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description Publicationkeyboard_double_arrow_right Article , Preprint , Other literature type , Review 2017 Netherlands, United States, Netherlands, Finland, Germany, Denmark, FrancePublisher:Copernicus GmbH Funded by:FWF | Carbonyl sulfide exchange..., AKA | Carbon Balance under Chan..., AKA | Biosphere-Atmosphere Feed... +7 projectsFWF| Carbonyl sulfide exchange between terrestrial ecosystems and the atmosphere ,AKA| Carbon Balance under Changing Processes of Arctic and Subarctic Cryosphere (CARB-ARC) / Consortium: CARB-ARC ,AKA| Biosphere-Atmosphere Feedbacks and Carbon-Water Cycles ,AKA| Biosphere-Atmosphere Feedbacks and Carbon-Water Cycles ,NSF| Collaborative Research: A 1500m Ice Core from South Pole ,NSF| CAREER: Disentangling CO2 Fluxes in a Tropical Rainforest Using Carbonyl Sulfide ,NSF| AGS-PRF: Soil Exchange of Carbonyl Sulfide (COS): Towards an Independent Proxy for Terrestrial Gross Primary Production (GPP) ,EC| SOLCA ,EC| USIFlux ,AKA| Centre of Excellence in Atmospheric Science From Molecular and Biolocigal processes to The Global ClimateM. E. Whelan; M. E. Whelan; S. T. Lennartz; T. E. Gimeno; R. Wehr; G. Wohlfahrt; Y. Wang; L. M. J. Kooijmans; T. W. Hilton; S. Belviso; P. Peylin; R. Commane; W. Sun; H. Chen; L. Kuai; I. Mammarella; K. Maseyk; M. Berkelhammer; K.-F. Li; D. Yakir; A. Zumkehr; Y. Katayama; J. Ogée; F. M. Spielmann; F. Kitz; B. Rastogi; J. Kesselmeier; J. Marshall; K.-M. Erkkilä; L. Wingate; L. K. Meredith; W. He; R. Bunk; T. Launois; T. Vesala; T. Vesala; T. Vesala; J. A. Schmidt; C. G. Fichot; U. Seibt; S. Saleska; E. S. Saltzman; S. A. Montzka; J. A. Berry; J. E. Campbell;For the past decade, observations of carbonyl sulfide (OCS or COS) have been investigated as a proxy for carbon uptake by plants. OCS is destroyed by enzymes that interact with CO2 during photosynthesis, namely carbonic anhydrase (CA) and RuBisCO, where CA is the more important one. The majority of sources of OCS to the atmosphere are geographically separated from this large plant sink, whereas the sources and sinks of CO2 are co-located in ecosystems. The drawdown of OCS can therefore be related to the uptake of CO2 without the added complication of co-located emissions comparable in magnitude. Here we review the state of our understanding of the global OCS cycle and its applications to ecosystem carbon cycle science. OCS uptake is correlated well to plant carbon uptake, especially at the regional scale. OCS can be used in conjunction with other independent measures of ecosystem function, like solar-induced fluorescence and carbon and water isotope studies. More work needs to be done to generate global coverage for OCS observations and to link this powerful atmospheric tracer to systems where fundamental questions concerning the carbon and water cycle remain.
OceanRep arrow_drop_down eScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of CaliforniaCopenhagen University Research Information SystemArticle . 2018Data sources: Copenhagen University Research Information SystemeScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of CaliforniaeScholarship - University of CaliforniaArticle . 2017Data sources: eScholarship - University of CaliforniaHELDA - Digital Repository of the University of HelsinkiReview . 2018 . Peer-reviewedData sources: HELDA - Digital Repository of the University of HelsinkiMémoires en Sciences de l'Information et de la Communication; HAL-CEAArticle . 2018License: CC BYFull-Text: https://hal.science/hal-02104411/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 94 citations 94 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!download 91download downloads 91 Powered bymore_vert OceanRep arrow_drop_down eScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of CaliforniaCopenhagen University Research Information SystemArticle . 2018Data sources: Copenhagen University Research Information SystemeScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of CaliforniaeScholarship - University of CaliforniaArticle . 2017Data sources: eScholarship - University of CaliforniaHELDA - Digital Repository of the University of HelsinkiReview . 2018 . Peer-reviewedData sources: HELDA - Digital Repository of the University of HelsinkiMémoires en Sciences de l'Information et de la Communication; HAL-CEAArticle . 2018License: CC BYFull-Text: https://hal.science/hal-02104411/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2017Embargo end date: 01 Jan 2017 Switzerland, Germany, Finland, France, Switzerland, Belgium, Netherlands EnglishPublisher:ETH Zurich Funded by:ARC | Special Research Initiati..., NSF | Collaborative Research: E..., EC | TITAN +6 projectsARC| Special Research Initiatives - Grant ID: SR140300001 ,NSF| Collaborative Research: EaSM2--Linking Near Term Future Changes in Weather and Hydroclimate in Western North America to Adaptation for Ecosystem and Water Management ,EC| TITAN ,NSF| P2C2: Continental Scale Droughts in North America: Their Frequency, Character and Causes Over the Past Millennium and Near Term Future ,EC| STRATOCLIM ,UKRI| PAlaeo-Constraints on Monsoon Evolution and Dynamics ,SNSF| Future and Past Solar Influence on the Terrestrial Climate II ,EC| ASTRA ,NSF| Collaborative Research: EaSM2--Quantifying and Conveying the Risk of Prolonged Drought in Coming DecadesJungclaus, J; Bard, E; Baroni, M; Braconnot, P; Cao, J; Chini, LP; Egorova, T; Evans, M; González-Rouco, JF; Goosse, H; Hurtt, GC; Joos, F; Kaplan, JO; Khodri, M; Goldewijk, KK; Krivova, N; LeGrande, AN; Lorenz, SJ; Luterbacher, J; Man, W; Maycock, AC; Meinshausen, M; Moberg, A; Muscheler, R; Nehrbass-Ahles, C; Otto-Bliesner, BI; Phipps, SJ; Pongratz, J; Rozanov, E; Schmidt, GA; Schmidt, H; Schmutz, W; Schurer, A; Shapiro, AI; Sigl, M; Smerdon, JE; Solanki, SK; Timmreck, C; Toohey, M; Usoskin, IG; Wagner, S; Wu, C-J; Yeo, KL; Zanchettin, D; Zhang, Q; Zorita, E;handle: 2078.1/191152 , 20.500.11850/223889
The pre-industrial millennium is among the periods selected by the Paleoclimate Model Intercomparison Project (PMIP) for experiments contributing to the sixth phase of the Coupled Model Intercomparison Project (CMIP6) and the fourth phase of the PMIP (PMIP4). The past1000 transient simulations serve to investigate the response to (mainly) natural forcing under background conditions not too different from today, and to discriminate between forced and internally generated variability on interannual to centennial timescales. This paper describes the motivation and the experimental set-ups for the PMIP4-CMIP6 past1000 simulations, and discusses the forcing agents orbital, solar, volcanic, and land use/land cover changes, and variations in greenhouse gas concentrations. The past1000 simulations covering the pre-industrial millennium from 850 Common Era (CE) to 1849 CE have to be complemented by historical simulations (1850 to 2014 CE) following the CMIP6 protocol. The external forcings for the past1000 experiments have been adapted to provide a seamless transition across these time periods. Protocols for the past1000 simulations have been divided into three tiers. A default forcing data set has been defined for the Tier 1 (the CMIP6 past1000) experiment. However, the PMIP community has maintained the flexibility to conduct coordinated sensitivity experiments to explore uncertainty in forcing reconstructions as well as parameter uncertainty in dedicated Tier 2 simulations. Additional experiments (Tier 3) are defined to foster collaborative model experiments focusing on the early instrumental period and to extend the temporal range and the scope of the simulations. This paper outlines current and future research foci and common analyses for collaborative work between the PMIP and the observational communities (reconstructions, instrumental data). Geoscientific Model Development, 10 (11) ISSN:1991-9603 ISSN:1991-959X
