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description Publicationkeyboard_double_arrow_right Article 2024Publisher:Elsevier BV Funded by:EC | RECoVEREC| RECoVERLaura Polivka; Marine Madrange; Cristina Bulai-Livideanu; Stéphane Barete; Thomas Ballul; Antoine Neuraz; Celine Greco; Julie Agopian; Fabienne Brenet; Patrice Dubreuil; Charles Burdet; Richard Lemal; Olivier Tournilhac; Louis Terriou; David Launay; Laurence Bouillet; Clément Gourguechon; Ghandi Damaj; Laurent Frenzel; Cécile Meni; Hassiba Bouktit; Anne Florence Collange; Caroline Gaudy-Marqueste; Marie Gousseff; Edwige Le Mouel; Mohamed Hamidou; Antoine Neel; Dana Ranta; Roland Jaussaud; Philippe Guilpain; Danielle Canioni; Thierry Jo Molina; Julie Bruneau; Ludovic Lhermitte; Nicolas Garcelon; Rose-Marie Javier; Fabien Pelletier; Florence Castelain; Frederique Retornaz; Quentin Cabrera; Patricia Zunic; Marie Pierre Gourin; Ewa Wierzbicka-Hainaut; Jean François Viallard; Christian Lavigne; Cyrille Hoarau; Isabelle Durieu; Maël Heiblig; Sophie Dimicoli-Salazar; Jose Miguel Torregrosa-Diaz; Angèle Soria; Michel Arock; Olivier Lortholary; Christine Bodemer; Olivier Hermine; Julien Rossignol;pmid: 37633651
Mastocytosis and monoclonal mast cell (MC) activation syndrome (MMAS) are heterogeneous conditions characterized by the accumulation of atypical MCs. Despite the recurrent involvement of KIT mutations, the pathophysiologic origin of mastocytosis and MMAS is unclear. Although hereditary α-tryptasemia (HαT, related to TPSAB1 gene duplication) is abnormally frequent in these diseases, it is not known whether the association is coincidental or causal.We evaluated the prevalence of HαT in all mastocytosis subtypes and MMAS and assessed the pathophysiologic association with HαT.Clinical data, laboratory data, KIT mutations, TPSAB1 duplication (assessed by droplet digital PCR), and HαT prevalence were retrospectively recorded for all patients with mastocytosis and MMAS registered in the French national referral center database and compared to a control cohort. To increase the power of our analysis for advanced systemic mastocytosis (advSM), we pooled our cohort with literature cases.We included 583 patients (27 with MMAS and 556 with mastocytosis). The prevalence of HαT in mastocytosis was 12.6%, significantly higher than in the general population (5.7%, P = .002) and lower than in MMAS (33.3%, P = .02). HαTHere we confirm the increase incidence of anaphylaxis in HαT
Journal of Allergy a... arrow_drop_down Journal of Allergy and Clinical ImmunologyArticle . 2024 . Peer-reviewedLicense: CC BY NC NDData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jaci.2023.08.015&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!more_vert Journal of Allergy a... arrow_drop_down Journal of Allergy and Clinical ImmunologyArticle . 2024 . Peer-reviewedLicense: CC BY NC NDData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.jaci.2023.08.015&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 United Kingdom, Italy, Spain, Former Yugoslav Republic of Macedonia, France, Finland, ItalyPublisher:American Association for the Advancement of Science (AAAS) Funded by:ANR | AABIFNCOV, NIH | CORE--BIOSTATISTICS FACIL..., NIH | Monogenic basis of resist... +6 projectsANR| AABIFNCOV ,NIH| CORE--BIOSTATISTICS FACILITY ,NIH| Monogenic basis of resistance to SARS-CoV2 and predisposition to severe COVID-19 ,EC| EASI-Genomics ,EC| CURE ,NIH| IL-13/17-regulated airway epithelial miRNAs in asthma ,EC| ImmunAID ,NIH| Inborn errors of immunity in patients with life-threatening COVID-19 ,NIH| Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessBastard, Paul; Vazquez, Sara; Liu, Jamin; Laurie, Matthew, T; Wang, Chung, Yu; Gervais, Adrian; Le Voyer, Tom; Bizien, Lucy; Zamecnik, Colin; Philippot, Quentin; Rosain, Jérémie; Catherinot, Emilie; Willmore, Andrew; Mitchell, Anthea, M; Bair, Rebecca; Garçon, Pierre; Kenney, Heather; Fekkar, Arnaud; Salagianni, Maria; Poulakou, Garyphallia; Siouti, Eleni; Sahanic, Sabina; Tancevski, Ivan; Weiss, Günter; Nagl, Laurenz; Manry, Jérémy; Duvlis, Sotirija; Arroyo-Sánchez, Daniel; Paz Artal, Estela; Rubio, Luis; Perani, Cristiano; Bezzi, Michela; Sottini, Alessandra; Quaresima, Virginia; Roussel, Lucie; Vinh, Donald, C; Reyes, Luis, Felipe; Garzaro, Margaux; Hatipoglu, Nevin; Boutboul, David; Tandjaoui-Lambiotte, Yacine; Borghesi, Alessandro; Aliberti, Anna; Cassaniti, Irene; Venet, Fabienne; Monneret, Guillaume; Halwani, Rabih; Sharif-Askari, Narjes, Saheb; Danielson, Jeffrey; Burrel, Sonia; Morbieu, Caroline; Stepanovskyy, Yurii; Bondarenko, Anastasia; Volokha, Alla; Boyarchuk, Oksana; Gagro, Alenka; Neuville, Mathilde; Neven, Bénédicte; Keles, Sevgi; Hernu, Romain; Bal, Antonin; Novelli, Antonio; Novelli, Giuseppe; Saker, Kahina; Ailioaie, Oana; Antolí, Arnau; Jeziorski, Eric; Rocamora-Blanch, Gemma; Teixeira, Carla; Delaunay, Clarisse; Lhuillier, Marine; Le Turnier, Paul; Zhang, Yu; Mahevas, Matthieu; Pan-Hammarström, Qiang; Abolhassani, Hassan; Bompoil, Thierry; Dorgham, Karim; Gorochov, Guy; Laouenan, Cédric; Rodríguez-Gallego, Carlos; Ng, Lisa, F P; Renia, Laurent; Pujol, Aurora; Belot, Alexandre; Raffi, François; Allende, Luis, M; Martinez-Picado, Javier; Ozcelik, Tayfun; Keles, Sevgi; Imberti, Luisa; Notarangelo, Luigi, D; Troya, Jesus; Solanich, Xavier; Zhang, Shen-Ying; Puel, Anne; Wilson, Michael, R; Trouillet-Assant, Sophie; Abel, Laurent; Jouanguy, Emmanuelle; Ye, Chun, Jimmie; Cobat, Aurélie; Thompson, Leslie, M; Andreakos, Evangelos; Zhang, Qian; Anderson, Mark, S; Casanova, Jean-Laurent; Derisi, Joseph, L; Abel, Laurent; Achille, Cristian; Aiuti, Alessandro; Al-Muhsen, Saleh; Al-Mulla, Fahd; Anderson, Mark, S; Andreakos, Evangelos; Angelini, Micol; Arias, Andrés, A; Aytekin, Gokhan; Baldanti, Fausto; Feldman, Hagit, Baris; Belot, Alexandre; Bergami, Federica; Biggs, Catherine, M; Bogunovic, Dusan; Bolze, Alexandre; Bondarenko, Anastasiia; Bousfiha, Ahmed, A; Brodin, Petter; Bryceson, Yenan; Bustamante, Carlos, D; Butte, Manish, J; Casari, Giorgio; Christodoulou, John; Condino-Neto, Antonio; Constantinescu, Stefan, N; Conti, Francesca; Cooper, Megan, A; Dalgard, Clifton, L; Desai, Murkesh; Drolet, Beth, A; El Baghdadi, Jamila; Ergun, Recai; Ergun, Dilek; Espinosa-Padilla, Sara; Fellay, Jacques; Flores, Carlos; Franco, José, Luis; Froidure, Antoine; Ghirardello, Stefano; Gregersen, Peter, K; Grimbacher, Bodo; Haerynck, Filomeen; Hagin, David; Halwani, Rabih; Hammarström, Lennart; Heath, James, R; Henrickson, Sarah, E; Hsieh, Elena, W Y; Husebye, Eystein; Imai, Kohsuke; Itan, Yuval; Jarvis, Erich, D; Kanat, Fikret; Karamitros, Timokratis; Kisand, Kai; Kopcha, Vasyl; Korda, Mykhaylo; Ku, Cheng-Lung; Lau, Yu-Lung; Ling, Yun; Lucas, Carrie, L; Maniatis, Tom; Mansouri, Davood; Maródi, László; Meyts, Isabelle; Milner, Joshua, D; Mironska, Kristina; Mogensen, Trine, H; Mojoli, Francesco; Morandeira, Francisco; Morio, Tomohiro; Ng, Lisa, F P; Notarangelo, Luigi, D; Novelli, Antonio; Novelli, Giuseppe; O'Farrelly, Cliona; Okada, Satoshi; Okamoto, Keisuke; Ozcelik, Tayfun; Pagani, Michele; Pan-Hammarström, Qiang; Pape, Jean, W; de Diego, Rebeca, Perez; Perlin, David, S; Pesole, Graziano; Pession, Andrea; Piralla, Antonio; Planas, Anna, M; Prando, Carolina; Pujol, Aurora; Rigo-Bonnin, Raúl; Seppänen, Mikko, R J; Uddin, K, M Furkan;handle: 2445/197264 , 10138/570722 , 2108/321962 , 20.500.11768/156344
pmid: 35857576
pmc: PMC9210448
handle: 2445/197264 , 10138/570722 , 2108/321962 , 20.500.11768/156344
pmid: 35857576
pmc: PMC9210448
Life-threatening ‘breakthrough’ cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS-CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; however, their contribution to hypoxemic breakthrough cases in vaccinated people remains unknown. Here, we studied a cohort of 48 individuals (age 20-86 years) who received 2 doses of an mRNA vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Antibody levels to the vaccine, neutralization of the virus, and auto-Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal antibody response to the vaccine. Among them, ten (24%) had auto-Abs neutralizing type I IFNs (aged 43-86 years). Eight of these ten patients had auto-Abs neutralizing both IFN-α2 and IFN-ω, while two neutralized IFN-ω only. No patient neutralized IFN-β. Seven neutralized 10 ng/mL of type I IFNs, and three 100 pg/mL only. Seven patients neutralized SARS-CoV-2 D614G and the Delta variant (B.1.617.2) efficiently, while one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only 100 pg/mL of type I IFNs neutralized both D61G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating antibodies capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a significant proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population. International audience
