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description Publicationkeyboard_double_arrow_right Article 2024 DenmarkPublisher:Wiley Anne Sophie Ågård; Gitte Susanne Rasmussen; Hanne Mainz; Merete Gregersen; Tina Wang Vedelø;doi: 10.1111/scs.13232
AbstractBackgroundWorldwide visitor restrictions forced nurses to separate patients from their relatives. However, the experience of implementing shifting restrictions from the frontline nurses' perspectives in a Danish context has yet to be assessed.AimThe aim of this descriptive qualitative study was to explore frontline nurses' experiences of managing shifting visitor restrictions in a Danish somatic university hospital during the COVID‐19 pandemic.MethodsAn online questionnaire, including open‐ended questions, was developed. Data were analysed using descriptive statistics and content analysis.Findings116 nurses from 29 departments participated; they were informed about restrictions primarily by their charge nurses and hospital intranet. Shifting visitor restrictions compelled the nurses to constantly adjust and negotiate their practices. When deciding to suggest deviating from the restrictions, they shared their decision‐making with colleagues. Visitor restrictions left the hospital environment quieter, but they also created a lack of overview and predictability, an emotional burden, and a negative impact on the quality of care.ConclusionRestricting relatives' access challenged the nurses' professional values, and it seems to have affirmed their appreciation of relatives' role as important partners in contemporary hospital‐based health care.
VBN; Aalborg Univers... arrow_drop_down VBN; Aalborg University Research PortalArticle . 2024Scandinavian Journal of Caring Sciences; PURE Aarhus UniversityArticle . 2024 . Peer-reviewedLicense: Wiley Online Library User Agreementadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/scs.13232&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert VBN; Aalborg Univers... arrow_drop_down VBN; Aalborg University Research PortalArticle . 2024Scandinavian Journal of Caring Sciences; PURE Aarhus UniversityArticle . 2024 . Peer-reviewedLicense: Wiley Online Library User Agreementadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/scs.13232&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024 DenmarkPublisher:Elsevier BV Lam, Carolyn S P; Lund, Lars H; Shah, Sanjiv J; Voors, Adriaan A; Erlinge, David; Saraste, Antti; Pirazzi, Carlo; Grove, Erik L; Barasa, Anders; Schou, Morten; Aziz, Ahmed; Svedlund, Sara; Wijngaarden, Jan VAN; Lindstedt, Eva-Lotte; Gustavsson, Andreas; Nelander, Karin; Garkaviy, Pavlo; Gan, Li-Ming; Gabrielsen, Anders;pmid: 37072105
BackgroundInflammation is a key driver of heart failure with preserved left ventricular ejection fraction. AZD4831 inhibits extracellular myeloperoxidase, decreases inflammation, and improves microvascular function in preclinical disease models.Methods and ResultsIn this double-blind phase 2a study (Safety and Tolerability Study of AZD4831 in Patients With Heart Failure [SATELLITE]; NCT03756285), patients with symptomatic heart failure, left ventricular ejection fraction of ≥40%, and elevated B-type natriuretic peptides were randomized 2:1 to once-daily oral AZD4831 5 mg or placebo for 90 days. We aimed to assess target engagement (primary end point: myeloperoxidase specific activity) and safety of AZD4831. Owing to coronavirus disease 2019, the study was terminated early after randomizing 41 patients (median age 74.0 years, 53.7% male). Myeloperoxidase activity was decreased by more than 50% from baseline to day 30 and day 90 in the AZD4831 group, with a placebo-adjusted decreased of 75% (95% confidence interval, 48, 88, nominal P < .001). No improvements were noted in secondary or exploratory end points, apart from a trend in Kansas City Cardiomyopathy Questionnaire overall summary score. No deaths or treatment-related serious adverse events occurred. AZD4831 treatment-related adverse events were generalized maculopapular rash, pruritus, and diarrhea (all n = 1).ConclusionsAZD4831 inhibited myeloperoxidase and was well tolerated in patients with heart failure and left ventricular ejection fraction of 40% or greater. Efficacy findings were exploratory owing to early termination, but warrant further clinical investigation of AZD4831.Lay SummaryFew treatments are available for patients with the forms of heart failure known as heart failure with preserved or mildly reduced ejection fraction. Current treatments do not target inflammation, which may play an important role in this condition. We tested a new drug called AZD4831 (mitiperstat), which decreases inflammation by inhibiting the enzyme myeloperoxidase. Among the 41 patients in our clinical trial, AZD4831 had a good safety profile and inhibited myeloperoxidase by the expected amount. Results mean we can conduct further trials to see whether AZD4831 decreases the symptoms of heart failure and improves patients’ ability to participate in physical exercise. Background: Inflammation is a key driver of heart failure with preserved left ventricular ejection fraction. AZD4831 inhibits extracellular myeloperoxidase, decreases inflammation, and improves microvascular function in preclinical disease models. Methods and Results: In this double-blind phase 2a study (Safety and Tolerability Study of AZD4831 in Patients With Heart Failure [SATELLITE]; NCT03756285), patients with symptomatic heart failure, left ventricular ejection fraction of ≥40%, and elevated B-type natriuretic peptides were randomized 2:1 to once-daily oral AZD4831 5 mg or placebo for 90 days. We aimed to assess target engagement (primary end point: myeloperoxidase specific activity) and safety of AZD4831. Owing to coronavirus disease 2019, the study was terminated early after randomizing 41 patients (median age 74.0 years, 53.7% male). Myeloperoxidase activity was decreased by more than 50% from baseline to day 30 and day 90 in the AZD4831 group, with a placebo-adjusted decreased of 75% (95% confidence interval, 48, 88, nominal P <.001). No improvements were noted in secondary or exploratory end points, apart from a trend in Kansas City Cardiomyopathy Questionnaire overall summary score. No deaths or treatment-related serious adverse events occurred. AZD4831 treatment-related adverse events were generalized maculopapular rash, pruritus, and diarrhea (all n = 1). Conclusions: AZD4831 inhibited myeloperoxidase and was well tolerated in patients with heart failure and left ventricular ejection fraction of 40% or greater. Efficacy findings were exploratory owing to early termination, but warrant further clinical investigation of AZD4831. Lay Summary: Few treatments are available for patients with the forms of heart failure known as heart failure with preserved or mildly reduced ejection fraction. Current treatments do not target inflammation, which may play an important role in this condition. We tested a new drug called AZD4831 (mitiperstat), which decreases inflammation by inhibiting the enzyme myeloperoxidase. Among the 41 patients in our clinical trial, AZD4831 had a good safety profile and inhibited myeloperoxidase by the expected amount. Results mean we can conduct further trials to see whether AZD4831 decreases the symptoms of heart failure and improves patients’ ability to participate in physical exercise.
PURE Aarhus Universi... arrow_drop_down Copenhagen University Research Information SystemArticle . 2024Data sources: Copenhagen University Research Information SystemJournal of Cardiac FailureArticle . 2023Data sources: University of Southern Denmark Research OutputJournal of Cardiac FailureArticle . 2024 . Peer-reviewedLicense: CC BY NC NDData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.cardfail.2023.04.003&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 6 citations 6 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert PURE Aarhus Universi... arrow_drop_down Copenhagen University Research Information SystemArticle . 2024Data sources: Copenhagen University Research Information SystemJournal of Cardiac FailureArticle . 2023Data sources: University of Southern Denmark Research OutputJournal of Cardiac FailureArticle . 2024 . Peer-reviewedLicense: CC BY NC NDData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.cardfail.2023.04.003&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024Publisher:Institute of Electrical and Electronics Engineers (IEEE) Authors: Yokoi, Tomoko; Obwegeser, Nikolaus; Beretta, Michela;Yokoi, Tomoko; Obwegeser, Nikolaus; Beretta, Michela;The COVID-19 crisis brought about an unprecedented wave of interest into rapid ideation and innovation. Among others, the pandemic triggered a series of collaborative innovation events-so-called hackathons-to leverage the power of the crowd for crisis response. In contrast to earlier hackathons, these events are different in their speed of mobilization, global scale, and their fully virtual nature with organizers and teams being geographically dispersed. Analyzing this new empirical phenomenon, we characterize COVID-19 hackathons against other forms of innovation crowdsourcing and describe challenges and best practices in the areas of people management, session management, technology, and knowledge management. Based on our empirical findings, we develop a conceptual framework that emphasizes the importance of managing virtual crisis hackathons as the integrated sum of its different parts. Empirical evidence is presented to demonstrate how open innovation efforts such as hackathons can be leveraged for crisis management and more generally for ideation activities in increasingly remote working environments. This article contributes to crowdsourcing research by highlighting key differences of virtual hackathons from the traditional crowdsourcing approaches and hackathons investigated by prior research. Moreover, we affirm the value of mobilizing knowledge from different sources, particularly from a broad spectrum of civil society.
PURE Aarhus Universi... arrow_drop_down IEEE Transactions on Engineering ManagementArticle . 2024 . Peer-reviewedLicense: IEEE CopyrightData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/tem.2021.3097238&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesbronze 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert PURE Aarhus Universi... arrow_drop_down IEEE Transactions on Engineering ManagementArticle . 2024 . Peer-reviewedLicense: IEEE CopyrightData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/tem.2021.3097238&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 Turkey, Hungary, Italy, Belgium, Netherlands, TurkeyPublisher:Wiley Pellegrino Musto; Jon Salmanton‐García; Nicola Sgherza; Rui Bergantim; Francesca Farina; Andreas Glenthøj; Guldane Cengiz Seval; Barbora Weinbergerová; Valentina Bonuomo; Yavuz M. Bilgin; Jaap van Doesum; Ozren Jaksic; Benjamín Víšek; Iker Falces‐Romero; Monia Marchetti; Julio Dávila‐Valls; Sonia Martín‐Pérez; Marcio Nucci; Alberto López‐García; Federico Itri; Caterina Buquicchio; Luisa Verga; Klára Piukovics; Milan Navrátil; Graham P. Collins; Moraima Jiménez; Nicola S. Fracchiolla; Jorge Labrador; Lucia Prezioso; Elena Rossi; Natasha Čolović; Stef Meers; Austin Kulasekararaj; Annarosa Cuccaro; Ola Blennow; Toni Valković; Uluhan Sili; Marie‐Pierre Ledoux; Josip Batinić; Francesco Passamonti; Marina Machado; Rafael F. Duarte; Christian Bjørn Poulsen; Gustavo‐Adolfo Méndez; Ildefonso Espigado; Fatih Demirkan; Martin Čerňan; Chiara Cattaneo; Verena Petzer; Gabriele Magliano; Carolina Garcia‐Vidal; Shaimaa El‐Ashwah; Maria Gomes‐Da‐Silva; Antonio Vena; Irati Ormazabal‐Vélez; Jens van Praet; Michelina Dargenio; Cristina De‐Ramón; Maria Ilaria Del Principe; Joyce Marques‐De‐Almeida; Dominik Wolf; Tomáš Szotkowski; Aleš Obr; Gökçe Melis Çolak; Anna Nordlander; Macarena Izuzquiza; Alba Cabirta; Giovanni Paolo Maria Zambrotta; Raul Cordoba; Pavel Žák; Emanuele Ammatuna; Jiří Mayer; Osman Ilhan; Ramón García‐Sanz; Martina Quattrone; Elena Arellano; Raquel Nunes‐Rodrigues; Ziad Emarah; Tommaso Francesco Aiello; Michaela Hanakova; Zdeněk Ráčil; Martina Bavastro; Alessandro Limongelli; Laman Rahimli; Francesco Marchesi; Oliver A. Cornely; Livio Pagano;COVID-19; SARS-CoV-2; Multiple myeloma COVID-19; SARS-CoV-2; Mieloma múltiple COVID-19; SARS-CoV-2; Mieloma múltiple Patients affected by multiple myeloma (MM) have an increased risk of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection and subsequent coronavirus (20)19 disease (COVID-19)-related death. The changing epidemiological and therapeutic scenarios suggest that there has been an improvement in severity and survival of COVID-19 during the different waves of the pandemic in the general population, but this has not been investigated yet in MM patients. Here we analyzed a large cohort of 1221 patients with MM and confirmed SARS-CoV-2 infection observed between February 2020, and August 2022, in the EPICOVIDEHA registry from 132 centers around the world. Median follow-up was 52 days for the entire cohort and 83 days for survivors. Three-hundred and three patients died (24%) and COVID-19 was the primary reason for death of around 89% of them. Overall survival (OS) was significantly higher in vaccinated patients with both stable and active MM versus unvaccinated, while only a trend favoring vaccinated patients was observed in subjects with responsive MM. Vaccinated patients with at least 2 doses showed a better OS than those with one or no vaccine dose. Overall, according to pandemic waves, mortality rate decreased over time from 34% to 10%. In multivariable analysis, age, renal failure, active disease, hospital, and intensive care unit admission, were independently associated with a higher number of deaths, while a neutrophil count above 0.5 × 109/L was found to be protective. This data suggests that MM patients remain at risk of SARS-CoV-2 infection even in the vaccination era, but their clinical outcome, in terms of OS, has progressively improved throughout the different viral phases of the pandemic. EPICOVIDEHA has received funds from Optics COMMIT (COVID-19 Unmet Medical Needs and Associated Research Extension) COVID-19 RFP program by GILEAD Science, United States (Project 2020–8223).
Hematological Oncolo... arrow_drop_down Hematological Oncology; Archivio della Ricerca - Università di Roma Tor vergata; SZTE Publicatio Repozitórium - SZTE - Repository of PublicationsArticle . 2024 . 2023 . Peer-reviewedLicense: CC BYGhent University Academic BibliographyArticle . 2024Data sources: Ghent University Academic BibliographyMarmara University Open Access SystemArticle . 2023Data sources: Marmara University Open Access SystemDokuz Eylul University Research Information SystemArticle . 2023Data sources: Dokuz Eylul University Research Information SystemGhent University Academic BibliographyArticle . 2024Data sources: Ghent University Academic Bibliographyadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/hon.3240&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Hematological Oncolo... arrow_drop_down Hematological Oncology; Archivio della Ricerca - Università di Roma Tor vergata; SZTE Publicatio Repozitórium - SZTE - Repository of PublicationsArticle . 2024 . 2023 . Peer-reviewedLicense: CC BYGhent University Academic BibliographyArticle . 2024Data sources: Ghent University Academic BibliographyMarmara University Open Access SystemArticle . 2023Data sources: Marmara University Open Access SystemDokuz Eylul University Research Information SystemArticle . 2023Data sources: Dokuz Eylul University Research Information SystemGhent University Academic BibliographyArticle . 2024Data sources: Ghent University Academic Bibliographyadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1002/hon.3240&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 DenmarkPublisher:Elsevier BV Authors: Jane Agergaard; Jesper Damsgaard Gunst; Berit Schiøttz-Christensen; Lars Østergaard; +1 AuthorsJane Agergaard; Jesper Damsgaard Gunst; Berit Schiøttz-Christensen; Lars Østergaard; Christian Wejse;pmid: 37907167
OBJECTIVES: Knowledge is limited on how changing SARS-CoV-2 variants may translate into different characteristics and affect the prognosis of patients with long COVID, especially following Omicron variants. We compared long-term prognosis of patients in a Danish Post-COVID Clinic infected with wild-type strain, Alpha, Delta, or Omicron variants as well as the pre-Omicron compared to the Omicron period.METHODS: At enrollment, a Post-COVID symptom Questionnaire (PCQ), and standard health scores, were registered and repeated four times until 1.5 years after infection. PCQ was the primary outcome to assess the severity of long COVID, and Delta PCQ to assess failure to improve.RESULTS: A total of 806 patients were enrolled. Patients infected with Omicron and Delta variants presented with more severe long COVID (median PCQ 43 in Delta vs 38 in wild-type, P = 0.003) and health scores (EuroQol five-dimension five-level-index was 0.70 in Omicron vs 0.76 in wild-type, P = 0.009 and 0.78 pre-Omicron, P = 0.006). At 1.5 years after infection, patients had no clinically meaningful decline in severity of long COVID, and 57% (245/429) of patients failed to improve 1.5 years after infection, with no differences between variants.CONCLUSION: More than half of patients referred to a Post-COVID Clinic failed to improve in long COVID severity 1.5 years after infection regardless of variants of SARS-CoV-2.
International Journa... arrow_drop_down International Journal of Infectious DiseasesArticle . 2023Data sources: University of Southern Denmark Research OutputInternational Journal of Infectious DiseasesArticle . 2023 . Peer-reviewedLicense: CC BY NC NDData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.ijid.2023.10.022&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 4 citations 4 popularity Average influence Average impulse Average Powered by BIP!more_vert International Journa... arrow_drop_down International Journal of Infectious DiseasesArticle . 2023Data sources: University of Southern Denmark Research OutputInternational Journal of Infectious DiseasesArticle . 2023 . Peer-reviewedLicense: CC BY NC NDData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.ijid.2023.10.022&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 Germany, DenmarkPublisher:SAGE Publications Authors: Rune Müller Kristensen; Kevin Dadaczynski; Orkan Okan; Venka Simovska;Rune Müller Kristensen; Kevin Dadaczynski; Orkan Okan; Venka Simovska;Objective: Studies have shown that school leaders’ health literacy is key to supporting health development in school. During the COVID-19 pandemic, the importance of school leaders’ health literacy became evident, as school leadership was characterised with uncertainty and demanded high levels of alertness to the need to implement rapidly changing health-related measures at short notice. This study sought to explore school leaders’ health literacy, mental health and work-related characteristics in Danish public primary and lower secondary schools during the pandemic. Methods: Selecting schools from the national Danish register of institutions a sample of 220 complete responses was achieved in a cross-sectional survey. School leaders or a member of the school management team completed a self-administered version of the COVID-HL: School Principals Survey, which assessed health literacy, three domains of mental health, sense of coherence and workload. Data were analysed using chi-square tests and logistic regression. Results: The majority of school leaders (71.4%) demonstrated a sufficient level of health literacy. However, there was a significant difference in workload increase between those with sufficient (66.0%) and insufficient (81.6%) health literacy. A high general workload was associated with lower well-being, while an increase in workload during the COVID-19 pandemic was linked to psychosomatic complaints. Sense of coherence explained variations in well-being, emotional exhaustion and psychosomatic complaints. Conclusion: This study highlights the importance of enhancing the health literacy of Danish school leaders, enabling them to deal effectively with complex health-related information and make informed decisions during health crises. Strengthening health literacy is crucial to promoting overall health and well-being in schools under normal circumstances, as well as navigating health crises.
PURE Aarhus Universi... arrow_drop_down PURE Aarhus University; Theses@asbArticle . 2023 . 2024add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/00178969231211853&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert PURE Aarhus Universi... arrow_drop_down PURE Aarhus University; Theses@asbArticle . 2023 . 2024add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/00178969231211853&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023Publisher:MDPI AG Authors: Ramsen Ghasan Hikmet; Christian Wejse; Jane Agergaard;Ramsen Ghasan Hikmet; Christian Wejse; Jane Agergaard;Vitamin D deficiency has been studied in the context of acute coronavirus disease 2019 (COVID-19), revealing associations with increased severity and mortality. Yet, the influence of vitamin D on long COVID symptoms remains unknown. The purpose of this study is to examine the effect of vitamin D on long COVID symptoms. Over the study period, 50,432 individuals within the catchment area of the outpatient COVID-19 clinic tested positive for SARS-CoV-2 via PCR, with 547 patients subsequently referred to a specialized Post-COVID Clinic, and 447 of them enrolled in the study. Patient-reported symptoms and paraclinical measures including vitamin D were evaluated in 442 patients. The majority of participants were female (72%, n = 320/442). The consumption of alcohol and number of current smokers were low. Low vitamin D was observed in 26% (n = 115/442) of the patients, most commonly in male participants (odds ratio (OR) = 1.77, 95% confidence interval (CI) (1.12, 2.79), p = 0.014). Additionally, low vitamin D was correlated with a younger mean age of 41 years (standard deviation (SD) = 12) as opposed to 48 years (SD = 13) in patients with normal vitamin D levels (OR = 0.96, 95% CI (0.94, 0.97), p < 0.001). While our study population indicated a potentially higher prevalence of vitamin D insufficiency in this population compared to the general population, no significant differences in prevalence of symptom or symptom severity scores were observed between the low and normal vitamin D groups. In patients in a Post-COVID Clinic, we found no association between vitamin D levels and long COVID symptoms.
PURE Aarhus Universi... arrow_drop_down International Journal of Environmental Research and Public HealthArticle . 2023Data sources: Europe PubMed CentralInternational Journal of Environmental Research and Public HealthArticle . 2023 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert PURE Aarhus Universi... arrow_drop_down International Journal of Environmental Research and Public HealthArticle . 2023Data sources: Europe PubMed CentralInternational Journal of Environmental Research and Public HealthArticle . 2023 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/ijerph20227058&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023Publisher:MDPI AG Authors: George Xydis; Evanthia Nanaki;George Xydis; Evanthia Nanaki;doi: 10.3390/en16217455
The COVID-19 pandemic has caused significant shifts in energy demand and generation patterns, going beyond geographical boundaries and demanding creative responses from the energy industry as a whole [...]
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/en16217455&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 Denmark, Netherlands, BelgiumPublisher:Springer Science and Business Media LLC Authors: Charalampous, Periklis; Haagsma, Juanita A.; Cuschieri, Sarah; Devleesschauwer, Brecht; +5 AuthorsCharalampous, Periklis; Haagsma, Juanita A.; Cuschieri, Sarah; Devleesschauwer, Brecht; Pires, Sara M.; Polinder, Suzanne; Wyper, Grant M. A.; Hatziyianni, Amalia; Pallari, Elena;AbstractKnowledge about the extent of the COVID-19 mortality burden is important to inform policy-making decisions. To gain greater insights into the population health impact of COVID-19 mortality, Years of Life Lost (YLL) can be estimated. We aimed to determine YLL linked to COVID-19 over the first two years (March 2020–March 2022) of the pandemic in Cyprus, by areas, and by age and sex. COVID-19 YLL was estimated by multiplying COVID-19 mortality counts by age-conditional life expectancy from the 2019 Global Burden of Disease life table. COVID-19 accounted for 16,704 YLL over the first two years of the pandemic—approximately 18.5 years lost per individual who died due to COVID-19 and 1881 YLL per 100,000 population. YLL per 100,000 was higher among males compared to females (2485 versus 1303 per 100,000) and higher among older than younger individuals. COVID-19 deaths and YLL per 100,000 were higher in high population-dense areas of Cyprus, such as Limassol. Continued evaluations of COVID-19 YLL are needed to inform on the proportionate population impact of COVID-19, over time and across areas of Cyprus.
Discover Health Syst... arrow_drop_down Discover Health Systems; Erasmus University Rotterdam - Research Information PortalArticle . 2023 . Peer-reviewedLicense: CC BYGhent University Academic BibliographyArticle . 2023Data sources: Ghent University Academic BibliographyOnline Research Database In TechnologyArticle . 2023Data sources: Online Research Database In TechnologyGhent University Academic BibliographyArticle . 2023Data sources: Ghent University Academic Bibliographyadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Discover Health Syst... arrow_drop_down Discover Health Systems; Erasmus University Rotterdam - Research Information PortalArticle . 2023 . Peer-reviewedLicense: CC BYGhent University Academic BibliographyArticle . 2023Data sources: Ghent University Academic BibliographyOnline Research Database In TechnologyArticle . 2023Data sources: Online Research Database In TechnologyGhent University Academic BibliographyArticle . 2023Data sources: Ghent University Academic Bibliographyadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Part of book or chapter of book 2023 DenmarkPublisher:Oxford University PressOxford Authors: Lippert-Rasmussen, Kasper; Vrist Rønn, Kira;Lippert-Rasmussen, Kasper; Vrist Rønn, Kira;Abstract The Covid-19 pandemic raises new questions regarding the moral permissibility of surveillance—in this context there is no human aggressor and, thus, the antagonistic relationship between the surveillant and the surveilled, which is commonly assumed to obtain in much of the literature on surveillance ethics, does not exist. This raises the question of the extent to which existing frameworks for ethical surveillance apply to the surveillance activities aiming at controlling virus transmission. In this chapter, we will address the question of whether and in what form liability should play a role in surveillance ethics in the context of pandemics. Can persons who are not responsible for catching Covid-19 and do not intend to harm or wrong others by transmitting the virus, be liable to being surveilled on account of their posing a threat of virus transmission to others? If so, are they innocent or culpable threats?