CORE (RIOXX-UK Aggre... arrow_drop_down Bern Open Repository and Information System (BORIS)Article . 2017 . Peer-reviewedData sources: Bern Open Repository and Information System (BORIS)University of Oulu Repository - JultikaArticle . 2017License: CC BYData sources: University of Oulu Repository - JultikaHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!visibility 12visibility views 12 download downloads 2 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down Bern Open Repository and Information System (BORIS)Article . 2017 . Peer-reviewedData sources: Bern Open Repository and Information System (BORIS)University of Oulu Repository - JultikaArticle . 2017License: CC BYData sources: University of Oulu Repository - JultikaHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2014 Italy, FrancePublisher:Ovid Technologies (Wolters Kluwer Health) Authors: Stéphanie Debette; Barbara Goeggel Simonetti; Sabrina Schilling; Juan Jose Martin; +37 AuthorsStéphanie Debette; Barbara Goeggel Simonetti; Sabrina Schilling; Juan Jose Martin; Manja Kloss; Hakan Sarikaya; Ingrid Hausser; Stefan T. Engelter; Tiina M. Metso; Alessandro Pezzini; Vincent Thijs; Emmanuel Touzé; Stefano Paolucci; Paolo Costa; Maria Sessa; Yves Samson; Yannick Béjot; Ayse Altintas; Antti J. Metso; Dominique Hervé; Christoph Lichy; Simon Jung; Urs Fischer; C. Lamy; Armin J. Grau; Hugues Chabriat; Valeria Caso; Philippe Lyrer; Christian Stapf; Turgut Tatlisumak; Tobias Brandt; Elisabeth Tournier-Lasserve; Dominique P. Germain; Michael Frank; Ralf W. Baumgartner; Caspar Grond-Ginsbach; Marie-Germaine Bousser; Didier Leys; Jean Dallongeville; Anna Bersano; Marcel Arnold;pmc: PMC4248448 , PMC5994721
handle: 11379/389710
Erratum in: Familial occurrence and heritable connective tissue disorders in cervical artery dissection. [Neurology. 2016]; International audience; In a large series of patients with cervical artery dissection (CeAD), a major cause of ischemic stroke in young and middle-aged adults, we aimed to examine frequencies and correlates of family history of CeAD and of inherited connective tissue disorders. We combined data from 2 large international multicenter cohorts of consecutive patients with CeAD in 23 neurologic departments participating in the CADISP-plus consortium, following a standardized protocol. Frequency of reported family history of CeAD and of inherited connective tissue disorders was assessed. Putative risk factors, baseline features, and 3-month outcome were compared between groups. Among 1,934 consecutive patients with CeAD, 20 patients (1.0%, 95% confidence interval: 0.6%-1.5%) from 17 families (0.9%, 0.5%-1.3%) had a family history of CeAD. Family history of CeAD was significantly more frequent in patients with carotid location of the dissection and elevated cholesterol levels. Two patients without a family history of CeAD had vascular Ehlers-Danlos syndrome with a mutation in COL3A1. This diagnosis was suspected in 2 additional patients, but COL3A1 sequencing was negative. Two patients were diagnosed with classic and hypermobile Ehlers-Danlos syndrome, one patient with Marfan syndrome, and one with osteogenesis imperfecta, based on clinical criteria only. In this largest series of patients with CeAD to date, family history of symptomatic CeAD was rare and inherited connective tissue disorders seemed exceptional. This finding supports the notion that CeAD is a multifactorial disease in the vast majority of cases.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 66 citations 66 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1212/wnl.0000000000001027&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2013 Singapore, France, United States, Croatia, GermanyPublisher:Proceedings of the National Academy of Sciences Funded by:EC | SYMBIOX, NSF | National Evolutionary Syn...EC| SYMBIOX ,NSF| National Evolutionary Synthesis CenterAuthors: McFall-Ngai, Margaret; Hadfield, Michael G.; Bosch, Thomas C. G.; Carey, Hannah V.; +22 AuthorsMcFall-Ngai, Margaret; Hadfield, Michael G.; Bosch, Thomas C. G.; Carey, Hannah V.; Domazet-Loso, Tomislav; Douglas, Angela E.; Dubilier, Nicole; Eberl, Gerard; Fukami, Tadashi; Gilbert, Scott F.; Hentschel, Ute; King, Nicole; Kjelleberg, Staffan; Knoll, Andrew H.; Kremer, Natacha; Mazmanian, Sarkis K.; Metcalf, Jessica L.; Nealson, Kenneth; Pierce, Naomi E.; Rawls, John F.; Reid, Ann; Ruby, Edward G.; Rumpho, Mary; Sanders, Jon G.; Tautz, Diethard; Wernegreen, Jennifer J.;International audience; In the last two decades, the widespread application of genetic and genomic approaches has revealed a bacterial world astonishing in its ubiquity and diversity. This review examines how a growing knowledge of the vast range of animal-bacterial interactions, whether in shared ecosystems or intimate symbioses, is fundamentally altering our understanding of animal biology. Specifically, we highlight recent technological and intellectual advances that have changed our thinking about five questions: how have bacteria facilitated the origin and evolution of animals; how do animals and bacteria affect each other's genomes; how does normal animal development depend on bacterial partners; how is homeostasis maintained between animals and their symbionts; and how can ecological approaches deepen our understanding of the multiple levels of animal-bacterial interaction. As answers to these fundamental questions emerge, all biologists will be challenged to broaden their appreciation of these interactions and to include investigations of the relationships between and among bacteria and their animal partners as we seek a better understanding of the natural world.
