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  • Authors: Caliendo, Giuditta; Battaglia, Elena;

    Le corpus UK-EU-DEBATE-20-21 a été recueilli dans le cadre du projet de recherche OLiNDiNUM (Observatoire LINguistique du DIscours NUMérique) et fait partie d'un réseau partagé de resources (cf. Corpus MIGR-TWIT sur Ortolang).Le corpus a été selectionné en vue d’examiner le débat médiatique post-Brexit entre le Royaume-Uni et l’Union européenne sur la campagne de vaccination COVID-19. Les données ont été récupérées via l’Application Programming Interface (API) du site du réseau Twitter en utilisant les comptes des principaux acteurs politiques du gouvernement britannique et des institutions de l’Ue sur une période de 14 mois (1er février 2020-31 mars 2021). https://hdl.handle.net/11403/uk-eu-debate-20-21/v2

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  • Authors: Chambon, Marion; Herrscher, Charline; Al Halabi, Dana; François, Nathan; +9 Authors

    Induced by the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the COVID-19 pandemic underlined the clear need for antivirals against coronaviruses. In an effort to identify new inhibitors of SARS-CoV-2, a screening of 824 extracts prepared from various parts of 400 plant species belonging to the Rutaceae and Annonaceae families was conducted using a cell-based HCoV-229E inhibition assay. Due to its significant activity, the ethyl acetate extract of the leaves of Clausena harmandiana was selected for further chemical and biological investigations. Mass spectrometry-guided fractionation afforded three undescribed phenolic lipids (1–3), whose structures were determined via spectroscopic analysis. The absolute configurations of 1 and 2 were determined by analyzing Mosher ester derivatives. The antiviral activity against SARS-CoV-2 was subsequently shown, with IC50 values of 0.20 and 0.05 µM for 2 and 3, respectively. The mechanism of action was further assessed, showing that both 2 and 3 are inhibitors of coronavirus entry by acting directly on the viral particle. Phenolic lipids from Clausena harmandiana might be a source of new antiviral agents against human coronaviruses.

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Evariste, Thomas; Frétigny, Jean-Baptiste; Fuzier, Anne; Gay, Christophe; +2 Authors

    La pandémie de Covid-19 est venue bousculer les mobilités sur fond d’exacerbation du changement climatique. Les adaptations observées durant la crise sanitaire seront-elles pérennes ? Métropolitiques et le Forum Vies Mobiles ouvrent un dossier commun pour éclairer les mutations de nos mobilités. Voir aussi : https://forumviesmobiles.org/recherches/15723/dossier-les-mobilites-post-covid-un-monde-dapres-plus-ecologique

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ HAL CY Cergy Paris U...arrow_drop_down
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  • Authors: Levratto, Nadine; Poinsot, Philippe;
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    Authors: Lahet, Delphine;

    International audience

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  • Authors: Blomberg, Niklas; Willems, Marieke; Martin, Corinne S.; Smith, Andy; +7 Authors

    As seen during the COVID-19 pandemic, and other infectious disease outbreaks, researchers, health care professionals and "citizens (in terms of consent to share)" need to store, document, share, access, analyse, link and process research and clinical data across disciplines and national borders in a coordinated response. Like other infectious disease outbreaks, such as haemorrhagic fevers (e.g. cholera), COVID-19 will remain a societal challenge beyond the immediate outbreak, considering its destructive and disruptive impact on healthcare systems and the global economy. In addition to SARS-CoV-2, the pathogen at the source of COVID-19, the risk from other emerging pathogens also persists, which will require similar concerted action to identify and characterise infections with pandemic potential, and enable rapid public health action to mitigate health and societal impacts. Provision of comprehensive open data on infectious agents and related diseases during outbreaks supports evidence-based decision-making across scientific, medical, public health and policy domains and promotes reproducibility of research outcomes. European readiness for future pandemics is of utmost importance, and whilst preparedness for such eventualities requires provisions for e.g. rapid vaccine production and public procurement for personal protective equipment - far outside the scope of BY-COVID - the ‘open data’ aspects is a key component that should be addressed to ensure the preparedness of infrastructure as part of existing frameworks such as the European Open Science Cloud (EOSC). Contributing to enhance data sharing and utility for streamlined local to global public health decision-making and action, as defined by the World Health Organisation (WHO) as a key objective in the Global genomic surveillance strategy. In pandemic times, the mobilisation of raw viral sequences and the identification and monitoring the spread of SARS-CoV-2 variants is particularly important. The BeYond-COVID (BY-COVID) project was funded by the European Union under the call “FAIR and open data sharing in support to European preparedness for COVID-19 and other infectious diseases” (HORIZON-INFRA-2021-EMERGENCY-01) and will run until 2024, to make COVID-19 data accessible to research scientists and others such as medical staff in hospitals or government officials. The world has generated vast amounts of data in response to the COVID-19 pandemic, and is still generating more. This data comes from many different sources, and identifying, connecting and integrating it for effective analysis is challenging on many fronts. This Policy Brief presents preliminary results from the BY-COVID project as part of its comprehensive, sustainable and evidence-informed plan to effectively promote and improve FAIR (Findability, Accessibility, Interoperability, and Reusability) and open data sharing in support for European preparedness for COVID-19 and other infectious diseases. The Brief also places the project and its results in the context of the upcoming EOSC Partnership, the development of the European Health Data Space (EHDS) and the European Health Emergency Preparedness and Response Authority (HERA).Policy paper in brief Authors: Niklas Blomberg (ELIXIR) ORCID: 0000-0003-4155-5910, Marieke Willems (ELIXIR) ORCID: 0000-0001-9664-6225, Corinne S. Martin (ELIXIR) ORCID: 0000-0002-5428-2766, Andy Smith (ELIXIR) ORCID: 0000-0002-6025-9271, Elaine Harrison (ELIXIR) ORCID: 0000-0003-1149-2242, Carazo, Jose-Maria (CNB-CSIC) ORCID: 0000-0003-0788-8447, Enrique Bernal-Delgado (IACS) ORCID: 0000-0002-0961-3298, Iris van Dam (ScienSano) ORCID: 0000-0002-3965-6184, Romain David (ERINHA) ORCID: 0000-0003-4073-7456, Patricia M. Palagi (SIB) ORCID: 0000-0001-9062-6303, Martina Draščić Capar (CESSDA) ORCID: 0000-0001-8848-3008

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  • Authors: Bouzouina, Louafi; Kourtit, Karima; Nijkamp, Peter;

    This special issue of Regional Science Policy & Practice (RSPP), entitled ‘Pandemics, People, and Places’ consists of 13 articles dealing with the consequences and causes of COVID-19, as well as the evaluation of the pandemic response in different parts of the world.

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  • Authors: Rozée, Virginie; Schantz, Clémence;
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  • Authors: Simard, David; Fischer, Frédéric; Besançon, Lonni; Rochoy, Michaël; +4 Authors

    À l’automne 2022, une épidémie de bronchiolite précoce et d’une ampleur inhabituelle a touché la France et d’autres pays de l’hémisphère nord, comme le Canada ou les États-Unis. Diverses explications ont été proposées pour rendre compte de ce phénomène exceptionnel.Une théorie a été avancée en particulier : celle de la « dette immunitaire ». Dans sa version initiale, elle a été présentée par ses auteurs comme la conséquence d’un « défaut de stimulation » du système immunitaire, en l’absence d’agents pathogènes. Trop protégé et « inactif », notre système immunitaire « s’affaiblirait », à la manière d’un muscle non sollicité. Dans le cas présent, un tel état serait la conséquence des mesures sanitaires (masques, distanciation, confinement, etc.) mises en œuvre en 2020 et 2021.Mais cette théorie, séduisante par sa simplicité, achoppe sur plusieurs incohérences. Explications.

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Coriat, Benjamin; Orsi, Fabienne; Alessandrini, Jean, François; Boulet, Pascale; +1 Authors

    During the Covid 19 Pandemic, there have been countless calls for the creation of “global public goods” or “global commons” issued by a variety of actors with sometimes diametrically opposed views, as if the two notions had the same meaning.And indeed, even today these notions are still often used as synonyms and interchangeable, leading to an amalgamation of concepts. The meaning and implications of using one notion or other notion (global public good, global commons) is never examined.We believe that, contrary to the dominant view, it is urgent to put an end to this confusion which is not only of a semantic order and has huge economic and social implications.In this article, we start by recalling what constitutes the notion of “Global Public Good” and by extension the content of what can be called the GPG approach (section 1). Then, by difference we present the notion of common good and the commons based approach (section 2). Finally, in a concluding section, we present some of the most significant initiatives taken during the covid-19 pandemic, designed and deployed to producing and distributing health products as common goods (section 3). Our overall ambition being to highlight that the deployment of the commons based approach that we are calling for, is not a utopia, as it is already moving on.

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ HAL AMU; Mémoires en...arrow_drop_down
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  • Authors: Caliendo, Giuditta; Battaglia, Elena;

    Le corpus UK-EU-DEBATE-20-21 a été recueilli dans le cadre du projet de recherche OLiNDiNUM (Observatoire LINguistique du DIscours NUMérique) et fait partie d'un réseau partagé de resources (cf. Corpus MIGR-TWIT sur Ortolang).Le corpus a été selectionné en vue d’examiner le débat médiatique post-Brexit entre le Royaume-Uni et l’Union européenne sur la campagne de vaccination COVID-19. Les données ont été récupérées via l’Application Programming Interface (API) du site du réseau Twitter en utilisant les comptes des principaux acteurs politiques du gouvernement britannique et des institutions de l’Ue sur une période de 14 mois (1er février 2020-31 mars 2021). https://hdl.handle.net/11403/uk-eu-debate-20-21/v2

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  • Authors: Chambon, Marion; Herrscher, Charline; Al Halabi, Dana; François, Nathan; +9 Authors

    Induced by the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the COVID-19 pandemic underlined the clear need for antivirals against coronaviruses. In an effort to identify new inhibitors of SARS-CoV-2, a screening of 824 extracts prepared from various parts of 400 plant species belonging to the Rutaceae and Annonaceae families was conducted using a cell-based HCoV-229E inhibition assay. Due to its significant activity, the ethyl acetate extract of the leaves of Clausena harmandiana was selected for further chemical and biological investigations. Mass spectrometry-guided fractionation afforded three undescribed phenolic lipids (1–3), whose structures were determined via spectroscopic analysis. The absolute configurations of 1 and 2 were determined by analyzing Mosher ester derivatives. The antiviral activity against SARS-CoV-2 was subsequently shown, with IC50 values of 0.20 and 0.05 µM for 2 and 3, respectively. The mechanism of action was further assessed, showing that both 2 and 3 are inhibitors of coronavirus entry by acting directly on the viral particle. Phenolic lipids from Clausena harmandiana might be a source of new antiviral agents against human coronaviruses.

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Evariste, Thomas; Frétigny, Jean-Baptiste; Fuzier, Anne; Gay, Christophe; +2 Authors

    La pandémie de Covid-19 est venue bousculer les mobilités sur fond d’exacerbation du changement climatique. Les adaptations observées durant la crise sanitaire seront-elles pérennes ? Métropolitiques et le Forum Vies Mobiles ouvrent un dossier commun pour éclairer les mutations de nos mobilités. Voir aussi : https://forumviesmobiles.org/recherches/15723/dossier-les-mobilites-post-covid-un-monde-dapres-plus-ecologique

    image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ HAL CY Cergy Paris U...arrow_drop_down
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  • Authors: Levratto, Nadine; Poinsot, Philippe;
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    Authors: Lahet, Delphine;

    International audience

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  • Authors: Blomberg, Niklas; Willems, Marieke; Martin, Corinne S.; Smith, Andy; +7 Authors

    As seen during the COVID-19 pandemic, and other infectious disease outbreaks, researchers, health care professionals and "citizens (in terms of consent to share)" need to store, document, share, access, analyse, link and process research and clinical data across disciplines and national borders in a coordinated response. Like other infectious disease outbreaks, such as haemorrhagic fevers (e.g. cholera), COVID-19 will remain a societal challenge beyond the immediate outbreak, considering its destructive and disruptive impact on healthcare systems and the global economy. In addition to SARS-CoV-2, the pathogen at the source of COVID-19, the risk from other emerging pathogens also persists, which will require similar concerted action to identify and characterise infections with pandemic potential, and enable rapid public health action to mitigate health and societal impacts. Provision of comprehensive open data on infectious agents and related diseases during outbreaks supports evidence-based decision-making across scientific, medical, public health and policy domains and promotes reproducibility of research outcomes. European readiness for future pandemics is of utmost importance, and whilst preparedness for such eventualities requires provisions for e.g. rapid vaccine production and public procurement for personal protective equipment - far outside the scope of BY-COVID - the ‘open data’ aspects is a key component that should be addressed to ensure the preparedness of infrastructure as part of existing frameworks such as the European Open Science Cloud (EOSC). Contributing to enhance data sharing and utility for streamlined local to global public health decision-making and action, as defined by the World Health Organisation (WHO) as a key objective in the Global genomic surveillance strategy. In pandemic times, the mobilisation of raw viral sequences and the identification and monitoring the spread of SARS-CoV-2 variants is particularly important. The BeYond-COVID (BY-COVID) project was funded by the European Union under the call “FAIR and open data sharing in support to European preparedness for COVID-19 and other infectious diseases” (HORIZON-INFRA-2021-EMERGENCY-01) and will run until 2024, to make COVID-19 data accessible to research scientists and others such as medical staff in hospitals or government officials. The world has generated vast amounts of data in response to the COVID-19 pandemic, and is still generating more. This data comes from many different sources, and identifying, connecting and integrating it for effective analysis is challenging on many fronts. This Policy Brief presents preliminary results from the BY-COVID project as part of its comprehensive, sustainable and evidence-informed plan to effectively promote and improve FAIR (Findability, Accessibility, Interoperability, and Reusability) and open data sharing in support for European preparedness for COVID-19 and other infectious diseases. The Brief also places the project and its results in the context of the upcoming EOSC Partnership, the development of the European Health Data Space (EHDS) and the European Health Emergency Preparedness and Response Authority (HERA).Policy paper in brief Authors: Niklas Blomberg (ELIXIR) ORCID: 0000-0003-4155-5910, Marieke Willems (ELIXIR) ORCID: 0000-0001-9664-6225, Corinne S. Martin (ELIXIR) ORCID: 0000-0002-5428-2766, Andy Smith (ELIXIR) ORCID: 0000-0002-6025-9271, Elaine Harrison (ELIXIR) ORCID: 0000-0003-1149-2242, Carazo, Jose-Maria (CNB-CSIC) ORCID: 0000-0003-0788-8447, Enrique Bernal-Delgado (IACS) ORCID: 0000-0002-0961-3298, Iris van Dam (ScienSano) ORCID: 0000-0002-3965-6184, Romain David (ERINHA) ORCID: 0000-0003-4073-7456, Patricia M. Palagi (SIB) ORCID: 0000-0001-9062-6303, Martina Draščić Capar (CESSDA) ORCID: 0000-0001-8848-3008

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  • Authors: Bouzouina, Louafi; Kourtit, Karima; Nijkamp, Peter;

    This special issue of Regional Science Policy & Practice (RSPP), entitled ‘Pandemics, People, and Places’ consists of 13 articles dealing with the consequences and causes of COVID-19, as well as the evaluation of the pandemic response in different parts of the world.

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  • Authors: Rozée, Virginie; Schantz, Clémence;
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  • Authors: Simard, David; Fischer, Frédéric; Besançon, Lonni; Rochoy, Michaël; +4 Authors

    À l’automne 2022, une épidémie de bronchiolite précoce et d’une ampleur inhabituelle a touché la France et d’autres pays de l’hémisphère nord, comme le Canada ou les États-Unis. Diverses explications ont été proposées pour rendre compte de ce phénomène exceptionnel.Une théorie a été avancée en particulier : celle de la « dette immunitaire ». Dans sa version initiale, elle a été présentée par ses auteurs comme la conséquence d’un « défaut de stimulation » du système immunitaire, en l’absence d’agents pathogènes. Trop protégé et « inactif », notre système immunitaire « s’affaiblirait », à la manière d’un muscle non sollicité. Dans le cas présent, un tel état serait la conséquence des mesures sanitaires (masques, distanciation, confinement, etc.) mises en œuvre en 2020 et 2021.Mais cette théorie, séduisante par sa simplicité, achoppe sur plusieurs incohérences. Explications.

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  • image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
    Authors: Coriat, Benjamin; Orsi, Fabienne; Alessandrini, Jean, François; Boulet, Pascale; +1 Authors

    During the Covid 19 Pandemic, there have been countless calls for the creation of “global public goods” or “global commons” issued by a variety of actors with sometimes diametrically opposed views, as if the two notions had the same meaning.And indeed, even today these notions are still often used as synonyms and interchangeable, leading to an amalgamation of concepts. The meaning and implications of using one notion or other notion (global public good, global commons) is never examined.We believe that, contrary to the dominant view, it is urgent to put an end to this confusion which is not only of a semantic order and has huge economic and social implications.In this article, we start by recalling what constitutes the notion of “Global Public Good” and by extension the content of what can be called the GPG approach (section 1). Then, by difference we present the notion of common good and the commons based approach (section 2). Finally, in a concluding section, we present some of the most significant initiatives taken during the covid-19 pandemic, designed and deployed to producing and distributing health products as common goods (section 3). Our overall ambition being to highlight that the deployment of the commons based approach that we are calling for, is not a utopia, as it is already moving on.

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      image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/ HAL AMU; Mémoires en...arrow_drop_down
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