UGD Academic Reposit... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2023 . 2022License: CC BYFull-Text: https://doi.org/10.1126/sciimmunol.abp8966Oxford University Research Archive; Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele; Science ImmunologyArticle . 2024 . 2023 . Peer-reviewedLicense: CC BYHELDA - Digital Repository of the University of HelsinkiArticle . 2023 . Peer-reviewedData sources: HELDA - Digital Repository of the University of HelsinkiArchivio della Ricerca - Università di Roma Tor vergataArticle . 2022Data sources: Archivio della Ricerca - Università di Roma Tor vergataadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesbronze 29 citations 29 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert UGD Academic Reposit... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2023 . 2022License: CC BYFull-Text: https://doi.org/10.1126/sciimmunol.abp8966Oxford University Research Archive; Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele; Science ImmunologyArticle . 2024 . 2023 . Peer-reviewedLicense: CC BYHELDA - Digital Repository of the University of HelsinkiArticle . 2023 . Peer-reviewedData sources: HELDA - Digital Repository of the University of HelsinkiArchivio della Ricerca - Università di Roma Tor vergataArticle . 2022Data sources: Archivio della Ricerca - Università di Roma Tor vergataadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1126/sciimmunol.abp8966&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 Belgium, FrancePublisher:BMJ Funded by:EC | RECoVEREC| RECoVERLeonardo W Heyerdahl; Yanina Borzykh; Benedetta Lana; Anna-Maria Volkmann; Lars Crusefalk; Elien Colman; Nastassia Tvardik; Sibyl Anthierens; Muriel Vray; Tamara Giles-Vernick;handle: 10067/2015510151162165141
Background In this era of global health crises, public trust in scientists is a crucial determinant of adherence to public health recommendations. Studies of trust in scientists often link sociodemographic and other factors to such adherence but rely on assumptions about scientists and neglect scientific uncertainty. We undertook a cross-sectional mixed-methods study evaluating factors associated with public trust of scientists in Europe, investigating how and why respondents embraced certain claims in scientific debates.Methods A survey was administered to 7000 participants across seven European countries in December 2020. Data concerning sociodemographic characteristics, trust in scientists, information source preferences, COVID-19 experiences and beliefs about pandemic origins were analysed using a multiple regression model. We employed thematic analysis to interpret open-text responses about pandemic origins and likely acceptance of treatments and vaccination.Results Trust in scientists was associated with multiple sociodemographic characteristics, including higher age and educational levels, left/centre political affiliation and use of certain information sources. Respondents claiming that COVID-19 was deliberately released and that 5G technology worsened COVID-19 symptoms had lower levels of trust in scientists. Explaining their positions in debates about pandemic origins, respondents trusting and not trusting scientists invoked scientific results and practices, arguing that scientists were not the most important actors in these debates.Conclusions Although our quantitative analyses align with prior studies, our qualitative analyses of scientists, their practices and perceived roles are more varied than prior research presumed. Further investigation of these variations is needed to strengthen scientific literacy and trust in scientists. International audience
https://repository.u... arrow_drop_down https://repository.uantwerpen....Article . 2023Data sources: Institutional Repository Universiteit Antwerpenhttps://doi.org/10.1136/bmjph-...Article . 2023 . Peer-reviewedLicense: CC BYData sources: CrossrefHAL Descartes; HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2023License: CC BYFull-Text: https://hal.science/hal-04368640/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert https://repository.u... arrow_drop_down https://repository.uantwerpen....Article . 2023Data sources: Institutional Repository Universiteit Antwerpenhttps://doi.org/10.1136/bmjph-...Article . 2023 . Peer-reviewedLicense: CC BYData sources: CrossrefHAL Descartes; HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2023License: CC BYFull-Text: https://hal.science/hal-04368640/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1136/bmjph-2023-000280&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 Belgium, Italy, Netherlands, United KingdomPublisher:Springer Science and Business Media LLC Funded by:EC | RESPONDEC| RESPONDMelchior, Maria; Figueiredo, Natasha; Roversi, Aurélia; Dubanchet, Alexandre; Bui, Eric; Vadell-Martínez, Julian; Barbui, Corrado; Purgato, Marianna; Ayuso-Mateos, José Luis; Mediavilla, Roberto; McDaid, David; Park, A-La; Petri-Romão, Papoula; Kalisch, Raffael; Nicaise, Pablo; Lorant, Vincent; Sijbrandij, Marit; Witteveen, Anke B; Bryant, Richard; Felez, Mireia; Underhill, James; Pollice, Giulia; Tortelli, Andrea;pmid: 37978577
pmc: PMC10656934
Abstract Background The COVID-19 pandemic has had an impact on population-wide mental health and well-being. Although people experiencing socioeconomic disadvantage may be especially vulnerable, they experience barriers in accessing mental health care. To overcome these barriers, the World Health Organization (WHO) designed two scalable psychosocial interventions, namely the web-based Doing What Matters in Times of Stress (DWM) and the face-to-face Problem Management Plus (PM+), to help people manage stressful situations. Our study aims to test the effectiveness of a stepped-care program using DWM and PM + among individuals experiencing unstable housing in France – a majority of whom are migrant or have sought asylum. Methods This is a randomised controlled trial to evaluate the effectiveness and cost effectiveness of a stepped-care program using DWM and PM + among persons with psychological distress and experiencing unstable housing, in comparison to enhanced care as usual (eCAU). Participants (N = 210) will be randomised to two parallel groups: eCAU or eCAU plus the stepped-care program. The main study outcomes are symptoms of depression and anxiety measured using the Patient Health Questionnaire Anxiety and Depression Scale (PHQ-ADS). Discussion This randomised controlled trial will contribute to a better understanding of effective community-based scalable strategies that can help address the mental health needs of persons experiencing socioeconomic disadvantage, whose needs are high yet who frequently have limited access to mental health care services. Trial registration this randomised trial has been registered at ClinicalTrials.gov under the number NCT05033210.
IRIS - Università de... arrow_drop_down IRIS - Università degli Studi di VeronaArticle . 2023Data sources: IRIS - Università degli Studi di VeronaBMC Public HealthArticle . 2023Fachrepositorium LebenswissenschaftenArticle . 2023Data sources: Fachrepositorium LebenswissenschaftenMémoires en Sciences de l'Information et de la CommunicationArticle . 2023Full-Text: https://hal.science/hal-04381856/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert IRIS - Università de... arrow_drop_down IRIS - Università degli Studi di VeronaArticle . 2023Data sources: IRIS - Università degli Studi di VeronaBMC Public HealthArticle . 2023Fachrepositorium LebenswissenschaftenArticle . 2023Data sources: Fachrepositorium LebenswissenschaftenMémoires en Sciences de l'Information et de la CommunicationArticle . 2023Full-Text: https://hal.science/hal-04381856/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s12889-023-17238-7&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023Publisher:Elsevier BV Funded by:EC | MuFFINEC| MuFFINBenjamin Dupuis; Akiko Kato; Nicolas Joly; Claire Saraux; Yan Ropert-Coudert; Andre Chiaradia; Marianna Chimienti;International audience; The COVID-19 pandemic and its lock-down measures have resulted in periods of reduced human activity, known as anthropause. While this period was expected to be favorable for the marine ecosystem, due to a probable reduction of pollution, shipping traffic, industrial activity and fishing pressure, negative counterparts such as reduced fisheries surveillance could counterbalance these positive effects. Simultaneously, on-land pressure due to human disturbance and tourism should have drastically decreased, potentially benefiting land-breeding marine animals such as seabirds. We analyzed 11 breeding seasons of data on several biological parameters of little penguins from a popular tourist attraction at Phillip Island, Australia. We investigated the impact of anthropogenic activities on penguin behavior during the breeding season measured by (1) distribution at sea, (2) colony attendance, (3) isotopic niche (4) chick meal mass, and (5) offspring investment against shipping traffic and number of tourists. The 2020 lock-downs resulted in a near absence of tourists visiting the Penguin Parade®, which was otherwise visited by 800,000+ visitors on average per breeding season. However, our long-term analysis showed no effect of the presence of visitors on little penguins' activities. Surprisingly, the anthropause did not trigger any changes in maritime traffic intensity and distribution in the region. We found inter- and intra-annual variations for most parameters, we detected a negative effect of marine traffic on the foraging efficiency. Our results suggest that environmental variations have a greater influence on the breeding behavior of little penguins compared to short-term anthropause events. Our long-term dataset was key to test whether changes in anthropogenic activities affected the wildlife during the COVID-19 pandemic.
ZENODO; Biological C... arrow_drop_down Mémoires en Sciences de l'Information et de la CommunicationArticle . 2023License: CC BYFull-Text: https://hal.science/hal-04256189/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.biocon.2023.110323&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert ZENODO; Biological C... arrow_drop_down Mémoires en Sciences de l'Information et de la CommunicationArticle . 2023License: CC BYFull-Text: https://hal.science/hal-04256189/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.biocon.2023.110323&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 FrancePublisher:JMIR Publications Inc. Funded by:EC | PANDEMEC| PANDEMAlessandro De Gaetano; Paolo Bajardi; Nicolò Gozzi; Nicola Perra; Daniela Perrotta; Daniela Paolotti;Background During the initial phases of the vaccination campaign worldwide, nonpharmaceutical interventions (NPIs) remained pivotal in the fight against the COVID-19 pandemic. In this context, it is important to understand how the arrival of vaccines affected the adoption of NPIs. Indeed, some individuals might have seen the start of mass vaccination campaigns as the end of the emergency and, as a result, relaxed their COVID-safe behaviors, facilitating the spread of the virus in a delicate epidemic phase such as the initial rollout.Objective The aim of this study was to collect information about the possible relaxation of protective behaviors following key events of the vaccination campaign in four countries and to analyze possible associations of these behavioral tendencies with the sociodemographic characteristics of participants. Methods We developed an online survey named “COVID-19 Prevention and Behavior Survey” that was conducted between November 26 and December 22, 2021. Participants were recruited using targeted ads on Facebook in four different countries: Brazil, Italy, South Africa, and the United Kingdom. We measured the onset of relaxation of protective measures in response to key events of the vaccination campaign, namely personal vaccination and vaccination of the most vulnerable population. Through calculation of odds ratios (ORs) and regression analysis, we assessed the strength of association between compliance with NPIs and sociodemographic characteristics of participants.Results We received 2263 questionnaires from the four countries. Participants reported the most significant changes in social activities such as going to a restaurant or the cinema and visiting relatives and friends. This is in good agreement with validated psychological models of health-related behavioral change such as the Health Belief Model, according to which activities with higher costs and perceived barriers (eg, social activities) are more prone to early relaxation. Multivariate analysis using a generalized linear model showed that the two main determinants of the drop of social NPIs were (1) having previously tested positive for COVID-19 (after the second vaccine dose: OR 2.46, 95% CI 1.73-3.49) and (2) living with people at risk (after the second vaccine dose: OR 1.57, 95% CI 1.22-2.03).Conclusions This work shows that particular caution has to be taken during vaccination campaigns. Indeed, people might relax their safe behaviors regardless of the dynamics of the epidemic. For this reason, it is crucial to maintain high compliance with NPIs to avoid hindering the beneficial effects of the vaccine. International audience
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 FrancePublisher:Proceedings of the National Academy of Sciences Funded by:ANR | RESP-REP, EC | STRUGGLEANR| RESP-REP ,EC| STRUGGLEAuthors: Victor Chardès; Andrea Mazzolini; Thierry Mora; Aleksandra M. Walczak;Victor Chardès; Andrea Mazzolini; Thierry Mora; Aleksandra M. Walczak;Antigenic variation is the main immune escape mechanism for RNA viruses like influenza or SARS-CoV-2. While high mutation rates promote antigenic escape, they also induce large mutational loads and reduced fitness. It remains unclear how this cost–benefit trade-off selects the mutation rate of viruses. Using a traveling wave model for the coevolution of viruses and host immune systems in a finite population, we investigate how immunity affects the evolution of the mutation rate and other nonantigenic traits, such as virulence. We first show that the nature of the wave depends on how cross-reactive immune systems are, reconciling previous approaches. The immune-virus system behaves like a Fisher wave at low cross-reactivities, and like a fitness wave at high cross-reactivities. These regimes predict different outcomes for the evolution of nonantigenic traits. At low cross-reactivities, the evolutionarily stable strategy is to maximize the speed of the wave, implying a higher mutation rate and increased virulence. At large cross-reactivities, where our estimates place H3N2 influenza, the stable strategy is to increase the basic reproductive number, keeping the mutation rate to a minimum and virulence low. International audience
Proceedings of the N... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2023 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefarXiv.org e-Print ArchiveOther literature type . Preprint . 2023Data sources: arXiv.org e-Print Archivehttps://doi.org/10.48550/arxiv...Article . 2023License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Proceedings of the N... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2023 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefarXiv.org e-Print ArchiveOther literature type . Preprint . 2023Data sources: arXiv.org e-Print Archivehttps://doi.org/10.48550/arxiv...Article . 2023License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2307712120&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Preprint 2023 Austria, France, United Kingdom, Netherlands, United Kingdom, Norway, Germany, FrancePublisher:Copernicus GmbH Funded by:UKRI | NCEO LTS-S, EC | ESM2025, UKRI | Climate change impacts on... +4 projectsUKRI| NCEO LTS-S ,EC| ESM2025 ,UKRI| Climate change impacts on global wildfire ignitions by lightning and the safe management of landscape fuels ,EC| JERICO-S3 ,EC| 4C ,UKRI| GREENHOUSE GAS FLUXES AND EARTH SYSTEM FEEDBACKS ,EC| EuroSeaAuthors: Pierre Friedlingstein; Michael O'Sullivan; Matthew W. Jones; Robbie M. Andrew; +119 AuthorsPierre Friedlingstein; Michael O'Sullivan; Matthew W. Jones; Robbie M. Andrew; Dorothee C. E. Bakker; Judith Hauck; Peter Landschützer; Corinne Le Quéré; Ingrid T. Luijkx; Glen P. Peters; Wouter Peters; Julia Pongratz; Clemens Schwingshackl; Stephen Sitch; Josep G. Canadell; Philippe Ciais; Robert B. Jackson; Simone R. Alin; Peter Anthoni; Leticia Barbero; Nicholas R. Bates; Meike Becker; Nicolas Bellouin; Bertrand Decharme; Laurent Bopp; Ida Bagus Mandhara Brasika; Patricia Cadule; Matthew A. Chamberlain; Naveen Chandra; Thi-Tuyet-Trang Chau; Frédéric Chevallier; Louise P. Chini; Margot Cronin; Xinyu Dou; Kazutaka Enyo; Wiley Evans; Stefanie Falk; Richard A. Feely; Liang Feng; Daniel J. Ford; Thomas Gasser; Josefine Ghattas; Thanos Gkritzalis; Giacomo Grassi; Luke Gregor; Nicolas Gruber; Özgür Gürses; Ian Harris; Matthew Hefner; Jens Heinke; Richard A. Houghton; George C. Hurtt; Yosuke Iida; Tatiana Ilyina; Andrew R. Jacobson; Atul Jain; Tereza Jarníková; Annika Jersild; Fei Jiang; Zhe Jin; Fortunat Joos; Etsushi Kato; Ralph F. Keeling; Daniel Kennedy; Kees Klein Goldewijk; Jürgen Knauer; Jan Ivar Korsbakken; Arne Körtzinger; Xin Lan; Nathalie Lefèvre; Hongmei Li; Junjie Liu; Zhiqiang Liu; Lei Ma; Greg Marland; Nicolas Mayot; Patrick C. McGuire; Galen A. McKinley; Gesa Meyer; Eric J. Morgan; David R. Munro; Shin-Ichiro Nakaoka; Yosuke Niwa; Kevin M. O'Brien; Are Olsen; Abdirahman M. Omar; Tsuneo Ono; Melf Paulsen; Denis Pierrot; Katie Pocock; Benjamin Poulter; Carter M. Powis; Gregor Rehder; Laure Resplandy; Eddy Robertson; Christian Rödenbeck; Thais M. Rosan; Jörg Schwinger; Roland Séférian; T. Luke Smallman; Stephen M. Smith; Reinel Sospedra-Alfonso; Qing Sun; Adrienne J. Sutton; Colm Sweeney; Shintaro Takao; Pieter P. Tans; Hanqin Tian; Bronte Tilbrook; Hiroyuki Tsujino; Francesco Tubiello; Guido R. van der Werf; Erik van Ooijen; Rik Wanninkhof; Michio Watanabe; Cathy Wimart-Rousseau; Dongxu Yang; Xiaojuan Yang; Wenping Yuan; Xu Yue; Sönke Zaehle; Jiye Zeng; Bo Zheng;Abstract. Accurate assessment of anthropogenic carbon dioxide (CO2) emissions and their redistribution among the atmosphere, ocean, and terrestrial biosphere in a changing climate is critical to better understand the global carbon cycle, support the development of climate policies, and project future climate change. Here we describe and synthesize data sets and methodology to quantify the five major components of the global carbon budget and their uncertainties. Fossil CO2 emissions (EFOS) are based on energy statistics and cement production data, while emissions from land-use change (ELUC), mainly deforestation, are based on land-use and land-use change data and bookkeeping models. Atmospheric CO2 concentration is measured directly, and its growth rate (GATM) is computed from the annual changes in concentration. The ocean CO2 sink (SOCEAN) is estimated with global ocean biogeochemistry models and observation-based fCO2 products. The terrestrial CO2 sink (SLAND) is estimated with dynamic global vegetation models. Additional lines of evidence on land and ocean sinks are provided by atmospheric inversions, atmospheric oxygen measurements, and Earth system models. The resulting carbon budget imbalance (BIM), the difference between the estimated total emissions and the estimated changes in the atmosphere, ocean, and terrestrial biosphere, is a measure of