proinsecticide activation by a cytochrome P450 enzyme was the main resistance mechanism, a powerful and rarely encountered evolutionary solution to insecticide selection pressure. After treatment with sublethal doses of [(14)C] coumaphos, susceptible mite extracts had substantial amounts of coroxon, the activated metabolite of coumaphos, while resistant mites had only trace amounts. This indicates a suppression of the P450 (CYP)-mediated activation step in the AN-CR mites. Bioassays with coroxon to bypass the activation step showed that resistance was dramatically reduced. There are 26 CYPs present in the V. destructor genome. Transcriptome analysis revealed overexpression in resistant mites of CYP4DP24 and underexpression of CYP3012A6 and CYP4EP4. RNA interference of CYP4EP4 in the susceptible population, to mimic underexpression seen in the resistant mites, prevented coumaphos activation and decreased coumaphos toxicity.
Proceedings of the N... arrow_drop_down Proceedings of the National Academy of SciencesOther literature type . Article . 2021 . Peer-reviewedGhent University Academic BibliographyArticle . 2021Data sources: Ghent University Academic BibliographyGhent University Academic BibliographyArticle . 2021Data sources: Ghent University Academic Bibliographyadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2020380118&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 40 citations 40 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 4visibility views 4 download downloads 13 Powered bymore_vert Proceedings of the N... arrow_drop_down Proceedings of the National Academy of SciencesOther literature type . Article . 2021 . Peer-reviewedGhent University Academic BibliographyArticle . 2021Data sources: Ghent University Academic BibliographyGhent University Academic BibliographyArticle . 2021Data sources: Ghent University Academic Bibliographyadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2020380118&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2021Publisher:Proceedings of the National Academy of Sciences Kevin M. Huang; Megan E. Zavorka Thomas; Tarek Magdy; Eric D. Eisenmann; Muhammad Erfan Uddin; Duncan DiGiacomo; Alexander Pan; Markus Keiser; Marcus Otter; Sherry H. Xia; Yang Li; Yan Jin; Qiang Fu; Alice A. Gibson; Ingrid M. Bonilla; Cynthia A. Carnes; Kara N. Corps; Vincenzo Coppola; Sakima A. Smith; Daniel Addison; Anne T. Nies; Ralf Bundschuh; Taosheng Chen; Maryam B. Lustberg; Joanne Wang; Stefan Oswald; Moray J. Campbell; Pearlly S. Yan; Sharyn D. Baker; Shuiying Hu; Paul W. Burridge; Alex Sparreboom;Doxorubicin is a commonly used anticancer agent that can cause debilitating and irreversible cardiac injury. The initiating mechanisms contributing to this side effect remain unknown, and current preventative strategies offer only modest protection. Using stem-cell-derived cardiomyocytes from patients receiving doxorubicin, we probed the transcriptomic landscape of solute carriers and identified organic cation transporter 3 (OCT3) (SLC22A3) as a critical transporter regulating the cardiac accumulation of doxorubicin. Functional validation studies in heterologous overexpression models confirmed that doxorubicin is transported into cardiomyocytes by OCT3 and that deficiency of OCT3 protected mice from acute and chronic doxorubicin-related changes in cardiovascular function and genetic pathways associated with cardiac damage. To provide proof-of-principle and demonstrate translational relevance of this transport mechanism, we identified several pharmacological inhibitors of OCT3, including nilotinib, and found that pharmacological targeting of OCT3 can also preserve cardiovascular function following treatment with doxorubicin without affecting its plasma levels or antitumor effects in multiple models of leukemia and breast cancer. Finally, we identified a previously unrecognized, OCT3-dependent pathway of doxorubicin-induced cardiotoxicity that results in a downstream signaling cascade involving the calcium-binding proteins S100A8 and S100A9. These collective findings not only shed light on the etiology of doxorubicin-induced cardiotoxicity, but also are of potential translational relevance and provide a rationale for the implementation of a targeted intervention strategy to prevent this debilitating side effect.
Proceedings of the N... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2021 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2020168118&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 34 citations 34 popularity Top 1% influence Average impulse Top 10% Powered by BIP!more_vert Proceedings of the N... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2021 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2020168118&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2020 FrancePublisher:Proceedings of the National Academy of Sciences Funded by:NSERCNSERCMatthew P. Duda; Sylvie Allen-Mahé; Christophe Barbraud; Jules M. Blais; Amaël Boudreau; Rachel Bryant; Karine Delord; Christopher Grooms; Linda E. Kimpe; Bruno Letournel; Joeline E Lim; Hervé Lormée; Neal Michelutti; Gregory J. Robertson; Frank Urtizbéréa; Sabina I. Wilhelm; John P. Smol;International audience; Recent estimates indicate that ∼70% of the world’s seabird populations have declined since the 1950s due to human activities. However, for almost all bird populations, there is insufficient long-term monitoring to understand baseline (i.e., preindustrial) conditions, which are required to distinguish natural versus anthropogenically driven changes. Here, we address this lack of long-term monitoring data with multiproxy paleolimnological approaches to examine the long-term population dynamics of a major colony of Leach’s Storm-petrel (Hydrobates leucorhous) on Grand Colombier Island in the St. Pierre and Miquelon archipelago—an overseas French territory in the northwest Atlantic Ocean. By reconstructing the last ∼5,800 y of storm-petrel dynamics, we demonstrate that this colony underwent substantial natural fluctuations until the start of the 19th century, when population cycles were disrupted, coinciding with the establishment and expansion of a European settlement. Our paleoenvironmental data, coupled with on-the-ground population surveys, indicate that the current colony is only ∼16% of the potential carrying capacity, reinforcing concerning trends of globally declining seabird populations. As seabirds are sentinel species of marine ecosystem health, such declines provide a call to action for global conservation. In response, we emphasize the need for enlarged protected areas and the rehabilitation of disturbed islands to protect ecologically critical seabird populations. Furthermore, long-term data, such as those provided by paleoecological approaches, are required to better understand shifting baselines in conservation to truly recognize current rates of ecological loss.
Europe PubMed Centra... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2020 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2016811117&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 12 citations 12 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2020 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2016811117&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2020 Italy, Brazil, United States, United Kingdom, Spain, FrancePublisher:Proceedings of the National Academy of Sciences Publicly fundedMatthew A. Whalen; Ross Whippo; John J. Stachowicz; Paul H. York; Erin Aiello; Teresa Alcoverro; Andrew H. Altieri; Lisandro Benedetti-Cecchi; Camilla Bertolini; Midoli Bresch; Fabio Bulleri; Paul E. Carnell; Stéphanie Cimon; Rod M. Connolly; Mathieu Cusson; Meredith S. Diskin; Elrika D’Souza; Augusto A. V. Flores; F. Joel Fodrie; Aaron W. E. Galloway; Lindsay C. Gaskins; Olivia J. Graham; Torrance C. Hanley; Christopher J. Henderson; Clara M. Hereu; Margot Hessing-Lewis; Kevin A. Hovel; Brent B. Hughes; A. Randall Hughes; Kristin M. Hultgren; Holger Jänes; Dean S. Janiak; Lane N. Johnston; Pablo Jorgensen; Brendan P. Kelaher; Claudia Kruschel; Brendan S. Lanham; Kun-Seop Lee; Jonathan S. Lefcheck; Enrique Lozano-Álvarez; Peter I. Macreadie; Zachary L. Monteith; Nessa E. O'Connor; Andrew D. Olds; Jennifer K. O'Leary; Christopher J. Patrick; Oscar Pino; Alistair G. B. Poore; Michael Rasheed; Wendel W. Raymond; Katrin Reiss; O. Kennedy Rhoades; Max T. Robinson; Paige G. Ross; Francesca Rossi; Thomas A. Schlacher; Janina Seemann; Brian R. Silliman; Delbert L. Smee; Martin Thiel; Richard K. F. Unsworth; Brigitta I. van Tussenbroek; Adriana Vergés; Mallarie E. Yeager; Bree K. Yednock; Shelby L. Ziegler; J. Emmett Duffy;The global distribution of primary production and consumption by humans (fisheries) is well-documented, but we have no map linking the central ecological process of consumption within food webs to temperature and other ecological drivers. Using standardized assays that span 105° of latitude on four continents, we show that rates of bait consumption by generalist predators in shallow marine ecosystems are tightly linked to both temperature and the composition of consumer assemblages. Unexpectedly, rates of consumption peaked at midlatitudes (25 to 35°) in both Northern and Southern Hemispheres across both seagrass and unvegetated sediment habitats. This pattern contrasts with terrestrial systems, where biotic interactions reportedly weaken away from the equator, but it parallels an emerging pattern of a subtropical peak in marine biodiversity. The higher consumption at midlatitudes was closely related to the type of consumers present, which explained rates of consumption better than consumer density, biomass, species diversity, or habitat. Indeed, the apparent effect of temperature on consumption was mostly driven by temperature-associated turnover in consumer community composition. Our findings reinforce the key influence of climate warming on altered species composition and highlight its implications for the functioning of Earth’s ecosystems. We acknowledge funding from the Smithsonian Institution and the Tula Foundation. Este artículo contiene 7 páginas, 3 figuras, 1 tabla. Peer reviewed
Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2020 . Peer-reviewedeScholarship - University of CaliforniaArticle . 2020Data sources: eScholarship - University of CaliforniaArchivio della Ricerca - Università di PisaArticle . 2020Data sources: Archivio della Ricerca - Università di Pisaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2005255117&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 28 citations 28 popularity Top 10% influence Average impulse Top 10% Powered by BIP!visibility 52visibility views 52 download downloads 183 Powered bymore_vert Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2020 . Peer-reviewedeScholarship - University of CaliforniaArticle . 2020Data sources: eScholarship - University of CaliforniaArchivio della Ricerca - Università di PisaArticle . 2020Data sources: Archivio della Ricerca - Università di Pisaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2005255117&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu