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description Publicationkeyboard_double_arrow_right Article 2024Publisher:Elsevier BV Funded by:EC | EMERGE, EC | SERENAEC| EMERGE ,EC| SERENAMarianna Rossetti; Chawin Srisomwat; Massimo Urban; Giulio Rosati; Gabriel Maroli; Hatice Gödze Yaman Akbay; Orawon Chailapakul; Arben Merkoçi;Biosensors and Bioel... arrow_drop_down Biosensors and BioelectronicsArticle . 2024 . Peer-reviewedLicense: CC BY NC NDData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.bios.2024.116079&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Biosensors and Bioel... arrow_drop_down Biosensors and BioelectronicsArticle . 2024 . Peer-reviewedLicense: CC BY NC NDData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.bios.2024.116079&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024Publisher:Elsevier BV Funded by:EC | One Health EJPEC| One Health EJPAuthors: Fabrizia Valleriani; Chiara Di Pancrazio; Massimo Spedicato; Giovanni Di Teodoro; +16 AuthorsFabrizia Valleriani; Chiara Di Pancrazio; Massimo Spedicato; Giovanni Di Teodoro; Daniela Malatesta; Tetyana Petrova; Francesca Profeta; Maria Loredana Colaianni; Shadia Berjaoui; Ilaria Puglia; Marialuigia Caporale; Emanuela Rossi; Maurilia Marcacci; Mirella Luciani; Flavio Sacchini; Ottavio Portanti; Francesco Bencivenga; Nicola Decaro; Francesco Bonfante; Alessio Lorusso;add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.virol.2024.109997&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.virol.2024.109997&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024 SwitzerlandPublisher:Elsevier BV Funded by:SNSF | Novel virucidal drugs: Fr..., EC | LIGHT-CAPSNSF| Novel virucidal drugs: From basic to in vivo studies ,EC| LIGHT-CAPHeyun Wang; Xufeng Xu; Rémi La Polla; Paulo Jacob Silva; Quy Khac Ong; Francesco Stellacci;pmid: 38043234
We have learned from the recent COVID-19 pandemic that the emergence of a new virus can quickly become a global health burden and kill millions of lives. Antiviral drugs are essential in our fight against viral diseases, but most of them are virus-specific and are prone to viral mutations. We have developed broad-spectrum antivirals based on multivalent nanoparticles grafted with ligands that mimic the target of viral attachment ligands (VALs). We have shown that when the ligand has a sufficiently long hydrophobic tail, the inhibition mechanism switches from reversible (virustatic) to irreversible (virucidal). Here, we investigate further how ligand density and particle size affect antiviral efficacy, both in terms of half-inhibitory concentration (IC50) and of reversible vs irreversible mechanism. We designed antiviral silica nanoparticles modified with 11-mercaptoundecane-1-sul-fonic acid (MUS), a ligand that mimics heparan sulfate proteoglycans (HSPG) and we showed that these nano -particles can be synthesized with different sizes (4-200 nm) and ligand grafting densities (0.59-10.70 /nm2). By testing these particles against herpes simplex virus type 2 (HSV-2), we show that within the size and density ranges studied, the antiviral IC50 is determined solely by equivalent ligand concentration. The nanoparticles are found to be virucidal at all sizes and densities studied.
Journal of Colloid a... arrow_drop_down Journal of Colloid and Interface ScienceArticle . 2024 . Peer-reviewedLicense: CC BYData sources: CrossrefInfoscience - EPFL scientific publicationsArticleData sources: Infoscience - EPFL scientific publicationsadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jcis.2023.11.122&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert Journal of Colloid a... arrow_drop_down Journal of Colloid and Interface ScienceArticle . 2024 . Peer-reviewedLicense: CC BYData sources: CrossrefInfoscience - EPFL scientific publicationsArticleData sources: Infoscience - EPFL scientific publicationsadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jcis.2023.11.122&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024Publisher:Elsevier BV Funded by:EC | SINE2020EC| SINE2020Samuel Watts; Eliane Hänni; Gregory N. Smith; Najet Mahmoudi; Rafael V.M. Freire; Sierin Lim; Stefan Salentinig;pmid: 38096780
Enveloped viruses are pivotal in causing various illnesses, including influenza and COVID-19. The antimicrobial peptide LL-37, a critical part of the human innate immune system, exhibits potential as an antiviral agent capable of thwarting these viral threats. Its mode of action involves versatile and non-specific interactions that culminate in dismantling the viral envelope, ultimately rendering the viruses inert. However, the exact mechanism of action is not yet understood.Here, the mechanism of LL-37 triggered changes in the structure and function of an enveloped virus is investigated. The bacteriophage "Phi6" is used as a surrogate for pathogenic enveloped viruses. Small angle X-ray and neutron scattering combined with light scattering techniques demonstrate that LL-37 actively integrates into the virus's lipid envelope.LL-37 addition to Phi6 leads to curvature modification in the lipid bilayer, ultimately separating the envelope from the nucleocapsid. Additional biological assays confirm the loss of virus infectivity in the presence of LL-37, which coincides with the structural transformations. The results provide a fundamental understanding of the structure-activity relationship related to enveloped viruses. The knowledge of peptide-virus interactions can guide the design of future peptide-based antiviral drugs and therapies.