Caltech Authors arrow_drop_down Croatian Scientific Bibliography - CROSBIOther literature type . 2013Data sources: Croatian Scientific Bibliography - CROSBIProceedings of the National Academy of SciencesOther literature type . Article . 2013 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 2K citations 2,076 popularity Top 0.01% influence Top 0.1% impulse Top 0.01% Powered by BIP!more_vert Caltech Authors arrow_drop_down Croatian Scientific Bibliography - CROSBIOther literature type . 2013Data sources: Croatian Scientific Bibliography - CROSBIProceedings of the National Academy of SciencesOther literature type . Article . 2013 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article , Preprint , Other literature type , Review 2017 Netherlands, United States, Netherlands, Finland, Germany, Denmark, FrancePublisher:Copernicus GmbH Funded by:FWF | Carbonyl sulfide exchange..., AKA | Carbon Balance under Chan..., AKA | Biosphere-Atmosphere Feed... +7 projectsFWF| Carbonyl sulfide exchange between terrestrial ecosystems and the atmosphere ,AKA| Carbon Balance under Changing Processes of Arctic and Subarctic Cryosphere (CARB-ARC) / Consortium: CARB-ARC ,AKA| Biosphere-Atmosphere Feedbacks and Carbon-Water Cycles ,AKA| Biosphere-Atmosphere Feedbacks and Carbon-Water Cycles ,NSF| Collaborative Research: A 1500m Ice Core from South Pole ,NSF| CAREER: Disentangling CO2 Fluxes in a Tropical Rainforest Using Carbonyl Sulfide ,NSF| AGS-PRF: Soil Exchange of Carbonyl Sulfide (COS): Towards an Independent Proxy for Terrestrial Gross Primary Production (GPP) ,EC| SOLCA ,EC| USIFlux ,AKA| Centre of Excellence in Atmospheric Science From Molecular and Biolocigal processes to The Global ClimateM. E. Whelan; M. E. Whelan; S. T. Lennartz; T. E. Gimeno; R. Wehr; G. Wohlfahrt; Y. Wang; L. M. J. Kooijmans; T. W. Hilton; S. Belviso; P. Peylin; R. Commane; W. Sun; H. Chen; L. Kuai; I. Mammarella; K. Maseyk; M. Berkelhammer; K.-F. Li; D. Yakir; A. Zumkehr; Y. Katayama; J. Ogée; F. M. Spielmann; F. Kitz; B. Rastogi; J. Kesselmeier; J. Marshall; K.-M. Erkkilä; L. Wingate; L. K. Meredith; W. He; R. Bunk; T. Launois; T. Vesala; T. Vesala; T. Vesala; J. A. Schmidt; C. G. Fichot; U. Seibt; S. Saleska; E. S. Saltzman; S. A. Montzka; J. A. Berry; J. E. Campbell;For the past decade, observations of carbonyl sulfide (OCS or COS) have been investigated as a proxy for carbon uptake by plants. OCS is destroyed by enzymes that interact with CO2 during photosynthesis, namely carbonic anhydrase (CA) and RuBisCO, where CA is the more important one. The majority of sources of OCS to the atmosphere are geographically separated from this large plant sink, whereas the sources and sinks of CO2 are co-located in ecosystems. The drawdown of OCS can therefore be related to the uptake of CO2 without the added complication of co-located emissions comparable in magnitude. Here we review the state of our understanding of the global OCS cycle and its applications to ecosystem carbon cycle science. OCS uptake is correlated well to plant carbon uptake, especially at the regional scale. OCS can be used in conjunction with other independent measures of ecosystem function, like solar-induced fluorescence and carbon and water isotope studies. More work needs to be done to generate global coverage for OCS observations and to link this powerful atmospheric tracer to systems where fundamental questions concerning the carbon and water cycle remain.
OceanRep arrow_drop_down eScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of CaliforniaCopenhagen University Research Information SystemArticle . 2018Data sources: Copenhagen University Research Information SystemeScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of CaliforniaeScholarship - University of CaliforniaArticle . 2017Data sources: eScholarship - University of CaliforniaHELDA - Digital Repository of the University of HelsinkiReview . 2018 . Peer-reviewedData sources: HELDA - Digital Repository of the University of HelsinkiMémoires en Sciences de l'Information et de la Communication; HAL-CEAArticle . 2018License: CC BYFull-Text: https://hal.science/hal-02104411/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 94 citations 94 popularity Top 1% influence Top 10% impulse Top 1% Powered by BIP!download 91download downloads 91 Powered bymore_vert OceanRep arrow_drop_down eScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of CaliforniaCopenhagen University Research Information SystemArticle . 2018Data sources: Copenhagen University Research Information SystemeScholarship - University of CaliforniaArticle . 2018Data sources: eScholarship - University of CaliforniaeScholarship - University of CaliforniaArticle . 2017Data sources: eScholarship - University of CaliforniaHELDA - Digital Repository of the University of HelsinkiReview . 2018 . Peer-reviewedData sources: HELDA - Digital Repository of the University of HelsinkiMémoires en Sciences de l'Information et de la Communication; HAL-CEAArticle . 2018License: CC BYFull-Text: https://hal.science/hal-02104411/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2017Embargo end date: 01 Jan 2017 Switzerland, Germany, Finland, France, Switzerland, Belgium, Netherlands EnglishPublisher:ETH Zurich Funded by:ARC | Special Research Initiati..., NSF | Collaborative Research: E..., EC | TITAN +6 projectsARC| Special Research Initiatives - Grant ID: SR140300001 ,NSF| Collaborative Research: EaSM2--Linking Near Term Future Changes in Weather and Hydroclimate in Western North America to Adaptation for Ecosystem and Water Management ,EC| TITAN ,NSF| P2C2: Continental Scale Droughts in North America: Their Frequency, Character and Causes Over the Past Millennium and Near Term Future ,EC| STRATOCLIM ,UKRI| PAlaeo-Constraints on Monsoon Evolution and Dynamics ,SNSF| Future and Past Solar Influence on the Terrestrial Climate II ,EC| ASTRA ,NSF| Collaborative Research: EaSM2--Quantifying and Conveying the Risk of Prolonged Drought in Coming DecadesJungclaus, J; Bard, E; Baroni, M; Braconnot, P; Cao, J; Chini, LP; Egorova, T; Evans, M; González-Rouco, JF; Goosse, H; Hurtt, GC; Joos, F; Kaplan, JO; Khodri, M; Goldewijk, KK; Krivova, N; LeGrande, AN; Lorenz, SJ; Luterbacher, J; Man, W; Maycock, AC; Meinshausen, M; Moberg, A; Muscheler, R; Nehrbass-Ahles, C; Otto-Bliesner, BI; Phipps, SJ; Pongratz, J; Rozanov, E; Schmidt, GA; Schmidt, H; Schmutz, W; Schurer, A; Shapiro, AI; Sigl, M; Smerdon, JE; Solanki, SK; Timmreck, C; Toohey, M; Usoskin, IG; Wagner, S; Wu, C-J; Yeo, KL; Zanchettin, D; Zhang, Q; Zorita, E;handle: 2078.1/191152 , 20.500.11850/223889
The pre-industrial millennium is among the periods selected by the Paleoclimate Model Intercomparison Project (PMIP) for experiments contributing to the sixth phase of the Coupled Model Intercomparison Project (CMIP6) and the fourth phase of the PMIP (PMIP4). The past1000 transient simulations serve to investigate the response to (mainly) natural forcing under background conditions not too different from today, and to discriminate between forced and internally generated variability on interannual to centennial timescales. This paper describes the motivation and the experimental set-ups for the PMIP4-CMIP6 past1000 simulations, and discusses the forcing agents orbital, solar, volcanic, and land use/land cover changes, and variations in greenhouse gas concentrations. The past1000 simulations covering the pre-industrial millennium from 850 Common Era (CE) to 1849 CE have to be complemented by historical simulations (1850 to 2014 CE) following the CMIP6 protocol. The external forcings for the past1000 experiments have been adapted to provide a seamless transition across these time periods. Protocols for the past1000 simulations have been divided into three tiers. A default forcing data set has been defined for the Tier 1 (the CMIP6 past1000) experiment. However, the PMIP community has maintained the flexibility to conduct coordinated sensitivity experiments to explore uncertainty in forcing reconstructions as well as parameter uncertainty in dedicated Tier 2 simulations. Additional experiments (Tier 3) are defined to foster collaborative model experiments focusing on the early instrumental period and to extend the temporal range and the scope of the simulations. This paper outlines current and future research foci and common analyses for collaborative work between the PMIP and the observational communities (reconstructions, instrumental data). Geoscientific Model Development, 10 (11) ISSN:1991-9603 ISSN:1991-959X
CORE (RIOXX-UK Aggre... arrow_drop_down Bern Open Repository and Information System (BORIS)Article . 2017 . Peer-reviewedData sources: Bern Open Repository and Information System (BORIS)University of Oulu Repository - JultikaArticle . 2017License: CC BYData sources: University of Oulu Repository - JultikaHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3929/ethz-b-000211928&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!visibility 12visibility views 12 download downloads 2 Powered bymore_vert CORE (RIOXX-UK Aggre... arrow_drop_down Bern Open Repository and Information System (BORIS)Article . 2017 . Peer-reviewedData sources: Bern Open Repository and Information System (BORIS)University of Oulu Repository - JultikaArticle . 2017License: CC BYData sources: University of Oulu Repository - JultikaHAL - UPEC / UPEM; HAL-Pasteur; HAL-Inserm; Hal-DiderotArticle . 2017add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3929/ethz-b-000211928&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type 2014 Italy, FrancePublisher:Ovid Technologies (Wolters Kluwer Health) Authors: Stéphanie Debette; Barbara Goeggel Simonetti; Sabrina Schilling; Juan Jose Martin; +37 AuthorsStéphanie Debette; Barbara Goeggel Simonetti; Sabrina Schilling; Juan Jose Martin; Manja Kloss; Hakan Sarikaya; Ingrid Hausser; Stefan T. Engelter; Tiina M. Metso; Alessandro Pezzini; Vincent Thijs; Emmanuel Touzé; Stefano Paolucci; Paolo Costa; Maria Sessa; Yves Samson; Yannick Béjot; Ayse Altintas; Antti J. Metso; Dominique Hervé; Christoph Lichy; Simon Jung; Urs Fischer; C. Lamy; Armin J. Grau; Hugues Chabriat; Valeria Caso; Philippe Lyrer; Christian Stapf; Turgut Tatlisumak; Tobias Brandt; Elisabeth Tournier-Lasserve; Dominique P. Germain; Michael Frank; Ralf W. Baumgartner; Caspar Grond-Ginsbach; Marie-Germaine Bousser; Didier Leys; Jean Dallongeville; Anna Bersano; Marcel Arnold;pmc: PMC4248448 , PMC5994721
handle: 11379/389710
Erratum in: Familial occurrence and heritable connective tissue disorders in cervical artery dissection. [Neurology. 2016]; International audience; In a large series of patients with cervical artery dissection (CeAD), a major cause of ischemic stroke in young and middle-aged adults, we aimed to examine frequencies and correlates of family history of CeAD and of inherited connective tissue disorders. We combined data from 2 large international multicenter cohorts of consecutive patients with CeAD in 23 neurologic departments participating in the CADISP-plus consortium, following a standardized protocol. Frequency of reported family history of CeAD and of inherited connective tissue disorders was assessed. Putative risk factors, baseline features, and 3-month outcome were compared between groups. Among 1,934 consecutive patients with CeAD, 20 patients (1.0%, 95% confidence interval: 0.6%-1.5%) from 17 families (0.9%, 