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20 research outcomes, page 1 of 2
  • publication . Preprint . Article . 2021
    Open Access English
    Authors:
    Jarek Juraszek; Lucy Rutten; Sven Blokland; Pascale Bouchier; Richard Voorzaat; Tina Ritschel; Mark J.G. Bakkers; Ludovic Renault; Johannes P. M. Langedijk;
    Project: EC | INSTRUCT-ULTRA (731005)

    SARS-CoV-2 S protein prematurely refolds to the post-fusion conformation, compromising immunogenic properties and prefusion trimer yield. Here, Juraszek et al. present a stable SARS-CoV-2 S-closed protein variant with increased expression and correct folding, predominan...

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  • publication . Preprint . Article . 2021
    Open Access English
    Authors:
    Erney Ramírez-Aportela; David Maluenda; Yunior C. Fonseca; Pablo Conesa; Roberto Marabini; J. Bernard Heymann; José María Carazo; Carlos Oscar S. Sorzano;
    Project: EC | INSTRUCT-ULTRA (731005), EC | CORBEL (654248), EC | HighResCells (810057), EC | EOSC-Life (824087)

    Here, the authors present a cryo-EM validation method for the local analysis of the map-to-model fit and introduce FSC-Q as a quality measure. FSC-Q provides a quantitative estimation of how much of the model is supported by the signal content of the map.

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  • publication . Article . 2021
    Open Access English
    Authors:
    Schiavina, Marco; Pontoriero, Letizia; Uversky, Vladimir N.; Felli, Isabella C.; Pierattelli, Roberta;
    Persistent Identifiers
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  • publication . Article . 2020
    Open Access English
    Authors:
    Annalisa Ciabattini; Paolo Garagnani; Francesco Santoro; Rino Rappuoli; Claudio Franceschi; Donata Medaglini;
    Persistent Identifiers
    Publisher: Springer Science and Business Media LLC
    Project: EC | TRANSVAC2 (730964)

    <jats:title>Abstract</jats:title><jats:p>The SARS-CoV-2 pandemic urgently calls for the development of effective preventive tools. COVID-19 hits greatly the elder and more fragile fraction of the population boosting the evergreen issue of the vaccination of older people...

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  • publication . Article . Preprint . 2020
    Open Access English
    Authors:
    Roberto Melero; Carlos Oscar S. Sorzano; Brent Foster; José Luis Vilas; Marta Martínez; Roberto Marabini; Erney Ramírez-Aportela; Rubén J. Sánchez-García; David Herreros; Laura del Cano; ...
    Publisher: BioRxiv
    Project: EC | EOSC-synergy (857647), EC | EOSC-Life (824087), EC | INSTRUCT-ULTRA (731005), EC | CORBEL (654248), EC | IMpaCT (857203), EC | HighResCells (810057)

    Peer reviewed

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  • publication . Article . 2020
    Open Access English
    Authors:
    Marc-André Hograindleur; Grégory Effantin; Daphna Fenel; Caroline Mas; André Lieber; Guy Schoehn; Pascal Fender; Emilie Vassal-Stermann;
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: ANR | Ad-Cadh (ANR-18-CE11-0001), ANR | CBH-EUR-GS (ANR-17-EURE-0003)

    International audience; The study of viruses causing acute respiratory distress syndromes (ARDS) is more essential than ever at a time when a virus can create a global pandemic in a matter of weeks. Among human adenoviruses, adenovirus of serotype 7 (HAdV7) is one of th...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Pauline Maisonnasse; Jeremie Guedj; Vanessa Contreras; Sylvie Behillil; Caroline Solas; Romain Marlin; Thibaut Naninck; Andrés Pizzorno; Julien Lemaitre; Antonio Gonçalves; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: EC | EVAg (653316), EC | EVA-GLOBAL (871029), ANR | IDMIT (ANR-11-INBS-0008), EC | TRANSVAC2 (730964)

    International audience; Coronavirus disease 2019 (COVID-19) has rapidly become a global pandemic and no antiviral drug or vaccine is yet available for the treatment of this disease1-3. Several clinical studies are ongoing to evaluate the efficacy of repurposed drugs tha...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Simon G. P. Funnell; W. E. Dowling; César Muñoz-Fontela; P.-S. Gsell; Donald E. Ingber; G. A. Hamilton; Leen Delang; J. Rocha-Pereira; Suzanne J. F. Kaptein; K. H. Dallmeier; ...
    Persistent Identifiers
    Publisher: HAL CCSD
    Project: NIH | Lung-on-a-Chip Disease Mo... (1UG3HL141797-01), ANR | IDMIT (ANR-11-INBS-0008), EC | EVAg (653316), EC | TRANSVAC2 (730964)

    International audience; There is an urgent need for drugs, therapies and vaccines to be available to protect the human population against COVID-19. One of the first approaches taken in the COVID-19 global response was to consider repurposing licensed drugs. This comment...

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  • publication . Preprint . Article . 2020
    Open Access English
    Authors:
    rafael leon; Jose Maria Carazo; Enrique Crisman; carlos oscar Sorzano;
    Project: EC | iNEXT-Discovery (871037), EC | EOSC-synergy (857647), EC | EOSC-Life (824087), EC | CORBEL (654248), EC | INSTRUCT-ULTRA (731005), EC | IMpaCT (857203), EC | HighResCells (810057)

    No

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  • publication . Article . Preprint . 2020
    Open Access
    Authors:
    Jiandong Huo; Yuguang Zhao; Jingshan Ren; D. Zhou; H.M.E. Duyvesteyn; Helen M. Ginn; L Carrique; Tomas Malinauskas; R.R. Ruza; Pranav Nm Shah; ...
    Publisher: Elsevier BV
    Project: WT | Studies of immunopathogen... (095541), WT | Improved control of endem... (101122), RCUK | Structural Biology in the... (EP/S025243/1), WT | Understanding the genetic... (090532)

    <jats:title>Summary</jats:title><jats:p>There are as yet no licenced therapeutics for the COVID-19 pandemic. The causal coronavirus (SARS-CoV-2) binds host cells via a trimeric Spike whose receptor binding domain (RBD) recognizes angiotensin-converting enzyme 2 (ACE2), ...

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20 research outcomes, page 1 of 2