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6,893 Research products, page 1 of 690

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  • Open Access
    Authors: 
    Murielle SALOME; Marina ECKERMANN; Martina VENERONI; Paola COAN; Alberto BRAVIN;
    Publisher: ESRF (European Synchrotron Radiation Facility)

    This project aims at gaining novel insight in two pathological mechanisms observed in the vascular system supplying the heart and brain of COVID-19 patients as an adverse consequence of a SARS-CoV-2 infection, i.e. the development of 1) macroscopic thrombi (MTs) in epicardial coronary and carotid arteries and 2) peripheral microscopic thrombi (µTs) in myocardial and brain microvasculature. Few pathology studies have been conducted thus far and a precise mechanistic understanding is still needed. We propose the use of a combination of different synchrotron analysis techniques (X-ray micro- & nano-CT, fluorescence & SAXS/WAXS) for the characterization of the morphology, composition and structure of the MTs and µTs. In this specific experiment, we will apply X-ray nano-holotomography and fluorescence microscopy to obtain an unprecedented morphological and chemical characterization of the MTs and µTs at the level of individual thrombi, endothelial cells and possibly SARS-CoV-2 virions.

  • Other research product . Other ORP type . 2025
    Open Access
    Authors: 
    Jasper LANDMAN; Andrei PETOUKHOV; Tatiana KOMAROVA; Narayanan THEYENCHERI; Christiaan LELIVELD;
    Publisher: ESRF (European Synchrotron Radiation Facility)

    This is a continuation of experiment SC-4987 (proposal round April 2020), for which the experimental plan was adjusted for the remote-access mode due to COVID-19 restrictions. Instead of the originally-planned pressure jump, a temperature- and concentration-dependent rheo-SAXS study was performed, which was easier to do with limited manpower. Aqueous solutions of β-cyclodextrin (β-CD) and sodium dodecyl sulphate (SDS) spontaneously form a rich variety of concentration-dependent assemblies with complex multiscale structure [1-3]. We have recently studied the kinetics of the self-assembly process using a temperature quench in a stopped-flow device [4]. These results, however, could suffer from the finite cooling rate. Here we propose to investigate the fast kinetics of the self-assembly process in pressure jump experiments. Preliminary results obtained by our local contact demonstrate the presence of pressure-induced assembly/melting transitions.

  • Open Access
    Authors: 
    Francesco STELLATO; Olivier PROUX; Silvia MORANTE; Pietro COSTANZI;
    Publisher: ESRF (European Synchrotron Radiation Facility)

    The most supported hypothesis for the orf7a function is the interference with virion budding operated by cellular antigens, while the orf8 function is still unknown. We aim at studying the interaction of orf7a and orf8 with the bone marrow stromal antigen 2 (BST2). BST2 dimerization and oligomerization involve intermolecular disulfide bonds between cysteine residues and are strongly influenced by the presence of divalent cations, such as Zn2+. We want to test the hypothesis [7] that the orf7a and orf8 proteins have been selected to counteract BST2 antiviral activity by bringing in situ Zn2+ cations owing to the presence of multiple Zn-finger domains. The formation of orf7a/BST2 and orf8/BST2 complexes assisted by the presence of Zn2+ may enable the virus to evade the antiviral activity of BST2. In this proposal we aim at determining the Zn2+coordination mode in orf7a, orf8 and BST2 to check the possible formation of orf7a/BST2 and orf8/BST2 complexes.

  • Open Access
    Authors: 
    Eaazhisai KANDIAH; Jacek PLEWKA; Krzysztof PYRC;
    Publisher: ESRF (European Synchrotron Radiation Facility)

    Coronaviruses protect their ssRNA genome with a methylated cap. The methylation is performed by two methyltransferases, nsp14 and nsp16. Additionally, nsp14 carries an exonuclease domain, which operates in the proofreading system. nsp14 and nsp16 were reported to independently bind nsp10, but the available structural information suggests that the concomitant interaction between these three proteins should be impossible due to steric clashes. In our work (https://www.biorxiv.org/content/10.1101/2022.01.25.477673v1 ), we show that nsp14, nsp10, and nsp16 can form a ternary complex (MST, enzymatic assays, SAXS, TEM). This interaction is expected to encourage formation of mature capped viral mRNA, modulating the nsp14 exonuclease activity, and protecting the viral RNA. A high-resolution structure of the triplex would greatly improve the understanding of how the component proteins are undergoing the structural changes upon the ternary complex formation.

  • Other research product . Other ORP type . 2025
    Open Access
    Authors: 
    Oded LIVNAH; Noam ADIR; David FLOT; Dikla HIYA;
    Publisher: ESRF (European Synchrotron Radiation Facility)

    The BAG includes numerous principal investigators which are the majority of structural biologists in Israel. The scientific topics are diverse and so different that depicting them in a short Abstract is extremely difficult. In this context BAG members are studying the parameters that govern protein assemblage, structural impacts of signaling processes in different cascades, Thermodynamics of proteolytic reaction. In addition, we have the ribosome project and the design of unique antibiotics with specific functional interactions from the mycinamycins family and their resistance related mechanism compared with other macrolides and the photosystem and how it converts light into energy. The current events promote several Covid-19 related projects but BAG members are and have been involved and virus infection and inhibitory strategies including Hepatitis C virus, arthropod borne viruses (e.g .dengue, West Nile, Zika, Israel Turkey Meningoencephalitis), chikungunya virus and more.

  • Open Access
    Authors: 
    Gregory EFFANTIN;
    Publisher: ESRF (European Synchrotron Radiation Facility)

    Single particle analysis of Sars Cov2 S glycoprotein and plastidial polymerase PEP Cryo tomography of Phaeodactylum cells

  • Other research product . Other ORP type . 2025
    Open Access
    Authors: 
    Jhonathan HAITIN RUBINSTEIN; Alexander ROUVINSKI; Reuven WIENER; Sylvain ENGILBERGE; Oded LIVNAH;
    Publisher: ESRF (European Synchrotron Radiation Facility)

    The BAG includes numerous principal investigators which are the majority of structural biologists in Israel. The scientific topics are diverse and so different that depicting them in a short Abstract is extremely difficult. In this context BAG members are studying the parameters that govern protein assemblage, structural impacts of signaling processes in different cascades, Thermodynamics of proteolytic reaction. In addition, we have the ribosome project and the design of unique antibiotics with specific functional interactions from the mycinamycins family and their resistance related mechanism compared with other macrolides and the photosystem and how it converts light into energy. The current events promote several Covid-19 related projects but BAG members are and have been involved and virus infection and inhibitory strategies including Hepatitis C virus, arthropod borne viruses (e.g .dengue, West Nile, Zika, Israel Turkey Meningoencephalitis), chikungunya virus and more.

  • Other research product . Other ORP type . 2025
    Open Access
    Authors: 
    Naama GATENIO; Sofia KOLUSHEV; Oded LIVNAH; Dihia MOUSSAOUI;
    Publisher: ESRF (European Synchrotron Radiation Facility)

    The BAG is quite large with 24 principal investigators covering almost all groups in Israel. The scientific topics are diverse and so different that depicting them in a short Abstract is extremely difficult. In this context BAG members are studying the parameters that govern protein assemblage, structural impacts of signaling processes in different cascades. There are several projects that are directed towards molecular recognition with implementation towards drug design. In addition, we still have the ribosome project and the design of unique antibiotics with specific functional interactions from the mycinamycins family and their resistance related mechanism compared with other macrolides and the photosystem and how it converts light into energy. Since Covid-19 is still a relevant topic as are other viral infections BAG members are and have been involved in the understanding of the infection process and the means to hinder it.

  • Other research product . Other ORP type . 2025
    Open Access
    Authors: 
    Yarden OPATOWSKY; Gordon LEONARD; Oded LIVNAH;
    Publisher: ESRF (European Synchrotron Radiation Facility)

    The BAG includes numerous principal investigators which are the majority of structural biologists in Israel. The scientific topics are diverse and so different that depicting them in a short Abstract is extremely difficult. In this context BAG members are studying the parameters that govern protein assemblage, structural impacts of signaling processes in different cascades, Thermodynamics of proteolytic reaction. In addition, we have the ribosome project and the design of unique antibiotics with specific functional interactions from the mycinamycins family and their resistance related mechanism compared with other macrolides and the photosystem and how it converts light into energy. The current events promote several Covid-19 related projects but BAG members are and have been involved and virus infection and inhibitory strategies including Hepatitis C virus, arthropod borne viruses (e.g .dengue, West Nile, Zika, Israel Turkey Meningoencephalitis), chikungunya virus and more.

  • Other research product . Other ORP type . 2025
    Open Access
    Authors: 
    Yael PAZY BENHAR; Daniele DE SANCTIS; Dikla HIYA; Oded LIVNAH;
    Publisher: ESRF (European Synchrotron Radiation Facility)

    The BAG is quite large with 24 principal investigators covering almost all groups in Israel. The scientific topics are diverse and so different that depicting them in a short Abstract is extremely difficult. In this context BAG members are studying the parameters that govern protein assemblage, structural impacts of signaling processes in different cascades. There are several projects that are directed towards molecular recognition with implementation towards drug design. In addition, we still have the ribosome project and the design of unique antibiotics with specific functional interactions from the mycinamycins family and their resistance related mechanism compared with other macrolides and the photosystem and how it converts light into energy. Since Covid-19 is still a relevant topic as are other viral infections BAG members are and have been involved in the understanding of the infection process and the means to hinder it.