Journal of Colloid a... arrow_drop_down Journal of Colloid and Interface ScienceArticle . 2024 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jcis.2023.11.055&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Journal of Colloid a... arrow_drop_down Journal of Colloid and Interface ScienceArticle . 2024 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jcis.2023.11.055&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024Publisher:Springer Science and Business Media LLC Funded by:EC | SENTINELEC| SENTINELAuthors: Marta Bermejo-Jambrina; Lieve EH van der Donk; John L van Hamme; Doris Wilflingseder; +7 AuthorsMarta Bermejo-Jambrina; Lieve EH van der Donk; John L van Hamme; Doris Wilflingseder; Godelieve de Bree; Maria Prins; Menno de Jong; Pythia Nieuwkerk; Marit J van Gils; Neeltje A Kootstra; Teunis BH Geijtenbeek;AbstractDysregulated immune responses contribute to the excessive and uncontrolled inflammation observed in severe COVID-19. However, how immunity to SARS-CoV-2 is induced and regulated remains unclear. Here, we uncover the role of the complement system in the induction of innate and adaptive immunity to SARS-CoV-2. Complement rapidly opsonizes SARS-CoV-2 particles via the lectin pathway. Complement-opsonized SARS-CoV-2 efficiently induces type-I interferon and pro-inflammatory cytokine responses via activation of dendritic cells, which are inhibited by antibodies against the complement receptors (CR) 3 and 4. Serum from COVID-19 patients, or monoclonal antibodies against SARS-CoV-2, attenuate innate and adaptive immunity induced by complement-opsonized SARS-CoV-2. Blocking of CD32, the FcγRII antibody receptor of dendritic cells, restores complement-induced immunity. These results suggest that opsonization of SARS-CoV-2 by complement is involved in the induction of innate and adaptive immunity to SARS-CoV-2 in the acute phase of infection. Subsequent antibody responses limit inflammation and restore immune homeostasis. These findings suggest that dysregulation of the complement system and FcγRII signaling may contribute to severe COVID-19.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s44318-024-00061-0&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s44318-024-00061-0&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024 PortugalPublisher:Springer Science and Business Media LLC Funded by:FCT | CEGE, EC | PAL-CYCLESFCT| CEGE ,EC| PAL-CYCLESAuthors: Paulo J. Borges; Pablo Hernández-Marrero; Sandra Martins Pereira;Paulo J. Borges; Pablo Hernández-Marrero; Sandra Martins Pereira;handle: 10400.14/44092
Abstract Background The expressions of a “wish to hasten death” or “wish to die” raise ethical concerns and challenges. These expressions are related to ethical principles intertwined within the field of medical ethics, particularly in end-of-life care. Although some reviews were conducted about this topic, none of them provides an in-depth analysis of the meanings behind the “wish to hasten death/die” based specifically on the ethical principles of autonomy, dignity, and vulnerability. The aim of this review is to understand if and how the meanings behind the “wish to hasten death/die” relate to and are interpreted in light of ethical principles in palliative care. Methods We conducted a meta-ethnographic review according to the PRISMA guidelines and aligned with Noblit and Hare’s framework. Searches were performed in three databases, Web of Science, PubMed, CINAHL, with no time restrictions. Original qualitative studies exploring the meanings given by patients, family caregivers and healthcare professionals in any context of palliative and end-of-life care were included. A narrative synthesis was undertaken. PROSPERO registration CRD42023360330. Results Out of 893 retrieved articles, 26 were included in the analysis, accounting for the meanings of a total of 2,398 participants. Several factors and meanings associated with the “wish to hasten death” and/or “wish to die” were identified and are mainly of a psychosocial and spiritual nature. The ethical principles of autonomy and dignity were the ones mostly associated with the “wish to hasten death”. Ethical principles were essentially inferred from the content of included articles, although not explicitly stated as bioethical principles. Conclusions This meta-ethnographic review shows a reduced number of qualitative studies on the “wish to hasten death” and/or “wish to die” explicitly stating ethical principles. This suggests a lack of bioethical reflection and reasoning in the empirical end-of-life literature and a lack of embedded ethics in clinical practice. There is a need for healthcare professionals to address these topics compassionately and ethically, taking into account the unique perspectives of patients and family members. More qualitative studies on the meanings behind a wish to hasten death, their ethical contours, ethical reasoning, and implications for clinical practice are needed.
