- home
- Advanced Search
- Neuroinformatics
- Publications
- Other literature type
- SG
- HAL-Pasteur
- Neuroinformatics
- Publications
- Other literature type
- SG
- HAL-Pasteur
Loading
description Publicationkeyboard_double_arrow_right Article , Other literature type , Preprint 2021 Spain, Canada, United Kingdom, France, Ireland, Germany, Netherlands, United KingdomPublisher:Cold Spring Harbor Laboratory Publicly fundedFunded by:UKRI | Systems Cognitive Neurosc..., UKRI | Innovative Technologies f..., NIH | Impact of Amyloid and Tau... +6 projectsUKRI| Systems Cognitive Neuroscience of Healthy Ageing: Population-Representative Studies of Functional Plasticity and Neural Change ,UKRI| Innovative Technologies for Stratified and Experimental Medicine ,NIH| Impact of Amyloid and Tau on the Aging Brain: The Harvard Aging Brain Study ,NIH| BIOSTATISTICS &NEUROINFORMATICS (STATNI) CORE ,NIH| SCHIZOPHRENIA: A NEUROPSYCHIATRIC PERSPECTIVE ,UKRI| Statistics for Stratified Medicine and Analysis of Complex Phenotypes ,NIH| Combined brain and gene network approaches to the developmental hypothesis of schizophrenia ,FCT| LA 5 ,WTRichard A. I. Bethlehem; Jakob Seidlitz; White; Jacob W. Vogel; Kevin M. Anderson; Adamson C; Sophie Adler; George S. Alexopoulos; Evdokia Anagnostou; Areces-Gonzalez A; Duncan E. Astle; Bonnie Auyeung; Ayub M; Gareth Ball; Simon Baron-Cohen; Richard Beare; Saashi A Bedford; Benegal; Frauke Beyer; Bin Bae J; Blesa Cabez M; James P. Boardman; Matthew Borzage; Jorge Bosch-Bayard; Niall J Bourke; Calhoun Vd; M. Mallar Chakravarty; Chixiang Chen; Chertavian C; Gaël Chételat; Yap Seng Chong; James H. Cole; Aiden Corvin; Eric Courchesne; Fabrice Crivello; Vanessa Cropley; Delarue M; Sylvane Desrivières; Gabriel A. Devenyi; Di Biase Ma; Raymond J. Dolan; Kirsten A. Donald; Katharine Dunlop; Alexander D. Edwards; Jed T. Elison; Cameron T. Ellis; Jeremy A. Elman; Lisa T. Eyler; Damien A. Fair; Paul C. Fletcher; Peter Fonagy; Carol E. Franz; Ali Gholipour; Jay N. Giedd; John H. Gilmore; Ian M. Goodyer; Patricia Ellen Grant; Nynke A. Groenewold; Faith M. Gunning; R.E. Gur; Hammill Cf; Oskar Hansson; Trey Hedden; A. Heinz; Richard N. Henson; Katja Heuer; Jacqueline Hoare; Bharath Holla; Avram J. Holmes; Rosemary Holt; Hua Huang; Jonathan C Ipser; Clifford R. Jack; Andrea Parolin Jackowski; Tianye Jia; Keith A. Johnson; David T.W. Jones; Peter B. Jones; René S. Kahn; Hasse Karlsson; Linnea Karlsson; Ryuta Kawashima; Elizabeth Kelley; Silke Kern; Kim K; Manfred G. Kitzbichler; William S. Kremen; Francois Lalonde; Sang Jae Lee; Jason P. Lerch; Jianfu Li; Wei Liao; Deirel Paz Linares; Conor Liston; Jinglei Lv; Charles J. Lynch; Travis T. Mallard; Ross D. Markello; Bernard Mazoyer; Phillip McGuire; Michael J. Meaney; Andrea Mechelli; Nenad Medic; Bratislav Misic; Sarah E. Morgan; Mothersill D; Joel T. Nigg; Ong Mq; Cynthia M. Ortinau; Rik Ossenkoppele; Minhui Ouyang; Lena Palaniyappan; Paly L; Pedro Mario Pan; C Pantelis; Park Mtm; Tomáš Paus; Zdenka Pausova; Pichet Binette A; Karen Pierce; Jiang Qiu; Armin Raznahan; Timothy Rittman; Caitlin K. Rollins; Romero-Garcia R; Lisa Ronan; Rosenberg; David H. Rowitch; Giovanni Abrahão Salum; Theodore D. Satterthwaite; Herma Lina Schaare; Russell Schachar; Michael Schöll; Aaron P. Schultz; Gunter Schumann; David J. Sharp; Russel T. Shinohara; Ingmar Skoog; Christopher D. Smyser; Reisa A. Sperling; Dan J. Stein; Stolicyn A; John Suckling; Gareth J. Sullivan; Taki Y; Thyreau B; Roberto Toro; Kamen A. Tsvetanov; Nicholas B. Turk-Browne; Tuulari Jj; Christophe Tzourio; Etienne Vachon-Presseau; Mitchell Valdés-Sosa; Pedro A. Valdes-Sosa; van Amelsvoort T; Simon N. Vandekar; Lana Vasung; Petra E. Vértes; Lindsay W. Victoria; Sylvia Villeneuve; Arno Villringer; Konrad Wagstyl; Wang Ys; Simon K. Warfield; Eric Westman; Margaret L. Westwater; Heather C. Whalley; A. V. Witte; Yang N; Yeo Bt; Yun Hj; Andrew Zalesky; Heather J. Zar; Anna Zettergren; Juan Zhou; Hisham Ziauddeen; André Zugman; Zuo Xn; E.T. Bullmore; Aaron Alexander-Bloch;doi: 10.1101/2021.06.08.447489 , 10.1038/s41586-022-04554-y , 10.17863/cam.83688 , 10.17863/cam.84341 , 10.17863/cam.81584 , 10.17863/cam.88753 , 10.17863/cam.83738
handle: 21.11116/0000-000A-52FD-D , 10668/19570 , 20.500.11820/2e7cb12a-fb41-4a36-bc10-41f2ed0bc783 , 2128/32314 , 10261/303918 , 21.11116/0000-000A-6461-8 , 21.11116/0000-000A-6463-6
pmid: 36151472
pmc: PMC9021021
doi: 10.1101/2021.06.08.447489 , 10.1038/s41586-022-04554-y , 10.17863/cam.83688 , 10.17863/cam.84341 , 10.17863/cam.81584 , 10.17863/cam.88753 , 10.17863/cam.83738
handle: 21.11116/0000-000A-52FD-D , 10668/19570 , 20.500.11820/2e7cb12a-fb41-4a36-bc10-41f2ed0bc783 , 2128/32314 , 10261/303918 , 21.11116/0000-000A-6461-8 , 21.11116/0000-000A-6463-6
pmid: 36151472
pmc: PMC9021021
Over the past few decades, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, no reference standards currently exist to quantify individual differences in neuroimaging metrics over time, in contrast to growth charts for anthropometric traits such as height and weight1. Here we assemble an interactive open resource to benchmark brain morphology derived from any current or future sample of MRI data ( http://www.brainchart.io/ ). With the goal of basing these reference charts on the largest and most inclusive dataset available, acknowledging limitations due to known biases of MRI studies relative to the diversity of the global population, we aggregated 123,984 MRI scans, across more than 100 primary studies, from 101,457 human participants between 115 days post-conception to 100 years of age. MRI metrics were quantified by centile scores, relative to non-linear trajectories2 of brain structural changes, and rates of change, over the lifespan. Brain charts identified previously unreported neurodevelopmental milestones3, showed high stability of individuals across longitudinal assessments, and demonstrated robustness to technical and methodological differences between primary studies. Centile scores showed increased heritability compared with non-centiled MRI phenotypes, and provided a standardized measure of atypical brain structure that revealed patterns of neuroanatomical variation across neurological and psychiatric disorders. In summary, brain charts are an essential step towards robust quantification of individual variation benchmarked to normative trajectories in multiple, commonly used neuroimaging phenotypes. R.A.I.B. was supported by a British Academy Postdoctoral fellowship and by the Autism Research Trust. J. Seidlitz was supported by NIMH T32MH019112-29 and K08MH120564. S.R.W. was funded by UKRI Medical Research Council MC_UU_00002/2 and was supported by the NIHR Cambridge Biomedical Research Centre (BRC-1215-20014). E.T.B. was supported by an NIHR Senior Investigator award and the Wellcome Trust collaborative award for the Neuroscience in Psychiatry Network. A.F.A.-B. was supported by NIMH K08MH120564. Data were curated and analysed using a computational facility funded by an MRC research infrastructure award (MR/M009041/1) to the School of Clinical Medicine, University of Cambridge and supported by the mental health theme of the NIHR Cambridge Biomedical Research Centre. Peer reviewed
Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2023 . 2022 . Peer-reviewedRepositorio Institucional de Salud de Andalucía - Andalusian Health RepositoryArticle . 2022License: CC BYHAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2021.06.08.447489&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 453 citations 453 popularity Top 0.1% influence Top 1% impulse Top 0.01% Powered by BIP!visibility 297visibility views 297 download downloads 498 Powered bymore_vert Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2023 . 2022 . Peer-reviewedRepositorio Institucional de Salud de Andalucía - Andalusian Health RepositoryArticle . 2022License: CC BYHAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2021.06.08.447489&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint , Other literature type 2020 France, United Kingdom, Italy, Belgium, France, France, France, France, NetherlandsPublisher:Center for Open Science Funded by:NIH | Large-scale Automated Syn..., EC | ImPRESS, NSF | CRCNS US-German Data Shar...NIH| Large-scale Automated Synthesis of Functional Neuroimaging Data ,EC| ImPRESS ,NSF| CRCNS US-German Data Sharing: DataGit - converging catalogues, warehouses, and deployment logistics into a federated 'data distribution'Elise Bannier; Gareth J. Barker; Valentina Borghesani; Nils Broeckx; Patricia Clement; Kyrre E. Emblem; Satrajit S. Ghosh; Enrico Glerean; Krzysztof J. Gorgolewski; Marko Havu; Yaroslav O. Halchenko; Peer Herholz; Anne Hespel; Stephan Heunis; Yue Hu; Chuan-Peng Hu; Dorien C. Huijser; María de la Iglesia Vayá; Radim Jančálek; Vasileios K. Katsaros; Marie-Luise Kieseler; Camille Maumet; Clara Moreau; Henk-Jan Mutsaerts; Robert Oostenveld; Esin Ozturk-Isik; Nicolas Pascual Leone Espinosa; John Pellman; Cyril Pernet; Francesca B. Pizzini; Amira Serifovic Trbalic; Paule-Joanne Toussaint; Matteo Visconti di Oleggio Castello; Fengjuan Wang; Cheng Wang; Hua Zhu;pmc: PMC8046140
pmid: 33522661
AbstractHaving the means to share research data openly is essential to modern science. For human research, a key aspect in this endeavor is obtaining consent from participants, not just to take part in a study, which is a basic ethical principle, but also to share their data with the scientific community. To ensure that the participants' privacy is respected, national and/or supranational regulations and laws are in place. It is, however, not always clear to researchers what the implications of those are, nor how to comply with them. The Open Brain Consent (https://open-brain-consent.readthedocs.io) is an international initiative that aims to provide researchers in the brain imaging community with information about data sharing options and tools. We present here a short history of this project and its latest developments, and share pointers to consent forms, including a template consent form that is compliant with the EU general data protection regulation. We also share pointers to an associated data user agreement that is not only useful in the EU context, but also for any researchers dealing with personal (clinical) data elsewhere.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8046140Data sources: PubMed CentralInstitutional Repository Universiteit AntwerpenArticle . 2021Data sources: Institutional Repository Universiteit AntwerpenRecolector de Ciencia Abierta, RECOLECTAArticle . Lecture . 2021Data sources: Recolector de Ciencia Abierta, RECOLECTAIRIS - Università degli Studi di VeronaArticle . 2021Data sources: IRIS - Università degli Studi di VeronaIRIS - Università degli Studi di VeronaArticle . 2021Data sources: IRIS - Università degli Studi di Veronaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.31234/osf.io/f6mnp&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 31 citations 31 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8046140Data sources: PubMed CentralInstitutional Repository Universiteit AntwerpenArticle . 2021Data sources: Institutional Repository Universiteit AntwerpenRecolector de Ciencia Abierta, RECOLECTAArticle . Lecture . 2021Data sources: Recolector de Ciencia Abierta, RECOLECTAIRIS - Università degli Studi di VeronaArticle . 2021Data sources: IRIS - Università degli Studi di VeronaIRIS - Università degli Studi di VeronaArticle . 2021Data sources: IRIS - Università degli Studi di Veronaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.31234/osf.io/f6mnp&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2019 Switzerland, United Kingdom, United Kingdom, France, United KingdomPublisher:Oxford University Press (OUP) Funded by:WTWTAuthors: Juliette Van Steenwinckel; Anne-Laure Schang; Michelle L. Krishnan; Vincent Degos; +28 AuthorsJuliette Van Steenwinckel; Anne-Laure Schang; Michelle L. Krishnan; Vincent Degos; Andrée Delahaye-Duriez; Cindy Bokobza; Zsolt Csaba; Franck Verdonk; Amélie Montané; Stéphanie Sigaut; Olivier Hennebert; Sophie Lebon; Leslie Schwendimann; Tifenn Le Charpentier; Rahma Hassan-Abdi; Gareth Ball; Paul Aljabar; Alka Saxena; Rebecca K. Holloway; Walter Birchmeier; Olivier Baud; David H. Rowitch; Veronique E. Miron; Fabrice Chrétien; Claire Leconte; Valérie C. Besson; Enrico Petretto; A. David Edwards; Henrik Hagberg; Nadia Soussi-Yanicostas; Bobbi Fleiss; Pierre Gressens;pmid: 31665242
pmc: PMC6906599
International audience; Microglia of the developing brain have unique functional properties but how their activation states are regulated is poorly understood. Inflammatory activation of microglia in the still-developing brain of preterm-born infants is associated with permanent neurological sequelae in 9 million infants every year. Investigating the regulators of microglial activation in the developing brain across models of neuroinflammation-mediated injury (mouse, zebrafish) and primary human and mouse microglia we found using analysis of genes and proteins that a reduction in Wnt/β-catenin signalling is necessary and sufficient to drive a microglial phenotype causing hypomyelination. We validated in a cohort of preterm-born infants that genomic variation in the Wnt pathway is associated with the levels of connectivity found in their brains. Using a Wnt agonist delivered by a blood-brain barrier penetrant microglia-specific targeting nanocarrier we prevented in our animal model the pro-inflammatory microglial activation, white matter injury and behavioural deficits. Collectively, these data validate that the Wnt pathway regulates microglial activation, is critical in the evolution of an important form of human brain injury and is a viable therapeutic target.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/brain/awz319&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 90 citations 90 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 2visibility views 2 download downloads 3 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/brain/awz319&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2019 United Kingdom, United Kingdom, United Kingdom, France, Italy, Norway, Germany, Netherlands, United Kingdom, France, FrancePublisher:Springer Science and Business Media LLC Publicly fundedFunded by:EC | SEGWAY, NWO | Language in Interaction, NHMRC | Depressive and bipolar di... +3 projectsEC| SEGWAY ,NWO| Language in Interaction ,NHMRC| Depressive and bipolar disorders: Pathophysiology, phenotypes and treatment innovations ,NHMRC| Uncovering the Function of Susceptibility Variants in Alzheimer's Disease: From GWAS to Cell-Type Specific eQTLs and mQTLs ,EC| JPco-fuND ,UKRI| Mendelian randomization to hypothesis-free causal inferenceClaudia L. Satizabal; Hieab H.H. Adams; Charles C. White; Maria J. Knol; Markus Scholz; Muralidharan Sargurupremraj; Gennady V. Roshchupkin; Albert V. Smith; Joshua C. Bis; Xueqiu Jian; Michelle Luciano; Edith Hofer; Alexander Teumer; Sven J. van der Lee; Jingyun Yang; Lisa R. Yanek; Tom V. Lee; Shuo Li; Yanhui Hu; Jia Yu Koh; John D. Eicher; Sylvane Desrivières; Alejandro Arias-Vasquez; Ganesh Chauhan; Lavinia Athanasiu; Miguel E. Rentería; D. Hoehn; Qiang Chen; Anouk den Braber; Micael Andersson; Thomas Espeseth; Oliver Grimm; Lucija Abramovic; Tomas Axelsson; Stefan Ehrlich; Roberto Roiz-Santiañez; Asta Håberg; Hannah J. Jones; Dan J. Stein; Janita Bralten; Meike W. Vernooij; Tamara B. Harris; Irina Filippi; A. Veronica Witte; Tulio Guadalupe; Katharina Wittfeld; Thomas H. Mosley; James T. Becker; Nhat Trung Doan; Saskia P. Hagenaars; Gabriel Cuellar-Partida; Najaf Amin; Saima Hilal; Kwangsik Nho; Nazanin Mirza-Schreiber; Konstantinos Arfanakis; David Ames; Aaron Goldman; Dorret I. Boomsma; Simon Lovestone; Sudheer Giddaluru; Stephanie Le Hellard; Manuel Mattheisen; Dalia Kasperaviciute; Stephen M. Lawrie; Ingrid Agartz; Esther Walton; Gareth E. Davies; Jean Shin; Jonathan C Ipser; Louis N. Vinke; Martine Hoogman; Tianye Jia; Ralph Burkhardt; Marieke Klein; Fabrice Crivello; Deborah Janowitz; Owen Carmichael; Unn K. Haukvik; Benjamin S. Aribisala; Lachlan T. Strike; Shannon L. Risacher; Benno Pütz; Debra A. Fleischman; Amelia A. Assareh; Venkata S. Mattay; Randy L. Buckner; Patrizia Mecocci; Anders M. Dale; Sven Cichon; Marco P. Boks; Brenda W.J.H. Penninx; Vince D. Calhoun; M. Mallar Chakravarty; Andre F. Marquand; Shahrzad Kharabian Masouleh; Philippe Amouyel; Katrin Hegenscheid; Jerome I. Rotter; Andrew J. Schork; David C. Liewald; Greig I. de Zubicaray; Tien Yin Wong; Li Shen; Philipp G. Sämann; Henry Brodaty; Eco J. C. de Geus; Magda Tsolaki; Susanne Erk; Gianpiero L. Cavalleri; Nic J.A. van der Wee; Andrew M. McIntosh; Randy L. Gollub; Kazima B. Bulayeva; Jayandra J. Himali; Markus Loeffler; Nanda Rommelse; Lars T. Westlye; Narelle K. Hansell; Theo G.M. van Erp; John B.J. Kwok; Loes M. Olde Loohuis; Norman Delanty; Beng-Choon Ho; Christopher R.K. Ching; Elena Shumskaya; Albert Hofman; Dennis van der Meer; Tatiana Foroud; Jouke-Jan Hottenga; Andrew Simmons; Andreas Meyer-Lindenberg; Wiepke Cahn; Christopher D. Whelan; Marjolein M.J. van Donkelaar; Qiong Yang; Robert C. Green; Anbupalam Thalamuthu; Sebastian Mohnke; Hilleke E. Hulshoff Pol; Honghuang Lin; Peter R. Schofield; Thomas W. Mühleisen; Pauline Maillard; Wei Wen; Evan Fletcher; Arthur W. Toga; George Davey Smith; Lars Nyberg; Erik G. Jönsson; Benedicto Crespo-Facorro; Nastassja Koen; André G. Uitterlinden; Daniel R. Weinberger; Vidar M. Steen; Iryna O. Fedko; Nynke A. Groenewold; Wiro J. Niessen; Christophe Tzourio; William T. Longstreth; Jordan W. Smoller; Marie-José van Tol; Tomáš Paus; Herve Lemaitre; Matthias L. Schroeter; Bernard Mazoyer; Ole A. Andreassen; Florian Holsboer; Jessica A. Turner; Gunter Schumann; Daan van Rooij; Srdjan Djurovic; Katie L. McMahon; Rachel M. Brouwer; Joshua W. Cheung; Thomas Wolfers; Marcel P. Zwiers; Matthias Nauck; Ingrid Melle; Nicholas G. Martin; Ryota Kanai; Eric Westman; Sanjay M. Sisodiya; Tonya White; Arvin Saremi; Hans van Bokhoven; Henry Völzke; Margaret J. Wright; Dennis van 't Ent; Markus M. Nöthen; Roel A. Ophoff; Jan K. Buitelaar; Perminder S. Sachdev; Marcella Rietschel; Simon E. Fisher; Clyde Francks; Andrew J. Saykin; Karen A. Mather; Nina Romanczuk-Seiferth; Anita L. DeStefano; Henrik Walter; Pieter J. Hoekstra; Paul A. Nyquist; Barbara Franke; Hans J. Grabe; Andrew D. Johnson; Cornelia M. van Duijn; Oscar L. Lopez; Myriam Fornage; Joanna M. Wardlaw; Charles DeCarli; Philip L. De Jager; Arno Villringer; Stéphanie Debette; Vilmundur Gudnason; Sarah E. Medland; Joshua M. Shulman; Sudha Seshadri;handle: 11370/3032873a-25e1-4fd9-ba14-f7afc84e1285 , 1887/122359 , 1765/120919 , 1874/387936 , 2066/209944 , 11250/2659957 , 11391/1459099 , 1983/59a217fb-a72b-4924-8f19-966ba56924bc , 1871.1/78126867-921a-42a4-9782-e8522f6ba4d4 , 20.500.11820/4a312d6d-37d5-4255-a7e6-5efdc7ab5159 , 21.11116/0000-0004-C26A-A
pmc: PMC7055269
pmid: 31636452
handle: 11370/3032873a-25e1-4fd9-ba14-f7afc84e1285 , 1887/122359 , 1765/120919 , 1874/387936 , 2066/209944 , 11250/2659957 , 11391/1459099 , 1983/59a217fb-a72b-4924-8f19-966ba56924bc , 1871.1/78126867-921a-42a4-9782-e8522f6ba4d4 , 20.500.11820/4a312d6d-37d5-4255-a7e6-5efdc7ab5159 , 21.11116/0000-0004-C26A-A
pmc: PMC7055269
pmid: 31636452
Aims/hypothesis MODY can be wrongly diagnosed as type 1 diabetes in children. We aimed to find the prevalence of MODY in a nationwide population-based registry of childhood diabetes. Methods Using next-generation sequencing, we screened the HNF1A, HNF4A, HNF1B, GCK and INS genes in all 469 children (12.1%) negative for both GAD and IA-2 autoantibodies and 469 antibody-positive matched controls selected from the Norwegian Childhood Diabetes Registry (3882 children). Variants were classified using clinical diagnostic criteria for pathogenicity ranging from class 1 (neutral) to class 5 (pathogenic). Results We identified 58 rare exonic and splice variants in cases and controls. Among antibody-negative patients, 6.5% had genetic variants of classes 3–5 (vs 2.4% in controls; p = 0.002). For the stricter classification (classes 4 and 5), the corresponding number was 4.1% (vs 0.2% in controls; p = 1.6 × 10−5). HNF1A showed the strongest enrichment of class 3–5 variants, with 3.9% among antibody-negative patients (vs 0.4% in controls; p = 0.0002). Antibody-negative carriers of variants in class 3 had a similar phenotype to those carrying variants in classes 4 and 5. Conclusions/interpretation This is the first study screening for MODY in all antibody-negative children in a nationwide population-based registry. Our results suggest that the prevalence of MODY in antibody-negative childhood diabetes may reach 6.5%. One-third of these MODY cases had not been recognised by clinicians. Since a precise diagnosis is important for treatment and genetic counselling, molecular screening of all antibody-negative children should be considered in routine diagnostics.
NARCIS arrow_drop_down University of Bath's research portalArticle . 2019Data sources: University of Bath's research portalNTNU Open; Norwegian Open Research ArchivesArticle . 2019Nature Genetics; Archivio Istituzionale della Ricerca - Università degli Studi di Perugia; NARCISOther literature type . Article . 2019 . Peer-reviewedLicense: Springer TDMData sources: European Union Open Data Portal; University of Groningen Research Portal; Vrije Universiteit Amsterdam (VU Amsterdam) - Institutional Repository; Vrije Universiteit Amsterdam (VU Amsterdam) – Research Portal; Crossref; Archivio Istituzionale della Ricerca - Università degli Studi di Perugia; NARCISNature Genetics; NARCISArticle . 2019Nature Genetics; NARCISArticle . 2019LUMC Scholarly Publications; Leiden University Scholarly Publications RepositoryOther literature type . 2019add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41588-019-0511-y&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 188 citations 188 popularity Top 1% influence Top 10% impulse Top 0.1% Powered by BIP!visibility 45visibility views 45 download downloads 5 Powered bymore_vert NARCIS arrow_drop_down University of Bath's research portalArticle . 2019Data sources: University of Bath's research portalNTNU Open; Norwegian Open Research ArchivesArticle . 2019Nature Genetics; Archivio Istituzionale della Ricerca - Università degli Studi di Perugia; NARCISOther literature type . Article . 2019 . Peer-reviewedLicense: Springer TDMData sources: European Union Open Data Portal; University of Groningen Research Portal; Vrije Universiteit Amsterdam (VU Amsterdam) - Institutional Repository; Vrije Universiteit Amsterdam (VU Amsterdam) – Research Portal; Crossref; Archivio Istituzionale della Ricerca - Università degli Studi di Perugia; NARCISNature Genetics; NARCISArticle . 2019Nature Genetics; NARCISArticle . 2019LUMC Scholarly Publications; Leiden University Scholarly Publications RepositoryOther literature type . 2019add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41588-019-0511-y&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Part of book or chapter of book , Other literature type 2019 FrancePublisher:WORLD SCIENTIFIC (EUROPE) Authors: Christophette Blanchet-Scalliet; Monique Jeanblanc; Ricardo Romo Romero;Christophette Blanchet-Scalliet; Monique Jeanblanc; Ricardo Romo Romero;International audience; We present some results on enlargement of filtration in discrete time. Many results known in continuous time extend immediately in a discrete time setting. Here, we provide direct proofs which are much more simpler. We study also arbitrages conditions in a financial setting and we present some specific cases, as immersion and pseudo-stopping times for which we obtain new results.
Hyper Article en Lig... arrow_drop_down https://doi.org/10.1007/978-98...Part of book or chapter of book . 2020 . Peer-reviewedLicense: Springer TDMData sources: CrossrefHAL Descartes; HAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotPreprint . Part of book or chapter of book . 2019 . 2016HAL Evry; Mémoires en Sciences de l'Information et de la CommunicationPart of book or chapter of book . 2019Full-Text: https://hal.science/hal-01253214/documenthttps://doi.org/10.1142/978178...Part of book or chapter of book . 2019 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1142/9781786341952_0007&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu3 citations 3 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Hyper Article en Lig... arrow_drop_down https://doi.org/10.1007/978-98...Part of book or chapter of book . 2020 . Peer-reviewedLicense: Springer TDMData sources: CrossrefHAL Descartes; HAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotPreprint . Part of book or chapter of book . 2019 . 2016HAL Evry; Mémoires en Sciences de l'Information et de la CommunicationPart of book or chapter of book . 2019Full-Text: https://hal.science/hal-01253214/documenthttps://doi.org/10.1142/978178...Part of book or chapter of book . 2019 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1142/9781786341952_0007&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018 Denmark, France, Spain, Italy, ItalyPublisher:Springer Science and Business Media LLC Botker H. E.; Hausenloy D.; Andreadou I.; Antonucci S.; Boengler K.; Davidson S. M.; Deshwal S.; Devaux Y.; Di Lisa F.; Di Sante M.; Efentakis P.; Femmino S.; Garcia-Dorado D.; Giricz Z.; Ibanez B.; Iliodromitis E.; Kaludercic N.; Kleinbongard P.; Neuhauser M.; Ovize M.; Pagliaro P.; Rahbek-Schmidt M.; Ruiz-Meana M.; Schluter K. -D.; Schulz R.; Skyschally A.; Wilder C.; Yellon D. M.; Ferdinandy P.; Heusch G.;HEB and MRS were supported by The Danish Council for Strategic Research (11-108354), Novo Nordisk Foundation (Conditioning Based Intervention Strategies-ConBis) and Trygfonden. DH was supported by the British Heart Foundation (FS/10/039/28270), the National Institute for Health Research University College London Hospitals Biomedical Research Centre, Duke National University Singapore Medical School, Singapore Ministry of Health's National Medical Research Council and its Clinician Scientist-Senior Investigator scheme (NMRC/CSA-SI/0011/2017) and Collaborative Centre Grant scheme (NMRC/GGAug16C006), and the Singapore Ministry of Education Academic Research Fund Tier 2 (MOE2016-T2-2-021). PF is supported by grants from the Hungarian National Research, Development, and Innovation Office (OTKA K 109737, OTKA KH\_17 125570, NVKP 16-1-2016-0017, and VEKOP-2.3.2-16-2016-00002) and the Ministry of Human Capacities (Institutional Excellence Program for Higher Education). ZG is supported by the Bolyai Scholarship by the Hungarian Academy of Sciences. GH and PK were supported by the German Research Foundation (He 1320/18-3 and SFB 1116 B8). Sí
Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTAArticle . 2018Full-Text: https://doi.org/10.1007/s00395-018-0696-8Data sources: Recolector de Ciencia Abierta, RECOLECTAArchivio Istituzionale (AperTO); Basic Research in CardiologyArticle . 2018 . Peer-reviewedLicense: CC BYEurope PubMed CentralArticle . 2018Full-Text: http://europepmc.org/articles/PMC6105267Data sources: PubMed CentralUniversitätsbibliographie, Universität Duisburg-EssenArticle . 2018Data sources: Universitätsbibliographie, Universität Duisburg-EssenHAL - UPEC / UPEM; HAL-Pasteur; Hyper Article en Ligne; HAL-Inserm; Hal-DiderotOther literature type . Article . 2018add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s00395-018-0696-8&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 342 citations 342 popularity Top 0.1% influence Top 10% impulse Top 0.1% Powered by BIP!more_vert Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTAArticle . 2018Full-Text: https://doi.org/10.1007/s00395-018-0696-8Data sources: Recolector de Ciencia Abierta, RECOLECTAArchivio Istituzionale (AperTO); Basic Research in CardiologyArticle . 2018 . Peer-reviewedLicense: CC BYEurope PubMed CentralArticle . 2018Full-Text: http://europepmc.org/articles/PMC6105267Data sources: PubMed CentralUniversitätsbibliographie, Universität Duisburg-EssenArticle . 2018Data sources: Universitätsbibliographie, Universität Duisburg-EssenHAL - UPEC / UPEM; HAL-Pasteur; Hyper Article en Ligne; HAL-Inserm; Hal-DiderotOther literature type . Article . 2018add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s00395-018-0696-8&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Conference object , Article , Other literature type , Preprint 2017 FrancePublisher:IEEE Authors: Bitar, Ahmad W.; Ovarlez, Jean-Philippe; Cheong, Loong-Fah;Bitar, Ahmad W.; Ovarlez, Jean-Philippe; Cheong, Loong-Fah;Estimating large covariance matrices has been a longstanding important problem in many applications and has attracted increased attention over several decades. This paper deals with two methods based on pre-existing works to impose sparsity on the covariance matrix via its unit lower triangular matrix (aka Cholesky factor) $\mathbf{T}$. The first method serves to estimate the entries of $\mathbf{T}$ using the Ordinary Least Squares (OLS), then imposes sparsity by exploiting some generalized thresholding techniques such as Soft and Smoothly Clipped Absolute Deviation (SCAD). The second method directly estimates a sparse version of $\mathbf{T}$ by penalizing the negative normal log-likelihood with $L_1$ and SCAD penalty functions. The resulting covariance estimators are always guaranteed to be positive definite. Some Monte-Carlo simulations as well as experimental data demonstrate the effectiveness of our estimators for hyperspectral anomaly detection using the Kelly anomaly detector. To be published on IEEE CAMSAP 2017
Hyper Article en Lig... arrow_drop_down Mémoires en Sciences de l'Information et de la CommunicationConference object . 2017Mémoires en Sciences de l'Information et de la CommunicationConference object . 2017HAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotConference object . 2017https://doi.org/10.48550/arxiv...Article . 2017License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/camsap.2017.8313124&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 3 citations 3 popularity Average influence Average impulse Average Powered by BIP!more_vert Hyper Article en Lig... arrow_drop_down Mémoires en Sciences de l'Information et de la CommunicationConference object . 2017Mémoires en Sciences de l'Information et de la CommunicationConference object . 2017HAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotConference object . 2017https://doi.org/10.48550/arxiv...Article . 2017License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/camsap.2017.8313124&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2017 Italy, Iceland, Netherlands, Netherlands, Netherlands, Sweden, Netherlands, Norway, Netherlands, Netherlands, Ireland, Sweden, Germany, Switzerland, Ireland, United Kingdom, Germany, France, United Kingdom, Netherlands, United Kingdom, Netherlands, Germany, Germany, Netherlands, Netherlands, Netherlands, Spain, Netherlands, United KingdomPublisher:Springer Science and Business Media LLC Publicly fundedFunded by:EC | TACTICS, EC | MATRICS, EC | AGGRESSOTYPE +2 projectsEC| TACTICS ,EC| MATRICS ,EC| AGGRESSOTYPE ,EC| IMAGEMEND ,EC| MiNDHieab H.H. Adams; Neda Jahanshad; Ganesh Chauhan; Jason L. Stein; Edith Hofer; Miguel E. Rentería; Joshua C. Bis; Sylvane Desrivières; Meike W. Vernooij; Saud Alhusaini; Najaf Amin; Konstantinos Arfanakis; Nicola J. Armstrong; Lavinia Athanasiu; Ashley Beecham; Alexa S. Beiser; Manon Bernard; Susan H. Blanton; Marco P. Boks; Janita Bralten; Adam M. Brickman; Owen Carmichael; Qiang Chen; Vincent Chouraki; Gabriel Cuellar-Partida; Fabrice Crivello; Anouk den Braber; Rebecca F. Gottesman; Oliver Grimm; Unn K. Haukvik; D. Hoehn; Tianye Jia; Kjetil Nordbø Jørgensen; Nazanin Karbalai; Marieke Klein; Bernd Kraemer; Phil Lee; Lorna M. Lopez; Christine Macare; Andre F. Marquand; Mar Matarin; Karen A. Mather; Manuel Mattheisen; David R. McKay; Susana Muñoz Maniega; Kwangsik Nho; Jaap Oosterlaan; Lukas Pirpamer; Adaikalavan Ramasamy; Shannon L. Risacher; Stefan Ropele; Natalie A. Royle; Philipp G. Sämann; Arvin Saremi; Claudia L. Satizabal; Lianne Schmaal; Li Shen; Elena Shumskaya; Emma Sprooten; Lachlan T. Strike; Alexander Teumer; Roberto Toro; Daniah Trabzuni; Stella Trompet; Dhananjay Vaidya; Jeroen van der Grond; Sven J. van der Lee; Dennis van der Meer; Kristel R. van Eijk; Daan van Rooij; Esther Walton; Lars T. Westlye; Christopher D. Whelan; Beverly G. Windham; Anderson M. Winkler; Christiane Wolf; Thomas Wolfers; Lisa R. Yanek; Jingyun Yang; Marcel P. Zwiers; Ingrid Agartz; Laura Almasy; Philippe Amouyel; Ole A. Andreassen; Mark E. Bastin; James T. Becker; David A. Bennett; John Blangero; Hans van Bokhoven; Dorret I. Boomsma; Henry Brodaty; Rachel M. Brouwer; Han G. Brunner; Wiepke Cahn; Vince D. Calhoun; Dara M. Cannon; Gianpiero L. Cavalleri; Ching-Yu Cheng; Sven Cichon; Aiden Corvin; Benedicto Crespo-Facorro; Joanne E. Curran; Michael Czisch; Anders M. Dale; Eco J. C. de Geus; Greig I. de Zubicaray; Ian J. Deary; Stéphanie Debette; Norman Delanty; Chantal Depondt; Anita L. DeStefano; Allissa Dillman; Srdjan Djurovic; G. Donohoe; Thomas D. Dyer; Susanne Erk; Thomas Espeseth; Iryna O. Fedko; Guillén Fernández; Luigi Ferrucci; Simon E. Fisher; Ian Ford; Tatiana Foroud; Clyde Francks; Masaki Fukunaga; J. Raphael Gibbs; Randy L. Gollub; Robert C. Green; Oliver Gruber; Vilmundur Gudnason; Narelle K. Hansell; John Hardy; Catharina A. Hartman; Ryota Hashimoto; K Hegenscheid; Andreas Heinz; Stephanie Le Hellard; Beng-Choon Ho; Pieter J. Hoekstra; Norbert Hosten; Matthew J. Huentelman; Hilleke E. Hulshoff Pol; Masashi Ikeda; Robert Johnson; Erik G. Jönsson; J. Wouter Jukema; Stephen M. Lawrie; Herve Lemaitre; Dan L. Longo; Simon Lovestone; Oliver Martinez; C. McDonald; Andrew M. McIntosh; Francis J. McMahon; Andreas Meyer-Lindenberg; Sebastian Mohnke; Grant W. Montgomery; Michael A. Nalls; Matthias Nauck; Thomas E. Nichols; Wiro J. Niessen; Markus M. Nöthen; Lars Nyberg; Kazutaka Ohi; Tomáš Paus; Brenda W.J.H. Penninx; G. Bruce Pike; Steven G. Potkin; Simone Reppermund; Marcella Rietschel; Joshua L. Roffman; Nina Romanczuk-Seiferth; Mina Ryten; Ralph L. Sacco; Perminder S. Sachdev; Andrew J. Saykin; Reinhold Schmidt; Helena Schmidt; Peter R. Schofield; Sigurdur Sigursson; Andrew Simmons; Colin Smith; Jordan W. Smoller; David J. Stott; Anbupalam Thalamuthu; Magda Tsolaki; Christophe Tzourio; Andre G. Uitterlinden; Maria del C. Valdés Hernández; Dennis van 't Ent; Marie-José van Tol; Badri N. Vardarajan; Henrik Walter; Joanna M. Wardlaw; Thomas H. Wassink; Michael E. Weale; Michael Weiner; Wei Wen; Eric Westman; Tonya White; Tien Yin Wong; Nicholas G. Martin; Cornelia M. van Duijn; Margaret J. Wright; Hans J. Grabe; Barbara Franke; Sarah E. Medland; Sudha Seshadri; Paul M. Thompson; M. Arfan Ikram;handle: 11858/00-001M-0000-002C-5334-C , 11858/00-001M-0000-002B-A1BC-7 , 11858/00-001M-0000-002C-5335-A , 11858/00-001M-0000-002C-5336-8 , 10902/13707 , 2128/13909 , 1871.1/8dcfd9e4-0a05-4a12-8a72-1a68533da704 , https://repository.ubn.ru.nl/handle/2066/168856 , 11370/ea0fe7e1-e942-4a3a-a770-9dd8add410ff , 1765/95645 , 21.11116/0000-0001-8841-C , 21.11116/0000-0001-8843-A , 1887/113252 , 20.500.11820/ed7d3305-c382-40a1-9f68-96fef0049e9a , 1983/d6c7fa9e-dd63-4301-9d2a-a002654b88e1 , 2066/168856 , 11391/1406264 , 11250/2485096 , 1874/348364
pmc: PMC5253632
pmid: 28098162
handle: 11858/00-001M-0000-002C-5334-C , 11858/00-001M-0000-002B-A1BC-7 , 11858/00-001M-0000-002C-5335-A , 11858/00-001M-0000-002C-5336-8 , 10902/13707 , 2128/13909 , 1871.1/8dcfd9e4-0a05-4a12-8a72-1a68533da704 , https://repository.ubn.ru.nl/handle/2066/168856 , 11370/ea0fe7e1-e942-4a3a-a770-9dd8add410ff , 1765/95645 , 21.11116/0000-0001-8841-C , 21.11116/0000-0001-8843-A , 1887/113252 , 20.500.11820/ed7d3305-c382-40a1-9f68-96fef0049e9a , 1983/d6c7fa9e-dd63-4301-9d2a-a002654b88e1 , 2066/168856 , 11391/1406264 , 11250/2485096 , 1874/348364
pmc: PMC5253632
pmid: 28098162
The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg=−0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness. The hippocampus in mammalian brain varies in size across individuals. Here, Hibar and colleagues perform a genome-wide association meta-analysis to find six genetic loci with significant association to hippocampus volume.
Norwegian Open Resea... arrow_drop_down Online-Publikations-Server der Universität WürzburgArticle . 2017License: CC BYData sources: Online-Publikations-Server der Universität WürzburgEurope PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5253632Data sources: PubMed CentralMaynooth University ePrints & eTheses ArchiveArticle . 2017 . Peer-reviewedData sources: Maynooth University ePrints & eTheses ArchiveNARCIS; Radboud RepositoryArticle . 2017Explore Bristol Research; Nature CommunicationsArticle . 2017METIS Research Information System; NARCIS; Nature CommunicationsArticle . 2017 . Peer-reviewedLicense: CC BYOxford University Research ArchiveOther literature type . 2017License: CC BYData sources: Oxford University Research ArchiveBern Open Repository and Information System (BORIS)Article . 2017 . Peer-reviewedData sources: Bern Open Repository and Information System (BORIS)Refubium - Repositorium der Freien Universität BerlinOther literature type . 2017License: CC BYData sources: Refubium - Repositorium der Freien Universität BerlinNARCIS; Nature CommunicationsArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/ncomms13624&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 246 citations 246 popularity Top 1% influence Top 10% impulse Top 0.1% Powered by BIP!visibility 112visibility views 112 download downloads 166 Powered bymore_vert Norwegian Open Resea... arrow_drop_down Online-Publikations-Server der Universität WürzburgArticle . 2017License: CC BYData sources: Online-Publikations-Server der Universität WürzburgEurope PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5253632Data sources: PubMed CentralMaynooth University ePrints & eTheses ArchiveArticle . 2017 . Peer-reviewedData sources: Maynooth University ePrints & eTheses ArchiveNARCIS; Radboud RepositoryArticle . 2017Explore Bristol Research; Nature CommunicationsArticle . 2017METIS Research Information System; NARCIS; Nature CommunicationsArticle . 2017 . Peer-reviewedLicense: CC BYOxford University Research ArchiveOther literature type . 2017License: CC BYData sources: Oxford University Research ArchiveBern Open Repository and Information System (BORIS)Article . 2017 . Peer-reviewedData sources: Bern Open Repository and Information System (BORIS)Refubium - Repositorium der Freien Universität BerlinOther literature type . 2017License: CC BYData sources: Refubium - Repositorium der Freien Universität BerlinNARCIS; Nature CommunicationsArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/ncomms13624&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint , Other literature type , Part of book or chapter of book 2017 FrancePublisher:Springer International Publishing Authors: Armenti, Yannick; Crépey, Stéphane; Zhou, Chao;Armenti, Yannick; Crépey, Stéphane; Zhou, Chao;In incomplete markets, a basic Black-Scholes perspective has to be complemented by the valuation of market imperfections. Otherwise this results in Black-Scholes Ponzi schemes, such as the ones at the core of the last global financial crisis, where always more derivatives need to be issued for remunerating the capital attracted by the already opened positions. In this paper we consider the sustainable Black-Scholes equations that arise for a portfolio of options if one adds to their trade additive Black-Scholes price, on top of a nonlinear funding cost, the cost of remunerating at a hurdle rate the residual risk left by imperfect hedging. We assess the impact of model uncertainty in this setup.
Hyper Article en Lig... arrow_drop_down https://doi.org/10.1007/978-3-...Part of book or chapter of book . 2017 . Peer-reviewedLicense: Springer TDMData sources: CrossrefHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotPreprint . 2018add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/978-3-319-66536-8_8&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Hyper Article en Lig... arrow_drop_down https://doi.org/10.1007/978-3-...Part of book or chapter of book . 2017 . Peer-reviewedLicense: Springer TDMData sources: CrossrefHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotPreprint . 2018add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/978-3-319-66536-8_8&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2016 Germany, Ireland, United Kingdom, Netherlands, Italy, Spain, United Kingdom, France, France, France, United Kingdom, France, France, France, United Kingdom, United Kingdom, France, IrelandPublisher:Springer Science and Business Media LLC Publicly fundedFunded by:EC | NEUROSCHEMA, NIH | The ARIC and Neurocogniti..., NIH | Functional genomics of bi... +110 projectsEC| NEUROSCHEMA ,NIH| The ARIC and Neurocognitive Longitudinal Study ,NIH| Functional genomics of bipolar disorder ,NIH| OBESITY, DIABETES &AGING ANIMAL RESOURCE ,NIH| Genotypic Determinants of Aspirin Response in High-Risk ,NHMRC| Cerebrovascular diseases and Brain Ageing – a program of research into novel mechanisms, risk prevention and innovative health care delivery ,NHMRC| The Older Australian Twins Study (OATS) of healthy brain ageing and age-related neurocognitive disorders ,NIH| National Cell Repository for Alzheimer's Disease (NCRAD) ,NIH| AGES STUDY-THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENNIUM-260012100 ,NIH| ENIGMA Center for Worldwide Medicine, Imaging & Genomics ,NIH| UCLA Clinical and Translational Science Institute ,NIH| HARDI Mapping of Disease Effects on the Brain ,NIH| Predicting Brain Changes in HIV/AIDS ,NSF| MRI: Acquisition of a Data Analytics Cluster for Computational Social Science ,NIH| CHS-Transition Phase -268055222 ,NIH| Searching for Endophenotypes of Bipolar Disorder ,NIH| Alzheimer's Disease Genetics Consortium ,EC| ORACLE ,NWO| Twin-family database for behavior genetics and genomics studies ,NWO| Networking through ADHD biology ,NIH| Alzheimer's Disease Genetics Consortium ,NIH| Empowering Personalized Medicine: Integrating Imaging, Genetics, and Biomarkers ,FWF| Mechanisms of Small Vessel Related Brain Damage and Cognitive Impairment ,WT| Genome-wide association studies in partial epilepsies. ,EC| MiND ,EC| TACTICS ,WT| Stratifying Resilience and Depression Longitudinally (STRADL) ,NIH| Risk Factors, Pathology, and Clinical Expressions of AD ,NIH| CHS Events Follow-up Study ,NIH| From GWAS loci to blood pressure genes, variants & mechanisms ,NIH| Genome-Wide Association for Loci Influencing CHD and Other Heart, Lung and Blood ,NIH| Genetic Epidemiology of Cognitive Decline in an Aging Population Sample ,NIH| An Integrated Genetic and Epigenetic Approach to Cerebral Small Vessel Disease ,NIH| Occult Small Vessel Cerebrovascular Disease in High Risk Families ,NHMRC| Type 2 Diabetes Mellitus and Cognitive Decline - a longitudinal study of effects and mechanisms ,NHMRC| The prevention, early detection, & effective management of neurocognitive disorders in the elderly ,EC| EU-AIMS ,NHMRC| Gene-environment interaction in healthy brain ageing and age related neurodegeneration ,EC| MATRICS ,NIH| CHARGE: Identifying Risk & Protective SNV for AD in ADSP Case-control Sample ,NIH| Prospective meta-analyses of drug-gene interactions: CHARGE GWAS consortium ,NHMRC| Prevention, early detection and effective management of neurocognitive disorders in the elderly ,NIH| GCRC-RENOVATION ,NIH| Epidemiologic Study of Neural Reserve and Neurobiology of Aging ,NIH| International Multi-Center ADHD Genetics Project ,NHMRC| A population-based study of cerebrovascular mechanisms underyling gait, balance and cognition in older people ,NIH| Exceptional aging: 12 year trajectories to function ,NWO| From genetic pathways to cognition in ADHD: a question of the right connections? ,NHMRC| Advancing our understanding of the genetics of Psychiatric and Neurological Disease ,EC| PHASE ,NIH| Hormonal trajectories in aging ,NIH| Using Genetics to Dissect Schizhoprenia, Bipolar Disorder, and Depression ,NIH| Major Depression: Stage 1 Genomewide Association in Population-Based Samples ,NIH| Role of Mitochondrial Health in Acute and Chronic Kidney Disease in Older Adults ,CIHR ,NHMRC| Genetics of brain structure and function ,NIH| Epidemiology of Biomarkers of Risk and Progression in LOAD ,NIH| Institute for Clinical and Translational Research (UL1) ,NIH| Laboratory of Neuro Imaging Resource (LONIR) ,NHMRC| Australian Twin Registry ,NWO| NCHA Subsidiebesluit 2008-2012 ,ARC| The articulate brain ,NIH| CORONARY HEART DISEASE &STROKE IN THE ELDERLY ,NIH| Genomic Studies of Bipolar Disorder in a Large Cohort from The Netherlands ,NWO| Neuro-imaging study in twins concordant or discordant for obsessive-compulsive symptoms. ,NIH| ALZHEIMERS DISEASE DATA COORDINATING CENTER ,NHMRC| Genetics of melanoma risk factors ,NIH| Structural Brain Abnormalities In Depression ,NIH| COGNITIVE TESTS, APOE, BRAIN MRI AND RISKS OF DEMENTIA ,NIH| CYCLINS AND CHEMICAL CARCINOGENESIS ,EC| IMAGEMEND ,NIH| Alzheimer's disease risk analyzed using population imaging genomics ,NHMRC| Prevention and management of mental disorders in older Australians ,NIH| Functional Neuroimaging In Unipolar And Bipolar Depresse ,NIH| GWA for Gene-Environment Interaction Effects Influencing CHD ,NIH| MOLECULAR AND BIOCHEMICAL GENETICS LABORATORY RENOVATION ,NIH| Risk Factors, Pathology, and Clinical Expressions of AD ,NIH| Dimensional Neurogenetic Markers of Limbic System Integrity & Psychiatric Illness ,NHMRC| Development and Evaluation of Statistical Methods and Software for Analysis of Complex Genetic Disease Data ,NIH| CHS research resources for the cardiovascular health of older adults ,WT| A Powerful, Genome-Wide Association Scan for Susceptibility Genes for late-onset Alzheimer's disease ,NHMRC| Genetic Repositories Australia ,NIH| Genetic Influences on Human Cortical Development ,NIH| Epidemiology of Venous Thrombosis &Pulmonary Embolism ,NIH| SHORT-TERM STABILITY OF CLINICAL TESTS ,NWO| Dissecting genetic complexity of Alzheimer's disease and cognitive function ,ARC| Elucidating the genetics of attention deficit hyperactivity disorder by integrating pathway and prediction analyses ,SFI| The application of MRI to identify endophenotypes in focal epilepsy ,NWO| Functional neural network plasticity in adolescent twins and sibs ,NIH| CORONARY HEART DISEASE AND STROKE ,NIH| Vascular Cognitive and Motor Decline: Impact of aPL ,NIH| Research and Mentoring on Integrating Psychiatric Genetics and Neuroscience ,EC| ENGAGE ,NIH| Genetic influences on the brain: A twin imaging study ,NIH| Rare variants and NHLBI traits in deeply phenotyped cohorts ,NIH| Genomics of Developmental Trajectories in Twins ,NIH| Neuroimaging genetics to study social cognitive deficits in ASD and schizophrenia ,NIH| WGA Study to Identify Genetic Variants Associated with CV Events in CHS ,NIH| Collaborative GWAS of Dementia, AD and related MRI and Cognitive Endophenotypes ,EC| AGGRESSOTYPE ,NIH| CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84 ,UKRI| Centre for Cognitive Ageing & Cognitive Epidemiology ,NIH| CHARGE consortium: gene discovery for CVD and aging phenotypes ,NIH| EXTRAMULAR RESEARCH FACILITIES CONSTRUCTION ,NIH| Genetic Influences on Human Neuroanatomical Shapes ,NIH| Neurodevelopment and Imaging among HIV-infected Children from the PREDICT study ,NIH| RISK FACTORS FOR INCIDENT AD IN A BIRACIAL COMMUNITY ,NIH| Alzheimers Disease in Mild Cognitive Impairment ,EC| GMI ,NIH| Alzheimers Disease Neuroimaging Initiative ,NIH| CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84 ,NIH| Integration of Genomics &Transcriptomics in Normal Twins &Major Depression ,NIH| CORONARY HEART DISEASE AND STROKEHieab H.H. Adams; Vincent Chouraki; Jason L. Stein; Miguel E. Rentería; Stella Trompet; Alejandro Arias-Vasquez; Sudha Seshadri; Sylvane Desrivières; Sven J. van der Lee; Najaf Amin; Micael Andersson; Konstantinos Arfanakis; Benjamin S. Aribisala; Nicola J. Armstrong; Alexa S. Beiser; Manon Bernard; Susan H. Blanton; Marco P. Boks; Janita Bralten; Owen Carmichael; Ganesh Chauhan; Qiang Chen; Gabriel Cuellar-Partida; Anouk den Braber; Stefan Ehrlich; Irina Filippi; Tian Ge; Rebecca F. Gottesman; Corina U. Greven; Tulio Guadalupe; Unn K. Haukvik; Saima Hilal; D. Hoehn; Tianye Jia; Marieke Klein; Phil H. Lee; David C. Liewald; Lorna M. Lopez; Michelle Luciano; Christine Macare; Andre F. Marquand; Karen A. Mather; Manuel Mattheisen; Bernard Mazoyer; Rebekah McWhirter; Yuri Milaneschi; Nazanin Mirza-Schreiber; Ryan L. Muetzel; Susana Muñoz Maniega; Kwangsik Nho; Loes M. Olde Loohuis; Jaap Oosterlaan; Irene Pappa; Lukas Pirpamer; Sara Pudas; Adaikalavan Ramasamy; Jennifer S. Richards; Shannon L. Risacher; Roberto Roiz-Santiañez; Nanda Rommelse; Emma J. Rose; Claudia L. Satizabal; Lianne Schmaal; Li Shen; Jean Shin; Albert V. Smith; Emma Sprooten; Lachlan T. Strike; Alexander Teumer; Russell Thomson; Diana Tordesillas-Gutiérrez; Roberto Toro; Daniah Trabzuni; Dhananjay Vaidya; Jeroen van der Grond; Dennis van der Meer; Marjolein M. J. Van Donkelaar; Kristel R. van Eijk; Theo G.M. van Erp; Esther Walton; Lars T. Westlye; Christopher D. Whelan; Beverly G Windham; Anderson M. Winkler; Girma Woldehawariat; Christiane Wolf; Thomas Wolfers; Bing Xu; Ingrid Agartz; David Ames; Philippe Amouyel; Ole A. Andreassen; Sampath Arepalli; Mark E. Bastin; Diane M. Becker; James T. Becker; John Blangero; Hans van Bokhoven; Dorret I. Boomsma; Henry Brodaty; Rachel M. Brouwer; Randy L. Buckner; Vince D. Calhoun; Dara M. Cannon; Gianpiero L. Cavalleri; Christopher Chen; Ching-Yu Cheng; Sven Cichon; Mark R. Cookson; Aiden Corvin; Benedicto Crespo-Facorro; Joanne E. Curran; Michael Czisch; Gareth E. Davies; Eco J. C. de Geus; Greig I. Zubicaray; Anita L. DeStefano; Srdjan Djurovic; Gary Donohoe; Wayne C. Drevets; Thomas D. Dyer; Susanne Erk; Thomas Espeseth; Denis A. Evans; Iryna O. Fedko; Simon E. Fisher; Debra A. Fleischman; Clyde Francks; Masaki Fukunaga; J. Raphael Gibbs; Randy L. Gollub; Harald H H Göring; Hans J. Grabe; Robert C. Green; Oliver Gruber; Vilmundur Gudnason; Narelle K. Hansell; John Hardy; Ryota Hashimoto; Andreas Heinz; Stephanie Le Hellard; Dirk J. Heslenfeld; Beng-Choon Ho; Wolfgang Hoffmann; Albert Hofman; Florian Holsboer; Georg Homuth; Hilleke E. Hulshoff Pol; M. Kamran Ikram; Clifford R. Jack; Mark Jenkinson; Robert Johnson; Erik G. Jönsson; J. Wouter Jukema; David S. Knopman; Peter Kochunov; Stephen M. Lawrie; Herve Lemaitre; Dan L. Longo; W.T. Longstreth; Oscar L. Lopez; Simon Lovestone; Jean-Luc Martinot; Colm McDonald; Andrew M. McIntosh; Katie L. McMahon; Francis J. McMahon; Patrizia Mecocci; Ingrid Melle; Andreas Meyer-Lindenberg; Sebastian Mohnke; Derek W. Morris; Thomas H. Mosley; Thomas W. Mühleisen; Thomas E. Nichols; Wiro J. Niessen; Markus M. Nöthen; Lars Nyberg; Kazutaka Ohi; Roel A. Ophoff; Massimo Pandolfo; G. Bruce Pike; Bruce M. Psaty; Marcella Rietschel; Joshua L. Roffman; Nina Romanczuk-Seiferth; Mina Ryten; Ralph L. Sacco; Perminder S. Sachdev; Andrew J. Saykin; Reinhold Schmidt; Peter R. Schofield; Andrew Singleton; Hilkka Soininen; Velandai Srikanth; Jessika E. Sussmann; Anbupalam Thalamuthu; Henning Tiemeier; Arthur W. Toga; Bryan J. Traynor; Juan C. Troncoso; Jessica A. Turner; Christophe Tzourio; André G. Uitterlinden; Aad van der Lugt; Nic J A van der Wee; Cornelia M. van Duijn; Dennis van 't Ent; Marie-José van Tol; Badri N. Vardarajan; Dick J. Veltman; Meike W. Vernooij; Henry Völzke; Henrik Walter; Joanna M. Wardlaw; Thomas H. Wassink; Michael E. Weale; Daniel R. Weinberger; Wei Wen; Eric Westman; Tonya White; Tien Yin Wong; H. Ronald Zielke; Alan B. Zonderman; Ian J. Deary; Nicholas G. Martin; Anton J. M. de Craen; Margaret J. Wright; Lenore J. Launer; Gunter Schumann; Barbara Franke; Stéphanie Debette; Sarah E. Medland; Paul M. Thompson;pmid: 27694991
pmc: PMC5227112
handle: 1871.1/e355ae09-2997-486e-98e5-c8968be7f4c4 , 10902/16311 , 11858/00-001M-0000-002B-7F28-6 , 11858/00-001M-0000-002C-2A97-4 , 2066/165723 , 11370/f227c90a-5d2a-41c8-a65b-5cb41250ef07 , 1887/112477 , 1983/ea8a2fa3-e92b-41d9-9147-c1b24d8515c3 , 11391/1406555 , 20.500.11820/cef4fd4e-02ab-4e12-8153-a6de64660b4d , 1874/343369
pmid: 27694991
pmc: PMC5227112
handle: 1871.1/e355ae09-2997-486e-98e5-c8968be7f4c4 , 10902/16311 , 11858/00-001M-0000-002B-7F28-6 , 11858/00-001M-0000-002C-2A97-4 , 2066/165723 , 11370/f227c90a-5d2a-41c8-a65b-5cb41250ef07 , 1887/112477 , 1983/ea8a2fa3-e92b-41d9-9147-c1b24d8515c3 , 11391/1406555 , 20.500.11820/cef4fd4e-02ab-4e12-8153-a6de64660b4d , 1874/343369
Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five previously unknown loci for intracranial volume and confirmed two known signals. Four of the loci were also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height. We found a high genetic correlation with child head circumference (rhogenetic = 0.748), which indicates a similar genetic background and allowed us to identify four additional loci through meta-analysis (Ncombined = 37,345). Variants for intracranial volume were also related to childhood and adult cognitive function, and Parkinson's disease, and were enriched near genes involved in growth pathways, including PI3K-AKT signaling. These findings identify the biological underpinnings of intracranial volume and their link to physiological and pathological traits. Contains fulltext : 165723pub.pdf (Publisher’s version ) (Closed access)
CORE (RIOXX-UK Aggre... arrow_drop_down CORE (RIOXX-UK Aggregator)Article . 2016Full-Text: http://livrepository.liverpool.ac.uk/3004351/1/ICV-GWAS-NN-acceptedAug31-2016embargoed.pdfData sources: CORE (RIOXX-UK Aggregator)Maynooth University ePrints & eTheses ArchiveArticle . 2016 . Peer-reviewedData sources: Maynooth University ePrints & eTheses ArchiveOxford University Research ArchiveOther literature type . 2017Data sources: Oxford University Research ArchiveRecolector de Ciencia Abierta, RECOLECTA; UCreaArticle . 2019 . 2016Spiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital RepositoryMETIS Research Information System; Nature Neuroscience; NARCIS; PURE Aarhus UniversityArticle . 2016 . Peer-reviewedLicense: Springer TDMFull-Text: http://www.nature.com/articles/nn.4398.pdfNARCIS; Nature NeuroscienceArticle . 2016LUMC Scholarly Publications; Leiden University Scholarly Publications RepositoryOther literature type . 2016NARCIS; Nature NeuroscienceArticle . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nn.4398&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 198 citations 198 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 141visibility views 141 download downloads 458 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down CORE (RIOXX-UK Aggregator)Article . 2016Full-Text: http://livrepository.liverpool.ac.uk/3004351/1/ICV-GWAS-NN-acceptedAug31-2016embargoed.pdfData sources: CORE (RIOXX-UK Aggregator)Maynooth University ePrints & eTheses ArchiveArticle . 2016 . Peer-reviewedData sources: Maynooth University ePrints & eTheses ArchiveOxford University Research ArchiveOther literature type . 2017Data sources: Oxford University Research ArchiveRecolector de Ciencia Abierta, RECOLECTA; UCreaArticle . 2019 . 2016Spiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital RepositoryMETIS Research Information System; Nature Neuroscience; NARCIS; PURE Aarhus UniversityArticle . 2016 . Peer-reviewedLicense: Springer TDMFull-Text: http://www.nature.com/articles/nn.4398.pdfNARCIS; Nature NeuroscienceArticle . 2016LUMC Scholarly Publications; Leiden University Scholarly Publications RepositoryOther literature type . 2016NARCIS; Nature NeuroscienceArticle . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nn.4398&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu
Loading
description Publicationkeyboard_double_arrow_right Article , Other literature type , Preprint 2021 Spain, Canada, United Kingdom, France, Ireland, Germany, Netherlands, United KingdomPublisher:Cold Spring Harbor Laboratory Publicly fundedFunded by:UKRI | Systems Cognitive Neurosc..., UKRI | Innovative Technologies f..., NIH | Impact of Amyloid and Tau... +6 projectsUKRI| Systems Cognitive Neuroscience of Healthy Ageing: Population-Representative Studies of Functional Plasticity and Neural Change ,UKRI| Innovative Technologies for Stratified and Experimental Medicine ,NIH| Impact of Amyloid and Tau on the Aging Brain: The Harvard Aging Brain Study ,NIH| BIOSTATISTICS &NEUROINFORMATICS (STATNI) CORE ,NIH| SCHIZOPHRENIA: A NEUROPSYCHIATRIC PERSPECTIVE ,UKRI| Statistics for Stratified Medicine and Analysis of Complex Phenotypes ,NIH| Combined brain and gene network approaches to the developmental hypothesis of schizophrenia ,FCT| LA 5 ,WTRichard A. I. Bethlehem; Jakob Seidlitz; White; Jacob W. Vogel; Kevin M. Anderson; Adamson C; Sophie Adler; George S. Alexopoulos; Evdokia Anagnostou; Areces-Gonzalez A; Duncan E. Astle; Bonnie Auyeung; Ayub M; Gareth Ball; Simon Baron-Cohen; Richard Beare; Saashi A Bedford; Benegal; Frauke Beyer; Bin Bae J; Blesa Cabez M; James P. Boardman; Matthew Borzage; Jorge Bosch-Bayard; Niall J Bourke; Calhoun Vd; M. Mallar Chakravarty; Chixiang Chen; Chertavian C; Gaël Chételat; Yap Seng Chong; James H. Cole; Aiden Corvin; Eric Courchesne; Fabrice Crivello; Vanessa Cropley; Delarue M; Sylvane Desrivières; Gabriel A. Devenyi; Di Biase Ma; Raymond J. Dolan; Kirsten A. Donald; Katharine Dunlop; Alexander D. Edwards; Jed T. Elison; Cameron T. Ellis; Jeremy A. Elman; Lisa T. Eyler; Damien A. Fair; Paul C. Fletcher; Peter Fonagy; Carol E. Franz; Ali Gholipour; Jay N. Giedd; John H. Gilmore; Ian M. Goodyer; Patricia Ellen Grant; Nynke A. Groenewold; Faith M. Gunning; R.E. Gur; Hammill Cf; Oskar Hansson; Trey Hedden; A. Heinz; Richard N. Henson; Katja Heuer; Jacqueline Hoare; Bharath Holla; Avram J. Holmes; Rosemary Holt; Hua Huang; Jonathan C Ipser; Clifford R. Jack; Andrea Parolin Jackowski; Tianye Jia; Keith A. Johnson; David T.W. Jones; Peter B. Jones; René S. Kahn; Hasse Karlsson; Linnea Karlsson; Ryuta Kawashima; Elizabeth Kelley; Silke Kern; Kim K; Manfred G. Kitzbichler; William S. Kremen; Francois Lalonde; Sang Jae Lee; Jason P. Lerch; Jianfu Li; Wei Liao; Deirel Paz Linares; Conor Liston; Jinglei Lv; Charles J. Lynch; Travis T. Mallard; Ross D. Markello; Bernard Mazoyer; Phillip McGuire; Michael J. Meaney; Andrea Mechelli; Nenad Medic; Bratislav Misic; Sarah E. Morgan; Mothersill D; Joel T. Nigg; Ong Mq; Cynthia M. Ortinau; Rik Ossenkoppele; Minhui Ouyang; Lena Palaniyappan; Paly L; Pedro Mario Pan; C Pantelis; Park Mtm; Tomáš Paus; Zdenka Pausova; Pichet Binette A; Karen Pierce; Jiang Qiu; Armin Raznahan; Timothy Rittman; Caitlin K. Rollins; Romero-Garcia R; Lisa Ronan; Rosenberg; David H. Rowitch; Giovanni Abrahão Salum; Theodore D. Satterthwaite; Herma Lina Schaare; Russell Schachar; Michael Schöll; Aaron P. Schultz; Gunter Schumann; David J. Sharp; Russel T. Shinohara; Ingmar Skoog; Christopher D. Smyser; Reisa A. Sperling; Dan J. Stein; Stolicyn A; John Suckling; Gareth J. Sullivan; Taki Y; Thyreau B; Roberto Toro; Kamen A. Tsvetanov; Nicholas B. Turk-Browne; Tuulari Jj; Christophe Tzourio; Etienne Vachon-Presseau; Mitchell Valdés-Sosa; Pedro A. Valdes-Sosa; van Amelsvoort T; Simon N. Vandekar; Lana Vasung; Petra E. Vértes; Lindsay W. Victoria; Sylvia Villeneuve; Arno Villringer; Konrad Wagstyl; Wang Ys; Simon K. Warfield; Eric Westman; Margaret L. Westwater; Heather C. Whalley; A. V. Witte; Yang N; Yeo Bt; Yun Hj; Andrew Zalesky; Heather J. Zar; Anna Zettergren; Juan Zhou; Hisham Ziauddeen; André Zugman; Zuo Xn; E.T. Bullmore; Aaron Alexander-Bloch;doi: 10.1101/2021.06.08.447489 , 10.1038/s41586-022-04554-y , 10.17863/cam.83688 , 10.17863/cam.84341 , 10.17863/cam.81584 , 10.17863/cam.88753 , 10.17863/cam.83738
handle: 21.11116/0000-000A-52FD-D , 10668/19570 , 20.500.11820/2e7cb12a-fb41-4a36-bc10-41f2ed0bc783 , 2128/32314 , 10261/303918 , 21.11116/0000-000A-6461-8 , 21.11116/0000-000A-6463-6
pmid: 36151472
pmc: PMC9021021
doi: 10.1101/2021.06.08.447489 , 10.1038/s41586-022-04554-y , 10.17863/cam.83688 , 10.17863/cam.84341 , 10.17863/cam.81584 , 10.17863/cam.88753 , 10.17863/cam.83738
handle: 21.11116/0000-000A-52FD-D , 10668/19570 , 20.500.11820/2e7cb12a-fb41-4a36-bc10-41f2ed0bc783 , 2128/32314 , 10261/303918 , 21.11116/0000-000A-6461-8 , 21.11116/0000-000A-6463-6
pmid: 36151472
pmc: PMC9021021
Over the past few decades, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, no reference standards currently exist to quantify individual differences in neuroimaging metrics over time, in contrast to growth charts for anthropometric traits such as height and weight1. Here we assemble an interactive open resource to benchmark brain morphology derived from any current or future sample of MRI data ( http://www.brainchart.io/ ). With the goal of basing these reference charts on the largest and most inclusive dataset available, acknowledging limitations due to known biases of MRI studies relative to the diversity of the global population, we aggregated 123,984 MRI scans, across more than 100 primary studies, from 101,457 human participants between 115 days post-conception to 100 years of age. MRI metrics were quantified by centile scores, relative to non-linear trajectories2 of brain structural changes, and rates of change, over the lifespan. Brain charts identified previously unreported neurodevelopmental milestones3, showed high stability of individuals across longitudinal assessments, and demonstrated robustness to technical and methodological differences between primary studies. Centile scores showed increased heritability compared with non-centiled MRI phenotypes, and provided a standardized measure of atypical brain structure that revealed patterns of neuroanatomical variation across neurological and psychiatric disorders. In summary, brain charts are an essential step towards robust quantification of individual variation benchmarked to normative trajectories in multiple, commonly used neuroimaging phenotypes. R.A.I.B. was supported by a British Academy Postdoctoral fellowship and by the Autism Research Trust. J. Seidlitz was supported by NIMH T32MH019112-29 and K08MH120564. S.R.W. was funded by UKRI Medical Research Council MC_UU_00002/2 and was supported by the NIHR Cambridge Biomedical Research Centre (BRC-1215-20014). E.T.B. was supported by an NIHR Senior Investigator award and the Wellcome Trust collaborative award for the Neuroscience in Psychiatry Network. A.F.A.-B. was supported by NIMH K08MH120564. Data were curated and analysed using a computational facility funded by an MRC research infrastructure award (MR/M009041/1) to the School of Clinical Medicine, University of Cambridge and supported by the mental health theme of the NIHR Cambridge Biomedical Research Centre. Peer reviewed
Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2023 . 2022 . Peer-reviewedRepositorio Institucional de Salud de Andalucía - Andalusian Health RepositoryArticle . 2022License: CC BYHAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2021.06.08.447489&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 453 citations 453 popularity Top 0.1% influence Top 1% impulse Top 0.01% Powered by BIP!visibility 297visibility views 297 download downloads 498 Powered bymore_vert Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; DIGITAL.CSICArticle . 2023 . 2022 . Peer-reviewedRepositorio Institucional de Salud de Andalucía - Andalusian Health RepositoryArticle . 2022License: CC BYHAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BYadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1101/2021.06.08.447489&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Preprint , Other literature type 2020 France, United Kingdom, Italy, Belgium, France, France, France, France, NetherlandsPublisher:Center for Open Science Funded by:NIH | Large-scale Automated Syn..., EC | ImPRESS, NSF | CRCNS US-German Data Shar...NIH| Large-scale Automated Synthesis of Functional Neuroimaging Data ,EC| ImPRESS ,NSF| CRCNS US-German Data Sharing: DataGit - converging catalogues, warehouses, and deployment logistics into a federated 'data distribution'Elise Bannier; Gareth J. Barker; Valentina Borghesani; Nils Broeckx; Patricia Clement; Kyrre E. Emblem; Satrajit S. Ghosh; Enrico Glerean; Krzysztof J. Gorgolewski; Marko Havu; Yaroslav O. Halchenko; Peer Herholz; Anne Hespel; Stephan Heunis; Yue Hu; Chuan-Peng Hu; Dorien C. Huijser; María de la Iglesia Vayá; Radim Jančálek; Vasileios K. Katsaros; Marie-Luise Kieseler; Camille Maumet; Clara Moreau; Henk-Jan Mutsaerts; Robert Oostenveld; Esin Ozturk-Isik; Nicolas Pascual Leone Espinosa; John Pellman; Cyril Pernet; Francesca B. Pizzini; Amira Serifovic Trbalic; Paule-Joanne Toussaint; Matteo Visconti di Oleggio Castello; Fengjuan Wang; Cheng Wang; Hua Zhu;pmc: PMC8046140
pmid: 33522661
AbstractHaving the means to share research data openly is essential to modern science. For human research, a key aspect in this endeavor is obtaining consent from participants, not just to take part in a study, which is a basic ethical principle, but also to share their data with the scientific community. To ensure that the participants' privacy is respected, national and/or supranational regulations and laws are in place. It is, however, not always clear to researchers what the implications of those are, nor how to comply with them. The Open Brain Consent (https://open-brain-consent.readthedocs.io) is an international initiative that aims to provide researchers in the brain imaging community with information about data sharing options and tools. We present here a short history of this project and its latest developments, and share pointers to consent forms, including a template consent form that is compliant with the EU general data protection regulation. We also share pointers to an associated data user agreement that is not only useful in the EU context, but also for any researchers dealing with personal (clinical) data elsewhere.
Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8046140Data sources: PubMed CentralInstitutional Repository Universiteit AntwerpenArticle . 2021Data sources: Institutional Repository Universiteit AntwerpenRecolector de Ciencia Abierta, RECOLECTAArticle . Lecture . 2021Data sources: Recolector de Ciencia Abierta, RECOLECTAIRIS - Università degli Studi di VeronaArticle . 2021Data sources: IRIS - Università degli Studi di VeronaIRIS - Università degli Studi di VeronaArticle . 2021Data sources: IRIS - Università degli Studi di Veronaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.31234/osf.io/f6mnp&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 31 citations 31 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert Europe PubMed Centra... arrow_drop_down Europe PubMed CentralArticle . 2021Full-Text: http://europepmc.org/articles/PMC8046140Data sources: PubMed CentralInstitutional Repository Universiteit AntwerpenArticle . 2021Data sources: Institutional Repository Universiteit AntwerpenRecolector de Ciencia Abierta, RECOLECTAArticle . Lecture . 2021Data sources: Recolector de Ciencia Abierta, RECOLECTAIRIS - Università degli Studi di VeronaArticle . 2021Data sources: IRIS - Università degli Studi di VeronaIRIS - Università degli Studi di VeronaArticle . 2021Data sources: IRIS - Università degli Studi di Veronaadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.31234/osf.io/f6mnp&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2019 Switzerland, United Kingdom, United Kingdom, France, United KingdomPublisher:Oxford University Press (OUP) Funded by:WTWTAuthors: Juliette Van Steenwinckel; Anne-Laure Schang; Michelle L. Krishnan; Vincent Degos; +28 AuthorsJuliette Van Steenwinckel; Anne-Laure Schang; Michelle L. Krishnan; Vincent Degos; Andrée Delahaye-Duriez; Cindy Bokobza; Zsolt Csaba; Franck Verdonk; Amélie Montané; Stéphanie Sigaut; Olivier Hennebert; Sophie Lebon; Leslie Schwendimann; Tifenn Le Charpentier; Rahma Hassan-Abdi; Gareth Ball; Paul Aljabar; Alka Saxena; Rebecca K. Holloway; Walter Birchmeier; Olivier Baud; David H. Rowitch; Veronique E. Miron; Fabrice Chrétien; Claire Leconte; Valérie C. Besson; Enrico Petretto; A. David Edwards; Henrik Hagberg; Nadia Soussi-Yanicostas; Bobbi Fleiss; Pierre Gressens;pmid: 31665242
pmc: PMC6906599
International audience; Microglia of the developing brain have unique functional properties but how their activation states are regulated is poorly understood. Inflammatory activation of microglia in the still-developing brain of preterm-born infants is associated with permanent neurological sequelae in 9 million infants every year. Investigating the regulators of microglial activation in the developing brain across models of neuroinflammation-mediated injury (mouse, zebrafish) and primary human and mouse microglia we found using analysis of genes and proteins that a reduction in Wnt/β-catenin signalling is necessary and sufficient to drive a microglial phenotype causing hypomyelination. We validated in a cohort of preterm-born infants that genomic variation in the Wnt pathway is associated with the levels of connectivity found in their brains. Using a Wnt agonist delivered by a blood-brain barrier penetrant microglia-specific targeting nanocarrier we prevented in our animal model the pro-inflammatory microglial activation, white matter injury and behavioural deficits. Collectively, these data validate that the Wnt pathway regulates microglial activation, is critical in the evolution of an important form of human brain injury and is a viable therapeutic target.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/brain/awz319&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 90 citations 90 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 2visibility views 2 download downloads 3 Powered bymore_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/brain/awz319&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2019 United Kingdom, United Kingdom, United Kingdom, France, Italy, Norway, Germany, Netherlands, United Kingdom, France, FrancePublisher:Springer Science and Business Media LLC Publicly fundedFunded by:EC | SEGWAY, NWO | Language in Interaction, NHMRC | Depressive and bipolar di... +3 projectsEC| SEGWAY ,NWO| Language in Interaction ,NHMRC| Depressive and bipolar disorders: Pathophysiology, phenotypes and treatment innovations ,NHMRC| Uncovering the Function of Susceptibility Variants in Alzheimer's Disease: From GWAS to Cell-Type Specific eQTLs and mQTLs ,EC| JPco-fuND ,UKRI| Mendelian randomization to hypothesis-free causal inferenceClaudia L. Satizabal; Hieab H.H. Adams; Charles C. White; Maria J. Knol; Markus Scholz; Muralidharan Sargurupremraj; Gennady V. Roshchupkin; Albert V. Smith; Joshua C. Bis; Xueqiu Jian; Michelle Luciano; Edith Hofer; Alexander Teumer; Sven J. van der Lee; Jingyun Yang; Lisa R. Yanek; Tom V. Lee; Shuo Li; Yanhui Hu; Jia Yu Koh; John D. Eicher; Sylvane Desrivières; Alejandro Arias-Vasquez; Ganesh Chauhan; Lavinia Athanasiu; Miguel E. Rentería; D. Hoehn; Qiang Chen; Anouk den Braber; Micael Andersson; Thomas Espeseth; Oliver Grimm; Lucija Abramovic; Tomas Axelsson; Stefan Ehrlich; Roberto Roiz-Santiañez; Asta Håberg; Hannah J. Jones; Dan J. Stein; Janita Bralten; Meike W. Vernooij; Tamara B. Harris; Irina Filippi; A. Veronica Witte; Tulio Guadalupe; Katharina Wittfeld; Thomas H. Mosley; James T. Becker; Nhat Trung Doan; Saskia P. Hagenaars; Gabriel Cuellar-Partida; Najaf Amin; Saima Hilal; Kwangsik Nho; Nazanin Mirza-Schreiber; Konstantinos Arfanakis; David Ames; Aaron Goldman; Dorret I. Boomsma; Simon Lovestone; Sudheer Giddaluru; Stephanie Le Hellard; Manuel Mattheisen; Dalia Kasperaviciute; Stephen M. Lawrie; Ingrid Agartz; Esther Walton; Gareth E. Davies; Jean Shin; Jonathan C Ipser; Louis N. Vinke; Martine Hoogman; Tianye Jia; Ralph Burkhardt; Marieke Klein; Fabrice Crivello; Deborah Janowitz; Owen Carmichael; Unn K. Haukvik; Benjamin S. Aribisala; Lachlan T. Strike; Shannon L. Risacher; Benno Pütz; Debra A. Fleischman; Amelia A. Assareh; Venkata S. Mattay; Randy L. Buckner; Patrizia Mecocci; Anders M. Dale; Sven Cichon; Marco P. Boks; Brenda W.J.H. Penninx; Vince D. Calhoun; M. Mallar Chakravarty; Andre F. Marquand; Shahrzad Kharabian Masouleh; Philippe Amouyel; Katrin Hegenscheid; Jerome I. Rotter; Andrew J. Schork; David C. Liewald; Greig I. de Zubicaray; Tien Yin Wong; Li Shen; Philipp G. Sämann; Henry Brodaty; Eco J. C. de Geus; Magda Tsolaki; Susanne Erk; Gianpiero L. Cavalleri; Nic J.A. van der Wee; Andrew M. McIntosh; Randy L. Gollub; Kazima B. Bulayeva; Jayandra J. Himali; Markus Loeffler; Nanda Rommelse; Lars T. Westlye; Narelle K. Hansell; Theo G.M. van Erp; John B.J. Kwok; Loes M. Olde Loohuis; Norman Delanty; Beng-Choon Ho; Christopher R.K. Ching; Elena Shumskaya; Albert Hofman; Dennis van der Meer; Tatiana Foroud; Jouke-Jan Hottenga; Andrew Simmons; Andreas Meyer-Lindenberg; Wiepke Cahn; Christopher D. Whelan; Marjolein M.J. van Donkelaar; Qiong Yang; Robert C. Green; Anbupalam Thalamuthu; Sebastian Mohnke; Hilleke E. Hulshoff Pol; Honghuang Lin; Peter R. Schofield; Thomas W. Mühleisen; Pauline Maillard; Wei Wen; Evan Fletcher; Arthur W. Toga; George Davey Smith; Lars Nyberg; Erik G. Jönsson; Benedicto Crespo-Facorro; Nastassja Koen; André G. Uitterlinden; Daniel R. Weinberger; Vidar M. Steen; Iryna O. Fedko; Nynke A. Groenewold; Wiro J. Niessen; Christophe Tzourio; William T. Longstreth; Jordan W. Smoller; Marie-José van Tol; Tomáš Paus; Herve Lemaitre; Matthias L. Schroeter; Bernard Mazoyer; Ole A. Andreassen; Florian Holsboer; Jessica A. Turner; Gunter Schumann; Daan van Rooij; Srdjan Djurovic; Katie L. McMahon; Rachel M. Brouwer; Joshua W. Cheung; Thomas Wolfers; Marcel P. Zwiers; Matthias Nauck; Ingrid Melle; Nicholas G. Martin; Ryota Kanai; Eric Westman; Sanjay M. Sisodiya; Tonya White; Arvin Saremi; Hans van Bokhoven; Henry Völzke; Margaret J. Wright; Dennis van 't Ent; Markus M. Nöthen; Roel A. Ophoff; Jan K. Buitelaar; Perminder S. Sachdev; Marcella Rietschel; Simon E. Fisher; Clyde Francks; Andrew J. Saykin; Karen A. Mather; Nina Romanczuk-Seiferth; Anita L. DeStefano; Henrik Walter; Pieter J. Hoekstra; Paul A. Nyquist; Barbara Franke; Hans J. Grabe; Andrew D. Johnson; Cornelia M. van Duijn; Oscar L. Lopez; Myriam Fornage; Joanna M. Wardlaw; Charles DeCarli; Philip L. De Jager; Arno Villringer; Stéphanie Debette; Vilmundur Gudnason; Sarah E. Medland; Joshua M. Shulman; Sudha Seshadri;handle: 11370/3032873a-25e1-4fd9-ba14-f7afc84e1285 , 1887/122359 , 1765/120919 , 1874/387936 , 2066/209944 , 11250/2659957 , 11391/1459099 , 1983/59a217fb-a72b-4924-8f19-966ba56924bc , 1871.1/78126867-921a-42a4-9782-e8522f6ba4d4 , 20.500.11820/4a312d6d-37d5-4255-a7e6-5efdc7ab5159 , 21.11116/0000-0004-C26A-A
pmc: PMC7055269
pmid: 31636452
handle: 11370/3032873a-25e1-4fd9-ba14-f7afc84e1285 , 1887/122359 , 1765/120919 , 1874/387936 , 2066/209944 , 11250/2659957 , 11391/1459099 , 1983/59a217fb-a72b-4924-8f19-966ba56924bc , 1871.1/78126867-921a-42a4-9782-e8522f6ba4d4 , 20.500.11820/4a312d6d-37d5-4255-a7e6-5efdc7ab5159 , 21.11116/0000-0004-C26A-A
pmc: PMC7055269
pmid: 31636452
Aims/hypothesis MODY can be wrongly diagnosed as type 1 diabetes in children. We aimed to find the prevalence of MODY in a nationwide population-based registry of childhood diabetes. Methods Using next-generation sequencing, we screened the HNF1A, HNF4A, HNF1B, GCK and INS genes in all 469 children (12.1%) negative for both GAD and IA-2 autoantibodies and 469 antibody-positive matched controls selected from the Norwegian Childhood Diabetes Registry (3882 children). Variants were classified using clinical diagnostic criteria for pathogenicity ranging from class 1 (neutral) to class 5 (pathogenic). Results We identified 58 rare exonic and splice variants in cases and controls. Among antibody-negative patients, 6.5% had genetic variants of classes 3–5 (vs 2.4% in controls; p = 0.002). For the stricter classification (classes 4 and 5), the corresponding number was 4.1% (vs 0.2% in controls; p = 1.6 × 10−5). HNF1A showed the strongest enrichment of class 3–5 variants, with 3.9% among antibody-negative patients (vs 0.4% in controls; p = 0.0002). Antibody-negative carriers of variants in class 3 had a similar phenotype to those carrying variants in classes 4 and 5. Conclusions/interpretation This is the first study screening for MODY in all antibody-negative children in a nationwide population-based registry. Our results suggest that the prevalence of MODY in antibody-negative childhood diabetes may reach 6.5%. One-third of these MODY cases had not been recognised by clinicians. Since a precise diagnosis is important for treatment and genetic counselling, molecular screening of all antibody-negative children should be considered in routine diagnostics.
NARCIS arrow_drop_down University of Bath's research portalArticle . 2019Data sources: University of Bath's research portalNTNU Open; Norwegian Open Research ArchivesArticle . 2019Nature Genetics; Archivio Istituzionale della Ricerca - Università degli Studi di Perugia; NARCISOther literature type . Article . 2019 . Peer-reviewedLicense: Springer TDMData sources: European Union Open Data Portal; University of Groningen Research Portal; Vrije Universiteit Amsterdam (VU Amsterdam) - Institutional Repository; Vrije Universiteit Amsterdam (VU Amsterdam) – Research Portal; Crossref; Archivio Istituzionale della Ricerca - Università degli Studi di Perugia; NARCISNature Genetics; NARCISArticle . 2019Nature Genetics; NARCISArticle . 2019LUMC Scholarly Publications; Leiden University Scholarly Publications RepositoryOther literature type . 2019add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41588-019-0511-y&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 188 citations 188 popularity Top 1% influence Top 10% impulse Top 0.1% Powered by BIP!visibility 45visibility views 45 download downloads 5 Powered bymore_vert NARCIS arrow_drop_down University of Bath's research portalArticle . 2019Data sources: University of Bath's research portalNTNU Open; Norwegian Open Research ArchivesArticle . 2019Nature Genetics; Archivio Istituzionale della Ricerca - Università degli Studi di Perugia; NARCISOther literature type . Article . 2019 . Peer-reviewedLicense: Springer TDMData sources: European Union Open Data Portal; University of Groningen Research Portal; Vrije Universiteit Amsterdam (VU Amsterdam) - Institutional Repository; Vrije Universiteit Amsterdam (VU Amsterdam) – Research Portal; Crossref; Archivio Istituzionale della Ricerca - Università degli Studi di Perugia; NARCISNature Genetics; NARCISArticle . 2019Nature Genetics; NARCISArticle . 2019LUMC Scholarly Publications; Leiden University Scholarly Publications RepositoryOther literature type . 2019add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s41588-019-0511-y&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Part of book or chapter of book , Other literature type 2019 FrancePublisher:WORLD SCIENTIFIC (EUROPE) Authors: Christophette Blanchet-Scalliet; Monique Jeanblanc; Ricardo Romo Romero;Christophette Blanchet-Scalliet; Monique Jeanblanc; Ricardo Romo Romero;International audience; We present some results on enlargement of filtration in discrete time. Many results known in continuous time extend immediately in a discrete time setting. Here, we provide direct proofs which are much more simpler. We study also arbitrages conditions in a financial setting and we present some specific cases, as immersion and pseudo-stopping times for which we obtain new results.
Hyper Article en Lig... arrow_drop_down https://doi.org/10.1007/978-98...Part of book or chapter of book . 2020 . Peer-reviewedLicense: Springer TDMData sources: CrossrefHAL Descartes; HAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotPreprint . Part of book or chapter of book . 2019 . 2016HAL Evry; Mémoires en Sciences de l'Information et de la CommunicationPart of book or chapter of book . 2019Full-Text: https://hal.science/hal-01253214/documenthttps://doi.org/10.1142/978178...Part of book or chapter of book . 2019 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1142/9781786341952_0007&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu3 citations 3 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Hyper Article en Lig... arrow_drop_down https://doi.org/10.1007/978-98...Part of book or chapter of book . 2020 . Peer-reviewedLicense: Springer TDMData sources: CrossrefHAL Descartes; HAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotPreprint . Part of book or chapter of book . 2019 . 2016HAL Evry; Mémoires en Sciences de l'Information et de la CommunicationPart of book or chapter of book . 2019Full-Text: https://hal.science/hal-01253214/documenthttps://doi.org/10.1142/978178...Part of book or chapter of book . 2019 . Peer-reviewedData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1142/9781786341952_0007&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2018 Denmark, France, Spain, Italy, ItalyPublisher:Springer Science and Business Media LLC Botker H. E.; Hausenloy D.; Andreadou I.; Antonucci S.; Boengler K.; Davidson S. M.; Deshwal S.; Devaux Y.; Di Lisa F.; Di Sante M.; Efentakis P.; Femmino S.; Garcia-Dorado D.; Giricz Z.; Ibanez B.; Iliodromitis E.; Kaludercic N.; Kleinbongard P.; Neuhauser M.; Ovize M.; Pagliaro P.; Rahbek-Schmidt M.; Ruiz-Meana M.; Schluter K. -D.; Schulz R.; Skyschally A.; Wilder C.; Yellon D. M.; Ferdinandy P.; Heusch G.;HEB and MRS were supported by The Danish Council for Strategic Research (11-108354), Novo Nordisk Foundation (Conditioning Based Intervention Strategies-ConBis) and Trygfonden. DH was supported by the British Heart Foundation (FS/10/039/28270), the National Institute for Health Research University College London Hospitals Biomedical Research Centre, Duke National University Singapore Medical School, Singapore Ministry of Health's National Medical Research Council and its Clinician Scientist-Senior Investigator scheme (NMRC/CSA-SI/0011/2017) and Collaborative Centre Grant scheme (NMRC/GGAug16C006), and the Singapore Ministry of Education Academic Research Fund Tier 2 (MOE2016-T2-2-021). PF is supported by grants from the Hungarian National Research, Development, and Innovation Office (OTKA K 109737, OTKA KH\_17 125570, NVKP 16-1-2016-0017, and VEKOP-2.3.2-16-2016-00002) and the Ministry of Human Capacities (Institutional Excellence Program for Higher Education). ZG is supported by the Bolyai Scholarship by the Hungarian Academy of Sciences. GH and PK were supported by the German Research Foundation (He 1320/18-3 and SFB 1116 B8). Sí
Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTAArticle . 2018Full-Text: https://doi.org/10.1007/s00395-018-0696-8Data sources: Recolector de Ciencia Abierta, RECOLECTAArchivio Istituzionale (AperTO); Basic Research in CardiologyArticle . 2018 . Peer-reviewedLicense: CC BYEurope PubMed CentralArticle . 2018Full-Text: http://europepmc.org/articles/PMC6105267Data sources: PubMed CentralUniversitätsbibliographie, Universität Duisburg-EssenArticle . 2018Data sources: Universitätsbibliographie, Universität Duisburg-EssenHAL - UPEC / UPEM; HAL-Pasteur; Hyper Article en Ligne; HAL-Inserm; Hal-DiderotOther literature type . Article . 2018add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s00395-018-0696-8&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 342 citations 342 popularity Top 0.1% influence Top 10% impulse Top 0.1% Powered by BIP!more_vert Recolector de Cienci... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTAArticle . 2018Full-Text: https://doi.org/10.1007/s00395-018-0696-8Data sources: Recolector de Ciencia Abierta, RECOLECTAArchivio Istituzionale (AperTO); Basic Research in CardiologyArticle . 2018 . Peer-reviewedLicense: CC BYEurope PubMed CentralArticle . 2018Full-Text: http://europepmc.org/articles/PMC6105267Data sources: PubMed CentralUniversitätsbibliographie, Universität Duisburg-EssenArticle . 2018Data sources: Universitätsbibliographie, Universität Duisburg-EssenHAL - UPEC / UPEM; HAL-Pasteur; Hyper Article en Ligne; HAL-Inserm; Hal-DiderotOther literature type . Article . 2018add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s00395-018-0696-8&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Conference object , Article , Other literature type , Preprint 2017 FrancePublisher:IEEE Authors: Bitar, Ahmad W.; Ovarlez, Jean-Philippe; Cheong, Loong-Fah;Bitar, Ahmad W.; Ovarlez, Jean-Philippe; Cheong, Loong-Fah;Estimating large covariance matrices has been a longstanding important problem in many applications and has attracted increased attention over several decades. This paper deals with two methods based on pre-existing works to impose sparsity on the covariance matrix via its unit lower triangular matrix (aka Cholesky factor) $\mathbf{T}$. The first method serves to estimate the entries of $\mathbf{T}$ using the Ordinary Least Squares (OLS), then imposes sparsity by exploiting some generalized thresholding techniques such as Soft and Smoothly Clipped Absolute Deviation (SCAD). The second method directly estimates a sparse version of $\mathbf{T}$ by penalizing the negative normal log-likelihood with $L_1$ and SCAD penalty functions. The resulting covariance estimators are always guaranteed to be positive definite. Some Monte-Carlo simulations as well as experimental data demonstrate the effectiveness of our estimators for hyperspectral anomaly detection using the Kelly anomaly detector. To be published on IEEE CAMSAP 2017
Hyper Article en Lig... arrow_drop_down Mémoires en Sciences de l'Information et de la CommunicationConference object . 2017Mémoires en Sciences de l'Information et de la CommunicationConference object . 2017HAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotConference object . 2017https://doi.org/10.48550/arxiv...Article . 2017License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/camsap.2017.8313124&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 3 citations 3 popularity Average influence Average impulse Average Powered by BIP!more_vert Hyper Article en Lig... arrow_drop_down Mémoires en Sciences de l'Information et de la CommunicationConference object . 2017Mémoires en Sciences de l'Information et de la CommunicationConference object . 2017HAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotConference object . 2017https://doi.org/10.48550/arxiv...Article . 2017License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/camsap.2017.8313124&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2017 Italy, Iceland, Netherlands, Netherlands, Netherlands, Sweden, Netherlands, Norway, Netherlands, Netherlands, Ireland, Sweden, Germany, Switzerland, Ireland, United Kingdom, Germany, France, United Kingdom, Netherlands, United Kingdom, Netherlands, Germany, Germany, Netherlands, Netherlands, Netherlands, Spain, Netherlands, United KingdomPublisher:Springer Science and Business Media LLC Publicly fundedFunded by:EC | TACTICS, EC | MATRICS, EC | AGGRESSOTYPE +2 projectsEC| TACTICS ,EC| MATRICS ,EC| AGGRESSOTYPE ,EC| IMAGEMEND ,EC| MiNDHieab H.H. Adams; Neda Jahanshad; Ganesh Chauhan; Jason L. Stein; Edith Hofer; Miguel E. Rentería; Joshua C. Bis; Sylvane Desrivières; Meike W. Vernooij; Saud Alhusaini; Najaf Amin; Konstantinos Arfanakis; Nicola J. Armstrong; Lavinia Athanasiu; Ashley Beecham; Alexa S. Beiser; Manon Bernard; Susan H. Blanton; Marco P. Boks; Janita Bralten; Adam M. Brickman; Owen Carmichael; Qiang Chen; Vincent Chouraki; Gabriel Cuellar-Partida; Fabrice Crivello; Anouk den Braber; Rebecca F. Gottesman; Oliver Grimm; Unn K. Haukvik; D. Hoehn; Tianye Jia; Kjetil Nordbø Jørgensen; Nazanin Karbalai; Marieke Klein; Bernd Kraemer; Phil Lee; Lorna M. Lopez; Christine Macare; Andre F. Marquand; Mar Matarin; Karen A. Mather; Manuel Mattheisen; David R. McKay; Susana Muñoz Maniega; Kwangsik Nho; Jaap Oosterlaan; Lukas Pirpamer; Adaikalavan Ramasamy; Shannon L. Risacher; Stefan Ropele; Natalie A. Royle; Philipp G. Sämann; Arvin Saremi; Claudia L. Satizabal; Lianne Schmaal; Li Shen; Elena Shumskaya; Emma Sprooten; Lachlan T. Strike; Alexander Teumer; Roberto Toro; Daniah Trabzuni; Stella Trompet; Dhananjay Vaidya; Jeroen van der Grond; Sven J. van der Lee; Dennis van der Meer; Kristel R. van Eijk; Daan van Rooij; Esther Walton; Lars T. Westlye; Christopher D. Whelan; Beverly G. Windham; Anderson M. Winkler; Christiane Wolf; Thomas Wolfers; Lisa R. Yanek; Jingyun Yang; Marcel P. Zwiers; Ingrid Agartz; Laura Almasy; Philippe Amouyel; Ole A. Andreassen; Mark E. Bastin; James T. Becker; David A. Bennett; John Blangero; Hans van Bokhoven; Dorret I. Boomsma; Henry Brodaty; Rachel M. Brouwer; Han G. Brunner; Wiepke Cahn; Vince D. Calhoun; Dara M. Cannon; Gianpiero L. Cavalleri; Ching-Yu Cheng; Sven Cichon; Aiden Corvin; Benedicto Crespo-Facorro; Joanne E. Curran; Michael Czisch; Anders M. Dale; Eco J. C. de Geus; Greig I. de Zubicaray; Ian J. Deary; Stéphanie Debette; Norman Delanty; Chantal Depondt; Anita L. DeStefano; Allissa Dillman; Srdjan Djurovic; G. Donohoe; Thomas D. Dyer; Susanne Erk; Thomas Espeseth; Iryna O. Fedko; Guillén Fernández; Luigi Ferrucci; Simon E. Fisher; Ian Ford; Tatiana Foroud; Clyde Francks; Masaki Fukunaga; J. Raphael Gibbs; Randy L. Gollub; Robert C. Green; Oliver Gruber; Vilmundur Gudnason; Narelle K. Hansell; John Hardy; Catharina A. Hartman; Ryota Hashimoto; K Hegenscheid; Andreas Heinz; Stephanie Le Hellard; Beng-Choon Ho; Pieter J. Hoekstra; Norbert Hosten; Matthew J. Huentelman; Hilleke E. Hulshoff Pol; Masashi Ikeda; Robert Johnson; Erik G. Jönsson; J. Wouter Jukema; Stephen M. Lawrie; Herve Lemaitre; Dan L. Longo; Simon Lovestone; Oliver Martinez; C. McDonald; Andrew M. McIntosh; Francis J. McMahon; Andreas Meyer-Lindenberg; Sebastian Mohnke; Grant W. Montgomery; Michael A. Nalls; Matthias Nauck; Thomas E. Nichols; Wiro J. Niessen; Markus M. Nöthen; Lars Nyberg; Kazutaka Ohi; Tomáš Paus; Brenda W.J.H. Penninx; G. Bruce Pike; Steven G. Potkin; Simone Reppermund; Marcella Rietschel; Joshua L. Roffman; Nina Romanczuk-Seiferth; Mina Ryten; Ralph L. Sacco; Perminder S. Sachdev; Andrew J. Saykin; Reinhold Schmidt; Helena Schmidt; Peter R. Schofield; Sigurdur Sigursson; Andrew Simmons; Colin Smith; Jordan W. Smoller; David J. Stott; Anbupalam Thalamuthu; Magda Tsolaki; Christophe Tzourio; Andre G. Uitterlinden; Maria del C. Valdés Hernández; Dennis van 't Ent; Marie-José van Tol; Badri N. Vardarajan; Henrik Walter; Joanna M. Wardlaw; Thomas H. Wassink; Michael E. Weale; Michael Weiner; Wei Wen; Eric Westman; Tonya White; Tien Yin Wong; Nicholas G. Martin; Cornelia M. van Duijn; Margaret J. Wright; Hans J. Grabe; Barbara Franke; Sarah E. Medland; Sudha Seshadri; Paul M. Thompson; M. Arfan Ikram;handle: 11858/00-001M-0000-002C-5334-C , 11858/00-001M-0000-002B-A1BC-7 , 11858/00-001M-0000-002C-5335-A , 11858/00-001M-0000-002C-5336-8 , 10902/13707 , 2128/13909 , 1871.1/8dcfd9e4-0a05-4a12-8a72-1a68533da704 , https://repository.ubn.ru.nl/handle/2066/168856 , 11370/ea0fe7e1-e942-4a3a-a770-9dd8add410ff , 1765/95645 , 21.11116/0000-0001-8841-C , 21.11116/0000-0001-8843-A , 1887/113252 , 20.500.11820/ed7d3305-c382-40a1-9f68-96fef0049e9a , 1983/d6c7fa9e-dd63-4301-9d2a-a002654b88e1 , 2066/168856 , 11391/1406264 , 11250/2485096 , 1874/348364
pmc: PMC5253632
pmid: 28098162
handle: 11858/00-001M-0000-002C-5334-C , 11858/00-001M-0000-002B-A1BC-7 , 11858/00-001M-0000-002C-5335-A , 11858/00-001M-0000-002C-5336-8 , 10902/13707 , 2128/13909 , 1871.1/8dcfd9e4-0a05-4a12-8a72-1a68533da704 , https://repository.ubn.ru.nl/handle/2066/168856 , 11370/ea0fe7e1-e942-4a3a-a770-9dd8add410ff , 1765/95645 , 21.11116/0000-0001-8841-C , 21.11116/0000-0001-8843-A , 1887/113252 , 20.500.11820/ed7d3305-c382-40a1-9f68-96fef0049e9a , 1983/d6c7fa9e-dd63-4301-9d2a-a002654b88e1 , 2066/168856 , 11391/1406264 , 11250/2485096 , 1874/348364
pmc: PMC5253632
pmid: 28098162
The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg=−0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness. The hippocampus in mammalian brain varies in size across individuals. Here, Hibar and colleagues perform a genome-wide association meta-analysis to find six genetic loci with significant association to hippocampus volume.
Norwegian Open Resea... arrow_drop_down Online-Publikations-Server der Universität WürzburgArticle . 2017License: CC BYData sources: Online-Publikations-Server der Universität WürzburgEurope PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5253632Data sources: PubMed CentralMaynooth University ePrints & eTheses ArchiveArticle . 2017 . Peer-reviewedData sources: Maynooth University ePrints & eTheses ArchiveNARCIS; Radboud RepositoryArticle . 2017Explore Bristol Research; Nature CommunicationsArticle . 2017METIS Research Information System; NARCIS; Nature CommunicationsArticle . 2017 . Peer-reviewedLicense: CC BYOxford University Research ArchiveOther literature type . 2017License: CC BYData sources: Oxford University Research ArchiveBern Open Repository and Information System (BORIS)Article . 2017 . Peer-reviewedData sources: Bern Open Repository and Information System (BORIS)Refubium - Repositorium der Freien Universität BerlinOther literature type . 2017License: CC BYData sources: Refubium - Repositorium der Freien Universität BerlinNARCIS; Nature CommunicationsArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/ncomms13624&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 246 citations 246 popularity Top 1% influence Top 10% impulse Top 0.1% Powered by BIP!visibility 112visibility views 112 download downloads 166 Powered bymore_vert Norwegian Open Resea... arrow_drop_down Online-Publikations-Server der Universität WürzburgArticle . 2017License: CC BYData sources: Online-Publikations-Server der Universität WürzburgEurope PubMed CentralArticle . 2017Full-Text: http://europepmc.org/articles/PMC5253632Data sources: PubMed CentralMaynooth University ePrints & eTheses ArchiveArticle . 2017 . Peer-reviewedData sources: Maynooth University ePrints & eTheses ArchiveNARCIS; Radboud RepositoryArticle . 2017Explore Bristol Research; Nature CommunicationsArticle . 2017METIS Research Information System; NARCIS; Nature CommunicationsArticle . 2017 . Peer-reviewedLicense: CC BYOxford University Research ArchiveOther literature type . 2017License: CC BYData sources: Oxford University Research ArchiveBern Open Repository and Information System (BORIS)Article . 2017 . Peer-reviewedData sources: Bern Open Repository and Information System (BORIS)Refubium - Repositorium der Freien Universität BerlinOther literature type . 2017License: CC BYData sources: Refubium - Repositorium der Freien Universität BerlinNARCIS; Nature CommunicationsArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/ncomms13624&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint , Other literature type , Part of book or chapter of book 2017 FrancePublisher:Springer International Publishing Authors: Armenti, Yannick; Crépey, Stéphane; Zhou, Chao;Armenti, Yannick; Crépey, Stéphane; Zhou, Chao;In incomplete markets, a basic Black-Scholes perspective has to be complemented by the valuation of market imperfections. Otherwise this results in Black-Scholes Ponzi schemes, such as the ones at the core of the last global financial crisis, where always more derivatives need to be issued for remunerating the capital attracted by the already opened positions. In this paper we consider the sustainable Black-Scholes equations that arise for a portfolio of options if one adds to their trade additive Black-Scholes price, on top of a nonlinear funding cost, the cost of remunerating at a hurdle rate the residual risk left by imperfect hedging. We assess the impact of model uncertainty in this setup.
Hyper Article en Lig... arrow_drop_down https://doi.org/10.1007/978-3-...Part of book or chapter of book . 2017 . Peer-reviewedLicense: Springer TDMData sources: CrossrefHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotPreprint . 2018add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/978-3-319-66536-8_8&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Hyper Article en Lig... arrow_drop_down https://doi.org/10.1007/978-3-...Part of book or chapter of book . 2017 . Peer-reviewedLicense: Springer TDMData sources: CrossrefHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotPreprint . 2018add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/978-3-319-66536-8_8&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2016 Germany, Ireland, United Kingdom, Netherlands, Italy, Spain, United Kingdom, France, France, France, United Kingdom, France, France, France, United Kingdom, United Kingdom, France, IrelandPublisher:Springer Science and Business Media LLC Publicly fundedFunded by:EC | NEUROSCHEMA, NIH | The ARIC and Neurocogniti..., NIH | Functional genomics of bi... +110 projectsEC| NEUROSCHEMA ,NIH| The ARIC and Neurocognitive Longitudinal Study ,NIH| Functional genomics of bipolar disorder ,NIH| OBESITY, DIABETES &AGING ANIMAL RESOURCE ,NIH| Genotypic Determinants of Aspirin Response in High-Risk ,NHMRC| Cerebrovascular diseases and Brain Ageing – a program of research into novel mechanisms, risk prevention and innovative health care delivery ,NHMRC| The Older Australian Twins Study (OATS) of healthy brain ageing and age-related neurocognitive disorders ,NIH| National Cell Repository for Alzheimer's Disease (NCRAD) ,NIH| AGES STUDY-THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENNIUM-260012100 ,NIH| ENIGMA Center for Worldwide Medicine, Imaging & Genomics ,NIH| UCLA Clinical and Translational Science Institute ,NIH| HARDI Mapping of Disease Effects on the Brain ,NIH| Predicting Brain Changes in HIV/AIDS ,NSF| MRI: Acquisition of a Data Analytics Cluster for Computational Social Science ,NIH| CHS-Transition Phase -268055222 ,NIH| Searching for Endophenotypes of Bipolar Disorder ,NIH| Alzheimer's Disease Genetics Consortium ,EC| ORACLE ,NWO| Twin-family database for behavior genetics and genomics studies ,NWO| Networking through ADHD biology ,NIH| Alzheimer's Disease Genetics Consortium ,NIH| Empowering Personalized Medicine: Integrating Imaging, Genetics, and Biomarkers ,FWF| Mechanisms of Small Vessel Related Brain Damage and Cognitive Impairment ,WT| Genome-wide association studies in partial epilepsies. ,EC| MiND ,EC| TACTICS ,WT| Stratifying Resilience and Depression Longitudinally (STRADL) ,NIH| Risk Factors, Pathology, and Clinical Expressions of AD ,NIH| CHS Events Follow-up Study ,NIH| From GWAS loci to blood pressure genes, variants & mechanisms ,NIH| Genome-Wide Association for Loci Influencing CHD and Other Heart, Lung and Blood ,NIH| Genetic Epidemiology of Cognitive Decline in an Aging Population Sample ,NIH| An Integrated Genetic and Epigenetic Approach to Cerebral Small Vessel Disease ,NIH| Occult Small Vessel Cerebrovascular Disease in High Risk Families ,NHMRC| Type 2 Diabetes Mellitus and Cognitive Decline - a longitudinal study of effects and mechanisms ,NHMRC| The prevention, early detection, & effective management of neurocognitive disorders in the elderly ,EC| EU-AIMS ,NHMRC| Gene-environment interaction in healthy brain ageing and age related neurodegeneration ,EC| MATRICS ,NIH| CHARGE: Identifying Risk & Protective SNV for AD in ADSP Case-control Sample ,NIH| Prospective meta-analyses of drug-gene interactions: CHARGE GWAS consortium ,NHMRC| Prevention, early detection and effective management of neurocognitive disorders in the elderly ,NIH| GCRC-RENOVATION ,NIH| Epidemiologic Study of Neural Reserve and Neurobiology of Aging ,NIH| International Multi-Center ADHD Genetics Project ,NHMRC| A population-based study of cerebrovascular mechanisms underyling gait, balance and cognition in older people ,NIH| Exceptional aging: 12 year trajectories to function ,NWO| From genetic pathways to cognition in ADHD: a question of the right connections? ,NHMRC| Advancing our understanding of the genetics of Psychiatric and Neurological Disease ,EC| PHASE ,NIH| Hormonal trajectories in aging ,NIH| Using Genetics to Dissect Schizhoprenia, Bipolar Disorder, and Depression ,NIH| Major Depression: Stage 1 Genomewide Association in Population-Based Samples ,NIH| Role of Mitochondrial Health in Acute and Chronic Kidney Disease in Older Adults ,CIHR ,NHMRC| Genetics of brain structure and function ,NIH| Epidemiology of Biomarkers of Risk and Progression in LOAD ,NIH| Institute for Clinical and Translational Research (UL1) ,NIH| Laboratory of Neuro Imaging Resource (LONIR) ,NHMRC| Australian Twin Registry ,NWO| NCHA Subsidiebesluit 2008-2012 ,ARC| The articulate brain ,NIH| CORONARY HEART DISEASE &STROKE IN THE ELDERLY ,NIH| Genomic Studies of Bipolar Disorder in a Large Cohort from The Netherlands ,NWO| Neuro-imaging study in twins concordant or discordant for obsessive-compulsive symptoms. ,NIH| ALZHEIMERS DISEASE DATA COORDINATING CENTER ,NHMRC| Genetics of melanoma risk factors ,NIH| Structural Brain Abnormalities In Depression ,NIH| COGNITIVE TESTS, APOE, BRAIN MRI AND RISKS OF DEMENTIA ,NIH| CYCLINS AND CHEMICAL CARCINOGENESIS ,EC| IMAGEMEND ,NIH| Alzheimer's disease risk analyzed using population imaging genomics ,NHMRC| Prevention and management of mental disorders in older Australians ,NIH| Functional Neuroimaging In Unipolar And Bipolar Depresse ,NIH| GWA for Gene-Environment Interaction Effects Influencing CHD ,NIH| MOLECULAR AND BIOCHEMICAL GENETICS LABORATORY RENOVATION ,NIH| Risk Factors, Pathology, and Clinical Expressions of AD ,NIH| Dimensional Neurogenetic Markers of Limbic System Integrity & Psychiatric Illness ,NHMRC| Development and Evaluation of Statistical Methods and Software for Analysis of Complex Genetic Disease Data ,NIH| CHS research resources for the cardiovascular health of older adults ,WT| A Powerful, Genome-Wide Association Scan for Susceptibility Genes for late-onset Alzheimer's disease ,NHMRC| Genetic Repositories Australia ,NIH| Genetic Influences on Human Cortical Development ,NIH| Epidemiology of Venous Thrombosis &Pulmonary Embolism ,NIH| SHORT-TERM STABILITY OF CLINICAL TESTS ,NWO| Dissecting genetic complexity of Alzheimer's disease and cognitive function ,ARC| Elucidating the genetics of attention deficit hyperactivity disorder by integrating pathway and prediction analyses ,SFI| The application of MRI to identify endophenotypes in focal epilepsy ,NWO| Functional neural network plasticity in adolescent twins and sibs ,NIH| CORONARY HEART DISEASE AND STROKE ,NIH| Vascular Cognitive and Motor Decline: Impact of aPL ,NIH| Research and Mentoring on Integrating Psychiatric Genetics and Neuroscience ,EC| ENGAGE ,NIH| Genetic influences on the brain: A twin imaging study ,NIH| Rare variants and NHLBI traits in deeply phenotyped cohorts ,NIH| Genomics of Developmental Trajectories in Twins ,NIH| Neuroimaging genetics to study social cognitive deficits in ASD and schizophrenia ,NIH| WGA Study to Identify Genetic Variants Associated with CV Events in CHS ,NIH| Collaborative GWAS of Dementia, AD and related MRI and Cognitive Endophenotypes ,EC| AGGRESSOTYPE ,NIH| CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84 ,UKRI| Centre for Cognitive Ageing & Cognitive Epidemiology ,NIH| CHARGE consortium: gene discovery for CVD and aging phenotypes ,NIH| EXTRAMULAR RESEARCH FACILITIES CONSTRUCTION ,NIH| Genetic Influences on Human Neuroanatomical Shapes ,NIH| Neurodevelopment and Imaging among HIV-infected Children from the PREDICT study ,NIH| RISK FACTORS FOR INCIDENT AD IN A BIRACIAL COMMUNITY ,NIH| Alzheimers Disease in Mild Cognitive Impairment ,EC| GMI ,NIH| Alzheimers Disease Neuroimaging Initiative ,NIH| CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84 ,NIH| Integration of Genomics &Transcriptomics in Normal Twins &Major Depression ,NIH| CORONARY HEART DISEASE AND STROKEHieab H.H. Adams; Vincent Chouraki; Jason L. Stein; Miguel E. Rentería; Stella Trompet; Alejandro Arias-Vasquez; Sudha Seshadri; Sylvane Desrivières; Sven J. van der Lee; Najaf Amin; Micael Andersson; Konstantinos Arfanakis; Benjamin S. Aribisala; Nicola J. Armstrong; Alexa S. Beiser; Manon Bernard; Susan H. Blanton; Marco P. Boks; Janita Bralten; Owen Carmichael; Ganesh Chauhan; Qiang Chen; Gabriel Cuellar-Partida; Anouk den Braber; Stefan Ehrlich; Irina Filippi; Tian Ge; Rebecca F. Gottesman; Corina U. Greven; Tulio Guadalupe; Unn K. Haukvik; Saima Hilal; D. Hoehn; Tianye Jia; Marieke Klein; Phil H. Lee; David C. Liewald; Lorna M. Lopez; Michelle Luciano; Christine Macare; Andre F. Marquand; Karen A. Mather; Manuel Mattheisen; Bernard Mazoyer; Rebekah McWhirter; Yuri Milaneschi; Nazanin Mirza-Schreiber; Ryan L. Muetzel; Susana Muñoz Maniega; Kwangsik Nho; Loes M. Olde Loohuis; Jaap Oosterlaan; Irene Pappa; Lukas Pirpamer; Sara Pudas; Adaikalavan Ramasamy; Jennifer S. Richards; Shannon L. Risacher; Roberto Roiz-Santiañez; Nanda Rommelse; Emma J. Rose; Claudia L. Satizabal; Lianne Schmaal; Li Shen; Jean Shin; Albert V. Smith; Emma Sprooten; Lachlan T. Strike; Alexander Teumer; Russell Thomson; Diana Tordesillas-Gutiérrez; Roberto Toro; Daniah Trabzuni; Dhananjay Vaidya; Jeroen van der Grond; Dennis van der Meer; Marjolein M. J. Van Donkelaar; Kristel R. van Eijk; Theo G.M. van Erp; Esther Walton; Lars T. Westlye; Christopher D. Whelan; Beverly G Windham; Anderson M. Winkler; Girma Woldehawariat; Christiane Wolf; Thomas Wolfers; Bing Xu; Ingrid Agartz; David Ames; Philippe Amouyel; Ole A. Andreassen; Sampath Arepalli; Mark E. Bastin; Diane M. Becker; James T. Becker; John Blangero; Hans van Bokhoven; Dorret I. Boomsma; Henry Brodaty; Rachel M. Brouwer; Randy L. Buckner; Vince D. Calhoun; Dara M. Cannon; Gianpiero L. Cavalleri; Christopher Chen; Ching-Yu Cheng; Sven Cichon; Mark R. Cookson; Aiden Corvin; Benedicto Crespo-Facorro; Joanne E. Curran; Michael Czisch; Gareth E. Davies; Eco J. C. de Geus; Greig I. Zubicaray; Anita L. DeStefano; Srdjan Djurovic; Gary Donohoe; Wayne C. Drevets; Thomas D. Dyer; Susanne Erk; Thomas Espeseth; Denis A. Evans; Iryna O. Fedko; Simon E. Fisher; Debra A. Fleischman; Clyde Francks; Masaki Fukunaga; J. Raphael Gibbs; Randy L. Gollub; Harald H H Göring; Hans J. Grabe; Robert C. Green; Oliver Gruber; Vilmundur Gudnason; Narelle K. Hansell; John Hardy; Ryota Hashimoto; Andreas Heinz; Stephanie Le Hellard; Dirk J. Heslenfeld; Beng-Choon Ho; Wolfgang Hoffmann; Albert Hofman; Florian Holsboer; Georg Homuth; Hilleke E. Hulshoff Pol; M. Kamran Ikram; Clifford R. Jack; Mark Jenkinson; Robert Johnson; Erik G. Jönsson; J. Wouter Jukema; David S. Knopman; Peter Kochunov; Stephen M. Lawrie; Herve Lemaitre; Dan L. Longo; W.T. Longstreth; Oscar L. Lopez; Simon Lovestone; Jean-Luc Martinot; Colm McDonald; Andrew M. McIntosh; Katie L. McMahon; Francis J. McMahon; Patrizia Mecocci; Ingrid Melle; Andreas Meyer-Lindenberg; Sebastian Mohnke; Derek W. Morris; Thomas H. Mosley; Thomas W. Mühleisen; Thomas E. Nichols; Wiro J. Niessen; Markus M. Nöthen; Lars Nyberg; Kazutaka Ohi; Roel A. Ophoff; Massimo Pandolfo; G. Bruce Pike; Bruce M. Psaty; Marcella Rietschel; Joshua L. Roffman; Nina Romanczuk-Seiferth; Mina Ryten; Ralph L. Sacco; Perminder S. Sachdev; Andrew J. Saykin; Reinhold Schmidt; Peter R. Schofield; Andrew Singleton; Hilkka Soininen; Velandai Srikanth; Jessika E. Sussmann; Anbupalam Thalamuthu; Henning Tiemeier; Arthur W. Toga; Bryan J. Traynor; Juan C. Troncoso; Jessica A. Turner; Christophe Tzourio; André G. Uitterlinden; Aad van der Lugt; Nic J A van der Wee; Cornelia M. van Duijn; Dennis van 't Ent; Marie-José van Tol; Badri N. Vardarajan; Dick J. Veltman; Meike W. Vernooij; Henry Völzke; Henrik Walter; Joanna M. Wardlaw; Thomas H. Wassink; Michael E. Weale; Daniel R. Weinberger; Wei Wen; Eric Westman; Tonya White; Tien Yin Wong; H. Ronald Zielke; Alan B. Zonderman; Ian J. Deary; Nicholas G. Martin; Anton J. M. de Craen; Margaret J. Wright; Lenore J. Launer; Gunter Schumann; Barbara Franke; Stéphanie Debette; Sarah E. Medland; Paul M. Thompson;pmid: 27694991
pmc: PMC5227112
handle: 1871.1/e355ae09-2997-486e-98e5-c8968be7f4c4 , 10902/16311 , 11858/00-001M-0000-002B-7F28-6 , 11858/00-001M-0000-002C-2A97-4 , 2066/165723 , 11370/f227c90a-5d2a-41c8-a65b-5cb41250ef07 , 1887/112477 , 1983/ea8a2fa3-e92b-41d9-9147-c1b24d8515c3 , 11391/1406555 , 20.500.11820/cef4fd4e-02ab-4e12-8153-a6de64660b4d , 1874/343369
pmid: 27694991
pmc: PMC5227112
handle: 1871.1/e355ae09-2997-486e-98e5-c8968be7f4c4 , 10902/16311 , 11858/00-001M-0000-002B-7F28-6 , 11858/00-001M-0000-002C-2A97-4 , 2066/165723 , 11370/f227c90a-5d2a-41c8-a65b-5cb41250ef07 , 1887/112477 , 1983/ea8a2fa3-e92b-41d9-9147-c1b24d8515c3 , 11391/1406555 , 20.500.11820/cef4fd4e-02ab-4e12-8153-a6de64660b4d , 1874/343369
Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable, but the underlying genes remain largely undetermined. In a genome-wide association study of 32,438 adults, we discovered five previously unknown loci for intracranial volume and confirmed two known signals. Four of the loci were also associated with adult human stature, but these remained associated with intracranial volume after adjusting for height. We found a high genetic correlation with child head circumference (rhogenetic = 0.748), which indicates a similar genetic background and allowed us to identify four additional loci through meta-analysis (Ncombined = 37,345). Variants for intracranial volume were also related to childhood and adult cognitive function, and Parkinson's disease, and were enriched near genes involved in growth pathways, including PI3K-AKT signaling. These findings identify the biological underpinnings of intracranial volume and their link to physiological and pathological traits. Contains fulltext : 165723pub.pdf (Publisher’s version ) (Closed access)
CORE (RIOXX-UK Aggre... arrow_drop_down CORE (RIOXX-UK Aggregator)Article . 2016Full-Text: http://livrepository.liverpool.ac.uk/3004351/1/ICV-GWAS-NN-acceptedAug31-2016embargoed.pdfData sources: CORE (RIOXX-UK Aggregator)Maynooth University ePrints & eTheses ArchiveArticle . 2016 . Peer-reviewedData sources: Maynooth University ePrints & eTheses ArchiveOxford University Research ArchiveOther literature type . 2017Data sources: Oxford University Research ArchiveRecolector de Ciencia Abierta, RECOLECTA; UCreaArticle . 2019 . 2016Spiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital RepositoryMETIS Research Information System; Nature Neuroscience; NARCIS; PURE Aarhus UniversityArticle . 2016 . Peer-reviewedLicense: Springer TDMFull-Text: http://www.nature.com/articles/nn.4398.pdfNARCIS; Nature NeuroscienceArticle . 2016LUMC Scholarly Publications; Leiden University Scholarly Publications RepositoryOther literature type . 2016NARCIS; Nature NeuroscienceArticle . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nn.4398&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 198 citations 198 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!visibility 141visibility views 141 download downloads 458 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down CORE (RIOXX-UK Aggregator)Article . 2016Full-Text: http://livrepository.liverpool.ac.uk/3004351/1/ICV-GWAS-NN-acceptedAug31-2016embargoed.pdfData sources: CORE (RIOXX-UK Aggregator)Maynooth University ePrints & eTheses ArchiveArticle . 2016 . Peer-reviewedData sources: Maynooth University ePrints & eTheses ArchiveOxford University Research ArchiveOther literature type . 2017Data sources: Oxford University Research ArchiveRecolector de Ciencia Abierta, RECOLECTA; UCreaArticle . 2019 . 2016Spiral - Imperial College Digital RepositoryArticle . 2016Data sources: Spiral - Imperial College Digital RepositoryMETIS Research Information System; Nature Neuroscience; NARCIS; PURE Aarhus UniversityArticle . 2016 . Peer-reviewedLicense: Springer TDMFull-Text: http://www.nature.com/articles/nn.4398.pdfNARCIS; Nature NeuroscienceArticle . 2016LUMC Scholarly Publications; Leiden University Scholarly Publications RepositoryOther literature type . 2016NARCIS; Nature NeuroscienceArticle . 2016add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/nn.4398&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu