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6 research outcomes, page 1 of 1
  • publication . Article . Preprint . Other literature type . 2020
    Open Access English
    Authors:
    P. Friedlingstein; P. Friedlingstein; M. O'Sullivan; M. W. Jones; R. M. Andrew; J. Hauck; A. Olsen; A. Olsen; G. P. Peters; W. Peters; ...
    Publisher: HAL CCSD
    Countries: France, Germany, France, United Kingdom, Germany, Germany, Norway, Austria, Germany, Germany ...
    Project: EC | CRESCENDO (641816), EC | 4C (821003), SNSF | Climate and Environmental... (200020_172476), EC | CONSTRAIN (820829), EC | VERIFY (776810)

    Accurate assessment of anthropogenic carbon dioxide (CO2) emissions and their redistribution among the atmosphere, ocean, and terrestrial biosphere in a changing climate – the “global carbon budget” – is important to better understand the global carbon cycle, support th...

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  • publication . Article . Other literature type . 2018
    Open Access English
    Authors:
    Mauthe, Mario; Orhon, Idil; Rocchi, Cecilia; Zhou, Xingdong; Luhr, Morten; Hijlkema, Kerst-Jan; Coppes, Robert P.; Engedal, Nikolai; Mari, Muriel; Reggiori, Fulvio;
    Country: Netherlands
    Project: EC | PRONKJEWAIL (713660), SNSF | ER-phagy mechanisms to ma... (CRSII3_154421)

    Macroautophagy/autophagy is a conserved transport pathway where targeted structures are sequestered by phagophores, which mature into autophagosomes, and then delivered into lysosomes for degradation. Autophagy is involved in the pathophysiology of numerous diseases and...

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  • other research product . Other ORP type . 2017
    Open Access English
    Authors:
    Cong, Yingying; Verlhac, Pauline; Reggiori, Fulvio;
    Project: EC | PRONKJEWAIL (713660), NWO | A three-dimensional look ... (2300175771), SNSF | ER-phagy mechanisms to ma... (CRSII3_154421)

    Autophagy is a conserved intracellular catabolic pathway that allows cells to maintain homeostasis through the degradation of deleterious components via specialized double-membrane vesicles called autophagosomes. During the past decades, it has been revealed that numero...

  • publication . Article . 2016
    Open Access English
    Authors:
    Mauthe, Mario; Langereis, Martijn; Jung, Jennifer; Zhou, Xingdong; Jones, Alex; Omta, Wienand; Tooze, Sharon A; Stork, Björn; Paludan, Søren Riis; Ahola, Tero; ...
    Country: Netherlands
    Project: WT , NWO | The role of autophagy in ... (2300175628), NWO | A three-dimensional look ... (2300175771), NWO | Viral strategies to evade... (2300180032), AKA | Mechanisms in the formati... (265997), EC | XABA (282333), SNSF | ER-phagy mechanisms to ma... (CRSII3_154421)

    Autophagy is a catabolic process regulated by the orchestrated action of the autophagy-related (ATG) proteins. Recent work indicates that some of the ATG proteins also have autophagy-independent roles. Using an unbiased siRNA screen approach, we explored the extent of t...

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  • publication . Article . 2013
    Open Access English
    Authors:
    Raj, V Stalin; Mou, Huihui; Smits, Saskia L; Dekkers, Dick H W; Müller, Marcel A; Dijkman, Ronald; Muth, Doreen; Demmers, Jeroen A A; Zaki, Ali; Fouchier, Ron A M; ...
    Publisher: Nature Publishing Group UK
    Country: Netherlands
    Project: EC | ANTIGONE (278976), EC | EMPERIE (223498), SNSF | Impact of RNA modificatio... (31003A_132898)

    Most human coronaviruses cause mild upper respiratory tract disease but may be associated with more severe pulmonary disease in immunocompromised individuals1. However, SARS coronavirus caused severe lower respiratory disease with nearly 10% mortality and evidence of sy...

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  • publication . Other literature type . Article . 2011
    Open Access English
    Authors:
    Adriaan H. de Wilde; Jessika C. Zevenhoven-Dobbe; Yvonne van der Meer; Volker Thiel; Krishna Narayanan; Shinji Makino; Eric J. Snijder; Martijn J. van Hemert;
    Persistent Identifiers
    Publisher: Society for General Microbiology
    Country: Netherlands
    Project: EC | SILVER (260644), NIH | Analysis of SARS Coronavi... (5R01AI072493-03), SNSF | Impact of RNA modificatio... (31003A_132898)

    Low micromolar, non-cytotoxic concentrations of cyclosporin A (CsA) strongly affected the replication of severe acute respiratory syndrome coronavirus (SARS-CoV), human coronavirus 229E and mouse hepatitis virus in cell culture, as was evident from the strong inhibition...

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6 research outcomes, page 1 of 1