BMC Medical Ethics arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s12910-024-01018-y&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert BMC Medical Ethics arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s12910-024-01018-y&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024Publisher:Wiley Funded by:EC | PERISCOPEEC| PERISCOPEAuthors: Henrike Sternberg; Janina Isabel Steinert; Tim Büthe;Henrike Sternberg; Janina Isabel Steinert; Tim Büthe;doi: 10.1002/hec.4807
AbstractTo what extent do economic preferences and institutional trust predict compliance with physical distancing rules during the COVID‐19 pandemic? We reexamine this question by introducing the theoretical and empirical distinction between individual health behaviors in the public and in the private domain (e.g., keeping a distance from strangers vs. abstaining from private gatherings with friends). Using structural equation modeling to analyze survey data from Germany's second wave of the pandemic (N = 3350), we reveal the following major differences between compliance in both domains: Social preferences, especially (positive) reciprocity, play an essential role in predicting compliance in the public domain but are barely relevant in the private domain. Conversely, individuals' degree of trust in the national government matters predominantly for increasing compliance in the private domain. The clearly strongest predictor in this domain is the perception pandemic‐related threats. Our findings encourage tailoring communication strategies to either domain‐specific circumstances or factors common across domains. Tailored communication may also help promote compliance with other health‐related regulatory policies beyond COVID‐19.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/hec.4807&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/hec.4807&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024Publisher:Oxford University Press (OUP) Funded by:EC | SoBigData-PlusPlusEC| SoBigData-PlusPlusChristian Diem; András Borsos; Tobias Reisch; János Kertész; Stefan Thurner;Abstract To estimate the reaction of economies to political interventions or external disturbances, input-output (IO) tables—constructed by aggregating data into industrial sectors—are extensively used. However, economic growth, robustness, and resilience crucially depend on the detailed structure of non-aggregated firm-level production networks (FPNs). Due to non-availability of data little is known about how much aggregated sector-based and detailed firm-level-based model-predictions differ. Using a nearly complete nationwide FPN, containing 243,399 Hungarian firms with 1,104,141 supplier-buyer-relations we self-consistently compare production losses on the aggregated industry-level production network (IPN) and the granular FPN. For this we model the propagation of shocks of the same size on both, the IPN and FPN, where the latter captures relevant heterogeneities within industries. In a COVID-19 inspired scenario we model the shock based on detailed firm-level data during the early pandemic. We find that using IPNs instead of FPNs leads to an underestimation of economic losses of up to 37%, demonstrating a natural limitation of industry-level IO-models in predicting economic outcomes. We ascribe the large discrepancy to the significant heterogeneity of firms within industries: we find that firms within one sector only sell 23.5% to and buy 19.3% from the same industries on average, emphasizing the strong limitations of industrial sectors for representing the firms they include. Similar error-levels are expected when estimating economic growth, CO2 emissions, and the impact of policy interventions with industry-level IO models. Granular data is key for reasonable predictions of dynamical economic systems.
arXiv.org e-Print Ar... arrow_drop_down arXiv.org e-Print ArchiveOther literature type . Preprint . 2023Data sources: arXiv.org e-Print Archivehttps://doi.org/10.48550/arxiv...Article . 2023License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/pnasnexus/pgae064&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert arXiv.org e-Print Ar... arrow_drop_down arXiv.org e-Print ArchiveOther literature type . Preprint . 2023Data sources: arXiv.org e-Print Archivehttps://doi.org/10.48550/arxiv...Article . 2023License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/pnasnexus/pgae064&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024Publisher:American Thoracic Society Funded by:EC | FAIREC| FAIRAuthors: Erik H. A. Michels; Brent Appelman; Justin de Brabander; Rombout B. E. van Amstel; +88 AuthorsErik H. A. Michels; Brent Appelman; Justin de Brabander; Rombout B. E. van Amstel; Christine C. A. van Linge; Osoul Chouchane; Tom D. Y. Reijnders; Alex R. Schuurman; Titia A. L. Sulzer; Augustijn M. Klarenbeek; Renée A. Douma; Lieuwe D. J. Bos; W. Joost Wiersinga; Hessel Peters-Sengers; Tom van der Poll; Michiel van Agtmael; Anne Geke Algera; Brent Appelman; Floor van Baarle; Martijn Beudel; Harm Jan Bogaard; Marije Bomers Peter Bonta; Lieuwe Bos; Michela Botta; Justin de Brabander; Godelieve de Bree; Sanne de Bruin; Marianna Bugiani; Esther Bulle; David T. P. Buis; Osoul Chouchane Alex Cloherty; Mirjam Dijkstra; Dave A. Dongelmans; Romein W. G. Dujardin; Paul Elbers; Lucas Fleuren; Suzanne Geerlings Theo Geijtenbeek; Armand Girbes; Bram Goorhuis; Martin P. Grobusch; Laura Hagens; Jorg Hamann; Vanessa Harris; Robert Hemke; Sabine M. Hermans Leo Heunks; Markus Hollmann; Janneke Horn; Joppe W. Hovius; Hanna K. de Jong; Menno D. de Jong; Rutger Koning; Bregje Lemkes; Endry H. T. Lim; Niels van Mourik; Jeaninne Nellen; Esther J. Nossent; Sabine Olie; Frederique Paulus; Edgar Peters; Dan A. I. Pina-Fuentes; Tom van der Poll; Bennedikt Preckel; Jorinde Raasveld; Tom Reijnders; Maurits C. F. J. de Rotte; Michiel Schinkel; Marcus J. Schultz; Femke A. P. Schrauwen; Alex Schuurman; Jaap Schuurmans; Kim Sigaloff; Marleen A. Slim; Patrick Smeele; Marry Smit; Cornelis S. Stijnis; Willemke Stilma; Charlotte Teunissen; Patrick Thoral; Anissa M. Tsonas; Pieter R. Tuinman; Marc van der Valk; Denise P. Veelo; Carolien Volleman; Heder de Vries; Lonneke A. Vught; Michèle van Vugt; Dorien Wouters; A. H. (Koos) Zwinderman; Matthijs C. Brouwer; W. Joost Wiersinga; Alexander P. J. Vlaar; Diederik van de Beek;pmid: 37948687
Lymphopenia in COVID-19 is associated with increased mortality.To explore the association between lymphopenia, host response aberrations and mortality in patients with lymphopenic COVID-19.We determined 43 plasma biomarkers reflective of four pathophysiological domains: endothelial cell and coagulation activation, inflammation and organ damage, and cytokine and chemokine release. We explored if decreased concentrations of lymphocyte-derived proteins in lymphopenic patients were associated with an increase in mortality. We sought to identify host response phenotypes in patients with lymphopenia by cluster analysis of plasma biomarkers.439 COVID-19 general ward patients were stratified by baseline lymphocyte counts: normal (1.0x10Lymphopenia in COVID-19 signifies a heterogenous group with distinct host response features. Specific host responses contribute to lymphopenia-associated mortality in COVID-19, including reduced CCL5 levels. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).
American Journal of ... arrow_drop_down American Journal of Respiratory and Critical Care MedicineArticle . 2024 . Peer-reviewedData sources: CrossrefAmerican Journal of Respiratory and Critical Care MedicineArticle . 2023Data sources: Europe PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1164/rccm.202305-0890oc&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert American Journal of ... arrow_drop_down American Journal of Respiratory and Critical Care MedicineArticle . 2024 . Peer-reviewedData sources: CrossrefAmerican Journal of Respiratory and Critical Care MedicineArticle . 2023Data sources: Europe PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1164/rccm.202305-0890oc&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024Publisher:Springer Science and Business Media LLC Funded by:EC | RECoVEREC| RECoVERAuthors: Yvette den Hartog; S. Reshwan K. Malahe; Wim J. R. Rietdijk; Marjolein Dieterich; +34 AuthorsYvette den Hartog; S. Reshwan K. Malahe; Wim J. R. Rietdijk; Marjolein Dieterich; Lennert Gommers; Debbie van Baarle; Dimitri A. Diavatopoulos; A. Lianne Messchendorp; Renate G. van der Molen; Ester B. M. Remmerswaal; Frederike J. Bemelman; Marcia M. L. Kho; Corine H. GeurtsvanKessel; Marion P. G. Koopmans; Ron T. Gansevoort; Luuk B. Hilbrands; Jan-Stephan Sanders; Marlies E. J. Reinders; Carla C. Baan; Rory D. de Vries; Alferso C. Abrahams; Marije C. Baas; Pim Bouwmans; Marc H. Hemmelder; Marc A. G. J. ten Dam; Sophie C. Frölke; Dorien Standaar; Marieke van der Heiden; Celine Imhof; Priya Vart; Yvonne M. R. Adema; Marieken J. Boer-Verschragen; Wouter B. Mattheussens; Ria Philipsen; Djenolan van Mourik; Nynke Rots; Gerco den Hartog; Rob van Binnendijk;AbstractKidney transplant recipients (KTRs) are at an increased risk of severe COVID-19 due to compromised immune responses. Although vaccination is critical in preventing severe disease, KTRs have attenuated vaccination-induced immune responses due to underlying kidney disease and immunosuppressive therapies. In this study, the effect of different COVID-19 booster strategies on SARS-CoV-2-specific T-cell responses was assessed in KTRs who showed a poor serological response after the first two mRNA-based primary vaccination doses. In these KTRs, a third vaccination dose led to an increase in antibody levels in the majority of patients. Production of IL-2 and IL-5 by SARS-CoV-2 specific T cells positively correlated with antibody levels, with stronger correlations compared to IFN-γ production, the ‘traditional’ cytokine to measure T-cell responses. Our study underscores the significance a balanced T-cell cytokine response to achieve robust antibody responses in KTRs. Furthermore, we show that multiple cytokines to assess T-cell responses should be explored to identify individuals in need of tailored vaccination strategies.
