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7 research outcomes, page 1 of 1
  • publication . Article . Other literature type . Preprint . 2019
    Open Access English
    Authors:
    Alessia Landi; Muriel Mari; Tobias Wolf; Svenja Kleiser; Christine Gretzmeier; Isabel Wilhelm; Dimitra Kiritsi; Roland Thuenauer; Roger Geiger; Alexander Nyström; ...
    Publisher: Life Science Alliance LLC
    Project: EC | DRIVE (765912), EC | PRONKJEWAIL (713660), NWO | A three-dimensional look ... (2300175771), EC | LEC&LIP2INVADE (282105)

    Lectins are glycan-binding proteins with no catalytic activity and ubiquitously expressed in nature. Numerous bacteria use lectins to efficiently bind to epithelia, thus facilitating tissue colonisation. Wounded skin is one of the preferred niches for Pseudomonas aerugi...

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  • publication . Article . 2017
    Open Access
    Authors:
    Charlotte E. Melia; Hilde M. van der Schaar; Heyrhyoung Lyoo; Ronald W. A. L. Limpens; Qian Feng; Maryam Wahedi; Gijs J. Overheul; Ronald P. van Rij; Eric J. Snijder; Abraham J. Koster; ...
    Publisher: Elsevier BV
    Project: NWO | The +RNA virus replicatio... (2300150213), EC | ANTIVIRALS (642434), NWO | Viral redesign of the cel... (2300174141), EC | EUVIRNA (264286), NWO | SysVirDrug: Translating S... (2300189186), EC | VIVARNASILENCING (615680)

    Summary Enteroviruses reorganize cellular endomembranes into replication organelles (ROs) for genome replication. Although enterovirus replication depends on phosphatidylinositol 4-kinase type IIIβ (PI4KB), its role, and that of its product, phosphatidylinositol 4-phosp...

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  • other research product . Other ORP type . 2017
    Open Access English
    Authors:
    Cong, Yingying; Verlhac, Pauline; Reggiori, Fulvio;
    Project: NWO | A three-dimensional look ... (2300175771), EC | PRONKJEWAIL (713660), SNSF | ER-phagy mechanisms to ma... (CRSII3_154421)

    Autophagy is a conserved intracellular catabolic pathway that allows cells to maintain homeostasis through the degradation of deleterious components via specialized double-membrane vesicles called autophagosomes. During the past decades, it has been revealed that numero...

  • publication . Article . Other literature type . 2017
    Open Access
    Authors:
    Yingying Cong; Pauline Verlhac; Fulvio Reggiori;
    Project: EC | PRONKJEWAIL (713660), NWO | A three-dimensional look ... (2300175771), SNSF | ER-phagy mechanisms to ma... (CRSII3_154421)

    Autophagy is a conserved intracellular catabolic pathway that allows cells to maintain homeostasis through the degradation of deleterious components via specialized double-membrane vesicles called autophagosomes. During the past decades, it has been revealed that numero...

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  • publication . Article . 2016
    Open Access English
    Authors:
    Mario Mauthe; Martijn A. Langereis; Jennifer Jung; Xingdong Zhou; Alex Jones; Wienand A. Omta; Sharon A. Tooze; Bjoern Stork; Søren R. Paludan; Tero Ahola; ...
    Project: NWO | A three-dimensional look ... (2300175771), SNSF | ER-phagy mechanisms to ma... (CRSII3_154421), EC | XABA (282333), WT , NWO | Viral strategies to evade... (2300180032), NWO | The role of autophagy in ... (2300175628), AKA | Mechanisms in the formati... (265997)

    Autophagy-related (ATG) proteins regulate autophagy, but recent work indicates that some also have autophagy-independent roles. Here, Mauthe et al. perform an unbiased siRNA screen to examine the effects of ATG protein depletion on viral replication and demonstrate auto...

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  • publication . Article . 2016
    Open Access English
    Authors:
    Dennis Flierman; Gerbrand J. van der Heden van Noort; Reggy Ekkebus; Paul P. Geurink; Tycho E. T. Mevissen; Manuela K. Hospenthal; David Komander; Huib Ovaa;
    Publisher: The Authors. Published by Elsevier Ltd.
    Project: NWO | Covalent Enzyme Capture (2300182105), EC | UBSPECIFIC (309756), EC | UBICODE (281699), NWO | Targeting poly-ubiquitin;... (2300185720)

    Deubiquitylating enzymes (DUBs) use multiple ubiquitin-binding pockets to disassemble polyubiquitin chains. Most tools probing DUB specificity target pockets adjacent to the active site. The protease-resistant diUb probes described here monitor linkage specificity of an...

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  • publication . Article . 2015 . Embargo End Date: 25 Sep 2015
    Open Access English
    Authors:
    Cristina M. Dorobantu; Lucian Albulescu; Christian Harak; Qian Feng; Mirjam van Kampen; Jeroen R.P.M. Strating; Alexander E. Gorbalenya; Volker Lohmann; Hilde M. van der Schaar; Frank J. M. van Kuppeveld;
    Publisher: ETH Zurich
    Project: NWO | Viral redesign of the cel... (2300174141), NWO | Greasing the viral life-c... (2300174167), EC | EUVIRNA (264286)

    Author Summary All positive-sense RNA viruses [(+)RNA viruses] replicate their viral genomes in tight association with reorganized membranous structures. Viruses generate these unique structures, often termed “replication organelles” (ROs), by efficiently manipulating t...

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7 research outcomes, page 1 of 1