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The Covid-19 crisis has been changing the whole life and business world. Previous fixed structures used in the companies before the Coronavirus Pandemic were followed by improvisation. Home office, short-time work, hygiene rules and social distancing were enforced by governmental corona regulations.

Background: Long COVID (coronavirus disease 2019) syndrome includes a group of patients who, after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), exhibit lingering mild-to-moderate symptoms and develop medical complications that can have lasting health problems. In this report, we propose a model for the pathophysiology of the long COVID presentation based on increased proinflammatory cytokine production that results from the persistence of the SARS-CoV-2 virus or one of its molecular components. Associated with this hyperproduction of inflammatory cytokines is a heightened activity of nuclear factor κ B (NF-κB) and p38 mitogen-activated protein kinase signaling pathways that regulate cytokine production. Objective: The purpose of the present report was to review the causes of long COVID syndrome and suggest ways that can provide a basis for a better understanding of the clinical symptomatology for the of improved diagnostic and therapeutic procedures for the condition. Methods: Extensive research was conducted in medical literature data bases by applying terms such as “long COVID” associated with “persistence of the SARS-CoV-2 virus” “spike protein' “COVID-19” and “biologic therapies.” Results and Conclusions: In this model of the long COVID syndrome, the persistence of SARS-CoV-2 is hypothesized to trigger a dysregulated immune system with subsequent heightened release of proinflammatory cytokines that lead to chronic low-grade inflammation and multiorgan symptomatology. The condition seems to have a genetic basis, which predisposes individuals to have a diminished immunologic capacity to completely clear the virus, with residual parts of the virus persisting. This persistence of virus and resultant hyperproduction of proinflammatory cytokines are proposed to form the basis of the syndrome.

Patients receiving chimeric antigen receptor T cells (CAR-T cells) therapy may be particularly susceptible to coronavirus disease 2019 (COVID-19) because of several factors including the immunosuppression associated to the underlying disease and delayed cytopenias. Regrettably, data on outcomes of CAR-T recipients with COVID-19 are extremely scarce. The aim of this study was to investigate the characteristics and outcomes of COVID-19 in patients treated with CAR-T therapy. The European Hematology Association - Scientific Working Group Infection in Hematology endorsed a survey to collect and analyze data from patients developing COVID-19 after CAR-T therapy. Overall, 459 patients treated with CAR-T cells were reported from 18 European centers. The prevalence of COVID-19 cases was 4.8%. Median time from CAR-T therapy and COVID-19 diagnosis was 169 days. Severe infection occurred in 66.7% of patients and 43.3% of the subjects required admission to ICU. The COVID-19 mortality was 33%. In multivariable analysis, the disease status at the time of COVID-19 trended marginally towards adverse outcome (P=0.075). In conclusion, we documented a high fatality rate for CAR-T patients with COVID-19, supporting the need to design successful interventions to mitigate the risk of infection in this vulnerable group of patients.

The transportation sector is a crucial sector of the sustainability of every national economy. Previous studies highlighted the core significance of transport enterprises in European countries over the past 60 years. The long-term sustainability of enterprises is determined by their ability to gain earnings. Thus, earnings are the synonym of significance in corporate life. The purpose of this study was to capture the lever year, the trend, and the slope of the development of earnings in the transport sector before the COVID-19 pandemic. Time series of the annual earnings of the enterprises from the close countries of the V4 region were used during a 10-year period. Buishand’s test sets the change-points of the development and indicated the values of specific central lines. The year 2013 was the lever date for the earnings of 830 Slovak and 1042 Hungarian enterprises. The year 2015 was the year of momentum for 757 Polish enterprises. The development of 397 Czech enterprises was mainly influenced by the year 2014. The results of the Mann–Kendall test detected a positive trend in the series of business finance in all countries. In addition, the Sen’s slope was estimated in the transport sector for the analyzed period 2010–2019.

COVID-19 pandemic has affected many areas of our lives including education. In the time of designing this study most schools, colleges, and universities across Europe were closed and psychology educators were expected to change their teaching methods rather quickly. This study investigates how they coped with this situation, which technology and methods they used to teach psychology distantly, and which barriers and outcomes they found in this situation. Participants were N = 660 secondary school and university teachers from 28 European countries. The results showed that the participants across Europe face similar challenges in adopting distance teaching methods, which were technical and organizational rather than pedagogical. Despite the fact they found distance teaching of specific psychological contents challenging, psychology teachers also described positive aspects of distance teaching, examples of good practice and lessons learned that could be generally implemented in the teaching of psychology beyond the pandemic situation.

In the Slovak Republic, a mass testing of the entire population was performed. Estimates show that this testing cost more than 400 million EUR and thousands of euros were paid for one positively identified case. Thus, it is possible to state a high cost for such a project, which has been criticized by many parties. On the other hand, from a public health point of view, mass testing has helped fight the pandemic. Both the health and economic perspectives are important in assessing the success of a pandemic strategy, but the social perspective is equally important. In fact, the situation is perceived from the position of public leaders who make decisions, but also from the position of the society that bears individual political decisions. It is not appropriate to forget about the society that is most affected by restrictions, testing, health status, but also the burden on the state budget. The objective of the presented research was to examine the perception of testing for coronavirus disease 2019 (COVID-19) in the Slovak population. Non-parametric difference tests and correspondence analysis were used for statistical processing. The research sample consisted of 806 respondents and data collection took place in February 2021. The main findings include significant differences in perceptions between the first and the last participation in testing in terms of gender, age, testing experience, and time aspect. The last participation in testing showed lower rates of positive aspects related to the internal motivation to test compared to the first participation. In contrast, external stimulation by government regulations related to restrictions in the absence of a negative result was higher in the last participation in testing. There were also differences between the first and the last test in the level of doubts about the accuracy of the test result, while a higher level was found at the last testing participation. It can be concluded that the frequency of testing and its requirements need to be approached very carefully over time, as it is likely that the positive perceptions may deteriorate. The recommendations include clear and timely government communication, trust building and health education.

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infects host cells through angiotensin-converting enzyme 2 (ACE2). Concurrently, the product of ACE2 action, angiotensin 1–7 (Ang 1–7), binds to Mas receptors within the cardiovascular system and provides protective effects. Therefore, it is crucial to reveal the role of ACE2 inhibition, especially within pre-existing cardiovascular pathologies. In our study, we imitated the action of SARS-CoV-2 in organisms using the low dose of the ACE2 inhibitor MLN-4760 with the aim of investigating to what degree ACE2 inhibition is detrimental to the cardiovascular system of spontaneously hypertensive rats (SHRs), which represent a model of human essential hypertension. Our study revealed the complex action of MLN-4760 in SHRs. On the one hand, we found that MLN-4760 had (1) (pro)obesogenic effects that negatively correlated with alternative renin-angiotensin system activity and Ang 1–7 in plasma, (2) negative effects on ACE1 inhibitor (captopril) action, (3) detrimental effects on the small arteries function and (4) anti-angiogenic effect in the model of chick chorioallantoic membrane. On the other hand, MLN-4760 induced compensatory mechanisms involving strengthened Mas receptor-, nitric oxide- and hydrogen sulfide-mediated signal transduction in the aorta, which was associated with unchanged blood pressure, suggesting beneficial action of MLN-4760 when administered at a low dose.

This contribution reviews and comments on recent scholarship on the politics of the COVID-19 pandemic, focusing on how vulnerability was constructed and studied. We reflect on the various meanings of vulnerability and suggest political science should go beyond individualized and identity-based approaches and see the pandemic conditions as shared and embedded within the already existing social, political, and economic structures. We also examine how our previously identified discursive frames of science and security work in the context of the later pandemic stages and the vaccination rollout and note how these frames continue to render certain lives ungrievable. Our contribution is intended to add to the growing interest in using the concepts of vulnerability, precariousness, and precarity in studies of politics and international relations, as well as in critical studies of public health and the coronavirus pandemic.

Spike glycoprotein of the SARS-CoV-2 virus and its structure play a crucial role in the infections of cells containing angiotensin-converting enzyme 2 (ACE2) as well as in the interactions of this virus with surfaces. Protection against viruses and often even their deactivation is one of a great variety of graphene applications. The structural changes of the non-glycosylated monomer of the spike glycoprotein trimer (denoted as S-protein in this work) triggered by its adsorption onto graphene at the initial stage are investigated by means of atomistic molecular dynamics simulations. The adsorption of the S-protein happens readily during the first 10 ns. The shape of the S-protein becomes more prolate during the adsorption but this trend, albeit less pronounced, is observed also for the freely relaxing S-protein in water. The receptor-binding domain (RBD) of the free and adsorbed S-protein manifests itself as the most rigid fragment of the whole S-protein. The adsorption even enhances the rigidity of the whole S-protein as well as its subunits. Only one residue of RBD involved in the specific interactions with ACE2 during the cell infection is involved in the direct contact of the adsorbed S-protein with the graphene. The new intramolecular hydrogen bonds formed during the S-protein adsorption replace the S-protein-water hydrogen bonds; this trend though less apparent, is observed also during the relaxation of the free S-protein in water. In the initial phase, the secondary structure of the RBD fragment specifically interacting with ACE2 receptor is not affected during the S-protein adsorption onto the graphene. Graphical abstract Initial (a) and final (b) conformation of the S-protein interacting with the graphene surface.Image 1

The issue of the evolution of consumer behavior is the subject of research since the transition from production to product marketing as consumer preferences evolve over time. The chapter presents the results of the initial phase of a study of changes in consumer behavior caused by the COVID-19 pandemic. The aim of the study is to examine specific changes in B2C interactions of Czech and Slovak consumers during the first lockdown in 2020. The starting point for changing consumer preferences was the fact that the dominant part of consumer interactions shifted from brick-and-mortar to virtual environment, where e-commerce was a safe alternative to traditional forms of trading. The results suggest that both the supply and demand sides of the market were able to adapt to the nonstandard situation in a relatively short time. From the point of view of customer behavior, an increase in B2C interactions was recorded in both monitored markets. The dominant part of the interactions shifts to the time of the standard working week, the weekend decline in interactions was significantly below the average on both sides of the market. The presented results can contribute to the formulation of qualitative assumptions for deeper empirical research in the field.