https://doi.org/10.1... arrow_drop_down https://doi.org/10.1038/s44298...Article . 2024 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s44298-024-00015-7&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert https://doi.org/10.1... arrow_drop_down https://doi.org/10.1038/s44298...Article . 2024 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s44298-024-00015-7&type=result"></script>'); --> </script>
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description Publicationkeyboard_double_arrow_right Article 2024Publisher:Elsevier BV Funded by:EC | EMERGE, EC | SERENAEC| EMERGE ,EC| SERENAMarianna Rossetti; Chawin Srisomwat; Massimo Urban; Giulio Rosati; Gabriel Maroli; Hatice Gödze Yaman Akbay; Orawon Chailapakul; Arben Merkoçi;Biosensors and Bioel... arrow_drop_down Biosensors and BioelectronicsArticle . 2024 . Peer-reviewedLicense: CC BY NC NDData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.bios.2024.116079&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Biosensors and Bioel... arrow_drop_down Biosensors and BioelectronicsArticle . 2024 . Peer-reviewedLicense: CC BY NC NDData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.bios.2024.116079&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024Publisher:Elsevier BV Funded by:EC | One Health EJPEC| One Health EJPAuthors: Fabrizia Valleriani; Chiara Di Pancrazio; Massimo Spedicato; Giovanni Di Teodoro; +16 AuthorsFabrizia Valleriani; Chiara Di Pancrazio; Massimo Spedicato; Giovanni Di Teodoro; Daniela Malatesta; Tetyana Petrova; Francesca Profeta; Maria Loredana Colaianni; Shadia Berjaoui; Ilaria Puglia; Marialuigia Caporale; Emanuela Rossi; Maurilia Marcacci; Mirella Luciani; Flavio Sacchini; Ottavio Portanti; Francesco Bencivenga; Nicola Decaro; Francesco Bonfante; Alessio Lorusso;add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.virol.2024.109997&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.virol.2024.109997&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024 SwitzerlandPublisher:Elsevier BV Funded by:SNSF | Novel virucidal drugs: Fr..., EC | LIGHT-CAPSNSF| Novel virucidal drugs: From basic to in vivo studies ,EC| LIGHT-CAPHeyun Wang; Xufeng Xu; Rémi La Polla; Paulo Jacob Silva; Quy Khac Ong; Francesco Stellacci;pmid: 38043234
We have learned from the recent COVID-19 pandemic that the emergence of a new virus can quickly become a global health burden and kill millions of lives. Antiviral drugs are essential in our fight against viral diseases, but most of them are virus-specific and are prone to viral mutations. We have developed broad-spectrum antivirals based on multivalent nanoparticles grafted with ligands that mimic the target of viral attachment ligands (VALs). We have shown that when the ligand has a sufficiently long hydrophobic tail, the inhibition mechanism switches from reversible (virustatic) to irreversible (virucidal). Here, we investigate further how ligand density and particle size affect antiviral efficacy, both in terms of half-inhibitory concentration (IC50) and of reversible vs irreversible mechanism. We designed antiviral silica nanoparticles modified with 11-mercaptoundecane-1-sul-fonic acid (MUS), a ligand that mimics heparan sulfate proteoglycans (HSPG) and we showed that these nano -particles can be synthesized with different sizes (4-200 nm) and ligand grafting densities (0.59-10.70 /nm2). By testing these particles against herpes simplex virus type 2 (HSV-2), we show that within the size and density ranges studied, the antiviral IC50 is determined solely by equivalent ligand concentration. The nanoparticles are found to be virucidal at all sizes and densities studied.
Journal of Colloid a... arrow_drop_down Journal of Colloid and Interface ScienceArticle . 2024 . Peer-reviewedLicense: CC BYData sources: CrossrefInfoscience - EPFL scientific publicationsArticleData sources: Infoscience - EPFL scientific publicationsadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jcis.2023.11.122&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert Journal of Colloid a... arrow_drop_down Journal of Colloid and Interface ScienceArticle . 2024 . Peer-reviewedLicense: CC BYData sources: CrossrefInfoscience - EPFL scientific publicationsArticleData sources: Infoscience - EPFL scientific publicationsadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jcis.2023.11.122&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024Publisher:Elsevier BV Funded by:EC | SINE2020EC| SINE2020Samuel Watts; Eliane Hänni; Gregory N. Smith; Najet Mahmoudi; Rafael V.M. Freire; Sierin Lim; Stefan Salentinig;pmid: 38096780
Enveloped viruses are pivotal in causing various illnesses, including influenza and COVID-19. The antimicrobial peptide LL-37, a critical part of the human innate immune system, exhibits potential as an antiviral agent capable of thwarting these viral threats. Its mode of action involves versatile and non-specific interactions that culminate in dismantling the viral envelope, ultimately rendering the viruses inert. However, the exact mechanism of action is not yet understood.Here, the mechanism of LL-37 triggered changes in the structure and function of an enveloped virus is investigated. The bacteriophage "Phi6" is used as a surrogate for pathogenic enveloped viruses. Small angle X-ray and neutron scattering combined with light scattering techniques demonstrate that LL-37 actively integrates into the virus's lipid envelope.LL-37 addition to Phi6 leads to curvature modification in the lipid bilayer, ultimately separating the envelope from the nucleocapsid. Additional biological assays confirm the loss of virus infectivity in the presence of LL-37, which coincides with the structural transformations. The results provide a fundamental understanding of the structure-activity relationship related to enveloped viruses. The knowledge of peptide-virus interactions can guide the design of future peptide-based antiviral drugs and therapies.
Journal of Colloid a... arrow_drop_down Journal of Colloid and Interface ScienceArticle . 2024 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jcis.2023.11.055&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Journal of Colloid a... arrow_drop_down Journal of Colloid and Interface ScienceArticle . 2024 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jcis.2023.11.055&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024Publisher:Springer Science and Business Media LLC Funded by:EC | SENTINELEC| SENTINELAuthors: Marta Bermejo-Jambrina; Lieve EH van der Donk; John L van Hamme; Doris Wilflingseder; +7 AuthorsMarta Bermejo-Jambrina; Lieve EH van der Donk; John L van Hamme; Doris Wilflingseder; Godelieve de Bree; Maria Prins; Menno de Jong; Pythia Nieuwkerk; Marit J van Gils; Neeltje A Kootstra; Teunis BH Geijtenbeek;AbstractDysregulated immune responses contribute to the excessive and uncontrolled inflammation observed in severe COVID-19. However, how immunity to SARS-CoV-2 is induced and regulated remains unclear. Here, we uncover the role of the complement system in the induction of innate and adaptive immunity to SARS-CoV-2. Complement rapidly opsonizes SARS-CoV-2 particles via the lectin pathway. Complement-opsonized SARS-CoV-2 efficiently induces type-I interferon and pro-inflammatory cytokine responses via activation of dendritic cells, which are inhibited by antibodies against the complement receptors (CR) 3 and 4. Serum from COVID-19 patients, or monoclonal antibodies against SARS-CoV-2, attenuate innate and adaptive immunity induced by complement-opsonized SARS-CoV-2. Blocking of CD32, the FcγRII antibody receptor of dendritic cells, restores complement-induced immunity. These results suggest that opsonization of SARS-CoV-2 by complement is involved in the induction of innate and adaptive immunity to SARS-CoV-2 in the acute phase of infection. Subsequent antibody responses limit inflammation and restore immune homeostasis. These findings suggest that dysregulation of the complement system and FcγRII signaling may contribute to severe COVID-19.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s44318-024-00061-0&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s44318-024-00061-0&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024 PortugalPublisher:Springer Science and Business Media LLC Funded by:FCT | CEGE, EC | PAL-CYCLESFCT| CEGE ,EC| PAL-CYCLESAuthors: Paulo J. Borges; Pablo Hernández-Marrero; Sandra Martins Pereira;Paulo J. Borges; Pablo Hernández-Marrero; Sandra Martins Pereira;handle: 10400.14/44092
Abstract Background The expressions of a “wish to hasten death” or “wish to die” raise ethical concerns and challenges. These expressions are related to ethical principles intertwined within the field of medical ethics, particularly in end-of-life care. Although some reviews were conducted about this topic, none of them provides an in-depth analysis of the meanings behind the “wish to hasten death/die” based specifically on the ethical principles of autonomy, dignity, and vulnerability. The aim of this review is to understand if and how the meanings behind the “wish to hasten death/die” relate to and are interpreted in light of ethical principles in palliative care. Methods We conducted a meta-ethnographic review according to the PRISMA guidelines and aligned with Noblit and Hare’s framework. Searches were performed in three databases, Web of Science, PubMed, CINAHL, with no time restrictions. Original qualitative studies exploring the meanings given by patients, family caregivers and healthcare professionals in any context of palliative and end-of-life care were included. A narrative synthesis was undertaken. PROSPERO registration CRD42023360330. Results Out of 893 retrieved articles, 26 were included in the analysis, accounting for the meanings of a total of 2,398 participants. Several factors and meanings associated with the “wish to hasten death” and/or “wish to die” were identified and are mainly of a psychosocial and spiritual nature. The ethical principles of autonomy and dignity were the ones mostly associated with the “wish to hasten death”. Ethical principles were essentially inferred from the content of included articles, although not explicitly stated as bioethical principles. Conclusions This meta-ethnographic review shows a reduced number of qualitative studies on the “wish to hasten death” and/or “wish to die” explicitly stating ethical principles. This suggests a lack of bioethical reflection and reasoning in the empirical end-of-life literature and a lack of embedded ethics in clinical practice. There is a need for healthcare professionals to address these topics compassionately and ethically, taking into account the unique perspectives of patients and family members. More qualitative studies on the meanings behind a wish to hasten death, their ethical contours, ethical reasoning, and implications for clinical practice are needed.
BMC Medical Ethics arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s12910-024-01018-y&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert BMC Medical Ethics arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s12910-024-01018-y&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024Publisher:Wiley Funded by:EC | PERISCOPEEC| PERISCOPEAuthors: Henrike Sternberg; Janina Isabel Steinert; Tim Büthe;Henrike Sternberg; Janina Isabel Steinert; Tim Büthe;doi: 10.1002/hec.4807
AbstractTo what extent do economic preferences and institutional trust predict compliance with physical distancing rules during the COVID‐19 pandemic? We reexamine this question by introducing the theoretical and empirical distinction between individual health behaviors in the public and in the private domain (e.g., keeping a distance from strangers vs. abstaining from private gatherings with friends). Using structural equation modeling to analyze survey data from Germany's second wave of the pandemic (N = 3350), we reveal the following major differences between compliance in both domains: Social preferences, especially (positive) reciprocity, play an essential role in predicting compliance in the public domain but are barely relevant in the private domain. Conversely, individuals' degree of trust in the national government matters predominantly for increasing compliance in the private domain. The clearly strongest predictor in this domain is the perception pandemic‐related threats. Our findings encourage tailoring communication strategies to either domain‐specific circumstances or factors common across domains. Tailored communication may also help promote compliance with other health‐related regulatory policies beyond COVID‐19.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/hec.4807&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/hec.4807&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024Publisher:Oxford University Press (OUP) Funded by:EC | SoBigData-PlusPlusEC| SoBigData-PlusPlusChristian Diem; András Borsos; Tobias Reisch; János Kertész; Stefan Thurner;Abstract To estimate the reaction of economies to political interventions or external disturbances, input-output (IO) tables—constructed by aggregating data into industrial sectors—are extensively used. However, economic growth, robustness, and resilience crucially depend on the detailed structure of non-aggregated firm-level production networks (FPNs). Due to non-availability of data little is known about how much aggregated sector-based and detailed firm-level-based model-predictions differ. Using a nearly complete nationwide FPN, containing 243,399 Hungarian firms with 1,104,141 supplier-buyer-relations we self-consistently compare production losses on the aggregated industry-level production network (IPN) and the granular FPN. For this we model the propagation of shocks of the same size on both, the IPN and FPN, where the latter captures relevant heterogeneities within industries. In a COVID-19 inspired scenario we model the shock based on detailed firm-level data during the early pandemic. We find that using IPNs instead of FPNs leads to an underestimation of economic losses of up to 37%, demonstrating a natural limitation of industry-level IO-models in predicting economic outcomes. We ascribe the large discrepancy to the significant heterogeneity of firms within industries: we find that firms within one sector only sell 23.5% to and buy 19.3% from the same industries on average, emphasizing the strong limitations of industrial sectors for representing the firms they include. Similar error-levels are expected when estimating economic growth, CO2 emissions, and the impact of policy interventions with industry-level IO models. Granular data is key for reasonable predictions of dynamical economic systems.
arXiv.org e-Print Ar... arrow_drop_down arXiv.org e-Print ArchiveOther literature type . Preprint . 2023Data sources: arXiv.org e-Print Archivehttps://doi.org/10.48550/arxiv...Article . 2023License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/pnasnexus/pgae064&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert arXiv.org e-Print Ar... arrow_drop_down arXiv.org e-Print ArchiveOther literature type . Preprint . 2023Data sources: arXiv.org e-Print Archivehttps://doi.org/10.48550/arxiv...Article . 2023License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/pnasnexus/pgae064&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024Publisher:American Thoracic Society Funded by:EC | FAIREC| FAIRAuthors: Erik H. A. Michels; Brent Appelman; Justin de Brabander; Rombout B. E. van Amstel; +88 AuthorsErik H. A. Michels; Brent Appelman; Justin de Brabander; Rombout B. E. van Amstel; Christine C. A. van Linge; Osoul Chouchane; Tom D. Y. Reijnders; Alex R. Schuurman; Titia A. L. Sulzer; Augustijn M. Klarenbeek; Renée A. Douma; Lieuwe D. J. Bos; W. Joost Wiersinga; Hessel Peters-Sengers; Tom van der Poll; Michiel van Agtmael; Anne Geke Algera; Brent Appelman; Floor van Baarle; Martijn Beudel; Harm Jan Bogaard; Marije Bomers Peter Bonta; Lieuwe Bos; Michela Botta; Justin de Brabander; Godelieve de Bree; Sanne de Bruin; Marianna Bugiani; Esther Bulle; David T. P. Buis; Osoul Chouchane Alex Cloherty; Mirjam Dijkstra; Dave A. Dongelmans; Romein W. G. Dujardin; Paul Elbers; Lucas Fleuren; Suzanne Geerlings