PURE Aarhus Universi... arrow_drop_down University of Southern Denmark Research OutputPart of book or chapter of book . 2023Data sources: University of Southern Denmark Research Outputhttps://doi.org/10.1093/oso/97...Part of book or chapter of book . 2023 . Peer-reviewedLicense: CC BY NC NDData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routeshybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert PURE Aarhus Universi... arrow_drop_down University of Southern Denmark Research OutputPart of book or chapter of book . 2023Data sources: University of Southern Denmark Research Outputhttps://doi.org/10.1093/oso/97...Part of book or chapter of book . 2023 . Peer-reviewedLicense: CC BY NC NDData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article 2024 DenmarkPublisher:Wiley Anne Sophie Ågård; Gitte Susanne Rasmussen; Hanne Mainz; Merete Gregersen; Tina Wang Vedelø;doi: 10.1111/scs.13232
AbstractBackgroundWorldwide visitor restrictions forced nurses to separate patients from their relatives. However, the experience of implementing shifting restrictions from the frontline nurses' perspectives in a Danish context has yet to be assessed.AimThe aim of this descriptive qualitative study was to explore frontline nurses' experiences of managing shifting visitor restrictions in a Danish somatic university hospital during the COVID‐19 pandemic.MethodsAn online questionnaire, including open‐ended questions, was developed. Data were analysed using descriptive statistics and content analysis.Findings116 nurses from 29 departments participated; they were informed about restrictions primarily by their charge nurses and hospital intranet. Shifting visitor restrictions compelled the nurses to constantly adjust and negotiate their practices. When deciding to suggest deviating from the restrictions, they shared their decision‐making with colleagues. Visitor restrictions left the hospital environment quieter, but they also created a lack of overview and predictability, an emotional burden, and a negative impact on the quality of care.ConclusionRestricting relatives' access challenged the nurses' professional values, and it seems to have affirmed their appreciation of relatives' role as important partners in contemporary hospital‐based health care.
VBN; Aalborg Univers... arrow_drop_down VBN; Aalborg University Research PortalArticle . 2024Scandinavian Journal of Caring Sciences; PURE Aarhus UniversityArticle . 2024 . Peer-reviewedLicense: Wiley Online Library User Agreementadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert VBN; Aalborg Univers... arrow_drop_down VBN; Aalborg University Research PortalArticle . 2024Scandinavian Journal of Caring Sciences; PURE Aarhus UniversityArticle . 2024 . Peer-reviewedLicense: Wiley Online Library User Agreementadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1111/scs.13232&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024 DenmarkPublisher:Elsevier BV Lam, Carolyn S P; Lund, Lars H; Shah, Sanjiv J; Voors, Adriaan A; Erlinge, David; Saraste, Antti; Pirazzi, Carlo; Grove, Erik L; Barasa, Anders; Schou, Morten; Aziz, Ahmed; Svedlund, Sara; Wijngaarden, Jan VAN; Lindstedt, Eva-Lotte; Gustavsson, Andreas; Nelander, Karin; Garkaviy, Pavlo; Gan, Li-Ming; Gabrielsen, Anders;pmid: 37072105
BackgroundInflammation is a key driver of heart failure with preserved left ventricular ejection fraction. AZD4831 inhibits extracellular myeloperoxidase, decreases inflammation, and improves microvascular function in preclinical disease models.Methods and ResultsIn this double-blind phase 2a study (Safety and Tolerability Study of AZD4831 in Patients With Heart Failure [SATELLITE]; NCT03756285), patients with symptomatic heart failure, left ventricular ejection fraction of ≥40%, and elevated B-type natriuretic peptides were randomized 2:1 to once-daily oral AZD4831 5 mg or placebo for 90 days. We aimed to assess target engagement (primary end point: myeloperoxidase specific activity) and safety of AZD4831. Owing to coronavirus disease 2019, the study was terminated early after randomizing 41 patients (median age 74.0 years, 53.7% male). Myeloperoxidase activity was decreased by more than 50% from baseline to day 30 and day 90 in the AZD4831 group, with a placebo-adjusted decreased of 75% (95% confidence interval, 48, 88, nominal P < .001). No improvements were noted in secondary or exploratory end points, apart from a trend in Kansas City Cardiomyopathy Questionnaire overall summary score. No deaths or treatment-related serious adverse events occurred. AZD4831 treatment-related adverse events were generalized maculopapular rash, pruritus, and diarrhea (all n = 1).ConclusionsAZD4831 inhibited myeloperoxidase and was well tolerated in patients with heart failure and left ventricular ejection fraction of 40% or greater. Efficacy findings were exploratory owing to early termination, but warrant further clinical investigation of AZD4831.Lay SummaryFew treatments are available for patients with the forms of heart failure known as heart failure with preserved or mildly reduced ejection fraction. Current treatments do not target inflammation, which may play an important role in this condition. We tested a new drug called AZD4831 (mitiperstat), which decreases inflammation by inhibiting the enzyme myeloperoxidase. Among the 41 patients in our clinical trial, AZD4831 had a good safety profile and inhibited myeloperoxidase by the expected amount. Results mean we can conduct further trials to see whether AZD4831 decreases the symptoms of heart failure and improves patients’ ability to participate in physical exercise. Background: Inflammation is a key driver of heart failure with preserved left ventricular ejection fraction. AZD4831 inhibits extracellular myeloperoxidase, decreases inflammation, and improves microvascular function in preclinical disease models. Methods and Results: In this double-blind phase 2a study (Safety and Tolerability Study of AZD4831 in Patients With Heart Failure [SATELLITE]; NCT03756285), patients with symptomatic heart failure, left ventricular ejection fraction of ≥40%, and elevated B-type natriuretic peptides were randomized 2:1 to once-daily oral AZD4831 5 mg or placebo for 90 days. We aimed to assess target engagement (primary end point: myeloperoxidase specific activity) and safety of AZD4831. Owing to coronavirus disease 2019, the study was terminated early after randomizing 41 patients (median age 74.0 years, 53.7% male). Myeloperoxidase activity was decreased by more than 50% from baseline to day 30 and day 90 in the AZD4831 group, with a placebo-adjusted decreased of 75% (95% confidence interval, 48, 88, nominal P <.001). No improvements were noted in secondary or exploratory end points, apart from a trend in Kansas City Cardiomyopathy Questionnaire overall summary score. No deaths or treatment-related serious adverse events occurred. AZD4831 treatment-related adverse events were generalized maculopapular rash, pruritus, and diarrhea (all n = 1). Conclusions: AZD4831 inhibited myeloperoxidase and was well tolerated in patients with heart failure and left ventricular ejection fraction of 40% or greater. Efficacy findings were exploratory owing to early termination, but warrant further clinical investigation of AZD4831. Lay Summary: Few treatments are available for patients with the forms of heart failure known as heart failure with preserved or mildly reduced ejection fraction. Current treatments do not target inflammation, which may play an important role in this condition. We tested a new drug called AZD4831 (mitiperstat), which decreases inflammation by inhibiting the enzyme myeloperoxidase. Among the 41 patients in our clinical trial, AZD4831 had a good safety profile and inhibited myeloperoxidase by the expected amount. Results mean we can conduct further trials to see whether AZD4831 decreases the symptoms of heart failure and improves patients’ ability to participate in physical exercise.
PURE Aarhus Universi... arrow_drop_down Copenhagen University Research Information SystemArticle . 2024Data sources: Copenhagen University Research Information SystemJournal of Cardiac FailureArticle . 2023Data sources: University of Southern Denmark Research OutputJournal of Cardiac FailureArticle . 2024 . Peer-reviewedLicense: CC BY NC NDData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routeshybrid 6 citations 6 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert PURE Aarhus Universi... arrow_drop_down Copenhagen University Research Information SystemArticle . 2024Data sources: Copenhagen University Research Information SystemJournal of Cardiac FailureArticle . 2023Data sources: University of Southern Denmark Research OutputJournal of Cardiac FailureArticle . 2024 . Peer-reviewedLicense: CC BY NC NDData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2024Publisher:Institute of Electrical and Electronics Engineers (IEEE) Authors: Yokoi, Tomoko; Obwegeser, Nikolaus; Beretta, Michela;Yokoi, Tomoko; Obwegeser, Nikolaus; Beretta, Michela;The COVID-19 crisis brought about an unprecedented wave of interest into rapid ideation and innovation. Among others, the pandemic triggered a series of collaborative innovation events-so-called hackathons-to leverage the power of the crowd for crisis response. In contrast to earlier hackathons, these events are different in their speed of mobilization, global scale, and their fully virtual nature with organizers and teams being geographically dispersed. Analyzing this new empirical phenomenon, we characterize COVID-19 hackathons against other forms of innovation crowdsourcing and describe challenges and best practices in the areas of people management, session management, technology, and knowledge management. Based on our empirical findings, we develop a conceptual framework that emphasizes the importance of managing virtual crisis hackathons as the integrated sum of its different parts. Empirical evidence is presented to demonstrate how open innovation efforts such as hackathons can be leveraged for crisis management and more generally for ideation activities in increasingly remote working environments. This article contributes to crowdsourcing research by highlighting key differences of virtual hackathons from the traditional crowdsourcing approaches and hackathons investigated by prior research. Moreover, we affirm the value of mobilizing knowledge from different sources, particularly from a broad spectrum of civil society.
PURE Aarhus Universi... arrow_drop_down IEEE Transactions on Engineering ManagementArticle . 2024 . Peer-reviewedLicense: IEEE CopyrightData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesbronze 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert PURE Aarhus Universi... arrow_drop_down IEEE Transactions on Engineering ManagementArticle . 2024 . Peer-reviewedLicense: IEEE CopyrightData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1109/tem.2021.3097238&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 Turkey, Hungary, Italy, Belgium, Netherlands, TurkeyPublisher:Wiley Pellegrino Musto; Jon Salmanton‐García; Nicola Sgherza; Rui Bergantim; Francesca Farina; Andreas Glenthøj; Guldane Cengiz Seval; Barbora Weinbergerová; Valentina Bonuomo; Yavuz M. Bilgin; Jaap van Doesum; Ozren Jaksic; Benjamín Víšek; Iker Falces‐Romero; Monia Marchetti; Julio Dávila‐Valls; Sonia Martín‐Pérez; Marcio Nucci; Alberto López‐García; Federico Itri; Caterina Buquicchio; Luisa Verga; Klára Piukovics; Milan Navrátil; Graham P. Collins; Moraima Jiménez; Nicola S. Fracchiolla; Jorge Labrador; Lucia Prezioso; Elena Rossi; Natasha Čolović; Stef Meers; Austin Kulasekararaj; Annarosa Cuccaro; Ola Blennow; Toni Valković; Uluhan Sili; Marie‐Pierre Ledoux; Josip Batinić; Francesco Passamonti; Marina Machado; Rafael F. Duarte; Christian Bjørn Poulsen; Gustavo‐Adolfo Méndez; Ildefonso Espigado; Fatih Demirkan; Martin Čerňan; Chiara Cattaneo; Verena Petzer; Gabriele Magliano; Carolina Garcia‐Vidal; Shaimaa El‐Ashwah; Maria Gomes‐Da‐Silva; Antonio Vena; Irati Ormazabal‐Vélez; Jens van Praet; Michelina Dargenio; Cristina De‐Ramón; Maria Ilaria Del Principe; Joyce Marques‐De‐Almeida; Dominik Wolf; Tomáš Szotkowski; Aleš Obr; Gökçe Melis Çolak; Anna Nordlander; Macarena Izuzquiza; Alba Cabirta; Giovanni Paolo Maria Zambrotta; Raul Cordoba; Pavel Žák; Emanuele Ammatuna; Jiří Mayer; Osman Ilhan; Ramón García‐Sanz; Martina Quattrone; Elena Arellano; Raquel Nunes‐Rodrigues; Ziad Emarah; Tommaso Francesco Aiello; Michaela Hanakova; Zdeněk Ráčil; Martina Bavastro; Alessandro Limongelli; Laman Rahimli; Francesco Marchesi; Oliver A. Cornely; Livio Pagano;COVID-19; SARS-CoV-2; Multiple myeloma COVID-19; SARS-CoV-2; Mieloma múltiple COVID-19; SARS-CoV-2; Mieloma múltiple Patients affected by multiple myeloma (MM) have an increased risk of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection and subsequent coronavirus (20)19 disease (COVID-19)-related death. The changing epidemiological and therapeutic scenarios suggest that there has been an improvement in severity and survival of COVID-19 during the different waves of the pandemic in the general population, but this has not been investigated yet in MM patients. Here we analyzed a large cohort of 1221 patients with MM and confirmed SARS-CoV-2 infection observed between February 2020, and August 2022, in the EPICOVIDEHA registry from 132 centers around the world. Median follow-up was 52 days for the entire cohort and 83 days for survivors. Three-hundred and three patients died (24%) and COVID-19 was the primary reason for death of around 89% of them. Overall survival (OS) was significantly higher in vaccinated patients with both stable and active MM versus unvaccinated, while only a trend favoring vaccinated patients was observed in subjects with responsive MM. Vaccinated patients with at least 2 doses showed a better OS than those with one or no vaccine dose. Overall, according to pandemic waves, mortality rate decreased over time from 34% to 10%. In multivariable analysis, age, renal failure, active disease, hospital, and intensive care unit admission, were independently associated with a higher number of deaths, while a neutrophil count above 0.5 × 109/L was found to be protective. This data suggests that MM patients remain at risk of SARS-CoV-2 infection even in the vaccination era, but their clinical outcome, in terms of OS, has progressively improved throughout the different viral phases of the pandemic. EPICOVIDEHA has received funds from Optics COMMIT (COVID-19 Unmet Medical Needs and Associated Research Extension) COVID-19 RFP program by GILEAD Science, United States (Project 2020–8223).
Hematological Oncolo... arrow_drop_down Hematological Oncology; Archivio della Ricerca - Università di Roma Tor vergata; SZTE Publicatio Repozitórium - SZTE - Repository of PublicationsArticle . 2024 . 2023 . Peer-reviewedLicense: CC BYGhent University Academic BibliographyArticle . 2024Data sources: Ghent University Academic BibliographyMarmara University Open Access SystemArticle . 2023Data sources: Marmara University Open Access SystemDokuz Eylul University Research Information SystemArticle . 2023Data sources: Dokuz Eylul University Research Information SystemGhent University Academic BibliographyArticle . 2024Data sources: Ghent University Academic Bibliographyadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Hematological Oncolo... arrow_drop_down Hematological Oncology; Archivio della Ricerca - Università di Roma Tor vergata; SZTE Publicatio Repozitórium - SZTE - Repository of PublicationsArticle . 2024 . 2023 . Peer-reviewedLicense: CC BYGhent University Academic BibliographyArticle . 2024Data sources: Ghent University Academic BibliographyMarmara University Open Access SystemArticle . 2023Data sources: Marmara University Open Access SystemDokuz Eylul University Research Information SystemArticle . 2023Data sources: Dokuz Eylul University Research Information SystemGhent University Academic BibliographyArticle . 2024Data sources: Ghent University Academic Bibliographyadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 DenmarkPublisher:Elsevier BV Authors: Jane Agergaard; Jesper Damsgaard Gunst; Berit Schiøttz-Christensen; Lars Østergaard; +1 AuthorsJane Agergaard; Jesper Damsgaard Gunst; Berit Schiøttz-Christensen; Lars Østergaard; Christian Wejse;pmid: 37907167
OBJECTIVES: Knowledge is limited on how changing SARS-CoV-2 variants may translate into different characteristics and affect the prognosis of patients with long COVID, especially following Omicron variants. We compared long-term prognosis of patients in a Danish Post-COVID Clinic infected with wild-type strain, Alpha, Delta, or Omicron variants as well as the pre-Omicron compared to the Omicron period.METHODS: At enrollment, a Post-COVID symptom Questionnaire (PCQ), and standard health scores, were registered and repeated four times until 1.5 years after infection. PCQ was the primary outcome to assess the severity of long COVID, and Delta PCQ to assess failure to improve.RESULTS: A total of 806 patients were enrolled. Patients infected with Omicron and Delta variants presented with more severe long COVID (median PCQ 43 in Delta vs 38 in wild-type, P = 0.003) and health scores (EuroQol five-dimension five-level-index was 0.70 in Omicron vs 0.76 in wild-type, P = 0.009 and 0.78 pre-Omicron, P = 0.006). At 1.5 years after infection, patients had no clinically meaningful decline in severity of long COVID, and 57% (245/429) of patients failed to improve 1.5 years after infection, with no differences between variants.CONCLUSION: More than half of patients referred to a Post-COVID Clinic failed to improve in long COVID severity 1.5 years after infection regardless of variants of SARS-CoV-2.
International Journa... arrow_drop_down International Journal of Infectious DiseasesArticle . 2023Data sources: University of Southern Denmark Research OutputInternational Journal of Infectious DiseasesArticle . 2023 . Peer-reviewedLicense: CC BY NC NDData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.ijid.2023.10.022&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 4 citations 4 popularity Average influence Average impulse Average Powered by BIP!more_vert International Journa... arrow_drop_down International Journal of Infectious DiseasesArticle . 2023Data sources: University of Southern Denmark Research OutputInternational Journal of Infectious DiseasesArticle . 2023 . Peer-reviewedLicense: CC BY NC NDData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.ijid.2023.10.022&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 Germany, DenmarkPublisher:SAGE Publications Authors: Rune Müller Kristensen; Kevin Dadaczynski; Orkan Okan; Venka Simovska;Rune Müller Kristensen; Kevin Dadaczynski; Orkan Okan; Venka Simovska;Objective: Studies have shown that school leaders’ health literacy is key to supporting health development in school. During the COVID-19 pandemic, the importance of school leaders’ health literacy became evident, as school leadership was characterised with uncertainty and demanded high levels of alertness to the need to implement rapidly changing health-related measures at short notice. This study sought to explore school leaders’ health literacy, mental health and work-related characteristics in Danish public primary and lower secondary schools during the pandemic. Methods: Selecting schools from the national Danish register of institutions a sample of 220 complete responses was achieved in a cross-sectional survey. School leaders or a member of the school management team completed a self-administered version of the COVID-HL: School Principals Survey, which assessed health literacy, three domains of mental health, sense of coherence and workload. Data were analysed using chi-square tests and logistic regression. Results: The majority of school leaders (71.4%) demonstrated a sufficient level of health literacy. However, there was a significant difference in workload increase between those with sufficient (66.0%) and insufficient (81.6%) health literacy. A high general workload was associated with lower well-being, while an increase in workload during the COVID-19 pandemic was linked to psychosomatic complaints. Sense of coherence explained variations in well-being, emotional exhaustion and psychosomatic complaints. Conclusion: This study highlights the importance of enhancing the health literacy of Danish school leaders, enabling them to deal effectively with complex health-related information and make informed decisions during health crises. Strengthening health literacy is crucial to promoting overall health and well-being in schools under normal circumstances, as well as navigating health crises.
PURE Aarhus Universi... arrow_drop_down PURE Aarhus University; Theses@asbArticle . 2023 . 2024add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/00178969231211853&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert PURE Aarhus Universi... arrow_drop_down PURE Aarhus University; Theses@asbArticle . 2023 . 2024add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1177/00178969231211853&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023Publisher:MDPI AG Authors: Ramsen Ghasan Hikmet; Christian Wejse; Jane Agergaard;Ramsen Ghasan Hikmet; Christian Wejse; Jane Agergaard;Vitamin D deficiency has been studied in the context of acute coronavirus disease 2019 (COVID-19), revealing associations with increased severity and mortality. Yet, the influence of vitamin D on long COVID symptoms remains unknown. The purpose of this study is to examine the effect of vitamin D on long COVID symptoms. Over the study period, 50,432 individuals within the catchment area of the outpatient COVID-19 clinic tested positive for SARS-CoV-2 via PCR, with 547 patients subsequently referred to a specialized Post-COVID Clinic, and 447 of them enrolled in the study. Patient-reported symptoms and paraclinical measures including vitamin D were evaluated in 442 patients. The majority of participants were female (72%, n = 320/442). The consumption of alcohol and number of current smokers were low. Low vitamin D was observed in 26% (n = 115/442) of the patients, most commonly in male participants (odds ratio (OR) = 1.77, 95% confidence interval (CI) (1.12, 2.79), p = 0.014). Additionally, low vitamin D was correlated with a younger mean age of 41 years (standard deviation (SD) = 12) as opposed to 48 years (SD = 13) in patients with normal vitamin D levels (OR = 0.96, 95% CI (0.94, 0.97), p < 0.001). While our study population indicated a potentially higher prevalence of vitamin D insufficiency in this population compared to the general population, no significant differences in prevalence of symptom or symptom severity scores were observed between the low and normal vitamin D groups. In patients in a Post-COVID Clinic, we found no association between vitamin D levels and long COVID symptoms.
PURE Aarhus Universi... arrow_drop_down International Journal of Environmental Research and Public HealthArticle . 2023Data sources: Europe PubMed CentralInternational Journal of Environmental Research and Public HealthArticle . 2023 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/ijerph20227058&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 1 citations 1 popularity Average influence Average impulse Average Powered by BIP!more_vert PURE Aarhus Universi... arrow_drop_down International Journal of Environmental Research and Public HealthArticle . 2023Data sources: Europe PubMed CentralInternational Journal of Environmental Research and Public HealthArticle . 2023 . Peer-reviewedLicense: CC BYData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/ijerph20227058&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023Publisher:MDPI AG Authors: George Xydis; Evanthia Nanaki;George Xydis; Evanthia Nanaki;doi: 10.3390/en16217455
The COVID-19 pandemic has caused significant shifts in energy demand and generation patterns, going beyond geographical boundaries and demanding creative responses from the energy industry as a whole [...]
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/en16217455&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.3390/en16217455&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 Denmark, Netherlands, BelgiumPublisher:Springer Science and Business Media LLC Authors: Charalampous, Periklis; Haagsma, Juanita A.; Cuschieri, Sarah; Devleesschauwer, Brecht; +5 AuthorsCharalampous, Periklis; Haagsma, Juanita A.; Cuschieri, Sarah; Devleesschauwer, Brecht; Pires, Sara M.; Polinder, Suzanne; Wyper, Grant M. A.; Hatziyianni, Amalia; Pallari, Elena;AbstractKnowledge about the extent of the COVID-19 mortality burden is important to inform policy-making decisions. To gain greater insights into the population health impact of COVID-19 mortality, Years of Life Lost (YLL) can be estimated. We aimed to determine YLL linked to COVID-19 over the first two years (March 2020–March 2022) of the pandemic in Cyprus, by areas, and by age and sex. COVID-19 YLL was estimated by multiplying COVID-19 mortality counts by age-conditional life expectancy from the 2019 Global Burden of Disease life table. COVID-19 accounted for 16,704 YLL over the first two years of the pandemic—approximately 18.5 years lost per individual who died due to COVID-19 and 1881 YLL per 100,000 population. YLL per 100,000 was higher among males compared to females (2485 versus 1303 per 100,000) and higher among older than younger individuals. COVID-19 deaths and YLL per 100,000 were higher in high population-dense areas of Cyprus, such as Limassol. Continued evaluations of COVID-19 YLL are needed to inform on the proportionate population impact of COVID-19, over time and across areas of Cyprus.
Discover Health Syst... arrow_drop_down Discover Health Systems; Erasmus University Rotterdam - Research Information PortalArticle . 2023 . Peer-reviewedLicense: CC BYGhent University Academic BibliographyArticle . 2023Data sources: Ghent University Academic BibliographyOnline Research Database In TechnologyArticle . 2023Data sources: Online Research Database In TechnologyGhent University Academic BibliographyArticle . 2023Data sources: Ghent University Academic Bibliographyadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s44250-023-00051-9&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen hybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Discover Health Syst... arrow_drop_down Discover Health Systems; Erasmus University Rotterdam - Research Information PortalArticle . 2023 . Peer-reviewedLicense: CC BYGhent University Academic BibliographyArticle . 2023Data sources: Ghent University Academic BibliographyOnline Research Database In TechnologyArticle . 2023Data sources: Online Research Database In TechnologyGhent University Academic BibliographyArticle . 2023Data sources: Ghent University Academic Bibliographyadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1007/s44250-023-00051-9&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Part of book or chapter of book 2023 DenmarkPublisher:Oxford University PressOxford Authors: Lippert-Rasmussen, Kasper; Vrist Rønn, Kira;Lippert-Rasmussen, Kasper; Vrist Rønn, Kira;Abstract The Covid-19 pandemic raises new questions regarding the moral permissibility of surveillance—in this context there is no human aggressor and, thus, the antagonistic relationship between the surveillant and the surveilled, which is commonly assumed to obtain in much of the literature on surveillance ethics, does not exist. This raises the question of the extent to which existing frameworks for ethical surveillance apply to the surveillance activities aiming at controlling virus transmission. In this chapter, we will address the question of whether and in what form liability should play a role in surveillance ethics in the context of pandemics. Can persons who are not responsible for catching Covid-19 and do not intend to harm or wrong others by transmitting the virus, be liable to being surveilled on account of their posing a threat of virus transmission to others? If so, are they innocent or culpable threats?
PURE Aarhus Universi... arrow_drop_down University of Southern Denmark Research OutputPart of book or chapter of book . 2023Data sources: University of Southern Denmark Research Outputhttps://doi.org/10.1093/oso/97...Part of book or chapter of book . 2023 . Peer-reviewedLicense: CC BY NC NDData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/oso/9780192864918.003.0007&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert PURE Aarhus Universi... arrow_drop_down University of Southern Denmark Research OutputPart of book or chapter of book . 2023Data sources: University of Southern Denmark Research Outputhttps://doi.org/10.1093/oso/97...Part of book or chapter of book . 2023 . Peer-reviewedLicense: CC BY NC NDData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1093/oso/9780192864918.003.0007&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu