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15 research outcomes, page 1 of 2
  • publication . Article . Preprint . 2020
    Open Access English
    Authors:
    Mart M. Lamers; Joep Beumer; Jelte van der Vaart; Kèvin Knoops; Jens Puschhof; Tim I. Breugem; Raimond B. G. Ravelli; J. Paul van Schayck; Anna Z. Mykytyn; Hans Duimel; ...
    Publisher: American Association for the Advancement of Science
    Project: EC | Q-SORT (766970), NWO | Erasmus Graduate Programm... (2300181109), NWO | Bio-MEMS for Structural B... (2300191194), EC | Organoid (670133)

    The virus severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) can cause coronavirus disease 2019 (COVID-19), an influenza-like disease that is primarily thought to infect the lungs with transmission via the respiratory route. However, clinical evidence suggests...

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  • publication . Article . 2020
    Open Access
    Authors:
    Kim M. Bouwman; Lisa M. Parsons; Alinda J. Berends; Robert P. de Vries; John F. Cipollo; Monique H. Verheije;
    Persistent Identifiers
    Publisher: American Society for Microbiology
    Project: NWO | Avian coronaviruses: host... (2300176967), EC | Sugar-Enable (802780)

    Infectious bronchitis virus is the causative agent of infectious bronchitis in chickens. Upon infection of chicken flocks, the poultry industry faces substantial economic losses by diminished egg quality and increased morbidity and mortality of infected animals. While a...

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  • publication . Article . Other literature type . Preprint . 2019
    Open Access
    Authors:
    Landi, Alessia; Mari, Muriel; Kleiser, Svenja; Wolf, Tobias; Gretzmeier, Christine; Wilhelm, Isabel; Kiritsi, Dimitra; Thünauer, Roland; Geiger, Roger; Nyström, Alexander; ...
    Publisher: Life Science Alliance, LLC
    Project: EC | LEC&LIP2INVADE (282105), EC | DRIVE (765912), NWO | A three-dimensional look ... (2300175771), EC | PRONKJEWAIL (713660)

    Lectins are glycan-binding proteins with no catalytic activity and ubiquitously expressed in nature. Numerous bacteria use lectins to efficiently bind to epithelia, thus facilitating tissue colonisation. Wounded skin is one of the preferred niches for Pseudomonas aerugi...

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  • publication . Article . 2019
    Open Access English
    Authors:
    Natacha S. Ogando; Francois Ferron; Francois Ferron; Etienne Decroly; Bruno Canard; Clara C. Posthuma; Eric J. Snijder;
    Publisher: HAL CCSD
    Project: NWO | Viral RNA polymerases: th... (2300162767), EC | ANTIVIRALS (642434)

    International audience; Among RNA viruses, the order Nidovirales stands out for including viruses with the largest RNA genomes currently known. Nidoviruses employ a complex RNA-synthesizing machinery comprising a variety of non-structural proteins (nsps). One of the pos...

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  • publication . Article . 2018
    Open Access English
    Authors:
    Hazel Stewart; Katherine A. Brown; Adam M. Dinan; Nerea Irigoyen; Eric J. Snijder; Andrew E. Firth;
    Publisher: American Society for Microbiology
    Project: NWO | Protein-directed ribosoma... (2300184220), WT | Encyclopedia of RNA Virus... (106207), EC | ERVE (646891)

    Toroviruses infect cattle, goats, pigs, and horses worldwide and can cause gastrointestinal disease. There is no treatment or vaccine, and their ability to spill over into humans has not been assessed. These viruses are related to important human pathogens, including se...

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  • publication . Article . 2018
    Open Access
    Authors:
    C. E. Melia; H. M. van der Schaar; A. W. M. de Jong; H. R. Lyoo; E. J. Snijder; A. J. Koster; F. J. M. van Kuppeveld; M. Bárcena; Mark R. Denison;
    Publisher: American Society for Microbiology
    Project: NWO | Viral redesign of the cel... (2300174141), NWO | Activating the VE-cadheri... (2300161085), EC | ANTIVIRALS (642434), EC | EUVIRNA (264286), NWO | SysVirDrug: Translating S... (2300189186)

    ABSTRACT Picornaviruses induce dramatic rearrangements of endomembranes in the cells that they infect to produce dedicated platforms for viral replication. These structures, termed replication organelles (ROs), have been well characterized for the Enterovirus genus of t...

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  • publication . Article . 2018
    Open Access
    Authors:
    Ederveen, Thomas H. A.; Ferwerda, Gerben; Ahout, Inge M.; Vissers, Marloes; de Groot, Ronald; Boekhorst, Jos; Timmerman, Harro M.; Huynen, Martijn A.; van Hijum, Sacha A. F. T.; de Jonge, Marien I.;
    Project: NWO | XCiDE: Crossing the Combu... (2300153186), EC | PoC-ID (634415)

    Background While almost all infants are infected with respiratory syncytial virus (RSV) before the age of 2 years, only a small percentage develops severe disease. Previous studies suggest that the nasopharyngeal microbiome affects disease development. We therefore stud...

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  • publication . Other literature type . 2018
    Authors:
    Ederveen, Thomas; Ferwerda, Gerben; Ahout, Inge; Vissers, Marloes; Groot, Ronald De; Boekhorst, Jos; Timmerman, Harro; Huynen, Martijn; Hijum, Sacha Van; Jonge, Marien De;
    Publisher: figshare
    Project: NWO | XCiDE: Crossing the Combu... (2300153186), EC | PoC-ID (634415)

    Potential confounding characteristics of this study. Figure S2 RSV disease and viral load in healthy and RSV-infected individuals can be explained by nasopharyngeal microbial makeup (OTU-level). Figure S3 Species richness, but not diversity, is reduced in RSV-infected i...

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  • other research product . Collection . 2018
    Authors:
    Ederveen, Thomas; Ferwerda, Gerben; Ahout, Inge; Vissers, Marloes; Groot, Ronald De; Boekhorst, Jos; Timmerman, Harro; Huynen, Martijn; Hijum, Sacha Van; Jonge, Marien De;
    Publisher: Figshare
    Project: EC | PoC-ID (634415), NWO | XCiDE: Crossing the Combu... (2300153186)

    Abstract Background While almost all infants are infected with respiratory syncytial virus (RSV) before the age of 2 years, only a small percentage develops severe disease. Previous studies suggest that the nasopharyngeal microbiome affects disease development. We there...

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  • publication . Other literature type . 2018
    Authors:
    Ederveen, Thomas; Ferwerda, Gerben; Ahout, Inge; Vissers, Marloes; Groot, Ronald De; Boekhorst, Jos; Timmerman, Harro; Huynen, Martijn; Hijum, Sacha Van; Jonge, Marien De;
    Publisher: figshare
    Project: NWO | XCiDE: Crossing the Combu... (2300153186), EC | PoC-ID (634415)

    Supplementary information on methods. (DOCX 20Â kb)

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15 research outcomes, page 1 of 2