Theo Geijtenbeek; Armand Girbes; Bram Goorhuis; Martin P. Grobusch; Laura Hagens; Jorg Hamann; Vanessa Harris; Robert Hemke; Sabine M. Hermans Leo Heunks; Markus Hollmann; Janneke Horn; Joppe W. Hovius; Hanna K. de Jong; Menno D. de Jong; Rutger Koning; Bregje Lemkes; Endry H. T. Lim; Niels van Mourik; Jeaninne Nellen; Esther J. Nossent; Sabine Olie; Frederique Paulus; Edgar Peters; Dan A. I. Pina-Fuentes; Tom van der Poll; Bennedikt Preckel; Jorinde Raasveld; Tom Reijnders; Maurits C. F. J. de Rotte; Michiel Schinkel; Marcus J. Schultz; Femke A. P. Schrauwen; Alex Schuurman; Jaap Schuurmans; Kim Sigaloff; Marleen A. Slim; Patrick Smeele; Marry Smit; Cornelis S. Stijnis; Willemke Stilma; Charlotte Teunissen; Patrick Thoral; Anissa M. Tsonas; Pieter R. Tuinman; Marc van der Valk; Denise P. Veelo; Carolien Volleman; Heder de Vries; Lonneke A. Vught; Michèle van Vugt; Dorien Wouters; A. H. (Koos) Zwinderman; Matthijs C. Brouwer; W. Joost Wiersinga; Alexander P. J. Vlaar; Diederik van de Beek;pmid: 37948687
Lymphopenia in COVID-19 is associated with increased mortality.To explore the association between lymphopenia, host response aberrations and mortality in patients with lymphopenic COVID-19.We determined 43 plasma biomarkers reflective of four pathophysiological domains: endothelial cell and coagulation activation, inflammation and organ damage, and cytokine and chemokine release. We explored if decreased concentrations of lymphocyte-derived proteins in lymphopenic patients were associated with an increase in mortality. We sought to identify host response phenotypes in patients with lymphopenia by cluster analysis of plasma biomarkers.439 COVID-19 general ward patients were stratified by baseline lymphocyte counts: normal (1.0x10Lymphopenia in COVID-19 signifies a heterogenous group with distinct host response features. Specific host responses contribute to lymphopenia-associated mortality in COVID-19, including reduced CCL5 levels. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).
American Journal of ... arrow_drop_down American Journal of Respiratory and Critical Care MedicineArticle . 2024 . Peer-reviewedData sources: CrossrefAmerican Journal of Respiratory and Critical Care MedicineArticle . 2023Data sources: Europe PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1164/rccm.202305-0890oc&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert American Journal of ... arrow_drop_down American Journal of Respiratory and Critical Care MedicineArticle . 2024 . Peer-reviewedData sources: CrossrefAmerican Journal of Respiratory and Critical Care MedicineArticle . 2023Data sources: Europe PubMed Centraladd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1164/rccm.202305-0890oc&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024Publisher:Springer Science and Business Media LLC Funded by:EC | RECoVEREC| RECoVERAuthors: Yvette den Hartog; S. Reshwan K. Malahe; Wim J. R. Rietdijk; Marjolein Dieterich; +34 AuthorsYvette den Hartog; S. Reshwan K. Malahe; Wim J. R. Rietdijk; Marjolein Dieterich; Lennert Gommers; Debbie van Baarle; Dimitri A. Diavatopoulos; A. Lianne Messchendorp; Renate G. van der Molen; Ester B. M. Remmerswaal; Frederike J. Bemelman; Marcia M. L. Kho; Corine H. GeurtsvanKessel; Marion P. G. Koopmans; Ron T. Gansevoort; Luuk B. Hilbrands; Jan-Stephan Sanders; Marlies E. J. Reinders; Carla C. Baan; Rory D. de Vries; Alferso C. Abrahams; Marije C. Baas; Pim Bouwmans; Marc H. Hemmelder; Marc A. G. J. ten Dam; Sophie C. Frölke; Dorien Standaar; Marieke van der Heiden; Celine Imhof; Priya Vart; Yvonne M. R. Adema; Marieken J. Boer-Verschragen; Wouter B. Mattheussens; Ria Philipsen; Djenolan van Mourik; Nynke Rots; Gerco den Hartog; Rob van Binnendijk;AbstractKidney transplant recipients (KTRs) are at an increased risk of severe COVID-19 due to compromised immune responses. Although vaccination is critical in preventing severe disease, KTRs have attenuated vaccination-induced immune responses due to underlying kidney disease and immunosuppressive therapies. In this study, the effect of different COVID-19 booster strategies on SARS-CoV-2-specific T-cell responses was assessed in KTRs who showed a poor serological response after the first two mRNA-based primary vaccination doses. In these KTRs, a third vaccination dose led to an increase in antibody levels in the majority of patients. Production of IL-2 and IL-5 by SARS-CoV-2 specific T cells positively correlated with antibody levels, with stronger correlations compared to IFN-γ production, the ‘traditional’ cytokine to measure T-cell responses. Our study underscores the significance a balanced T-cell cytokine response to achieve robust antibody responses in KTRs. Furthermore, we show that multiple cytokines to assess T-cell responses should be explored to identify individuals in need of tailored vaccination strategies.
https://doi.org/10.1... arrow_drop_down https://doi.org/10.1038/s44298...Article . 2024 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s44298-024-00015-7&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert https://doi.org/10.1... arrow_drop_down https://doi.org/10.1038/s44298...Article . 2024 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1038/s44298-024-00015-7&type=result"></script>'); --> </script>
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