Many steps of the MHC class I antigen processing pathway can be predicted using computational methods. Here we show that epitope predictions can be further improved by considering abundance levels of peptides’ source proteins. We utilized biophysical principles and exis...

The logistics sector has undergone profound changes over the past decade, mainly due to growing demand and shipping time requirements. For example, the global volume of parcel shipment has doubled in the last five years and is expected to double again in the next five [...

Today's manufacturing is based on ample fossil fuel sources, large and centralized plants, and high waste intensity. Climate change, aging infrastructure, dwindling resources, increasing population, changing geopolitical landscape, and the COVID-19 pandemic have laid ba...

BackgroundTo date, most efforts to understand the comparative population health impact of COVID-19 have been made using mortality-based metrics [1,2]. This has intensified discussion over methodological choices; in particular, how we value the life-years prematurely los...

New lineages of SARS-CoV-2 are of potential concern due to higher transmissibility, risk of severe outcomes, and/or escape from neutralizing antibodies. Lineage B.1.1.7 (the Alpha variant) became dominant in early 2021, but the association between transmissibility and r...

The COVID-19 pandemic is the first serious test of how science can inform decision-making in the face of an immediate global threat, yielding important lessons on how science, society and policy interact. The global societal and economic impact of COVID-19 has shown tha...

Funder: Aerospace Technology Institute Funder: UK Research and Innovation Funder: The Alan Turing Institute A large evidence base demonstrates that the outcomes of COVID-19 and national and local interventions are not distributed equally across different communities. Th...

Abstract Introduction The diagnosis of COVID-19 is normally based on the qualitative detection of viral nucleic acid sequences. Properties of the host response are not measured but are key in determining outcome. Although metabolic profiles are well suited to capture ho...

Abstract This work examines a mathematical model of COVID-19 among two subgroups: low-risk and high-risk populations with two preventive measures; non-pharmaceutical interventions including wearing masks, maintaining social distance, and washing hands regularly by the l...

We have used phase-contrast X-ray tomography to characterize the three-dimensional (3d) structure of cardiac tissue from patients who succumbed to Covid-19. By extending conventional histopathological examination by a third dimension, the delicate pathological changes o...