imperfect data and incomplete understanding of the contemporary carbon cycle. All uncertainties are reported as ±1σ. For the year 2022, EFOS increased by 0.9 % relative to 2021, with fossil emissions at 9.9±0.5 Gt C yr−1 (10.2±0.5 Gt C yr−1 when the cement carbonation sink is not included), and ELUC was 1.2±0.7 Gt C yr−1, for a total anthropogenic CO2 emission (including the cement carbonation sink) of 11.1±0.8 Gt C yr−1 (40.7±3.2 Gt CO2 yr−1). Also, for 2022, GATM was 4.6±0.2 Gt C yr−1 (2.18±0.1 ppm yr−1; ppm denotes parts per million), SOCEAN was 2.8±0.4 Gt C yr−1, and SLAND was 3.8±0.8 Gt C yr−1, with a BIM of −0.1 Gt C yr−1 (i.e. total estimated sources marginally too low or sinks marginally too high). The global atmospheric CO2 concentration averaged over 2022 reached 417.1±0.1 ppm. Preliminary data for 2023 suggest an increase in EFOS relative to 2022 of +1.1 % (0.0 % to 2.1 %) globally and atmospheric CO2 concentration reaching 419.3 ppm, 51 % above the pre-industrial level (around 278 ppm in 1750). Overall, the mean of and trend in the components of the global carbon budget are consistently estimated over the period 1959–2022, with a near-zero overall budget imbalance, although discrepancies of up to around 1 Gt C yr−1 persist for the representation of annual to semi-decadal variability in CO2 fluxes. Comparison of estimates from multiple approaches and observations shows the following: (1) a persistent large uncertainty in the estimate of land-use changes emissions, (2) a low agreement between the different methods on the magnitude of the land CO2 flux in the northern extra-tropics, and (3) a discrepancy between the different methods on the strength of the ocean sink over the last decade. This living-data update documents changes in methods and data sets applied to this most recent global carbon budget as well as evolving community understanding of the global carbon cycle. The data presented in this work are available at https://doi.org/10.18160/GCP-2023 (Friedlingstein et al., 2023). International audience
HAL-IRD arrow_drop_down University of East Anglia digital repositoryArticle . 2023 . Peer-reviewedData sources: University of East Anglia digital repositoryEarth System Science Data (ESSD)Article . 2023 . Peer-reviewedLicense: CC BYData sources: Crossrefhttps://doi.org/10.5194/essd-2...Preprint . 2023 . Peer-reviewedLicense: CC BYData sources: CrossrefElectronic Publication Information CenterArticle . 2023Data sources: Electronic Publication Information CenterCopernicus Publications; Earth System Science Data (ESSD)Other literature type . 2023Data sources: Copernicus Publicationsadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 13 citations 13 popularity Average influence Average impulse Top 10% Powered by BIP!more_vert HAL-IRD arrow_drop_down University of East Anglia digital repositoryArticle . 2023 . Peer-reviewedData sources: University of East Anglia digital repositoryEarth System Science Data (ESSD)Article . 2023 . Peer-reviewedLicense: CC BYData sources: Crossrefhttps://doi.org/10.5194/essd-2...Preprint . 2023 . Peer-reviewedLicense: CC BYData sources: CrossrefElectronic Publication Information CenterArticle . 2023Data sources: Electronic Publication Information CenterCopernicus Publications; Earth System Science Data (ESSD)Other literature type . 2023Data sources: Copernicus Publicationsadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 United Kingdom, FrancePublisher:Wiley Funded by:EC | NICI, ANR | PRIMESEC| NICI ,ANR| PRIMESAntoine Naëgel; Hélène Ratiney; Jabrane Karkouri; Djahid Kennouche; Nicolas Royer; Jill M. Slade; Jérôme Morel; Pierre Croisille; Magalie Viallon;Background: In this second part of a two-part paper, we intend to demonstrate the impact of the previously proposed advanced quality control pipeline. To understand its benefit and challenge the proposed methodology in a real scenario, we chose to compare the outcome when applying it to the analysis of two patient populations with a significant but highly different types of fatigue: COVID19 and multiple sclerosis (MS). Experimental: 31P-MRS was performed on a 3T clinical MRI, in 19 COVID19 patients, 38 MS patients, and 40 matched healthy controls. Dynamic acquisitions using an MR-compatible ergometer ran over a rest(40s), exercise(2min), and a recovery phase(6min). Long and short TR acquisitions were also made at rest for T1 correction. The advanced data quality control pipeline presented in part 1 is applied to the selected patient cohorts to investigate its impact on clinical outcomes. We first used power and sample size analysis to estimate objectively the impact of adding QCS. Then, comparisons between patients and healthy control groups using validated QCS were performed using unpaired T-tests or Mann-Whitney tests (p<0.05).Results: The application of the QCS resulted in increased statistical power, changed the values of several outcome measures, and reduced variability (SD). A significant difference was found between the T1PCr and T1Pi of MS patients and healthy controls. Furthermore, the use of a fixed correction factor led to systematically higher estimated concentrations of PCr and Pi than when using individually corrected factors. We observed significant differences between the two patient populations and healthy controls for resting [PCr] -- MS only, [Pi], [ADP], [H2PO4-] and pH -- COVID19 only, and post-exercise [PCr],[Pi] and [H2PO4-] - MS only. The dynamic indicators $\tau$PCr, $\tau$Pi, ViPCr and Vmax were reduced for COVID19 and MS patients compared to controls. Conclusion: Our results show that QCS in dynamic 31P-MRS studies results in smaller data variability and therefore impacts study sample size and power. Although QCS resulted in discarded data and therefore reduced the acceptable data and subject numbers, this rigorous and unbiased approach allowed for proper assessment of muscle metabolites and metabolism in patient populations. The outcomes include an increased metabolite T1, which directly affect the T1 correction factor applied to the amplitudes of the metabolite, and a prolonged $\tau$PCr indicating reduced muscle oxidative capacity for patients with MS and COVID19. Comment: NMR in Biomedicine, In press
arXiv.org e-Print Ar... arrow_drop_down arXiv.org e-Print ArchiveOther literature type . Preprint . 2023Data sources: arXiv.org e-Print ArchiveHAL Descartes; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2023License: CC BY NC NDFull-Text: https://hal.science/hal-04212013/documenthttps://doi.org/10.48550/arxiv...Article . 2023License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert arXiv.org e-Print Ar... arrow_drop_down arXiv.org e-Print ArchiveOther literature type . Preprint . 2023Data sources: arXiv.org e-Print ArchiveHAL Descartes; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2023License: CC BY NC NDFull-Text: https://hal.science/hal-04212013/documenthttps://doi.org/10.48550/arxiv...Article . 2023License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/nbm.5031&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 FrancePublisher:Oxford University Press (OUP) Funded by:EC | DNA-DOCK, UKRI | The production and applic..., UKRI | Analysis of flavivirus in... +4 projectsEC| DNA-DOCK ,UKRI| The production and application of SARS-CoV-2 reverse genetic systems to facilitate vaccine development and biosafe drug discovery platforms. ,UKRI| Analysis of flavivirus infection on the cellular lipidome - implications for virus particle production and replication. ,EC| ADDovenom ,UKRI| CCP-BioSim: Biomolecular Simulation at the Life Sciences Interface ,EC| SYNAD ,UKRI| BlueCryo Image Processing Computing ClusterDora Buzas; Adrian H Bunzel; Oskar Staufer; Emily J Milodowski; Grace L Edmunds; Joshua C Bufton; Beatriz V Vidana Mateo; Sathish K N Yadav; Kapil Gupta; Charlotte Fletcher; Maia K Williamson; Alexandra Harrison; Ufuk Borucu; Julien Capin; Ore Francis; Georgia Balchin; Sophie Hall; Mirella V Vega; Fabien Durbesson; Srikanth Lingappa; Renaud Vincentelli; Joe Roe; Linda Wooldridge; Rachel Burt; Ross J L Anderson; Adrian J Mulholland; null Bristol UNCOVER Group; Jonathan Hare; Mick Bailey; Andrew D Davidson; Adam Finn; David Morgan; Jamie Mann; Joachim Spatz; Frederic Garzoni; Christiane Schaffitzel; Imre Berger;doi: 10.1093/abt/tbad024
Abstract Background Due to COVID-19, pandemic preparedness emerges as a key imperative, necessitating new approaches to accelerate development of reagents against infectious pathogens. Methods Here, we developed an integrated approach combining synthetic, computational and structural methods with in vitro antibody selection and in vivo immunization to design, produce and validate nature-inspired nanoparticle-based reagents against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Results Our approach resulted in two innovations: (i) a thermostable nasal vaccine called ADDoCoV, displaying multiple copies of a SARS-CoV-2 receptor binding motif derived epitope and (ii) a multivalent nanoparticle superbinder, called Gigabody, against SARS-CoV-2 including immune-evasive variants of concern (VOCs). In vitro generated neutralizing nanobodies and electron cryo-microscopy established authenticity and accessibility of epitopes displayed by ADDoCoV. Gigabody comprising multimerized nanobodies prevented SARS-CoV-2 virion attachment with picomolar EC50. Vaccinating mice resulted in antibodies cross-reacting with VOCs including Delta and Omicron. Conclusion Our study elucidates Adenovirus-derived dodecamer (ADDomer)-based nanoparticles for use in active and passive immunization and provides a blueprint for crafting reagents to combat respiratory viral infections.
Antibody Therapeutic... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/abt/tbad024&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert Antibody Therapeutic... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article 2024Publisher:Elsevier BV Funded by:EC | RECoVEREC| RECoVERLaura Polivka; Marine Madrange; Cristina Bulai-Livideanu; Stéphane Barete; Thomas Ballul; Antoine Neuraz; Celine Greco; Julie Agopian; Fabienne Brenet; Patrice Dubreuil; Charles Burdet; Richard Lemal; Olivier Tournilhac; Louis Terriou; David Launay; Laurence Bouillet; Clément Gourguechon; Ghandi Damaj; Laurent Frenzel; Cécile Meni; Hassiba Bouktit; Anne Florence Collange; Caroline Gaudy-Marqueste; Marie Gousseff; Edwige Le Mouel; Mohamed Hamidou; Antoine Neel; Dana Ranta; Roland Jaussaud; Philippe Guilpain; Danielle Canioni; Thierry Jo Molina; Julie Bruneau; Ludovic Lhermitte; Nicolas Garcelon; Rose-Marie Javier; Fabien Pelletier; Florence Castelain; Frederique Retornaz; Quentin Cabrera; Patricia Zunic; Marie Pierre Gourin; Ewa Wierzbicka-Hainaut; Jean François Viallard; Christian Lavigne; Cyrille Hoarau; Isabelle Durieu; Maël Heiblig; Sophie Dimicoli-Salazar; Jose Miguel Torregrosa-Diaz; Angèle Soria; Michel Arock; Olivier Lortholary; Christine Bodemer; Olivier Hermine; Julien Rossignol;pmid: 37633651
Mastocytosis and monoclonal mast cell (MC) activation syndrome (MMAS) are heterogeneous conditions characterized by the accumulation of atypical MCs. Despite the recurrent involvement of KIT mutations, the pathophysiologic origin of mastocytosis and MMAS is unclear. Although hereditary α-tryptasemia (HαT, related to TPSAB1 gene duplication) is abnormally frequent in these diseases, it is not known whether the association is coincidental or causal.We evaluated the prevalence of HαT in all mastocytosis subtypes and MMAS and assessed the pathophysiologic association with HαT.Clinical data, laboratory data, KIT mutations, TPSAB1 duplication (assessed by droplet digital PCR), and HαT prevalence were retrospectively recorded for all patients with mastocytosis and MMAS registered in the French national referral center database and compared to a control cohort. To increase the power of our analysis for advanced systemic mastocytosis (advSM), we pooled our cohort with literature cases.We included 583 patients (27 with MMAS and 556 with mastocytosis). The prevalence of HαT in mastocytosis was 12.6%, significantly higher than in the general population (5.7%, P = .002) and lower than in MMAS (33.3%, P = .02). HαTHere we confirm the increase incidence of anaphylaxis in HαT
Journal of Allergy a... arrow_drop_down Journal of Allergy and Clinical ImmunologyArticle . 2024 . Peer-reviewedLicense: CC BY NC NDData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routeshybrid 2 citations 2 popularity Average influence Average impulse Average Powered by BIP!more_vert Journal of Allergy a... arrow_drop_down Journal of Allergy and Clinical ImmunologyArticle . 2024 . Peer-reviewedLicense: CC BY NC NDData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 United Kingdom, Italy, Spain, Former Yugoslav Republic of Macedonia, France, Finland, ItalyPublisher:American Association for the Advancement of Science (AAAS) Funded by:ANR | AABIFNCOV, NIH | CORE--BIOSTATISTICS FACIL..., NIH | Monogenic basis of resist... +6 projectsANR| AABIFNCOV ,NIH| CORE--BIOSTATISTICS FACILITY ,NIH| Monogenic basis of resistance to SARS-CoV2 and predisposition to severe COVID-19 ,EC| EASI-Genomics ,EC| CURE ,NIH| IL-13/17-regulated airway epithelial miRNAs in asthma ,EC| ImmunAID ,NIH| Inborn errors of immunity in patients with life-threatening COVID-19 ,NIH| Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessBastard, Paul; Vazquez, Sara; Liu, Jamin; Laurie, Matthew, T; Wang, Chung, Yu; Gervais, Adrian; Le Voyer, Tom; Bizien, Lucy; Zamecnik, Colin; Philippot, Quentin; Rosain, Jérémie; Catherinot, Emilie; Willmore, Andrew; Mitchell, Anthea, M; Bair, Rebecca; Garçon, Pierre; Kenney, Heather; Fekkar, Arnaud; Salagianni, Maria; Poulakou, Garyphallia; Siouti, Eleni; Sahanic, Sabina; Tancevski, Ivan; Weiss, Günter; Nagl, Laurenz; Manry, Jérémy; Duvlis, Sotirija; Arroyo-Sánchez, Daniel; Paz Artal, Estela; Rubio, Luis; Perani, Cristiano; Bezzi, Michela; Sottini, Alessandra; Quaresima, Virginia; Roussel, Lucie; Vinh, Donald, C; Reyes, Luis, Felipe; Garzaro, Margaux; Hatipoglu, Nevin; Boutboul, David; Tandjaoui-Lambiotte, Yacine; Borghesi, Alessandro; Aliberti, Anna; Cassaniti, Irene; Venet, Fabienne; Monneret, Guillaume; Halwani, Rabih; Sharif-Askari, Narjes, Saheb; Danielson, Jeffrey; Burrel, Sonia; Morbieu, Caroline; Stepanovskyy, Yurii; Bondarenko, Anastasia; Volokha, Alla; Boyarchuk, Oksana; Gagro, Alenka; Neuville, Mathilde; Neven, Bénédicte; Keles, Sevgi; Hernu, Romain; Bal, Antonin; Novelli, Antonio; Novelli, Giuseppe; Saker, Kahina; Ailioaie, Oana; Antolí, Arnau; Jeziorski, Eric; Rocamora-Blanch, Gemma; Teixeira, Carla; Delaunay, Clarisse; Lhuillier, Marine; Le Turnier, Paul; Zhang, Yu; Mahevas, Matthieu; Pan-Hammarström, Qiang; Abolhassani, Hassan; Bompoil, Thierry; Dorgham, Karim; Gorochov, Guy; Laouenan, Cédric; Rodríguez-Gallego, Carlos; Ng, Lisa, F P; Renia, Laurent; Pujol, Aurora; Belot, Alexandre; Raffi, François; Allende, Luis, M; Martinez-Picado, Javier; Ozcelik, Tayfun; Keles, Sevgi; Imberti, Luisa; Notarangelo, Luigi, D; Troya, Jesus; Solanich, Xavier; Zhang, Shen-Ying; Puel, Anne; Wilson, Michael, R; Trouillet-Assant, Sophie; Abel, Laurent; Jouanguy, Emmanuelle; Ye, Chun, Jimmie; Cobat, Aurélie; Thompson, Leslie, M; Andreakos, Evangelos; Zhang, Qian; Anderson, Mark, S; Casanova, Jean-Laurent; Derisi, Joseph, L; Abel, Laurent; Achille, Cristian; Aiuti, Alessandro; Al-Muhsen, Saleh; Al-Mulla, Fahd; Anderson, Mark, S; Andreakos, Evangelos; Angelini, Micol; Arias, Andrés, A; Aytekin, Gokhan; Baldanti, Fausto; Feldman, Hagit, Baris; Belot, Alexandre; Bergami, Federica; Biggs, Catherine, M; Bogunovic, Dusan; Bolze, Alexandre; Bondarenko, Anastasiia; Bousfiha, Ahmed, A; Brodin, Petter; Bryceson, Yenan; Bustamante, Carlos, D; Butte, Manish, J; Casari, Giorgio; Christodoulou, John; Condino-Neto, Antonio; Constantinescu, Stefan, N; Conti, Francesca; Cooper, Megan, A; Dalgard, Clifton, L; Desai, Murkesh; Drolet, Beth, A; El Baghdadi, Jamila; Ergun, Recai; Ergun, Dilek; Espinosa-Padilla, Sara; Fellay, Jacques; Flores, Carlos; Franco, José, Luis; Froidure, Antoine; Ghirardello, Stefano; Gregersen, Peter, K; Grimbacher, Bodo; Haerynck, Filomeen; Hagin, David; Halwani, Rabih; Hammarström, Lennart; Heath, James, R; Henrickson, Sarah, E; Hsieh, Elena, W Y; Husebye, Eystein; Imai, Kohsuke; Itan, Yuval; Jarvis, Erich, D; Kanat, Fikret; Karamitros, Timokratis; Kisand, Kai; Kopcha, Vasyl; Korda, Mykhaylo; Ku, Cheng-Lung; Lau, Yu-Lung; Ling, Yun; Lucas, Carrie, L; Maniatis, Tom; Mansouri, Davood; Maródi, László; Meyts, Isabelle; Milner, Joshua, D; Mironska, Kristina; Mogensen, Trine, H; Mojoli, Francesco; Morandeira, Francisco; Morio, Tomohiro; Ng, Lisa, F P; Notarangelo, Luigi, D; Novelli, Antonio; Novelli, Giuseppe; O'Farrelly, Cliona; Okada, Satoshi; Okamoto, Keisuke; Ozcelik, Tayfun; Pagani, Michele; Pan-Hammarström, Qiang; Pape, Jean, W; de Diego, Rebeca, Perez; Perlin, David, S; Pesole, Graziano; Pession, Andrea; Piralla, Antonio; Planas, Anna, M; Prando, Carolina; Pujol, Aurora; Rigo-Bonnin, Raúl; Seppänen, Mikko, R J; Uddin, K, M Furkan;handle: 2445/197264 , 10138/570722 , 2108/321962 , 20.500.11768/156344
pmid: 35857576
pmc: PMC9210448
handle: 2445/197264 , 10138/570722 , 2108/321962 , 20.500.11768/156344
pmid: 35857576
pmc: PMC9210448
Life-threatening ‘breakthrough’ cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS-CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; however, their contribution to hypoxemic breakthrough cases in vaccinated people remains unknown. Here, we studied a cohort of 48 individuals (age 20-86 years) who received 2 doses of an mRNA vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Antibody levels to the vaccine, neutralization of the virus, and auto-Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal antibody response to the vaccine. Among them, ten (24%) had auto-Abs neutralizing type I IFNs (aged 43-86 years). Eight of these ten patients had auto-Abs neutralizing both IFN-α2 and IFN-ω, while two neutralized IFN-ω only. No patient neutralized IFN-β. Seven neutralized 10 ng/mL of type I IFNs, and three 100 pg/mL only. Seven patients neutralized SARS-CoV-2 D614G and the Delta variant (B.1.617.2) efficiently, while one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only 100 pg/mL of type I IFNs neutralized both D61G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating antibodies capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a significant proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population. International audience