0.5%-1.3%) had a family history of CeAD. Family history of CeAD was significantly more frequent in patients with carotid location of the dissection and elevated cholesterol levels. Two patients without a family history of CeAD had vascular Ehlers-Danlos syndrome with a mutation in COL3A1. This diagnosis was suspected in 2 additional patients, but COL3A1 sequencing was negative. Two patients were diagnosed with classic and hypermobile Ehlers-Danlos syndrome, one patient with Marfan syndrome, and one with osteogenesis imperfecta, based on clinical criteria only. In this largest series of patients with CeAD to date, family history of symptomatic CeAD was rare and inherited connective tissue disorders seemed exceptional. This finding supports the notion that CeAD is a multifactorial disease in the vast majority of cases.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1212/wnl.0000000000001027&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 66 citations 66 popularity Top 10% influence Top 10% impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1212/wnl.0000000000001027&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2013 Singapore, France, United States, Croatia, GermanyPublisher:Proceedings of the National Academy of Sciences Funded by:EC | SYMBIOX, NSF | National Evolutionary Syn...EC| SYMBIOX ,NSF| National Evolutionary Synthesis CenterAuthors: McFall-Ngai, Margaret; Hadfield, Michael G.; Bosch, Thomas C. G.; Carey, Hannah V.; +22 AuthorsMcFall-Ngai, Margaret; Hadfield, Michael G.; Bosch, Thomas C. G.; Carey, Hannah V.; Domazet-Loso, Tomislav; Douglas, Angela E.; Dubilier, Nicole; Eberl, Gerard; Fukami, Tadashi; Gilbert, Scott F.; Hentschel, Ute; King, Nicole; Kjelleberg, Staffan; Knoll, Andrew H.; Kremer, Natacha; Mazmanian, Sarkis K.; Metcalf, Jessica L.; Nealson, Kenneth; Pierce, Naomi E.; Rawls, John F.; Reid, Ann; Ruby, Edward G.; Rumpho, Mary; Sanders, Jon G.; Tautz, Diethard; Wernegreen, Jennifer J.;International audience; In the last two decades, the widespread application of genetic and genomic approaches has revealed a bacterial world astonishing in its ubiquity and diversity. This review examines how a growing knowledge of the vast range of animal-bacterial interactions, whether in shared ecosystems or intimate symbioses, is fundamentally altering our understanding of animal biology. Specifically, we highlight recent technological and intellectual advances that have changed our thinking about five questions: how have bacteria facilitated the origin and evolution of animals; how do animals and bacteria affect each other's genomes; how does normal animal development depend on bacterial partners; how is homeostasis maintained between animals and their symbionts; and how can ecological approaches deepen our understanding of the multiple levels of animal-bacterial interaction. As answers to these fundamental questions emerge, all biologists will be challenged to broaden their appreciation of these interactions and to include investigations of the relationships between and among bacteria and their animal partners as we seek a better understanding of the natural world.
Caltech Authors arrow_drop_down Croatian Scientific Bibliography - CROSBIOther literature type . 2013Data sources: Croatian Scientific Bibliography - CROSBIProceedings of the National Academy of SciencesOther literature type . Article . 2013 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.1218525110&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 2K citations 2,076 popularity Top 0.01% influence Top 0.1% impulse Top 0.01% Powered by BIP!more_vert Caltech Authors arrow_drop_down Croatian Scientific Bibliography - CROSBIOther literature type . 2013Data sources: Croatian Scientific Bibliography - CROSBIProceedings of the National Academy of SciencesOther literature type . Article . 2013 . Peer-reviewedadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.1218525110&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu