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description Publicationkeyboard_double_arrow_right Article 2023 United Kingdom, Former Yugoslav Republic of Macedonia, France, Finland, Spain, Italy, ItalyPublisher:American Association for the Advancement of Science (AAAS) Funded by:EC | CURE, NIH | Developing, Demonstrating..., NIH | Inborn errors of immunity... +6 projectsEC| CURE ,NIH| Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success ,NIH| Inborn errors of immunity in patients with life-threatening COVID-19 ,NIH| IL-13/17-regulated airway epithelial miRNAs in asthma ,EC| ImmunAID ,NIH| Monogenic basis of resistance to SARS-CoV2 and predisposition to severe COVID-19 ,NIH| CORE--BIOSTATISTICS FACILITY ,EC| EASI-Genomics ,ANR| AABIFNCOVBastard, Paul; Vazquez, Sara; Liu, Jamin; Laurie, Matthew, T; Wang, Chung, Yu; Gervais, Adrian; Le Voyer, Tom; Bizien, Lucy; Zamecnik, Colin; Philippot, Quentin; Rosain, Jérémie; Catherinot, Emilie; Willmore, Andrew; Mitchell, Anthea, M; Bair, Rebecca; Garçon, Pierre; Kenney, Heather; Fekkar, Arnaud; Salagianni, Maria; Poulakou, Garyphallia; Siouti, Eleni; Sahanic, Sabina; Tancevski, Ivan; Weiss, Günter; Nagl, Laurenz; Manry, Jérémy; Duvlis, Sotirija; Arroyo-Sánchez, Daniel; Paz Artal, Estela; Rubio, Luis; Perani, Cristiano; Bezzi, Michela; Sottini, Alessandra; Quaresima, Virginia; Roussel, Lucie; Vinh, Donald, C; Reyes, Luis, Felipe; Garzaro, Margaux; Hatipoglu, Nevin; Boutboul, David; Tandjaoui-Lambiotte, Yacine; Borghesi, Alessandro; Aliberti, Anna; Cassaniti, Irene; Venet, Fabienne; Monneret, Guillaume; Halwani, Rabih; Sharif-Askari, Narjes, Saheb; Danielson, Jeffrey; Burrel, Sonia; Morbieu, Caroline; Stepanovskyy, Yurii; Bondarenko, Anastasia; Volokha, Alla; Boyarchuk, Oksana; Gagro, Alenka; Neuville, Mathilde; Neven, Bénédicte; Keles, Sevgi; Hernu, Romain; Bal, Antonin; Novelli, Antonio; Novelli, Giuseppe; Saker, Kahina; Ailioaie, Oana; Antolí, Arnau; Jeziorski, Eric; Rocamora-Blanch, Gemma; Teixeira, Carla; Delaunay, Clarisse; Lhuillier, Marine; Le Turnier, Paul; Zhang, Yu; Mahevas, Matthieu; Pan-Hammarström, Qiang; Abolhassani, Hassan; Bompoil, Thierry; Dorgham, Karim; Gorochov, Guy; Laouenan, Cédric; Rodríguez-Gallego, Carlos; Ng, Lisa, F P; Renia, Laurent; Pujol, Aurora; Belot, Alexandre; Raffi, François; Allende, Luis, M; Martinez-Picado, Javier; Ozcelik, Tayfun; Keles, Sevgi; Imberti, Luisa; Notarangelo, Luigi, D; Troya, Jesus; Solanich, Xavier; Zhang, Shen-Ying; Puel, Anne; Wilson, Michael, R; Trouillet-Assant, Sophie; Abel, Laurent; Jouanguy, Emmanuelle; Ye, Chun, Jimmie; Cobat, Aurélie; Thompson, Leslie, M; Andreakos, Evangelos; Zhang, Qian; Anderson, Mark, S; Casanova, Jean-Laurent; Derisi, Joseph, L; Abel, Laurent; Achille, Cristian; Aiuti, Alessandro; Al-Muhsen, Saleh; Al-Mulla, Fahd; Anderson, Mark, S; Andreakos, Evangelos; Angelini, Micol; Arias, Andrés, A; Aytekin, Gokhan; Baldanti, Fausto; Feldman, Hagit, Baris; Belot, Alexandre; Bergami, Federica; Biggs, Catherine, M; Bogunovic, Dusan; Bolze, Alexandre; Bondarenko, Anastasiia; Bousfiha, Ahmed, A; Brodin, Petter; Bryceson, Yenan; Bustamante, Carlos, D; Butte, Manish, J; Casari, Giorgio; Christodoulou, John; Condino-Neto, Antonio; Constantinescu, Stefan, N; Conti, Francesca; Cooper, Megan, A; Dalgard, Clifton, L; Desai, Murkesh; Drolet, Beth, A; El Baghdadi, Jamila; Ergun, Recai; Ergun, Dilek; Espinosa-Padilla, Sara; Fellay, Jacques; Flores, Carlos; Franco, José, Luis; Froidure, Antoine; Ghirardello, Stefano; Gregersen, Peter, K; Grimbacher, Bodo; Haerynck, Filomeen; Hagin, David; Halwani, Rabih; Hammarström, Lennart; Heath, James, R; Henrickson, Sarah, E; Hsieh, Elena, W Y; Husebye, Eystein; Imai, Kohsuke; Itan, Yuval; Jarvis, Erich, D; Kanat, Fikret; Karamitros, Timokratis; Kisand, Kai; Kopcha, Vasyl; Korda, Mykhaylo; Ku, Cheng-Lung; Lau, Yu-Lung; Ling, Yun; Lucas, Carrie, L; Maniatis, Tom; Mansouri, Davood; Maródi, László; Meyts, Isabelle; Milner, Joshua, D; Mironska, Kristina; Mogensen, Trine, H; Mojoli, Francesco; Morandeira, Francisco; Morio, Tomohiro; Ng, Lisa, F P; Notarangelo, Luigi, D; Novelli, Antonio; Novelli, Giuseppe; O'Farrelly, Cliona; Okada, Satoshi; Okamoto, Keisuke; Ozcelik, Tayfun; Pagani, Michele; Pan-Hammarström, Qiang; Pape, Jean, W; de Diego, Rebeca, Perez; Perlin, David, S; Pesole, Graziano; Pession, Andrea; Piralla, Antonio; Planas, Anna, M; Prando, Carolina; Pujol, Aurora; Rigo-Bonnin, Raúl; Seppänen, Mikko, R J; Uddin, K, M Furkan;International audience; Life-threatening ‘breakthrough’ cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS-CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; however, their contribution to hypoxemic breakthrough cases in vaccinated people remains unknown. Here, we studied a cohort of 48 individuals (age 20-86 years) who received 2 doses of an mRNA vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Antibody levels to the vaccine, neutralization of the virus, and auto-Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal antibody response to the vaccine. Among them, ten (24%) had auto-Abs neutralizing type I IFNs (aged 43-86 years). Eight of these ten patients had auto-Abs neutralizing both IFN-α2 and IFN-ω, while two neutralized IFN-ω only. No patient neutralized IFN-β. Seven neutralized 10 ng/mL of type I IFNs, and three 100 pg/mL only. Seven patients neutralized SARS-CoV-2 D614G and the Delta variant (B.1.617.2) efficiently, while one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only 100 pg/mL of type I IFNs neutralized both D61G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating antibodies capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a significant proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population.
UGD Academic Reposit... arrow_drop_down Oxford University Research Archive; Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele; Archivio della Ricerca - Università di Roma Tor vergata; Science ImmunologyOther literature type . Article . 2024 . 2023 . 2022 . Peer-reviewedLicense: CC BYHELDA - Digital Repository of the University of HelsinkiArticle . 2023 . Peer-reviewedData sources: HELDA - Digital Repository of the University of HelsinkiRecolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2022License: CC BYArchivio della Ricerca - Università di Roma Tor vergataArticle . 2022Data sources: Archivio della Ricerca - Università di Roma Tor vergataadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesbronze 28 citations 28 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert UGD Academic Reposit... arrow_drop_down Oxford University Research Archive; Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele; Archivio della Ricerca - Università di Roma Tor vergata; Science ImmunologyOther literature type . Article . 2024 . 2023 . 2022 . Peer-reviewedLicense: CC BYHELDA - Digital Repository of the University of HelsinkiArticle . 2023 . Peer-reviewedData sources: HELDA - Digital Repository of the University of HelsinkiRecolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2022License: CC BYArchivio della Ricerca - Università di Roma Tor vergataArticle . 2022Data sources: Archivio della Ricerca - Università di Roma Tor vergataadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint , Other literature type 2023 FrancePublisher:Cold Spring Harbor Laboratory William Bolland; Vincent Michel; Delphine Planas; Mathieu Hubert; Florence Guivel-Benhassine; Françoise Porrot; Isabelle Staropoli; Mélissa N’Debi; Christophe Rodriguez; Slim Fourati; Matthieu Prot; Cyril Planchais; Laurent Hocqueloux; Etienne Simon-Lorière; Hugo Mouquet; Thierry Prazuck; Jean-Michel Pawlotsky; Timothée Bruel; Olivier Schwartz; Julian Buchrieser;ABSTRACT SARS-CoV-2 variants with undetermined properties have emerged intermittently throughout the COVID-19 pandemic. Some variants possess unique phenotypes and mutations which allow further characterization of viral evolution and Spike functions. Around 1,100 cases of the B.1.640.1 variant were reported in Africa and Europe between 2021 and 2022, before the expansion of Omicron. Here, we analyzed the biological properties of a B.1.640.1 isolate and its Spike. Compared to the ancestral Spike, B.1.640.1 carried 14 amino acid substitutions and deletions. B.1.640.1 escaped binding by some anti-N-terminal domain and anti-receptor-binding domain monoclonal antibodies, and neutralization by sera from convalescent and vaccinated individuals. In cell lines, infection generated large syncytia and a high cytopathic effect. In primary airway cells, B.1.640.1 replicated less than Omicron BA.1 and triggered more syncytia and cell death than other variants. The B.1.640.1 Spike was highly fusogenic when expressed alone. This was mediated by two poorly characterized and infrequent mutations located in the Spike S2 domain, T859N and D936H. Altogether, our results highlight the cytopathy of a hyper-fusogenic SARS-CoV-2 variant, supplanted upon the emergence of Omicron BA.1. (This study has been registered at ClinicalTrials.gov under registration no. NCT04750720.) IMPORTANCE Our results highlight the plasticity of SARS-CoV-2 Spike to generate highly fusogenic and cytopathic strains with the causative mutations being uncharacterized in previous variants. We describe mechanisms regulating the formation of syncytia and the subsequent consequences in a primary culture model, which are poorly understood.
Europe PubMed Centra... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesbronze 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 France, Switzerland, Spain, United KingdomPublisher:Elsevier BV Funded by:WT | PubMLST: Disseminating an..., WT | Human Genetics and Diseas..., WT | Investigating the diversi...WT| PubMLST: Disseminating and exploiting bacterial diversity data for public health benefit ,WT| Human Genetics and Disease Biology: Core Renewal for the Wellcome Trust Centre for Human Genetics ,WT| Investigating the diversity, molecular epidemiology, competitive influence and therapeutic potential of pneumococcal bacteriocins using large genome datasetsShaw, David; Abad, Raquel; Amin-Chowdhury, Zahin; Bautista, Adriana; Bennett, Desiree; Broughton, Karen; Cao, Bin; Casanova, Carlo; Choi, Eun Hwa; Chu, Yiu-Wai; Claus, Heike; Coelho, Juliana; Corcoran, Mary; Cottrell, Simon; Cunney, Robert; Cuypers, Lize; Dalby, Tine; Davies, Heather; de Gouveia, Linda; Deghmane, Ala-Eddine; Demczuk, Walter; Desmet, Stefanie; Domenech, Mirian; Drew, Richard; du Plessis, Mignon; Duarte, Carolina; Erlendsdóttir, Helga; Fry, Norman K; Fuursted, Kurt; Hale, Thomas; Henares, Desiree; Henriques-Normark, Birgitta; Hilty, Markus; Hoffmann, Steen; Humphreys, Hilary; Ip, Margaret; Jacobsson, Susanne; Johnson, Christopher; Johnston, Jillian; Jolley, Keith A; Kawabata, Aníbal; Kozakova, Jana; Kristinsson, Karl G; Krizova, Pavla; Kuch, Alicja; Ladhani, Shamez; Lâm, Thiên-Trí; León, María Eugenia; Lindholm, Laura; Litt, David; Maiden, Martin C J; Martin, Irene; Martiny, Delphine; Mattheus, Wesley; McCarthy, Noel D; Meehan, Mary; Meiring, Susan; Mölling, Paula; Morfeldt, Eva; Morgan, Julie; Mulhall, Robert; Muñoz-Almagro, Carmen; Murdoch, David; Murphy, Joy; Musilek, Martin; Mzabi, Alexandre; Novakova, Ludmila; Oftadeh, Shahin; Perez-Argüello, Amaresh; Pérez-Vázquez, Maria; Perrin, Monique; Perry, Malorie; Prevost, Benoit; Roberts, Maria; Rokney, Assaf; Ron, Merav; Sanabria, Olga Marina; Scott, Kevin J; Sheppard, Carmen; Siira, Lotta; Sintchenko, Vitali; Skoczyńska, Anna; Sloan, Monica; Slotved, Hans-Christian; Smith, Andrew J; Steens, Anneke; Taha, Muhamed-Kheir; Toropainen, Maija; Tzanakaki, Georgina; Vainio, Anni; van der Linden, Mark P G; van Sorge, Nina M; Varon, Emmanuelle; Vohrnova, Sandra; von Gottberg, Anne; Yuste, Jose; Zanella, Rosemeire; Zhou, Fei; Brueggemann, Angela B;handle: 20.500.12105/16380
Background: The Invasive Respiratory Infection Surveillance (IRIS) Consortium was established to assess the impact of the COVID-19 pandemic on invasive diseases caused by Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, and Streptococcus agalactiae. We aimed to analyse the incidence and distribution of these diseases during the first 2 years of the COVID-19 pandemic compared to the 2 years preceding the pandemic. Methods: For this prospective analysis, laboratories in 30 countries and territories representing five continents submitted surveillance data from Jan 1, 2018, to Jan 2, 2022, to private projects within databases in PubMLST. The impact of COVID-19 containment measures on the overall number of cases was analysed, and changes in disease distributions by patient age and serotype or group were examined. Interrupted time-series analyses were done to quantify the impact of pandemic response measures and their relaxation on disease rates, and autoregressive integrated moving average models were used to estimate effect sizes and forecast counterfactual trends by hemisphere. Findings: Overall, 116 841 cases were analysed: 76 481 in 2018-19, before the pandemic, and 40 360 in 2020-21, during the pandemic. During the pandemic there was a significant reduction in the risk of disease caused by S pneumoniae (risk ratio 0·47; 95% CI 0·40-0·55), H influenzae (0·51; 0·40-0·66) and N meningitidis (0·26; 0·21-0·31), while no significant changes were observed for S agalactiae (1·02; 0·75-1·40), which is not transmitted via the respiratory route. No major changes in the distribution of cases were observed when stratified by patient age or serotype or group. An estimated 36 289 (95% prediction interval 17 145-55 434) cases of invasive bacterial disease were averted during the first 2 years of the pandemic among IRIS-participating countries and territories. Interpretation: COVID-19 containment measures were associated with a sustained decrease in the incidence of invasive disease caused by S pneumoniae, H influenzae, and N meningitidis during the first 2 years of the pandemic, but cases began to increase in some countries towards the end of 2021 as pandemic restrictions were lifted. These IRIS data provide a better understanding of microbial transmission, will inform vaccine development and implementation, and can contribute to health-care service planning and provision of policies. The infrastructure for the IRIS Consortium is funded by a Wellcome Trust Investigator Award to ABB (grant number 206394/Z/17/Z). The IRIS databases are part of PubMLST, which is funded by a Wellcome Trust Biomedical Resource Grant awarded to MJCM, ABB, and KAJ (grant number 218205/Z/19/Z). The high-performance computing requirements of the data analyses were supported by the Wellcome Trust Core Award (grant number 203141/Z/16/Z) and the NIHR Oxford Biomedical Research Centre. This work was also partially supported by research funding from the Spanish Ministry of Science and Innovation (grant PID2020-119298RB-I00 to JY); research grants from Pfizer (grant 69765907) to Seoul National University Hospital, and from the Korea Disease Control and Prevention Agency (grant 2018F240600) to Seoul National University College of Medicine; research funding from the Torsten Söderberg Foundation, Stockholm County Council, and the Swedish Research Council to the Karolinska Institutet, Sweden; research funding from the German Federal Ministry of Health and the Robert Koch Institute (grant 1369-237) to the National Reference Centre for Meningococci and Haemophilus influenzae; research funding from the Robert Koch Institute, Pfizer, and Merck, to the German National Reference Centre for Streptococci; and research funding from the Greek National Public Health Organization (EODY) to the Greek National Meningitis Reference laboratory. The authors were deeply saddened by the sudden death of Professor Ulrich Vogel, who contributed to the IRIS Consortium but more importantly was a dear friend and colleague to many of the authors. The authors are grateful to all those working in the clinical microbiology laboratories who have processed and characterised bacterial isolates that contribute to the IRIS Consortium. Sí
Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTAArticle . 2023Data sources: Recolector de Ciencia Abierta, RECOLECTAOxford University Research Archive; The Lancet: Digital HealthOther literature type . Article . 2023 . Peer-reviewedLicense: CC BYBern Open Repository and Information System (BORIS)Article . 2023 . Peer-reviewedData sources: Bern Open Repository and Information System (BORIS)HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2023License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!visibility 3visibility views 3 download downloads 1 Powered bymore_vert Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTAArticle . 2023Data sources: Recolector de Ciencia Abierta, RECOLECTAOxford University Research Archive; The Lancet: Digital HealthOther literature type . Article . 2023 . Peer-reviewedLicense: CC BYBern Open Repository and Information System (BORIS)Article . 2023 . Peer-reviewedData sources: Bern Open Repository and Information System (BORIS)HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2023License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publication2023 France EnglishPublisher:HAL CCSD Deghmane, Ala-Eddine; Hong, Eva; Terrade, Aude; Denizon, Mélanie; Taha, Muhamed-Kheir;International audience; Background: In 2013, France modified its Haemophilus influenzae b (Hib) vaccination schedule to remove one dose at 3 months of age and change the age of the booster dose from 16 to 11 months. During the COVID-19 pandemic, most respiratory-transmitted diseases decreased as a result of containment measures. In this work, we aimed to provide the evolution of invasive Hib disease between the pre-and post-COVID-19 pandemic and explore the immune response of vaccine failure cases in France during the period 2017-2022. Methods: The numbers and proportions of Hib invasive isolates during the period 2017-2022 were analyzed. The vaccine failure cases were explored by measuring the concentration of antipolyribosyl-ribitol phosphate (PRP) IgG using specific ELISA in the sera of patients at the admission and at least one month after the onset of the disease. Anti-Hib antibodiesdependent opsonophagocytosis and complement activation assays were performed to monitor the functionality of these antibodies. Results: During the period 2017-2022, the number of Hib invasive disease increased, particularly in children under 5 years-old, despite the measures implemented to stop COVID-19. Several cases of vaccine failure were registered with a proportion significantly higher in toddlers vaccinated according to the current scheme (2+1). The increased vaccine failure was associated with a decline in anti-PRP IgG response after the last dose to levels below the protective threshold (1 µg/ml). These levels correlated with reduced antibody-dependent opsonophagocytosis and complement activation. However, the levels of bactericidal antibodies increased significantly 1 month after the admission suggesting a secondary immune response to the Hib. Conclusions : The simplification of the vaccination to a 2 + 1 scheme seems to reduce the level of anti PRP IgG. Hib antibodies wane rapidly after the 11 months booster and may not be enough to ensure long term protection. Surveillance of cases and monitoring of titres need to be continued to informe future vaccination Policy.
HAL-Pasteur; Mémoire... arrow_drop_down HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationOther literature type . Conference object . 2023Full-Text: https://hal.science/hal-04270161/documentAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______212::18662f130da50fc251269d17d10ee5e2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert HAL-Pasteur; Mémoire... arrow_drop_down HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationOther literature type . Conference object . 2023Full-Text: https://hal.science/hal-04270161/documentAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______212::18662f130da50fc251269d17d10ee5e2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2023Publisher:American Society for Microbiology James C. Alwine; Arturo Casadevall; Lynn W. Enquist; Felicia D. Goodrum; Michael J. Imperiale;pmc: PMC10134824 , PMC10127682 , PMC10117112
ABSTRACT When humans experience a new, devastating viral infection such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), significant challenges arise. How should individuals as well as societies respond to the situation? One of the primary questions concerns the origin of the SARS-CoV-2 virus that infected and was transmitted efficiently among humans, resulting in a pandemic. At first glance, the question appears straightforward to answer. However, the origin of SARS-CoV-2 has been the topic of substantial debate primarily because we do not have access to some relevant data. At least two major hypotheses have been suggested: a natural origin through zoonosis followed by sustained human-to-human spread or the introduction of a natural virus into humans from a laboratory source. Here, we summarize the scientific evidence that informs this debate to provide our fellow scientists and the public with the tools to join the discussion in a constructive and informed manner. Our goal is to dissect the evidence to make it more accessible to those interested in this important problem. The engagement of a broad representation of scientists is critical to ensure that the public and policy-makers can draw on relevant expertise in navigating this controversy.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1128/msphere.00119-23&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 7 citations 7 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Preprint 2023 France, United KingdomPublisher:Cold Spring Harbor Laboratory Smith, DRM; Chervet, S; Pinettes, T; Shirreff, G; Jijón, S; Oodally, A; Jean, K; Opatowski, L; Kernéis, S; Temime, L;AbstractBackgroundSince the onset of the COVID-19 pandemic, mathematical models have been widely used to inform public health recommendations regarding COVID-19 control in healthcare settings.ObjectivesTo systematically review SARS-CoV-2 transmission models in healthcare settings, and summarise their contributions to understanding nosocomial COVID-19.MethodsSystematic search and review.Data sourcesPublished articles indexed in PubMed.Study eligibility criteriaModelling studies describing dynamic inter-individual transmission of SARS-CoV-2 in healthcare settings, published by mid-February 2022.Participants and interventionsAny population and intervention described by included models.Assessment of risk of biasNot appropriate for modelling studies.Methods of data synthesisStructured narrative review.ResultsModels have mostly focused on acute care and long-term care facilities in high-income countries. Models have quantified outbreak risk across different types of individuals and facilities, showing great variation across settings and pandemic periods. Regarding surveillance, routine testing – rather than symptom-based testing – was highlighted as essential for COVID-19 prevention due to high rates of silent transmission. Surveillance impacts were found to depend critically on testing frequency, diagnostic sensitivity, and turn-around time. Healthcare re-organization was also found to have large epidemiological impacts: beyond obvious benefits of isolating cases and limiting inter-individual contact, more complex strategies such as staggered staff scheduling and immune-based cohorting reduced infection risk. Finally, vaccination impact, while highly effective for limiting COVID-19 burden, varied substantially depending on assumed mechanistic impacts on infection acquisition, symptom onset and transmission. Studies were inconsistent regarding which individuals to prioritize for interventions, probably due to the high diversity of settings and populations investigated.ConclusionsModelling results form an extensive evidence base that may inform control strategies for future waves of SARS-CoV-2 and other viral respiratory pathogens. We propose new avenues for future models of healthcare-associated outbreaks, with the aim of enhancing their efficiency and contributions to decision-making.
Journal of Hospital ... arrow_drop_down Journal of Hospital InfectionArticle . 2023 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefOxford University Research ArchiveOther literature type . 2023License: CC BY NCData sources: Oxford University Research Archiveadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2023.03.17.23287403&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 2 citations 2 popularity Top 10% influence Average impulse Average Powered by BIP!visibility 3visibility views 3 download downloads 61 Powered bymore_vert Journal of Hospital ... arrow_drop_down Journal of Hospital InfectionArticle . 2023 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefOxford University Research ArchiveOther literature type . 2023License: CC BY NCData sources: Oxford University Research Archiveadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2023.03.17.23287403&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2023 United Kingdom, FrancePublisher:BMJ Smith, DRM; Jijón, S; Oodally, A; Shirreff, G; Aït Bouziad, K; Ante-Testard, PA; Bastard, J; Bouziri, H; Daouda, OS; Duchemin, T; Godon-Rensonnet, A-S; Henriot, P; Houri, Y; Neynaud, H; Perozziello, A; Thonon, F; Crépey, P; Dab, W; Jean, K; Temime, L;ObjectivesTo quantify the burden of COVID-19-related sick leave during the first pandemic wave in France, accounting for sick leaves due to symptomatic COVID-19 (‘symptomatic sick leaves’) and those due to close contact with COVID-19 cases (‘contact sick leaves’).MethodsWe combined data from a national demographic database, an occupational health survey, a social behaviour survey and a dynamic SARS-CoV-2 transmission model. Sick leave incidence from 1 March 2020 to 31 May 2020 was estimated by summing daily probabilities of symptomatic and contact sick leaves, stratified by age and administrative region.ResultsThere were an estimated 1.70M COVID-19-related sick leaves among France’s 40M working-age adults during the first pandemic wave, including 0.42M due to COVID-19 symptoms and 1.28M due to COVID-19 contacts. There was great geographical variation, with peak daily sick leave incidence ranging from 230 in Corse (Corsica) to 33 000 in Île-de-France (the greater Paris region), and greatest overall burden in regions of north-eastern France. Regional sick leave burden was generally proportional to local COVID-19 prevalence, but age-adjusted employment rates and contact behaviours also contributed. For instance, 37% of symptomatic infections occurred in Île-de-France, but 45% of sick leaves. Middle-aged workers bore disproportionately high sick leave burden, owing predominantly to greater incidence of contact sick leaves.ConclusionsFrance was heavily impacted by sick leave during the first pandemic wave, with COVID-19 contacts accounting for approximately three-quarters of COVID-19-related sick leaves. In the absence of representative sick leave registry data, local demography, employment patterns, epidemiological trends and contact behaviours can be synthesised to quantify sick leave burden and, in turn, predict economic consequences of infectious disease epidemics.
Oxford University Re... arrow_drop_down Oxford University Research ArchiveOther literature type . 2023License: CC BY NCData sources: Oxford University Research ArchiveOccupational and Environmental MedicineArticle . 2023 . Peer-reviewedLicense: CC BY NCData sources: CrossrefHAL-Rennes 1; HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2023License: CC BY NCadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routeshybrid 2 citations 2 popularity Top 10% influence Average impulse Average Powered by BIP!visibility 3visibility views 3 download downloads 2 Powered bymore_vert Oxford University Re... arrow_drop_down Oxford University Research ArchiveOther literature type . 2023License: CC BY NCData sources: Oxford University Research ArchiveOccupational and Environmental MedicineArticle . 2023 . Peer-reviewedLicense: CC BY NCData sources: CrossrefHAL-Rennes 1; HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2023License: CC BY NCadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article , Preprint 2023Publisher:Cold Spring Harbor Laboratory Fangfeng Yuan; Chi Chen; Lina M. Covaleda; Mathias Martins; Jennifer M. Reinhart; Drew R. Sullivan; Diego G. Diel; Ying Fang;pmc: PMC10449516 , PMC10055009
ABSTRACT The global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a significant threat to public health. Besides humans, SARS-CoV-2 can infect several animal species. Highly sensitive and specific diagnostic reagents and assays are urgently needed for rapid detection and implementation of strategies for prevention and control of the infection in animals. In this study, we initially developed a panel of monoclonal antibodies (mAbs) against SARS-CoV-2 nucleocapsid protein. To detect SARS-CoV-2 antibodies in a broad spectrum of animal species, an mAb-based blocking enzyme-linked immunosorbent assay (bELISA) was developed. Test validation using a set of animal serum samples with known infection status obtained an optimal percentage of inhibition cut-off value of 17.6% with diagnostic sensitivity of 97.8% and diagnostic specificity of 98.9%. The assay demonstrates high repeatability as determined by a low coefficient of variation (7.23%, 4.89%, and 3.16%) between-runs, within-run, and within-plate, respectively. Testing of samples collected over time from experimentally infected cats showed that the bELISA was able to detect seroconversion as early as 7 days post-infection. Subsequently, the bELISA was applied for testing pet animals with coronavirus disease 2019 (COVID-19)-like symptoms and specific antibody responses were detected in two dogs. The panel of mAbs generated in this study provides a valuable tool for SARS-CoV-2 diagnostics and research. The mAb-based bELISA provides a serological test in aid of COVID-19 surveillance in animals. IMPORTANCE Antibody tests are commonly used as a diagnostic tool for detecting host immune response following infection. Serology (antibody) tests complement nucleic acid assays by providing a history of virus exposure, no matter symptoms developed from infection or the infection was asymptomatic. Serology tests for COVID-19 are in high demand, especially when the vaccines become available. They are important to determine the prevalence of the viral infection in a population and identify individuals who have been infected or vaccinated. ELISA is a simple and practically reliable serological test, which allows high-throughput implementation in surveillance studies. Several COVID-19 ELISA kits are available. However, they are mostly designed for human samples and species-specific secondary antibody is required for indirect ELISA format. This paper describes the development of an all species applicable monoclonal antibody (mAb)-based blocking ELISA to facilitate the detection and surveillance of COVID-19 in animals.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2023 France EnglishPublisher:Free Neuropathology Funded by:ANR | NeurATRIS, WTANR| NeurATRIS ,WTBoluda, Susana; Mokhtari, Karima; Mégarbane, Bruno; Annane, Djillali; Mathon, Bertrand; Cao, Albert; Adam, Clovis; Androuin, Alexandre; Bielle, Franck; Brochier, Guy; Charlotte, Frédéric; Chougar, Lydia; El Hachimi, Khalid Hamid; Eloit, Marc; Haïk, Stéphane; Hervé, Dominique; Kasri, Amal; Leducq, Valentin; Lehéricy, Stéphane; Levavasseur, Etienne; Lobsiger, Christian; Lorin de La Grandmaison, Geoffroy; Malet, Isabelle; Malissin, Isabelle; Marot, Stéphane; Marty, Serge; Pérot, Philippe; Plu, Isabelle; Prigent, Annick; Stimmer, Lev; Potier, Marie-Claude; Marcelin, Anne-Geneviève; Delatour, Benoît; Duyckaerts, Charles; Seilhean, Danielle;In a neuropathological series of 20 COVID-19 cases, we analyzed six cases (three biopsies and three autopsies) with multiple foci predominantly affecting the white matter as shown by MRI. The cases presented with microhemorrhages evocative of small artery diseases. This COVID-19 associated cerebral microangiopathy (CCM) was characterized by perivascular changes: arterioles were surrounded by vacuolized tissue, clustered macrophages, large axonal swellings and a crown arrangement of aquaporin-4 immunoreactivity. There was evidence of blood-brain-barrier leakage. Fibrinoid necrosis, vascular occlusion, perivascular cuffing and demyelination were absent. While no viral particle or viral RNA was found in the brain, the SARS-CoV-2 spike protein was detected in the Golgi apparatus of brain endothelial cells where it closely associated with furin, a host protease known to play a key role in virus replication. Endothelial cells in culture were not permissive to SARS-CoV-2 replication. The distribution of the spike protein in brain endothelial cells differed from that observed in pneumocytes. In the latter, the diffuse cytoplasmic labeling suggested a complete replication cycle with viral release, notably through the lysosomal pathway. In contrast, in cerebral endothelial cells the excretion cycle was blocked in the Golgi apparatus. Interruption of the excretion cycle could explain the difficulty of SARS-CoV-2 to infect endothelial cells in vitro and to produce viral RNA in the brain. Specific metabolism of the virus in brain endothelial cells could weaken the cell walls and eventually lead to the characteristic lesions of COVID-19 associated cerebral microangiopathy. Furin as a modulator of vascular permeability could provide some clues for the control of late effects of microangiopathy. Free Neuropathology, Vol. 4 (2023)
Europe PubMed Centra... arrow_drop_down HAL-Pasteur; Mémoires en Sciences de l'Information et de la Communication; HAL-CEAArticle . 2023License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down HAL-Pasteur; Mémoires en Sciences de l'Information et de la Communication; HAL-CEAArticle . 2023License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2023 FrancePublisher:Frontiers Media SA Elias A. Said; Petronela Ancuta; Petronela Ancuta; Jean-Pierre Routy; Jean-Pierre Routy; Jean-Pierre Vartanian; Ali A. Al-Jabri;Frontiers in Immunol... arrow_drop_down HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2023License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert Frontiers in Immunol... arrow_drop_down HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2023License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article 2023 United Kingdom, Former Yugoslav Republic of Macedonia, France, Finland, Spain, Italy, ItalyPublisher:American Association for the Advancement of Science (AAAS) Funded by:EC | CURE, NIH | Developing, Demonstrating..., NIH | Inborn errors of immunity... +6 projectsEC| CURE ,NIH| Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success ,NIH| Inborn errors of immunity in patients with life-threatening COVID-19 ,NIH| IL-13/17-regulated airway epithelial miRNAs in asthma ,EC| ImmunAID ,NIH| Monogenic basis of resistance to SARS-CoV2 and predisposition to severe COVID-19 ,NIH| CORE--BIOSTATISTICS FACILITY ,EC| EASI-Genomics ,ANR| AABIFNCOVBastard, Paul; Vazquez, Sara; Liu, Jamin; Laurie, Matthew, T; Wang, Chung, Yu; Gervais, Adrian; Le Voyer, Tom; Bizien, Lucy; Zamecnik, Colin; Philippot, Quentin; Rosain, Jérémie; Catherinot, Emilie; Willmore, Andrew; Mitchell, Anthea, M; Bair, Rebecca; Garçon, Pierre; Kenney, Heather; Fekkar, Arnaud; Salagianni, Maria; Poulakou, Garyphallia; Siouti, Eleni; Sahanic, Sabina; Tancevski, Ivan; Weiss, Günter; Nagl, Laurenz; Manry, Jérémy; Duvlis, Sotirija; Arroyo-Sánchez, Daniel; Paz Artal, Estela; Rubio, Luis; Perani, Cristiano; Bezzi, Michela; Sottini, Alessandra; Quaresima, Virginia; Roussel, Lucie; Vinh, Donald, C; Reyes, Luis, Felipe; Garzaro, Margaux; Hatipoglu, Nevin; Boutboul, David; Tandjaoui-Lambiotte, Yacine; Borghesi, Alessandro; Aliberti, Anna; Cassaniti, Irene; Venet, Fabienne; Monneret, Guillaume; Halwani, Rabih; Sharif-Askari, Narjes, Saheb; Danielson, Jeffrey; Burrel, Sonia; Morbieu, Caroline; Stepanovskyy, Yurii; Bondarenko, Anastasia; Volokha, Alla; Boyarchuk, Oksana; Gagro, Alenka; Neuville, Mathilde; Neven, Bénédicte; Keles, Sevgi; Hernu, Romain; Bal, Antonin; Novelli, Antonio; Novelli, Giuseppe; Saker, Kahina; Ailioaie, Oana; Antolí, Arnau; Jeziorski, Eric; Rocamora-Blanch, Gemma; Teixeira, Carla; Delaunay, Clarisse; Lhuillier, Marine; Le Turnier, Paul; Zhang, Yu; Mahevas, Matthieu; Pan-Hammarström, Qiang; Abolhassani, Hassan; Bompoil, Thierry; Dorgham, Karim; Gorochov, Guy; Laouenan, Cédric; Rodríguez-Gallego, Carlos; Ng, Lisa, F P; Renia, Laurent; Pujol, Aurora; Belot, Alexandre; Raffi, François; Allende, Luis, M; Martinez-Picado, Javier; Ozcelik, Tayfun; Keles, Sevgi; Imberti, Luisa; Notarangelo, Luigi, D; Troya, Jesus; Solanich, Xavier; Zhang, Shen-Ying; Puel, Anne; Wilson, Michael, R; Trouillet-Assant, Sophie; Abel, Laurent; Jouanguy, Emmanuelle; Ye, Chun, Jimmie; Cobat, Aurélie; Thompson, Leslie, M; Andreakos, Evangelos; Zhang, Qian; Anderson, Mark, S; Casanova, Jean-Laurent; Derisi, Joseph, L; Abel, Laurent; Achille, Cristian; Aiuti, Alessandro; Al-Muhsen, Saleh; Al-Mulla, Fahd; Anderson, Mark, S; Andreakos, Evangelos; Angelini, Micol; Arias, Andrés, A; Aytekin, Gokhan; Baldanti, Fausto; Feldman, Hagit, Baris; Belot, Alexandre; Bergami, Federica; Biggs, Catherine, M; Bogunovic, Dusan; Bolze, Alexandre; Bondarenko, Anastasiia; Bousfiha, Ahmed, A; Brodin, Petter; Bryceson, Yenan; Bustamante, Carlos, D; Butte, Manish, J; Casari, Giorgio; Christodoulou, John; Condino-Neto, Antonio; Constantinescu, Stefan, N; Conti, Francesca; Cooper, Megan, A; Dalgard, Clifton, L; Desai, Murkesh; Drolet, Beth, A; El Baghdadi, Jamila; Ergun, Recai; Ergun, Dilek; Espinosa-Padilla, Sara; Fellay, Jacques; Flores, Carlos; Franco, José, Luis; Froidure, Antoine; Ghirardello, Stefano; Gregersen, Peter, K; Grimbacher, Bodo; Haerynck, Filomeen; Hagin, David; Halwani, Rabih; Hammarström, Lennart; Heath, James, R; Henrickson, Sarah, E; Hsieh, Elena, W Y; Husebye, Eystein; Imai, Kohsuke; Itan, Yuval; Jarvis, Erich, D; Kanat, Fikret; Karamitros, Timokratis; Kisand, Kai; Kopcha, Vasyl; Korda, Mykhaylo; Ku, Cheng-Lung; Lau, Yu-Lung; Ling, Yun; Lucas, Carrie, L; Maniatis, Tom; Mansouri, Davood; Maródi, László; Meyts, Isabelle; Milner, Joshua, D; Mironska, Kristina; Mogensen, Trine, H; Mojoli, Francesco; Morandeira, Francisco; Morio, Tomohiro; Ng, Lisa, F P; Notarangelo, Luigi, D; Novelli, Antonio; Novelli, Giuseppe; O'Farrelly, Cliona; Okada, Satoshi; Okamoto, Keisuke; Ozcelik, Tayfun; Pagani, Michele; Pan-Hammarström, Qiang; Pape, Jean, W; de Diego, Rebeca, Perez; Perlin, David, S; Pesole, Graziano; Pession, Andrea; Piralla, Antonio; Planas, Anna, M; Prando, Carolina; Pujol, Aurora; Rigo-Bonnin, Raúl; Seppänen, Mikko, R J; Uddin, K, M Furkan;International audience; Life-threatening ‘breakthrough’ cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS-CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; however, their contribution to hypoxemic breakthrough cases in vaccinated people remains unknown. Here, we studied a cohort of 48 individuals (age 20-86 years) who received 2 doses of an mRNA vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Antibody levels to the vaccine, neutralization of the virus, and auto-Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal antibody response to the vaccine. Among them, ten (24%) had auto-Abs neutralizing type I IFNs (aged 43-86 years). Eight of these ten patients had auto-Abs neutralizing both IFN-α2 and IFN-ω, while two neutralized IFN-ω only. No patient neutralized IFN-β. Seven neutralized 10 ng/mL of type I IFNs, and three 100 pg/mL only. Seven patients neutralized SARS-CoV-2 D614G and the Delta variant (B.1.617.2) efficiently, while one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only 100 pg/mL of type I IFNs neutralized both D61G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating antibodies capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a significant proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population.
UGD Academic Reposit... arrow_drop_down Oxford University Research Archive; Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele; Archivio della Ricerca - Università di Roma Tor vergata; Science ImmunologyOther literature type . Article . 2024 . 2023 . 2022 . Peer-reviewedLicense: CC BYHELDA - Digital Repository of the University of HelsinkiArticle . 2023 . Peer-reviewedData sources: HELDA - Digital Repository of the University of HelsinkiRecolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2022License: CC BYArchivio della Ricerca - Università di Roma Tor vergataArticle . 2022Data sources: Archivio della Ricerca - Università di Roma Tor vergataadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesbronze 28 citations 28 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert UGD Academic Reposit... arrow_drop_down Oxford University Research Archive; Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele; Archivio della Ricerca - Università di Roma Tor vergata; Science ImmunologyOther literature type . Article . 2024 . 2023 . 2022 . Peer-reviewedLicense: CC BYHELDA - Digital Repository of the University of HelsinkiArticle . 2023 . Peer-reviewedData sources: HELDA - Digital Repository of the University of HelsinkiRecolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2022License: CC BYArchivio della Ricerca - Università di Roma Tor vergataArticle . 2022Data sources: Archivio della Ricerca - Università di Roma Tor vergataadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint , Other literature type 2023 FrancePublisher:Cold Spring Harbor Laboratory William Bolland; Vincent Michel; Delphine Planas; Mathieu Hubert; Florence Guivel-Benhassine; Françoise Porrot; Isabelle Staropoli; Mélissa N’Debi; Christophe Rodriguez; Slim Fourati; Matthieu Prot; Cyril Planchais; Laurent Hocqueloux; Etienne Simon-Lorière; Hugo Mouquet; Thierry Prazuck; Jean-Michel Pawlotsky; Timothée Bruel; Olivier Schwartz; Julian Buchrieser;ABSTRACT SARS-CoV-2 variants with undetermined properties have emerged intermittently throughout the COVID-19 pandemic. Some variants possess unique phenotypes and mutations which allow further characterization of viral evolution and Spike functions. Around 1,100 cases of the B.1.640.1 variant were reported in Africa and Europe between 2021 and 2022, before the expansion of Omicron. Here, we analyzed the biological properties of a B.1.640.1 isolate and its Spike. Compared to the ancestral Spike, B.1.640.1 carried 14 amino acid substitutions and deletions. B.1.640.1 escaped binding by some anti-N-terminal domain and anti-receptor-binding domain monoclonal antibodies, and neutralization by sera from convalescent and vaccinated individuals. In cell lines, infection generated large syncytia and a high cytopathic effect. In primary airway cells, B.1.640.1 replicated less than Omicron BA.1 and triggered more syncytia and cell death than other variants. The B.1.640.1 Spike was highly fusogenic when expressed alone. This was mediated by two poorly characterized and infrequent mutations located in the Spike S2 domain, T859N and D936H. Altogether, our results highlight the cytopathy of a hyper-fusogenic SARS-CoV-2 variant, supplanted upon the emergence of Omicron BA.1. (This study has been registered at ClinicalTrials.gov under registration no. NCT04750720.) IMPORTANCE Our results highlight the plasticity of SARS-CoV-2 Spike to generate highly fusogenic and cytopathic strains with the causative mutations being uncharacterized in previous variants. We describe mechanisms regulating the formation of syncytia and the subsequent consequences in a primary culture model, which are poorly understood.
Europe PubMed Centra... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesbronze 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 France, Switzerland, Spain, United KingdomPublisher:Elsevier BV Funded by:WT | PubMLST: Disseminating an..., WT | Human Genetics and Diseas..., WT | Investigating the diversi...WT| PubMLST: Disseminating and exploiting bacterial diversity data for public health benefit ,WT| Human Genetics and Disease Biology: Core Renewal for the Wellcome Trust Centre for Human Genetics ,WT| Investigating the diversity, molecular epidemiology, competitive influence and therapeutic potential of pneumococcal bacteriocins using large genome datasetsShaw, David; Abad, Raquel; Amin-Chowdhury, Zahin; Bautista, Adriana; Bennett, Desiree; Broughton, Karen; Cao, Bin; Casanova, Carlo; Choi, Eun Hwa; Chu, Yiu-Wai; Claus, Heike; Coelho, Juliana; Corcoran, Mary; Cottrell, Simon; Cunney, Robert; Cuypers, Lize; Dalby, Tine; Davies, Heather; de Gouveia, Linda; Deghmane, Ala-Eddine; Demczuk, Walter; Desmet, Stefanie; Domenech, Mirian; Drew, Richard; du Plessis, Mignon; Duarte, Carolina; Erlendsdóttir, Helga; Fry, Norman K; Fuursted, Kurt; Hale, Thomas; Henares, Desiree; Henriques-Normark, Birgitta; Hilty, Markus; Hoffmann, Steen; Humphreys, Hilary; Ip, Margaret; Jacobsson, Susanne; Johnson, Christopher; Johnston, Jillian; Jolley, Keith A; Kawabata, Aníbal; Kozakova, Jana; Kristinsson, Karl G; Krizova, Pavla; Kuch, Alicja; Ladhani, Shamez; Lâm, Thiên-Trí; León, María Eugenia; Lindholm, Laura; Litt, David; Maiden, Martin C J; Martin, Irene; Martiny, Delphine; Mattheus, Wesley; McCarthy, Noel D; Meehan, Mary; Meiring, Susan; Mölling, Paula; Morfeldt, Eva; Morgan, Julie; Mulhall, Robert; Muñoz-Almagro, Carmen; Murdoch, David; Murphy, Joy; Musilek, Martin; Mzabi, Alexandre; Novakova, Ludmila; Oftadeh, Shahin; Perez-Argüello, Amaresh; Pérez-Vázquez, Maria; Perrin, Monique; Perry, Malorie; Prevost, Benoit; Roberts, Maria; Rokney, Assaf; Ron, Merav; Sanabria, Olga Marina; Scott, Kevin J; Sheppard, Carmen; Siira, Lotta; Sintchenko, Vitali; Skoczyńska, Anna; Sloan, Monica; Slotved, Hans-Christian; Smith, Andrew J; Steens, Anneke; Taha, Muhamed-Kheir; Toropainen, Maija; Tzanakaki, Georgina; Vainio, Anni; van der Linden, Mark P G; van Sorge, Nina M; Varon, Emmanuelle; Vohrnova, Sandra; von Gottberg, Anne; Yuste, Jose; Zanella, Rosemeire; Zhou, Fei; Brueggemann, Angela B;handle: 20.500.12105/16380
Background: The Invasive Respiratory Infection Surveillance (IRIS) Consortium was established to assess the impact of the COVID-19 pandemic on invasive diseases caused by Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis, and Streptococcus agalactiae. We aimed to analyse the incidence and distribution of these diseases during the first 2 years of the COVID-19 pandemic compared to the 2 years preceding the pandemic. Methods: For this prospective analysis, laboratories in 30 countries and territories representing five continents submitted surveillance data from Jan 1, 2018, to Jan 2, 2022, to private projects within databases in PubMLST. The impact of COVID-19 containment measures on the overall number of cases was analysed, and changes in disease distributions by patient age and serotype or group were examined. Interrupted time-series analyses were done to quantify the impact of pandemic response measures and their relaxation on disease rates, and autoregressive integrated moving average models were used to estimate effect sizes and forecast counterfactual trends by hemisphere. Findings: Overall, 116 841 cases were analysed: 76 481 in 2018-19, before the pandemic, and 40 360 in 2020-21, during the pandemic. During the pandemic there was a significant reduction in the risk of disease caused by S pneumoniae (risk ratio 0·47; 95% CI 0·40-0·55), H influenzae (0·51; 0·40-0·66) and N meningitidis (0·26; 0·21-0·31), while no significant changes were observed for S agalactiae (1·02; 0·75-1·40), which is not transmitted via the respiratory route. No major changes in the distribution of cases were observed when stratified by patient age or serotype or group. An estimated 36 289 (95% prediction interval 17 145-55 434) cases of invasive bacterial disease were averted during the first 2 years of the pandemic among IRIS-participating countries and territories. Interpretation: COVID-19 containment measures were associated with a sustained decrease in the incidence of invasive disease caused by S pneumoniae, H influenzae, and N meningitidis during the first 2 years of the pandemic, but cases began to increase in some countries towards the end of 2021 as pandemic restrictions were lifted. These IRIS data provide a better understanding of microbial transmission, will inform vaccine development and implementation, and can contribute to health-care service planning and provision of policies. The infrastructure for the IRIS Consortium is funded by a Wellcome Trust Investigator Award to ABB (grant number 206394/Z/17/Z). The IRIS databases are part of PubMLST, which is funded by a Wellcome Trust Biomedical Resource Grant awarded to MJCM, ABB, and KAJ (grant number 218205/Z/19/Z). The high-performance computing requirements of the data analyses were supported by the Wellcome Trust Core Award (grant number 203141/Z/16/Z) and the NIHR Oxford Biomedical Research Centre. This work was also partially supported by research funding from the Spanish Ministry of Science and Innovation (grant PID2020-119298RB-I00 to JY); research grants from Pfizer (grant 69765907) to Seoul National University Hospital, and from the Korea Disease Control and Prevention Agency (grant 2018F240600) to Seoul National University College of Medicine; research funding from the Torsten Söderberg Foundation, Stockholm County Council, and the Swedish Research Council to the Karolinska Institutet, Sweden; research funding from the German Federal Ministry of Health and the Robert Koch Institute (grant 1369-237) to the National Reference Centre for Meningococci and Haemophilus influenzae; research funding from the Robert Koch Institute, Pfizer, and Merck, to the German National Reference Centre for Streptococci; and research funding from the Greek National Public Health Organization (EODY) to the Greek National Meningitis Reference laboratory. The authors were deeply saddened by the sudden death of Professor Ulrich Vogel, who contributed to the IRIS Consortium but more importantly was a dear friend and colleague to many of the authors. The authors are grateful to all those working in the clinical microbiology laboratories who have processed and characterised bacterial isolates that contribute to the IRIS Consortium. Sí
Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTAArticle . 2023Data sources: Recolector de Ciencia Abierta, RECOLECTAOxford University Research Archive; The Lancet: Digital HealthOther literature type . Article . 2023 . Peer-reviewedLicense: CC BYBern Open Repository and Information System (BORIS)Article . 2023 . Peer-reviewedData sources: Bern Open Repository and Information System (BORIS)HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2023License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!visibility 3visibility views 3 download downloads 1 Powered bymore_vert Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTAArticle . 2023Data sources: Recolector de Ciencia Abierta, RECOLECTAOxford University Research Archive; The Lancet: Digital HealthOther literature type . Article . 2023 . Peer-reviewedLicense: CC BYBern Open Repository and Information System (BORIS)Article . 2023 . Peer-reviewedData sources: Bern Open Repository and Information System (BORIS)HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2023License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publication2023 France EnglishPublisher:HAL CCSD Deghmane, Ala-Eddine; Hong, Eva; Terrade, Aude; Denizon, Mélanie; Taha, Muhamed-Kheir;International audience; Background: In 2013, France modified its Haemophilus influenzae b (Hib) vaccination schedule to remove one dose at 3 months of age and change the age of the booster dose from 16 to 11 months. During the COVID-19 pandemic, most respiratory-transmitted diseases decreased as a result of containment measures. In this work, we aimed to provide the evolution of invasive Hib disease between the pre-and post-COVID-19 pandemic and explore the immune response of vaccine failure cases in France during the period 2017-2022. Methods: The numbers and proportions of Hib invasive isolates during the period 2017-2022 were analyzed. The vaccine failure cases were explored by measuring the concentration of antipolyribosyl-ribitol phosphate (PRP) IgG using specific ELISA in the sera of patients at the admission and at least one month after the onset of the disease. Anti-Hib antibodiesdependent opsonophagocytosis and complement activation assays were performed to monitor the functionality of these antibodies. Results: During the period 2017-2022, the number of Hib invasive disease increased, particularly in children under 5 years-old, despite the measures implemented to stop COVID-19. Several cases of vaccine failure were registered with a proportion significantly higher in toddlers vaccinated according to the current scheme (2+1). The increased vaccine failure was associated with a decline in anti-PRP IgG response after the last dose to levels below the protective threshold (1 µg/ml). These levels correlated with reduced antibody-dependent opsonophagocytosis and complement activation. However, the levels of bactericidal antibodies increased significantly 1 month after the admission suggesting a secondary immune response to the Hib. Conclusions : The simplification of the vaccination to a 2 + 1 scheme seems to reduce the level of anti PRP IgG. Hib antibodies wane rapidly after the 11 months booster and may not be enough to ensure long term protection. Surveillance of cases and monitoring of titres need to be continued to informe future vaccination Policy.
HAL-Pasteur; Mémoire... arrow_drop_down HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationOther literature type . Conference object . 2023Full-Text: https://hal.science/hal-04270161/documentAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______212::18662f130da50fc251269d17d10ee5e2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert HAL-Pasteur; Mémoire... arrow_drop_down HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationOther literature type . Conference object . 2023Full-Text: https://hal.science/hal-04270161/documentAll Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______212::18662f130da50fc251269d17d10ee5e2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2023Publisher:American Society for Microbiology James C. Alwine; Arturo Casadevall; Lynn W. Enquist; Felicia D. Goodrum; Michael J. Imperiale;pmc: PMC10134824 , PMC10127682 , PMC10117112
ABSTRACT When humans experience a new, devastating viral infection such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), significant challenges arise. How should individuals as well as societies respond to the situation? One of the primary questions concerns the origin of the SARS-CoV-2 virus that infected and was transmitted efficiently among humans, resulting in a pandemic. At first glance, the question appears straightforward to answer. However, the origin of SARS-CoV-2 has been the topic of substantial debate primarily because we do not have access to some relevant data. At least two major hypotheses have been suggested: a natural origin through zoonosis followed by sustained human-to-human spread or the introduction of a natural virus into humans from a laboratory source. Here, we summarize the scientific evidence that informs this debate to provide our fellow scientists and the public with the tools to join the discussion in a constructive and informed manner. Our goal is to dissect the evidence to make it more accessible to those interested in this important problem. The engagement of a broad representation of scientists is critical to ensure that the public and policy-makers can draw on relevant expertise in navigating this controversy.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 7 citations 7 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1128/msphere.00119-23&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Preprint 2023 France, United KingdomPublisher:Cold Spring Harbor Laboratory Smith, DRM; Chervet, S; Pinettes, T; Shirreff, G; Jijón, S; Oodally, A; Jean, K; Opatowski, L; Kernéis, S; Temime, L;AbstractBackgroundSince the onset of the COVID-19 pandemic, mathematical models have been widely used to inform public health recommendations regarding COVID-19 control in healthcare settings.ObjectivesTo systematically review SARS-CoV-2 transmission models in healthcare settings, and summarise their contributions to understanding nosocomial COVID-19.MethodsSystematic search and review.Data sourcesPublished articles indexed in PubMed.Study eligibility criteriaModelling studies describing dynamic inter-individual transmission of SARS-CoV-2 in healthcare settings, published by mid-February 2022.Participants and interventionsAny population and intervention described by included models.Assessment of risk of biasNot appropriate for modelling studies.Methods of data synthesisStructured narrative review.ResultsModels have mostly focused on acute care and long-term care facilities in high-income countries. Models have quantified outbreak risk across different types of individuals and facilities, showing great variation across settings and pandemic periods. Regarding surveillance, routine testing – rather than symptom-based testing – was highlighted as essential for COVID-19 prevention due to high rates of silent transmission. Surveillance impacts were found to depend critically on testing frequency, diagnostic sensitivity, and turn-around time. Healthcare re-organization was also found to have large epidemiological impacts: beyond obvious benefits of isolating cases and limiting inter-individual contact, more complex strategies such as staggered staff scheduling and immune-based cohorting reduced infection risk. Finally, vaccination impact, while highly effective for limiting COVID-19 burden, varied substantially depending on assumed mechanistic impacts on infection acquisition, symptom onset and transmission. Studies were inconsistent regarding which individuals to prioritize for interventions, probably due to the high diversity of settings and populations investigated.ConclusionsModelling results form an extensive evidence base that may inform control strategies for future waves of SARS-CoV-2 and other viral respiratory pathogens. We propose new avenues for future models of healthcare-associated outbreaks, with the aim of enhancing their efficiency and contributions to decision-making.
Journal of Hospital ... arrow_drop_down Journal of Hospital InfectionArticle . 2023 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefOxford University Research ArchiveOther literature type . 2023License: CC BY NCData sources: Oxford University Research Archiveadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2023.03.17.23287403&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 2 citations 2 popularity Top 10% influence Average impulse Average Powered by BIP!visibility 3visibility views 3 download downloads 61 Powered bymore_vert Journal of Hospital ... arrow_drop_down Journal of Hospital InfectionArticle . 2023 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefOxford University Research ArchiveOther literature type . 2023License: CC BY NCData sources: Oxford University Research Archiveadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2023.03.17.23287403&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2023 United Kingdom, FrancePublisher:BMJ Smith, DRM; Jijón, S; Oodally, A; Shirreff, G; Aït Bouziad, K; Ante-Testard, PA; Bastard, J; Bouziri, H; Daouda, OS; Duchemin, T; Godon-Rensonnet, A-S; Henriot, P; Houri, Y; Neynaud, H; Perozziello, A; Thonon, F; Crépey, P; Dab, W; Jean, K; Temime, L;ObjectivesTo quantify the burden of COVID-19-related sick leave during the first pandemic wave in France, accounting for sick leaves due to symptomatic COVID-19 (‘symptomatic sick leaves’) and those due to close contact with COVID-19 cases (‘contact sick leaves’).MethodsWe combined data from a national demographic database, an occupational health survey, a social behaviour survey and a dynamic SARS-CoV-2 transmission model. Sick leave incidence from 1 March 2020 to 31 May 2020 was estimated by summing daily probabilities of symptomatic and contact sick leaves, stratified by age and administrative region.ResultsThere were an estimated 1.70M COVID-19-related sick leaves among France’s 40M working-age adults during the first pandemic wave, including 0.42M due to COVID-19 symptoms and 1.28M due to COVID-19 contacts. There was great geographical variation, with peak daily sick leave incidence ranging from 230 in Corse (Corsica) to 33 000 in Île-de-France (the greater Paris region), and greatest overall burden in regions of north-eastern France. Regional sick leave burden was generally proportional to local COVID-19 prevalence, but age-adjusted employment rates and contact behaviours also contributed. For instance, 37% of symptomatic infections occurred in Île-de-France, but 45% of sick leaves. Middle-aged workers bore disproportionately high sick leave burden, owing predominantly to greater incidence of contact sick leaves.ConclusionsFrance was heavily impacted by sick leave during the first pandemic wave, with COVID-19 contacts accounting for approximately three-quarters of COVID-19-related sick leaves. In the absence of representative sick leave registry data, local demography, employment patterns, epidemiological trends and contact behaviours can be synthesised to quantify sick leave burden and, in turn, predict economic consequences of infectious disease epidemics.
Oxford University Re... arrow_drop_down Oxford University Research ArchiveOther literature type . 2023License: CC BY NCData sources: Oxford University Research ArchiveOccupational and Environmental MedicineArticle . 2023 . Peer-reviewedLicense: CC BY NCData sources: CrossrefHAL-Rennes 1; HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2023License: CC BY NCadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1136/oemed-2022-108451&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 2 citations 2 popularity Top 10% influence Average impulse Average Powered by BIP!visibility 3visibility views 3 download downloads 2 Powered bymore_vert Oxford University Re... arrow_drop_down Oxford University Research ArchiveOther literature type . 2023License: CC BY NCData sources: Oxford University Research ArchiveOccupational and Environmental MedicineArticle . 2023 . Peer-reviewedLicense: CC BY NCData sources: CrossrefHAL-Rennes 1; HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2023License: CC BY NCadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article , Preprint 2023Publisher:Cold Spring Harbor Laboratory Fangfeng Yuan; Chi Chen; Lina M. Covaleda; Mathias Martins; Jennifer M. Reinhart; Drew R. Sullivan; Diego G. Diel; Ying Fang;pmc: PMC10449516 , PMC10055009
ABSTRACT The global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a significant threat to public health. Besides humans, SARS-CoV-2 can infect several animal species. Highly sensitive and specific diagnostic reagents and assays are urgently needed for rapid detection and implementation of strategies for prevention and control of the infection in animals. In this study, we initially developed a panel of monoclonal antibodies (mAbs) against SARS-CoV-2 nucleocapsid protein. To detect SARS-CoV-2 antibodies in a broad spectrum of animal species, an mAb-based blocking enzyme-linked immunosorbent assay (bELISA) was developed. Test validation using a set of animal serum samples with known infection status obtained an optimal percentage of inhibition cut-off value of 17.6% with diagnostic sensitivity of 97.8% and diagnostic specificity of 98.9%. The assay demonstrates high repeatability as determined by a low coefficient of variation (7.23%, 4.89%, and 3.16%) between-runs, within-run, and within-plate, respectively. Testing of samples collected over time from experimentally infected cats showed that the bELISA was able to detect seroconversion as early as 7 days post-infection. Subsequently, the bELISA was applied for testing pet animals with coronavirus disease 2019 (COVID-19)-like symptoms and specific antibody responses were detected in two dogs. The panel of mAbs generated in this study provides a valuable tool for SARS-CoV-2 diagnostics and research. The mAb-based bELISA provides a serological test in aid of COVID-19 surveillance in animals. IMPORTANCE Antibody tests are commonly used as a diagnostic tool for detecting host immune response following infection. Serology (antibody) tests complement nucleic acid assays by providing a history of virus exposure, no matter symptoms developed from infection or the infection was asymptomatic. Serology tests for COVID-19 are in high demand, especially when the vaccines become available. They are important to determine the prevalence of the viral infection in a population and identify individuals who have been infected or vaccinated. ELISA is a simple and practically reliable serological test, which allows high-throughput implementation in surveillance studies. Several COVID-19 ELISA kits are available. However, they are mostly designed for human samples and species-specific secondary antibody is required for indirect ELISA format. This paper describes the development of an all species applicable monoclonal antibody (mAb)-based blocking ELISA to facilitate the detection and surveillance of COVID-19 in animals.
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You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2023 France EnglishPublisher:Free Neuropathology Funded by:ANR | NeurATRIS, WTANR| NeurATRIS ,WTBoluda, Susana; Mokhtari, Karima; Mégarbane, Bruno; Annane, Djillali; Mathon, Bertrand; Cao, Albert; Adam, Clovis; Androuin, Alexandre; Bielle, Franck; Brochier, Guy; Charlotte, Frédéric; Chougar, Lydia; El Hachimi, Khalid Hamid; Eloit, Marc; Haïk, Stéphane; Hervé, Dominique; Kasri, Amal; Leducq, Valentin; Lehéricy, Stéphane; Levavasseur, Etienne; Lobsiger, Christian; Lorin de La Grandmaison, Geoffroy; Malet, Isabelle; Malissin, Isabelle; Marot, Stéphane; Marty, Serge; Pérot, Philippe; Plu, Isabelle; Prigent, Annick; Stimmer, Lev; Potier, Marie-Claude; Marcelin, Anne-Geneviève; Delatour, Benoît; Duyckaerts, Charles; Seilhean, Danielle;In a neuropathological series of 20 COVID-19 cases, we analyzed six cases (three biopsies and three autopsies) with multiple foci predominantly affecting the white matter as shown by MRI. The cases presented with microhemorrhages evocative of small artery diseases. This COVID-19 associated cerebral microangiopathy (CCM) was characterized by perivascular changes: arterioles were surrounded by vacuolized tissue, clustered macrophages, large axonal swellings and a crown arrangement of aquaporin-4 immunoreactivity. There was evidence of blood-brain-barrier leakage. Fibrinoid necrosis, vascular occlusion, perivascular cuffing and demyelination were absent. While no viral particle or viral RNA was found in the brain, the SARS-CoV-2 spike protein was detected in the Golgi apparatus of brain endothelial cells where it closely associated with furin, a host protease known to play a key role in virus replication. Endothelial cells in culture were not permissive to SARS-CoV-2 replication. The distribution of the spike protein in brain endothelial cells differed from that observed in pneumocytes. In the latter, the diffuse cytoplasmic labeling suggested a complete replication cycle with viral release, notably through the lysosomal pathway. In contrast, in cerebral endothelial cells the excretion cycle was blocked in the Golgi apparatus. Interruption of the excretion cycle could explain the difficulty of SARS-CoV-2 to infect endothelial cells in vitro and to produce viral RNA in the brain. Specific metabolism of the virus in brain endothelial cells could weaken the cell walls and eventually lead to the characteristic lesions of COVID-19 associated cerebral microangiopathy. Furin as a modulator of vascular permeability could provide some clues for the control of late effects of microangiopathy. Free Neuropathology, Vol. 4 (2023)
Europe PubMed Centra... arrow_drop_down HAL-Pasteur; Mémoires en Sciences de l'Information et de la Communication; HAL-CEAArticle . 2023License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.17879/freeneuropathology-2023-4584&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down HAL-Pasteur; Mémoires en Sciences de l'Information et de la Communication; HAL-CEAArticle . 2023License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.17879/freeneuropathology-2023-4584&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2023 FrancePublisher:Frontiers Media SA Elias A. Said; Petronela Ancuta; Petronela Ancuta; Jean-Pierre Routy; Jean-Pierre Routy; Jean-Pierre Vartanian; Ali A. Al-Jabri;Frontiers in Immunol... arrow_drop_down HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2023License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fimmu.2023.1137399&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert Frontiers in Immunol... arrow_drop_down HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2023License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3389/fimmu.2023.1137399&type=result"></script>'); --> </script>
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