UGD Academic Reposit... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2023 . 2022License: CC BYFull-Text: https://doi.org/10.1126/sciimmunol.abp8966Oxford University Research Archive; Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele; Science ImmunologyArticle . 2024 . 2023 . Peer-reviewedLicense: CC BYHELDA - Digital Repository of the University of HelsinkiArticle . 2023 . Peer-reviewedData sources: HELDA - Digital Repository of the University of HelsinkiArchivio della Ricerca - Università di Roma Tor vergataArticle . 2022Data sources: Archivio della Ricerca - Università di Roma Tor vergataadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesbronze 29 citations 29 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert UGD Academic Reposit... arrow_drop_down Recolector de Ciencia Abierta, RECOLECTA; Diposit Digital de la Universitat de BarcelonaArticle . 2023 . 2022License: CC BYFull-Text: https://doi.org/10.1126/sciimmunol.abp8966Oxford University Research Archive; Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele; Science ImmunologyArticle . 2024 . 2023 . Peer-reviewedLicense: CC BYHELDA - Digital Repository of the University of HelsinkiArticle . 2023 . Peer-reviewedData sources: HELDA - Digital Repository of the University of HelsinkiArchivio della Ricerca - Università di Roma Tor vergataArticle . 2022Data sources: Archivio della Ricerca - Università di Roma Tor vergataadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1126/sciimmunol.abp8966&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 Belgium, FrancePublisher:BMJ Funded by:EC | RECoVEREC| RECoVERLeonardo W Heyerdahl; Yanina Borzykh; Benedetta Lana; Anna-Maria Volkmann; Lars Crusefalk; Elien Colman; Nastassia Tvardik; Sibyl Anthierens; Muriel Vray; Tamara Giles-Vernick;handle: 10067/2015510151162165141
Background In this era of global health crises, public trust in scientists is a crucial determinant of adherence to public health recommendations. Studies of trust in scientists often link sociodemographic and other factors to such adherence but rely on assumptions about scientists and neglect scientific uncertainty. We undertook a cross-sectional mixed-methods study evaluating factors associated with public trust of scientists in Europe, investigating how and why respondents embraced certain claims in scientific debates.Methods A survey was administered to 7000 participants across seven European countries in December 2020. Data concerning sociodemographic characteristics, trust in scientists, information source preferences, COVID-19 experiences and beliefs about pandemic origins were analysed using a multiple regression model. We employed thematic analysis to interpret open-text responses about pandemic origins and likely acceptance of treatments and vaccination.Results Trust in scientists was associated with multiple sociodemographic characteristics, including higher age and educational levels, left/centre political affiliation and use of certain information sources. Respondents claiming that COVID-19 was deliberately released and that 5G technology worsened COVID-19 symptoms had lower levels of trust in scientists. Explaining their positions in debates about pandemic origins, respondents trusting and not trusting scientists invoked scientific results and practices, arguing that scientists were not the most important actors in these debates.Conclusions Although our quantitative analyses align with prior studies, our qualitative analyses of scientists, their practices and perceived roles are more varied than prior research presumed. Further investigation of these variations is needed to strengthen scientific literacy and trust in scientists. International audience
https://repository.u... arrow_drop_down https://repository.uantwerpen....Article . 2023Data sources: Institutional Repository Universiteit Antwerpenhttps://doi.org/10.1136/bmjph-...Article . 2023 . Peer-reviewedLicense: CC BYData sources: CrossrefHAL Descartes; HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2023License: CC BYFull-Text: https://hal.science/hal-04368640/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1136/bmjph-2023-000280&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert https://repository.u... arrow_drop_down https://repository.uantwerpen....Article . 2023Data sources: Institutional Repository Universiteit Antwerpenhttps://doi.org/10.1136/bmjph-...Article . 2023 . Peer-reviewedLicense: CC BYData sources: CrossrefHAL Descartes; HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2023License: CC BYFull-Text: https://hal.science/hal-04368640/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1136/bmjph-2023-000280&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 Belgium, Italy, Netherlands, United KingdomPublisher:Springer Science and Business Media LLC Funded by:EC | RESPONDEC| RESPONDMelchior, Maria; Figueiredo, Natasha; Roversi, Aurélia; Dubanchet, Alexandre; Bui, Eric; Vadell-Martínez, Julian; Barbui, Corrado; Purgato, Marianna; Ayuso-Mateos, José Luis; Mediavilla, Roberto; McDaid, David; Park, A-La; Petri-Romão, Papoula; Kalisch, Raffael; Nicaise, Pablo; Lorant, Vincent; Sijbrandij, Marit; Witteveen, Anke B; Bryant, Richard; Felez, Mireia; Underhill, James; Pollice, Giulia; Tortelli, Andrea;pmid: 37978577
pmc: PMC10656934
Abstract Background The COVID-19 pandemic has had an impact on population-wide mental health and well-being. Although people experiencing socioeconomic disadvantage may be especially vulnerable, they experience barriers in accessing mental health care. To overcome these barriers, the World Health Organization (WHO) designed two scalable psychosocial interventions, namely the web-based Doing What Matters in Times of Stress (DWM) and the face-to-face Problem Management Plus (PM+), to help people manage stressful situations. Our study aims to test the effectiveness of a stepped-care program using DWM and PM + among individuals experiencing unstable housing in France – a majority of whom are migrant or have sought asylum. Methods This is a randomised controlled trial to evaluate the effectiveness and cost effectiveness of a stepped-care program using DWM and PM + among persons with psychological distress and experiencing unstable housing, in comparison to enhanced care as usual (eCAU). Participants (N = 210) will be randomised to two parallel groups: eCAU or eCAU plus the stepped-care program. The main study outcomes are symptoms of depression and anxiety measured using the Patient Health Questionnaire Anxiety and Depression Scale (PHQ-ADS). Discussion This randomised controlled trial will contribute to a better understanding of effective community-based scalable strategies that can help address the mental health needs of persons experiencing socioeconomic disadvantage, whose needs are high yet who frequently have limited access to mental health care services. Trial registration this randomised trial has been registered at ClinicalTrials.gov under the number NCT05033210.
IRIS - Università de... arrow_drop_down IRIS - Università degli Studi di VeronaArticle . 2023Data sources: IRIS - Università degli Studi di VeronaBMC Public HealthArticle . 2023Fachrepositorium LebenswissenschaftenArticle . 2023Data sources: Fachrepositorium LebenswissenschaftenMémoires en Sciences de l'Information et de la CommunicationArticle . 2023Full-Text: https://hal.science/hal-04381856/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s12889-023-17238-7&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert IRIS - Università de... arrow_drop_down IRIS - Università degli Studi di VeronaArticle . 2023Data sources: IRIS - Università degli Studi di VeronaBMC Public HealthArticle . 2023Fachrepositorium LebenswissenschaftenArticle . 2023Data sources: Fachrepositorium LebenswissenschaftenMémoires en Sciences de l'Information et de la CommunicationArticle . 2023Full-Text: https://hal.science/hal-04381856/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1186/s12889-023-17238-7&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023Publisher:Elsevier BV Funded by:EC | MuFFINEC| MuFFINBenjamin Dupuis; Akiko Kato; Nicolas Joly; Claire Saraux; Yan Ropert-Coudert; Andre Chiaradia; Marianna Chimienti;International audience; The COVID-19 pandemic and its lock-down measures have resulted in periods of reduced human activity, known as anthropause. While this period was expected to be favorable for the marine ecosystem, due to a probable reduction of pollution, shipping traffic, industrial activity and fishing pressure, negative counterparts such as reduced fisheries surveillance could counterbalance these positive effects. Simultaneously, on-land pressure due to human disturbance and tourism should have drastically decreased, potentially benefiting land-breeding marine animals such as seabirds. We analyzed 11 breeding seasons of data on several biological parameters of little penguins from a popular tourist attraction at Phillip Island, Australia. We investigated the impact of anthropogenic activities on penguin behavior during the breeding season measured by (1) distribution at sea, (2) colony attendance, (3) isotopic niche (4) chick meal mass, and (5) offspring investment against shipping traffic and number of tourists. The 2020 lock-downs resulted in a near absence of tourists visiting the Penguin Parade®, which was otherwise visited by 800,000+ visitors on average per breeding season. However, our long-term analysis showed no effect of the presence of visitors on little penguins' activities. Surprisingly, the anthropause did not trigger any changes in maritime traffic intensity and distribution in the region. We found inter- and intra-annual variations for most parameters, we detected a negative effect of marine traffic on the foraging efficiency. Our results suggest that environmental variations have a greater influence on the breeding behavior of little penguins compared to short-term anthropause events. Our long-term dataset was key to test whether changes in anthropogenic activities affected the wildlife during the COVID-19 pandemic.
ZENODO; Biological C... arrow_drop_down Mémoires en Sciences de l'Information et de la CommunicationArticle . 2023License: CC BYFull-Text: https://hal.science/hal-04256189/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.biocon.2023.110323&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert ZENODO; Biological C... arrow_drop_down Mémoires en Sciences de l'Information et de la CommunicationArticle . 2023License: CC BYFull-Text: https://hal.science/hal-04256189/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.biocon.2023.110323&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 FrancePublisher:JMIR Publications Inc. Funded by:EC | PANDEMEC| PANDEMAlessandro De Gaetano; Paolo Bajardi; Nicolò Gozzi; Nicola Perra; Daniela Perrotta; Daniela Paolotti;Background During the initial phases of the vaccination campaign worldwide, nonpharmaceutical interventions (NPIs) remained pivotal in the fight against the COVID-19 pandemic. In this context, it is important to understand how the arrival of vaccines affected the adoption of NPIs. Indeed, some individuals might have seen the start of mass vaccination campaigns as the end of the emergency and, as a result, relaxed their COVID-safe behaviors, facilitating the spread of the virus in a delicate epidemic phase such as the initial rollout.Objective The aim of this study was to collect information about the possible relaxation of protective behaviors following key events of the vaccination campaign in four countries and to analyze possible associations of these behavioral tendencies with the sociodemographic characteristics of participants. Methods We developed an online survey named “COVID-19 Prevention and Behavior Survey” that was conducted between November 26 and December 22, 2021. Participants were recruited using targeted ads on Facebook in four different countries: Brazil, Italy, South Africa, and the United Kingdom. We measured the onset of relaxation of protective measures in response to key events of the vaccination campaign, namely personal vaccination and vaccination of the most vulnerable population. Through calculation of odds ratios (ORs) and regression analysis, we assessed the strength of association between compliance with NPIs and sociodemographic characteristics of participants.Results We received 2263 questionnaires from the four countries. Participants reported the most significant changes in social activities such as going to a restaurant or the cinema and visiting relatives and friends. This is in good agreement with validated psychological models of health-related behavioral change such as the Health Belief Model, according to which activities with higher costs and perceived barriers (eg, social activities) are more prone to early relaxation. Multivariate analysis using a generalized linear model showed that the two main determinants of the drop of social NPIs were (1) having previously tested positive for COVID-19 (after the second vaccine dose: OR 2.46, 95% CI 1.73-3.49) and (2) living with people at risk (after the second vaccine dose: OR 1.57, 95% CI 1.22-2.03).Conclusions This work shows that particular caution has to be taken during vaccination campaigns. Indeed, people might relax their safe behaviors regardless of the dynamics of the epidemic. For this reason, it is crucial to maintain high compliance with NPIs to avoid hindering the beneficial effects of the vaccine. International audience
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2196/47563&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.2196/47563&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 FrancePublisher:Proceedings of the National Academy of Sciences Funded by:ANR | RESP-REP, EC | STRUGGLEANR| RESP-REP ,EC| STRUGGLEAuthors: Victor Chardès; Andrea Mazzolini; Thierry Mora; Aleksandra M. Walczak;Victor Chardès; Andrea Mazzolini; Thierry Mora; Aleksandra M. Walczak;Antigenic variation is the main immune escape mechanism for RNA viruses like influenza or SARS-CoV-2. While high mutation rates promote antigenic escape, they also induce large mutational loads and reduced fitness. It remains unclear how this cost–benefit trade-off selects the mutation rate of viruses. Using a traveling wave model for the coevolution of viruses and host immune systems in a finite population, we investigate how immunity affects the evolution of the mutation rate and other nonantigenic traits, such as virulence. We first show that the nature of the wave depends on how cross-reactive immune systems are, reconciling previous approaches. The immune-virus system behaves like a Fisher wave at low cross-reactivities, and like a fitness wave at high cross-reactivities. These regimes predict different outcomes for the evolution of nonantigenic traits. At low cross-reactivities, the evolutionarily stable strategy is to maximize the speed of the wave, implying a higher mutation rate and increased virulence. At large cross-reactivities, where our estimates place H3N2 influenza, the stable strategy is to increase the basic reproductive number, keeping the mutation rate to a minimum and virulence low. International audience
Proceedings of the N... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2023 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefarXiv.org e-Print ArchiveOther literature type . Preprint . 2023Data sources: arXiv.org e-Print Archivehttps://doi.org/10.48550/arxiv...Article . 2023License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1073/pnas.2307712120&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Proceedings of the N... arrow_drop_down Proceedings of the National Academy of SciencesArticle . 2023 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefarXiv.org e-Print ArchiveOther literature type . Preprint . 2023Data sources: arXiv.org e-Print Archivehttps://doi.org/10.48550/arxiv...Article . 2023License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article , Other literature type , Preprint 2023 Austria, France, United Kingdom, Netherlands, United Kingdom, Norway, Germany, FrancePublisher:Copernicus GmbH Funded by:UKRI | NCEO LTS-S, EC | ESM2025, UKRI | Climate change impacts on... +4 projectsUKRI| NCEO LTS-S ,EC| ESM2025 ,UKRI| Climate change impacts on global wildfire ignitions by lightning and the safe management of landscape fuels ,EC| JERICO-S3 ,EC| 4C ,UKRI| GREENHOUSE GAS FLUXES AND EARTH SYSTEM FEEDBACKS ,EC| EuroSeaAuthors: Pierre Friedlingstein; Michael O'Sullivan; Matthew W. Jones; Robbie M. Andrew; +119 AuthorsPierre Friedlingstein; Michael O'Sullivan; Matthew W. Jones; Robbie M. Andrew; Dorothee C. E. Bakker; Judith Hauck; Peter Landschützer; Corinne Le Quéré; Ingrid T. Luijkx; Glen P. Peters; Wouter Peters; Julia Pongratz; Clemens Schwingshackl; Stephen Sitch; Josep G. Canadell; Philippe Ciais; Robert B. Jackson; Simone R. Alin; Peter Anthoni; Leticia Barbero; Nicholas R. Bates; Meike Becker; Nicolas Bellouin; Bertrand Decharme; Laurent Bopp; Ida Bagus Mandhara Brasika; Patricia Cadule; Matthew A. Chamberlain; Naveen Chandra; Thi-Tuyet-Trang Chau; Frédéric Chevallier; Louise P. Chini; Margot Cronin; Xinyu Dou; Kazutaka Enyo; Wiley Evans; Stefanie Falk; Richard A. Feely; Liang Feng; Daniel J. Ford; Thomas Gasser; Josefine Ghattas; Thanos Gkritzalis; Giacomo Grassi; Luke Gregor; Nicolas Gruber; Özgür Gürses; Ian Harris; Matthew Hefner; Jens Heinke; Richard A. Houghton; George C. Hurtt; Yosuke Iida; Tatiana Ilyina; Andrew R. Jacobson; Atul Jain; Tereza Jarníková; Annika Jersild; Fei Jiang; Zhe Jin; Fortunat Joos; Etsushi Kato; Ralph F. Keeling; Daniel Kennedy; Kees Klein Goldewijk; Jürgen Knauer; Jan Ivar Korsbakken; Arne Körtzinger; Xin Lan; Nathalie Lefèvre; Hongmei Li; Junjie Liu; Zhiqiang Liu; Lei Ma; Greg Marland; Nicolas Mayot; Patrick C. McGuire; Galen A. McKinley; Gesa Meyer; Eric J. Morgan; David R. Munro; Shin-Ichiro Nakaoka; Yosuke Niwa; Kevin M. O'Brien; Are Olsen; Abdirahman M. Omar; Tsuneo Ono; Melf Paulsen; Denis Pierrot; Katie Pocock; Benjamin Poulter; Carter M. Powis; Gregor Rehder; Laure Resplandy; Eddy Robertson; Christian Rödenbeck; Thais M. Rosan; Jörg Schwinger; Roland Séférian; T. Luke Smallman; Stephen M. Smith; Reinel Sospedra-Alfonso; Qing Sun; Adrienne J. Sutton; Colm Sweeney; Shintaro Takao; Pieter P. Tans; Hanqin Tian; Bronte Tilbrook; Hiroyuki Tsujino; Francesco Tubiello; Guido R. van der Werf; Erik van Ooijen; Rik Wanninkhof; Michio Watanabe; Cathy Wimart-Rousseau; Dongxu Yang; Xiaojuan Yang; Wenping Yuan; Xu Yue; Sönke Zaehle; Jiye Zeng; Bo Zheng;Abstract. Accurate assessment of anthropogenic carbon dioxide (CO2) emissions and their redistribution among the atmosphere, ocean, and terrestrial biosphere in a changing climate is critical to better understand the global carbon cycle, support the development of climate policies, and project future climate change. Here we describe and synthesize data sets and methodology to quantify the five major components of the global carbon budget and their uncertainties. Fossil CO2 emissions (EFOS) are based on energy statistics and cement production data, while emissions from land-use change (ELUC), mainly deforestation, are based on land-use and land-use change data and bookkeeping models. Atmospheric CO2 concentration is measured directly, and its growth rate (GATM) is computed from the annual changes in concentration. The ocean CO2 sink (SOCEAN) is estimated with global ocean biogeochemistry models and observation-based fCO2 products. The terrestrial CO2 sink (SLAND) is estimated with dynamic global vegetation models. Additional lines of evidence on land and ocean sinks are provided by atmospheric inversions, atmospheric oxygen measurements, and Earth system models. The resulting carbon budget imbalance (BIM), the difference between the estimated total emissions and the estimated changes in the atmosphere, ocean, and terrestrial biosphere, is a measure of imperfect data and incomplete understanding of the contemporary carbon cycle. All uncertainties are reported as ±1σ. For the year 2022, EFOS increased by 0.9 % relative to 2021, with fossil emissions at 9.9±0.5 Gt C yr−1 (10.2±0.5 Gt C yr−1 when the cement carbonation sink is not included), and ELUC was 1.2±0.7 Gt C yr−1, for a total anthropogenic CO2 emission (including the cement carbonation sink) of 11.1±0.8 Gt C yr−1 (40.7±3.2 Gt CO2 yr−1). Also, for 2022, GATM was 4.6±0.2 Gt C yr−1 (2.18±0.1 ppm yr−1; ppm denotes parts per million), SOCEAN was 2.8±0.4 Gt C yr−1, and SLAND was 3.8±0.8 Gt C yr−1, with a BIM of −0.1 Gt C yr−1 (i.e. total estimated sources marginally too low or sinks marginally too high). The global atmospheric CO2 concentration averaged over 2022 reached 417.1±0.1 ppm. Preliminary data for 2023 suggest an increase in EFOS relative to 2022 of +1.1 % (0.0 % to 2.1 %) globally and atmospheric CO2 concentration reaching 419.3 ppm, 51 % above the pre-industrial level (around 278 ppm in 1750). Overall, the mean of and trend in the components of the global carbon budget are consistently estimated over the period 1959–2022, with a near-zero overall budget imbalance, although discrepancies of up to around 1 Gt C yr−1 persist for the representation of annual to semi-decadal variability in CO2 fluxes. Comparison of estimates from multiple approaches and observations shows the following: (1) a persistent large uncertainty in the estimate of land-use changes emissions, (2) a low agreement between the different methods on the magnitude of the land CO2 flux in the northern extra-tropics, and (3) a discrepancy between the different methods on the strength of the ocean sink over the last decade. This living-data update documents changes in methods and data sets applied to this most recent global carbon budget as well as evolving community understanding of the global carbon cycle. The data presented in this work are available at https://doi.org/10.18160/GCP-2023 (Friedlingstein et al., 2023). International audience
HAL-IRD arrow_drop_down University of East Anglia digital repositoryArticle . 2023 . Peer-reviewedData sources: University of East Anglia digital repositoryEarth System Science Data (ESSD)Article . 2023 . Peer-reviewedLicense: CC BYData sources: Crossrefhttps://doi.org/10.5194/essd-2...Preprint . 2023 . Peer-reviewedLicense: CC BYData sources: CrossrefElectronic Publication Information CenterArticle . 2023Data sources: Electronic Publication Information CenterCopernicus Publications; Earth System Science Data (ESSD)Other literature type . 2023Data sources: Copernicus Publicationsadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen gold 13 citations 13 popularity Average influence Average impulse Top 10% Powered by BIP!more_vert HAL-IRD arrow_drop_down University of East Anglia digital repositoryArticle . 2023 . Peer-reviewedData sources: University of East Anglia digital repositoryEarth System Science Data (ESSD)Article . 2023 . Peer-reviewedLicense: CC BYData sources: Crossrefhttps://doi.org/10.5194/essd-2...Preprint . 2023 . Peer-reviewedLicense: CC BYData sources: CrossrefElectronic Publication Information CenterArticle . 2023Data sources: Electronic Publication Information CenterCopernicus Publications; Earth System Science Data (ESSD)Other literature type . 2023Data sources: Copernicus Publicationsadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.5194/essd-2023-409&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 United Kingdom, FrancePublisher:Wiley Funded by:EC | NICI, ANR | PRIMESEC| NICI ,ANR| PRIMESAntoine Naëgel; Hélène Ratiney; Jabrane Karkouri; Djahid Kennouche; Nicolas Royer; Jill M. Slade; Jérôme Morel; Pierre Croisille; Magalie Viallon;Background: In this second part of a two-part paper, we intend to demonstrate the impact of the previously proposed advanced quality control pipeline. To understand its benefit and challenge the proposed methodology in a real scenario, we chose to compare the outcome when applying it to the analysis of two patient populations with a significant but highly different types of fatigue: COVID19 and multiple sclerosis (MS). Experimental: 31P-MRS was performed on a 3T clinical MRI, in 19 COVID19 patients, 38 MS patients, and 40 matched healthy controls. Dynamic acquisitions using an MR-compatible ergometer ran over a rest(40s), exercise(2min), and a recovery phase(6min). Long and short TR acquisitions were also made at rest for T1 correction. The advanced data quality control pipeline presented in part 1 is applied to the selected patient cohorts to investigate its impact on clinical outcomes. We first used power and sample size analysis to estimate objectively the impact of adding QCS. Then, comparisons between patients and healthy control groups using validated QCS were performed using unpaired T-tests or Mann-Whitney tests (p<0.05).Results: The application of the QCS resulted in increased statistical power, changed the values of several outcome measures, and reduced variability (SD). A significant difference was found between the T1PCr and T1Pi of MS patients and healthy controls. Furthermore, the use of a fixed correction factor led to systematically higher estimated concentrations of PCr and Pi than when using individually corrected factors. We observed significant differences between the two patient populations and healthy controls for resting [PCr] -- MS only, [Pi], [ADP], [H2PO4-] and pH -- COVID19 only, and post-exercise [PCr],[Pi] and [H2PO4-] - MS only. The dynamic indicators $\tau$PCr, $\tau$Pi, ViPCr and Vmax were reduced for COVID19 and MS patients compared to controls. Conclusion: Our results show that QCS in dynamic 31P-MRS studies results in smaller data variability and therefore impacts study sample size and power. Although QCS resulted in discarded data and therefore reduced the acceptable data and subject numbers, this rigorous and unbiased approach allowed for proper assessment of muscle metabolites and metabolism in patient populations. The outcomes include an increased metabolite T1, which directly affect the T1 correction factor applied to the amplitudes of the metabolite, and a prolonged $\tau$PCr indicating reduced muscle oxidative capacity for patients with MS and COVID19. Comment: NMR in Biomedicine, In press
arXiv.org e-Print Ar... arrow_drop_down arXiv.org e-Print ArchiveOther literature type . Preprint . 2023Data sources: arXiv.org e-Print ArchiveHAL Descartes; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2023License: CC BY NC NDFull-Text: https://hal.science/hal-04212013/documenthttps://doi.org/10.48550/arxiv...Article . 2023License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/nbm.5031&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert arXiv.org e-Print Ar... arrow_drop_down arXiv.org e-Print ArchiveOther literature type . Preprint . 2023Data sources: arXiv.org e-Print ArchiveHAL Descartes; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2023License: CC BY NC NDFull-Text: https://hal.science/hal-04212013/documenthttps://doi.org/10.48550/arxiv...Article . 2023License: arXiv Non-Exclusive DistributionData sources: Dataciteadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/nbm.5031&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 FrancePublisher:Oxford University Press (OUP) Funded by:EC | DNA-DOCK, UKRI | The production and applic..., UKRI | Analysis of flavivirus in... +4 projectsEC| DNA-DOCK ,UKRI| The production and application of SARS-CoV-2 reverse genetic systems to facilitate vaccine development and biosafe drug discovery platforms. ,UKRI| Analysis of flavivirus infection on the cellular lipidome - implications for virus particle production and replication. ,EC| ADDovenom ,UKRI| CCP-BioSim: Biomolecular Simulation at the Life Sciences Interface ,EC| SYNAD ,UKRI| BlueCryo Image Processing Computing ClusterDora Buzas; Adrian H Bunzel; Oskar Staufer; Emily J Milodowski; Grace L Edmunds; Joshua C Bufton; Beatriz V Vidana Mateo; Sathish K N Yadav; Kapil Gupta; Charlotte Fletcher; Maia K Williamson; Alexandra Harrison; Ufuk Borucu; Julien Capin; Ore Francis; Georgia Balchin; Sophie Hall; Mirella V Vega; Fabien Durbesson; Srikanth Lingappa; Renaud Vincentelli; Joe Roe; Linda Wooldridge; Rachel Burt; Ross J L Anderson; Adrian J Mulholland; null Bristol UNCOVER Group; Jonathan Hare; Mick Bailey; Andrew D Davidson; Adam Finn; David Morgan; Jamie Mann; Joachim Spatz; Frederic Garzoni; Christiane Schaffitzel; Imre Berger;doi: 10.1093/abt/tbad024
Abstract Background Due to COVID-19, pandemic preparedness emerges as a key imperative, necessitating new approaches to accelerate development of reagents against infectious pathogens. Methods Here, we developed an integrated approach combining synthetic, computational and structural methods with in vitro antibody selection and in vivo immunization to design, produce and validate nature-inspired nanoparticle-based reagents against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Results Our approach resulted in two innovations: (i) a thermostable nasal vaccine called ADDoCoV, displaying multiple copies of a SARS-CoV-2 receptor binding motif derived epitope and (ii) a multivalent nanoparticle superbinder, called Gigabody, against SARS-CoV-2 including immune-evasive variants of concern (VOCs). In vitro generated neutralizing nanobodies and electron cryo-microscopy established authenticity and accessibility of epitopes displayed by ADDoCoV. Gigabody comprising multimerized nanobodies prevented SARS-CoV-2 virion attachment with picomolar EC50. Vaccinating mice resulted in antibodies cross-reacting with VOCs including Delta and Omicron. Conclusion Our study elucidates Adenovirus-derived dodecamer (ADDomer)-based nanoparticles for use in active and passive immunization and provides a blueprint for crafting reagents to combat respiratory viral infections.
Antibody Therapeutic... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/abt/tbad024&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert Antibody Therapeutic... arrow_drop_down add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/abt/tbad024&type=result"></script>'); --> </script>
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