The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden. To estimate cancer burden and trends globally fo...

New lineages of SARS-CoV-2 are of potential concern due to higher transmissibility, risk of severe outcomes, and/or escape from neutralizing antibodies. Lineage B.1.1.7 (the Alpha variant) became dominant in early 2021, but the association between transmissibility and r...

The COVID-19 pandemic is the first serious test of how science can inform decision-making in the face of an immediate global threat, yielding important lessons on how science, society and policy interact. The global societal and economic impact of COVID-19 has shown tha...

SARS-CoV-2 variants are emerging with potential increased transmissibility highlighting the great unmet medical need for new therapies. Niclosamide is a potent anti-SARS-CoV-2 agent that has advanced in clinical development. We validate the potent antiviral efficacy of ...

Funder: Aerospace Technology Institute Funder: UK Research and Innovation Funder: The Alan Turing Institute A large evidence base demonstrates that the outcomes of COVID-19 and national and local interventions are not distributed equally across different communities. Th...

Abstract Introduction The diagnosis of COVID-19 is normally based on the qualitative detection of viral nucleic acid sequences. Properties of the host response are not measured but are key in determining outcome. Although metabolic profiles are well suited to capture ho...

Abstract This work examines a mathematical model of COVID-19 among two subgroups: low-risk and high-risk populations with two preventive measures; non-pharmaceutical interventions including wearing masks, maintaining social distance, and washing hands regularly by the l...

For the first time, we have used phase-contrast X-ray tomography to characterize the three-dimensional (3d) structure of cardiac tissue from patients who succumbed to Covid-19. By extending conventional histopathological examination by a third dimension, the delicate pa...

Travel restrictions have proven to be an effective strategy to control the spread of the COVID-19 epidemics, in part because they help delay disease propagation across territories. The question, however, as to how different types of travel behaviour, from commuting to h...

Public transport is a critical service in Copenhagen, Denmark, because many residents do not own a car, and in any event, car travel is not practical in the city center due to narrow roads and lack of parking. In response to COVID-19, Danish public health authorities ha...