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30 research outcomes, page 1 of 3
  • publication . Article . Preprint . 2020
    Open Access English
    Authors:
    Mart M. Lamers; Joep Beumer; Jelte van der Vaart; Kèvin Knoops; Jens Puschhof; Tim I Breugem; Raimond B. G. Ravelli; J. Paul van Schayck; Anna Z Mykytyn; Hans Duimel; ...
    Publisher: American Association for the Advancement of Science (AAAS)
    Country: Netherlands
    Project: NWO | Erasmus Graduate Programm... (2300181109), NWO | Bio-MEMS for Structural B... (2300191194), EC | Q-SORT (766970), EC | Organoid (670133)

    Intestinal organoids as an infection model Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes an influenza-like disease with a respiratory transmission route; however, patients often present with gastrointestinal symptoms such as diarrhea, vomiting, an...

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  • publication . Article . 2020
    Open Access English
    Authors:
    Bouwman, Kim M; Parsons, Lisa M; Berends, Alinda J; de Vries, Robert P; Cipollo, John F; Verheije, Monique H; Chemical Biology and Drug Discovery; Afd Chemical Biology and Drug Discovery; dPB I&I; LS Pathologie; ...
    Persistent Identifiers
    Publisher: American Society for Microbiology
    Country: Netherlands
    Project: NWO | Avian coronaviruses: host... (2300176967), EC | Sugar-Enable (802780)

    ABSTRACT Infectious bronchitis virus (IBV) infects ciliated epithelial cells in the chicken respiratory tract. While some IBV strains replicate locally, others can disseminate to various organs, including the kidney. Here, we elucidate the determinants for kidney tropis...

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  • publication . Article . 2019
    Open Access
    Authors:
    Landi, Alessia; Mari, Muriel; Kleiser, Svenja; Wolf, Tobias; Gretzmeier, Christine; Wilhelm, Isabel; Kiritsi, Dimitra; Thünauer, Roland; Geiger, Roger; Nyström, Alexander; ...
    Publisher: Life Science Alliance, LLC
    Country: Netherlands
    Project: EC | DRIVE (765912), EC | PRONKJEWAIL (713660), EC | LEC&LIP2INVADE (282105), NWO | A three-dimensional look ... (2300175771)

    Lectins are glycan-binding proteins with no catalytic activity and ubiquitously expressed in nature. Numerous bacteria use lectins to efficiently bind to epithelia, thus facilitating tissue colonisation. Wounded skin is one of the preferred niches for Pseudomonas aerugi...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Natacha S. Ogando; Francois Ferron; Francois Ferron; Etienne Decroly; Bruno Canard; Clara C. Posthuma; Eric J. Snijder;
    Publisher: Frontiers Media S.A.
    Countries: France, Netherlands
    Project: NWO | Viral RNA polymerases: th... (2300162767), EC | ANTIVIRALS (642434)

    International audience; Among RNA viruses, the order Nidovirales stands out for including viruses with the largest RNA genomes currently known. Nidoviruses employ a complex RNA-synthesizing machinery comprising a variety of non-structural proteins (nsps). One of the pos...

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  • publication . Article . Other literature type . 2019
    Open Access English
    Authors:
    Melia, Charlotte E; Peddie, Christopher J; de Jong, Anja W M; Snijder, Eric J; Collinson, Lucy M; Koster, Abraham J; van der Schaar, Hilde M; van Kuppeveld, Frank J M; Bárcena, Montserrat; LS Virologie; ...
    Publisher: American Society for Microbiology
    Country: Netherlands
    Project: WT , EC | EUVIRNA (264286), NWO | SysVirDrug: Translating S... (2300189186), NWO | Viral redesign of the cel... (2300174141), UKRI | MICA: Bio-Continuum Micro... (MR/K01580X/1)

    ABSTRACT Enterovirus genome replication occurs at virus-induced structures derived from cellular membranes and lipids. However, the origin of these replication organelles (ROs) remains uncertain. Ultrastructural evidence of the membrane donor is lacking, suggesting that...

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  • publication . Article . 2018 . Embargo End Date: 10 Oct 2018
    Open Access
    Authors:
    Stewart, Hazel; Brown, Katherine; Dinan, Adam; Irigoyen, Nerea; Snijder, Eric J; Firth, Andrew;
    Publisher: Apollo - University of Cambridge Repository
    Countries: United Kingdom, Netherlands
    Project: WT | Encyclopedia of RNA Virus... (106207), NWO | Protein-directed ribosoma... (2300184220), EC | ERVE (646891)

    ABSTRACT The genus Torovirus (subfamily Torovirinae, family Coronaviridae, order Nidovirales) encompasses a range of species that infect domestic ungulates, including cattle, sheep, goats, pigs, and horses, causing an acute self-limiting gastroenteritis. Using the proto...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Melia, C E; van der Schaar, H M; de Jong, A W M; Lyoo, H R; Snijder, Eric J; Koster, A J; van Kuppeveld, F J M; Bárcena, Montserrat; dI&I I&I-1; LS Virologie; ...
    Publisher: American Society for Microbiology
    Country: Netherlands
    Project: EC | ANTIVIRALS (642434), NWO | Activating the VE-cadheri... (2300161085), EC | EUVIRNA (264286), NWO | Viral redesign of the cel... (2300174141), NWO | SysVirDrug: Translating S... (2300189186)

    ABSTRACT Picornaviruses induce dramatic rearrangements of endomembranes in the cells that they infect to produce dedicated platforms for viral replication. These structures, termed replication organelles (ROs), have been well characterized for the Enterovirus genus of t...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Ederveen, Thomas H. A.; Ferwerda, Gerben; Ahout, Inge M.; Vissers, Marloes; de Groot, Ronald; Boekhorst, Jos; Timmerman, Harro M.; Huynen, Martijn A.; van Hijum, Sacha A. F. T.; de Jonge, Marien I.;
    Country: Netherlands
    Project: EC | PoC-ID (634415), NWO | XCiDE: Crossing the Combu... (2300153186)

    Background While almost all infants are infected with respiratory syncytial virus (RSV) before the age of 2 years, only a small percentage develops severe disease. Previous studies suggest that the nasopharyngeal microbiome affects disease development. We therefore stud...

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  • publication . Other literature type . 2018
    Authors:
    Ederveen, Thomas; Ferwerda, Gerben; Ahout, Inge; Vissers, Marloes; Groot, Ronald De; Boekhorst, Jos; Timmerman, Harro; Huynen, Martijn; Hijum, Sacha Van; Jonge, Marien De;
    Publisher: figshare
    Project: EC | PoC-ID (634415), NWO | XCiDE: Crossing the Combu... (2300153186)

    Supplementary information on methods. (DOCX 20Â kb)

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  • publication . Other literature type . 2018
    Authors:
    Ederveen, Thomas; Ferwerda, Gerben; Ahout, Inge; Vissers, Marloes; Groot, Ronald De; Boekhorst, Jos; Timmerman, Harro; Huynen, Martijn; Hijum, Sacha Van; Jonge, Marien De;
    Publisher: figshare
    Project: EC | PoC-ID (634415), NWO | XCiDE: Crossing the Combu... (2300153186)

    Potential confounding characteristics of this study. Figure S2 RSV disease and viral load in healthy and RSV-infected individuals can be explained by nasopharyngeal microbial makeup (OTU-level). Figure S3 Species richness, but not diversity, is reduced in RSV-infected i...

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30 research outcomes, page 1 of 3