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description Publicationkeyboard_double_arrow_right Article 2023 FrancePublisher:Elsevier BV Rishma Amarsy; Sandra Fournier; David Trystram; Catherine Monteil; Xavier Raynaud; Vincent Jarlier; Jérôme Robert; Guillaume Arlet; LaurenceArmand Lefevre; Alexandra Aubry; Laurent Belec; Béatrice Bercot; Stéphane Bonacorsi; Vincent Calvez; Emmanuelle Cambau; Etienne Carbonnelle; Stéphane Chevaliez; Jean-Winoc Decousser; Constance Delaugerre; Diane Descamps; Florence Doucet-Populaire; Jean-Louis Gaillard; Antoine Garbarg-Chenon; Elyanne Gault; Jean-Louis Herrmann; Vincent Jarlier; Jérôme Le Goff; Jean-Christophe Lucet; Jean-Luc Mainardi; Anne-Geneviève Marcellin; Laurence Morand-Joubert; Xavier Nassif; Jean-Michel Pawlotsky; Jérôme Robert; Anne-Marie Roque Afonso; Martin Rottman; Christine Rouzioux; Flore Rozenberg; François Simon; Nicolas Veziris; David Skurnik; Jean-Ralph Zahar; Guilene Barnaud; Typhaine Billard Pomares; Gaëlle Cuzon; Dominique Decré; Alexandra Doloy; Jean-Luc Donay; Laurence Drieux-Rouzet; Isabelle Durand; Agnès Ferroni; Vincent Fihman; Nicolas Fortineau; Camille Gomart; Nathalie Grall; Christelle Guillet Caruba; Françoise Jaureguy; Valérie Lalande; Luce Landraud; Véronique Leflon; Patricia Mariani; Liliana Mihaila; Didier Moissenet; Latifa Noussair; Isabelle Podglajen; Isabelle Poilane; Hélène Poupet; Emilie Rondinaud; Valérie Sivadon Tardy; David Trystram; Charlotte Verdet; Emmanuelle Vigier; Sophie Vimont Billarant;The impact of the COVID-19 pandemic on bloodstream infections (BSIs) due to Streptococcus pneumoniae and Streptococcus pyogenes was assessed in 25 university hospitals of Paris. Monthly BSIs incidence rates that appeared stable in 2018 and 2019, decreased for the 2 pathogens during the 2 COVID-19 lockdown periods of 2020. Containment policies, including social distancing, masking and hand hygiene strengthening in both community and hospital settings are likely to reduce BSIs due to these pathogens.
American Journal of ... arrow_drop_down American Journal of Infection ControlArticle . 2023 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert American Journal of ... arrow_drop_down American Journal of Infection ControlArticle . 2023 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.ajic.2022.09.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 FrancePublisher:Elsevier BV Funded by:EC | CAREEC| CARELévy, Yves; Wiedemann, Aurélie; Hejblum, Boris P.; Durand, Mélany; Lefebvre, Cécile; Surénaud, Mathieu; Lacabaratz, Christine; Perreau, Matthieu; Foucat, Emile; Déchenaud, Marie; Tisserand, Pascaline; Blengio, Fabiola; Hivert, Benjamin; Gauthier, Marine; Cervantes-Gonzalez, Minerva; Bachelet, Delphine; Laouénan, Cédric; Bouadma, Lila; Timsit, Jean-François; Yazdanpanah, Yazdan; Pantaleo, Giuseppe; Hocini, Hakim; Thiébaut, Rodolphe;The identification of patients with coronavirus disease 2019 and high risk of severe disease is a challenge in routine care. We performed cell phenotypic, serum, and RNA sequencing gene expression analyses in severe hospitalized patients (n = 61). Relative to healthy donors, results showed abnormalities of 27 cell populations and an elevation of 42 cytokines, neutrophil chemo-attractants, and inflammatory components in patients. Supervised and unsupervised analyses revealed a high abundance of CD177, a specific neutrophil activation marker, contributing to the clustering of severe patients. Gene abundance correlated with high serum levels of CD177 in severe patients. Higher levels were confirmed in a second cohort and in intensive care unit (ICU) than non-ICU patients (P < 0.001). Longitudinal measurements discriminated between patients with the worst prognosis, leading to death, and those who recovered (P = 0.01). These results highlight neutrophil activation as a hallmark of severe disease and CD177 assessment as a reliable prognostic marker for routine care. Immunology; Virology Graphical abstract
iScience arrow_drop_down iScienceArticle . 2021Full-Text: http://europepmc.org/articles/PMC8189740Data sources: PubMed CentralINRIA a CCSD electronic archive server; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2021License: CC BY NCHAL - UPEC / UPEM; HAL-Inserm; Hal-DiderotArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 19 citations 19 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert iScience arrow_drop_down iScienceArticle . 2021Full-Text: http://europepmc.org/articles/PMC8189740Data sources: PubMed CentralINRIA a CCSD electronic archive server; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2021License: CC BY NCHAL - UPEC / UPEM; HAL-Inserm; Hal-DiderotArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.isci.2022.105715&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 FrancePublisher:Elsevier BV Berger, Bastien; Hazzan, Marc; Kamar, Nassim; Francois, Hélène; Matignon, Marie; Greze, Clarisse; Gatault, Philippe; Frimat, Luc; Westeel, Pierre; Goutaudier, Valentin; Snanoudj, Renaud; Colosio, Charlotte; Sicard, Antoine; Bertrand, Dominique; Mousson, Christiane; Bamoulid, Jamal; Malvezzi, Paolo; Thierry, Antoine; Anglicheau, Dany; Couzi, Lionel; Chemouny, Jonathan; Duveau, Agnes; Moal, Valerie; Le Meur, Yannick; Blancho, Gilles; Tourret, Jérôme; Mariat, Christophe; Rerolle, Jean-Philippe; Bouvier, Nicolas; Caillard, Sophie; Thaunat, Olivier;Introduction - SARS-CoV-2 pandemic evolved in 2 consecutive waves during 2020. Improvements in the management of COVID-19 led to a reduction in mortality rates among hospitalized patients during the second wave. Whether this progress benefited kidney transplant recipients (KTRs), a population particularly vulnerable to severe COVID-19, remained unclear. Methods - In France, 957 KTRs were hospitalized for COVID-19 in 2020 and their data were prospectively collected into the French Solid Organ Transplant (SOT) COVID registry. The presentation, management, and outcomes of the 359 KTRs diagnosed during the first wave were compared to those of the 598 of the second wave. Results - Baseline comorbidities were similar between KTRs of the 2 waves. Maintenance immunosuppression was reduced in most patients but withdrawal of antimetabolite (73.7% vs. 58.4%, < 0.001) or calcineurin inhibitor (32.1% vs. 16.6%, < 0.001) was less frequent during the second wave. Hydroxychloroquine and azithromycin that were commonly used during the first wave (21.7% and 30.9%, respectively) but were almost abandoned during the second wave. In contrast, the use of high dose corticosteroids doubled (19.5% vs. 41.6%, < 0.001). Despite these changing trends in COVID-19 management, 60-day mortality was not statistically different between the 2 waves (25.3% vs. 23.9%; Log Rank, = 0.48) and COVID-19 hospitalization period was not associated with death due to COVID-19 in multivariate analysis (Hazard ratio 0.89, 95% confidence interval 0.67-1.17, = 0.4). Conclusion - We conclude that changing of therapeutic trends during 2020 did not reduce COVID-19 related mortality among KTRs. Our data indirectly support the importance of vaccination and neutralizing monoclonal anti-SARS-CoV-2 antibodies to protect KTRS from severe COVID-19. International audience
Kidney International... arrow_drop_down Kidney International ReportsArticle . 2022 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefHAL-Rennes 1; HAL-ENS-LYON; HAL - Université de Lille; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BY NC NDHAL-Rennes 1; HAL - UPEC / UPEM; HAL-ENS-LYONArticle . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 2 citations 2 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Kidney International... arrow_drop_down Kidney International ReportsArticle . 2022 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefHAL-Rennes 1; HAL-ENS-LYON; HAL - Université de Lille; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BY NC NDHAL-Rennes 1; HAL - UPEC / UPEM; HAL-ENS-LYONArticle . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint 2022 France EnglishPublisher:HAL CCSD Authors: Kloeckner, Benoît; Tolle, Pierrick;Kloeckner, Benoît; Tolle, Pierrick;HAL-ENS-LYON; Mémoir... arrow_drop_down All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od______3393::0c2bc862a654ac3931ebfa014d78dde2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert HAL-ENS-LYON; Mémoir... arrow_drop_down All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od______3393::0c2bc862a654ac3931ebfa014d78dde2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2022 FrancePublisher:Informa UK Limited Raffaele Brustia; Giuliana Amaddeo; Rami Rhaiem; Eric Levesque; Antoine Monsel; Vanessa Baaroun; Mylène Dimmock; Marc-Antoine Rousseau; Oriane Wagner-Ballon; Francoise Botterel; Pascal Andujar; Daniele Sommacale;International audience; Background: The SARS-CoV-2 (COVID-19) pandemic required a rapid surge of healthcare capacity to face a growing number of critically ill patients. For this reason, a support reserve of physicians, including surgeons, were required to be reassigned to offer support.Objective: To realize a survey on the educational programs deployed (face-to-face or e-learning focusing on infective area, basic gestures, COVID clinical management and intensive care medicine), and their impact on behavior change (Kirkpatrick 3) of the target population of surgeons, measured on a five modalities Likert scale.Design: Cross-sectional online e-survey (NCT04732858) within surgeons from the Assistance Publique - Hôpitaux de Paris network, metropolitan area of Paris, France.Results: Cross-sectional e-Survey: among 382 surgeons invited, 37 (9.7%) participated. The effectiveness of the educational interventions on behavior changes was rated within the highest region of the Likert scale by 15% (n = 3) and 22% (n = 6) for 'e-learning' and 'face-to-face' delivery modes, respectively.Conclusions: Despite the low response rate, this survey suggests an overall low impact on behaviour change among responders affiliated to a surgical discipline.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/00015458.2022.2145720&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/00015458.2022.2145720&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 France, BelgiumPublisher:Rockefeller University Press Funded by:EC | EVAg, NIH | Monogenic basis of resist..., EC | EASI-Genomics +4 projectsEC| EVAg ,NIH| Monogenic basis of resistance to SARS-CoV2 and predisposition to severe COVID-19 ,EC| EASI-Genomics ,EC| MORE2ADA2 ,NIH| Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success ,ANR| COVIFERON ,NIH| Inborn errors of immunity in patients with life-threatening COVID-19Aurélien Sokal; Paul Bastard; Pascal Chappert; Giovanna Barba-Spaeth; Slim Fourati; Alexis Vanderberghe; Pauline Lagouge-Roussey; Isabelle Meyts; Adrian Gervais; Magali Bouvier-Alias; Imane Azzaoui; Ignacio Fernández; Andréa de la Selle; Qian Zhang; Lucy Bizien; Isabelle Pellier; Agnès Linglart; Anya Rothenbuhler; Estelle Marcoux; Raphael Anxionnat; Nathalie Cheikh; Juliane Léger; Blanca Amador-Borrero; Fanny Fouyssac; Vanessa Menut; Jean-Christophe Goffard; Caroline Storey; Caroline Demily; Coralie Mallebranche; Jesus Troya; Aurora Pujol; Marie Zins; Pierre Tiberghien; Paul E. Gray; Peter McNaughton; Anna Sullivan; Jane Peake; Romain Levy; Laetitia Languille; Carlos Rodiguez-Gallego; Bertrand Boisson; Sébastien Gallien; Bénédicte Neven; Marc Michel; Bertrand Godeau; Laurent Abel; Felix A. Rey; Jean-Claude Weill; Claude-Agnès Reynaud; Stuart G. Tangye; Jean-Laurent Casanova; Matthieu Mahévas;doi: 10.1084/jem.20220258
pmid: 36342455
Inborn and acquired deficits of type I interferon (IFN) immunity predispose to life-threatening COVID-19 pneumonia. We longitudinally profiled the B cell response to mRNA vaccination in SARS-CoV-2 naive patients with inherited TLR7, IRF7, or IFNAR1 deficiency, as well as young patients with autoantibodies neutralizing type I IFNs due to autoimmune polyendocrine syndrome type-1 (APS-1) and older individuals with age-associated autoantibodies to type I IFNs. The receptor-binding domain spike protein (RBD)-specific memory B cell response in all patients was quantitatively and qualitatively similar to healthy donors. Sustained germinal center responses led to accumulation of somatic hypermutations in immunoglobulin heavy chain genes. The amplitude and duration of, and viral neutralization by, RBD-specific IgG serological response were also largely unaffected by TLR7, IRF7, or IFNAR1 deficiencies up to 7 mo after vaccination in all patients. These results suggest that induction of type I IFN is not required for efficient generation of a humoral response against SARS-CoV-2 by mRNA vaccines. ispartof: JOURNAL OF EXPERIMENTAL MEDICINE vol:220 issue:1 ispartof: location:United States status: published
The Journal of Exper... arrow_drop_down HAL Descartes; HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2023License: CC BY NC SAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1084/jem.20220258&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 15 citations 15 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert The Journal of Exper... arrow_drop_down HAL Descartes; HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2023License: CC BY NC SAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1084/jem.20220258&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Conference object 2022 France FrenchPublisher:HAL CCSD Delaplace, Manon; Huet, Hélène; Adèle, Gambino; Allee, Chantal; Brown, Paul; Ahmed-Belkacem, Abdelhakim; Le Poder, Sophie;AMI transversalité CycloCov; National audience
Mémoires en Sciences... arrow_drop_down Mémoires en Sciences de l'Information et de la CommunicationConference object . 2022All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______212::576fc99dd1b1994c22780c224766a024&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Mémoires en Sciences... arrow_drop_down Mémoires en Sciences de l'Information et de la CommunicationConference object . 2022All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______212::576fc99dd1b1994c22780c224766a024&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 France EnglishPublisher:HAL CCSD Loubet, Paul; Wittkop, Linda; Ninove, Laetitia; Chalouni, Mathieu; Barrou, Benoit; Blay, Jean-Yves; Hourmant, Maryvonne; Thouvenot, Eric; Laville, Martine; Laviolle, Bruno; Lelievre, Jean-Daniel; Morel, Jacques; Quoc, Stéphanie Nguyen; Spano, Jean-Philippe; Terrier, Benjamin; Thiebaut, Anne; Viallard, Jean-Francois; Vrtovsnik, François; Circosta, Sophie; Esterle, Laure; Levier, Axel; Vanhems, Philippe; Tartour, Eric; Parfait, Beatrice; de Lamballerie, Xavier; Launay, Odile;Objectives - We aimed to investigate the 1-month humoral response to two or three doses of a messenger RNA coronavirus disease 2019 (COVID-19) vaccine as a primary vaccination regimen in specific populations compared with that in healthy adults. Methods - Agence Nationale Recherche contre le Sida (ANRS)0001S-COV-POPART (NCT04824651) is a French nation-wide, multi-centre, prospective, observational cohort study assessing the immune response to COVID-19 vaccines routinely administered to 11 sub-groups of patients with chronic conditions and two control groups. Patients and controls who received at least two vaccine doses and whose results 1 month after the second dose were available were included. The humoral response was assessed 1 month after the first, second and third doses (if applicable) based on the percentage of responders (positive for anti-Spike severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2] IgG antibodies), geometric means of anti-Spike SARS-CoV-2 IgG antibodies (enzyme-linked immunosorbent assay) and proportion of participants with anti-SARS-CoV-2-specific neutralizing antibodies (in vitro neutralization assay for the original SARS-CoV-2 strain). All analyses were centralized. Results - We included 4091 participants in this analysis: 2979 participants from specific sub-populations and 1112 controls. Only 522 (17.5%) participants from the specific populations received three doses as a primary vaccination regimen. Patients living with human immunodeficiency virus, cancer and diabetes had high percentages of responders after two doses, whereas patients with solid organ transplants, allogeneic hematopoietic stem cell transplants and hypogammaglobulinaemia had the lowest percentage of responders (35.9% [95% CI, 29.2-43.0], 57.4% [95% CI, 48.1-66.3] and 77.1% [95% CI, 65.6-86.3], respectively). In those who received the third dose, the percentage of responders reached 54.2% (95% CI, 42.9-65.2) (vs. 32.3% [95% CI, 16.7-51.4] after 2 doses) among those with solid organ transplants and 73.9% (95% CI, 58.9-85.7) (vs. 56.1% [95% CI, 46.2-65.7] after 2 doses) among those with hematopoietic stem cell transplants. Similar results were found with anti-SARS-CoV-2-specific neutralizing antibodies. Conclusions - A lower humoral response to COVID-19 vaccines was observed in the specific populations compared with that in the controls. The third dose of this vaccine in the primary regimen had a positive effect on the percentages of patients who developed anti-Spike IgG antibodies and specific neutralizing antibodies. International audience
HAL-Rennes 1; HAL-In... arrow_drop_down All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od______4325::642934251711e113b71941bacb041f1c&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert HAL-Rennes 1; HAL-In... arrow_drop_down All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od______4325::642934251711e113b71941bacb041f1c&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 FrancePublisher:Elsevier BV Funded by:EC | EVAgEC| EVAgAuthors: Laplantine, Emmanuel; Chable-Bessia, Christine; Oudin, Anne; Swain, Jitendryia; +17 AuthorsLaplantine, Emmanuel; Chable-Bessia, Christine; Oudin, Anne; Swain, Jitendryia; Soria, Adèle; Merida, Peggy; Gourdelier, Manon; Mestiri, Sarra; Besseghe, Indira; Bremaud, Erwan; Neyret, Aymeric; Lyonnais, Sebastien; Favard, Cyril; Benaroch, Philippe; Hubert, Mathieu; Schwartz, Olivier; Guerin, Maryse; Danckaert, Anne; del Nery, Elaine; Muriaux, Delphine; Weil, Robert;Patients with severe COVID-19 show an altered immune response that fails to control the viral spread and suffer from exacerbated inflammatory response, which eventually can lead to death. A major challenge is to develop an effective treatment for COVID-19. NF-κB is a major player in innate immunity and inflammatory process. By a high-throughput screening approach, we identified FDA-approved compounds that inhibit the NF-κB pathway and thus dampen inflammation. Among these, we show that Auranofin prevents post-translational modifications of NF-κB effectors and their recruitment into activating complexes in response to SARS-CoV-2 infection or cytokine stimulation. In addition, we demonstrate that Auranofin counteracts several steps of SARS-CoV-2 infection. First, it inhibits a raft-dependent endocytic pathway involved in SARS-CoV-2 entry into host cells; Second, Auranofin alters the ACE2 mobility at the plasma membrane. Overall, Auranofin should prevent SARS-CoV-2 infection and inflammatory damages, offering new opportunities as a repurposable drug candidate to treat COVID-19. International audience
iScience arrow_drop_down HAL-Pasteur; HAL-Inserm; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BYFull-Text: https://hal.science/hal-03827370/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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For further information contact us at helpdesk@openaire.euAccess Routesgold 7 citations 7 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert iScience arrow_drop_down HAL-Pasteur; HAL-Inserm; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BYFull-Text: https://hal.science/hal-03827370/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.isci.2022.105066&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 FrancePublisher:Elsevier BV Ming Liu; Zhongzheng Liu; Feng Chu; Alexandre Dolgui; Chengbin Chu; Feifeng Zheng;The outbreak of extraordinary disruptive events, e.g., the COVID-19 pandemic, has greatly impacted the orderly operation in global supply chains (SCs), and may lead to the SC breakdown. Regulatory actions, such as government interventions during the pandemic, can greatly mitigate the disruption propagation (i.e., the ripple effect) and improve SC viability. However, existing works that focus on the disruption propagation management have not considered the possibility of such interventions. Motivated by the fact, in this study, we investigate a new disruption propagation management problem in a multi-echelon SC with limited intervention budget. The aim is to minimize disruption risk measured by the disrupted probability of target participants in the SC. For the problem, a novel approach, combining the Causal Bayesian Network (CBN), the do-calculus and the mathematical programming, is developed. Specially, two mixed-integer non-linear programming models are constructed to determine appropriate interventions. To enhance the proposed mathematical models, two valid inequalities are proposed. Then, a problem-specific genetic algorithm (GA) is developed for handling large-scale problem instances. Numerical experiments on a case study and randomly generated instances are conducted to evaluate the efficiency of the proposed models, the valid inequalities and the GA. Based on experiment analysis, managerial insights are drawn. International audience
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.omega.2022.102683&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu19 citations 19 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
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description Publicationkeyboard_double_arrow_right Article 2023 FrancePublisher:Elsevier BV Rishma Amarsy; Sandra Fournier; David Trystram; Catherine Monteil; Xavier Raynaud; Vincent Jarlier; Jérôme Robert; Guillaume Arlet; LaurenceArmand Lefevre; Alexandra Aubry; Laurent Belec; Béatrice Bercot; Stéphane Bonacorsi; Vincent Calvez; Emmanuelle Cambau; Etienne Carbonnelle; Stéphane Chevaliez; Jean-Winoc Decousser; Constance Delaugerre; Diane Descamps; Florence Doucet-Populaire; Jean-Louis Gaillard; Antoine Garbarg-Chenon; Elyanne Gault; Jean-Louis Herrmann; Vincent Jarlier; Jérôme Le Goff; Jean-Christophe Lucet; Jean-Luc Mainardi; Anne-Geneviève Marcellin; Laurence Morand-Joubert; Xavier Nassif; Jean-Michel Pawlotsky; Jérôme Robert; Anne-Marie Roque Afonso; Martin Rottman; Christine Rouzioux; Flore Rozenberg; François Simon; Nicolas Veziris; David Skurnik; Jean-Ralph Zahar; Guilene Barnaud; Typhaine Billard Pomares; Gaëlle Cuzon; Dominique Decré; Alexandra Doloy; Jean-Luc Donay; Laurence Drieux-Rouzet; Isabelle Durand; Agnès Ferroni; Vincent Fihman; Nicolas Fortineau; Camille Gomart; Nathalie Grall; Christelle Guillet Caruba; Françoise Jaureguy; Valérie Lalande; Luce Landraud; Véronique Leflon; Patricia Mariani; Liliana Mihaila; Didier Moissenet; Latifa Noussair; Isabelle Podglajen; Isabelle Poilane; Hélène Poupet; Emilie Rondinaud; Valérie Sivadon Tardy; David Trystram; Charlotte Verdet; Emmanuelle Vigier; Sophie Vimont Billarant;The impact of the COVID-19 pandemic on bloodstream infections (BSIs) due to Streptococcus pneumoniae and Streptococcus pyogenes was assessed in 25 university hospitals of Paris. Monthly BSIs incidence rates that appeared stable in 2018 and 2019, decreased for the 2 pathogens during the 2 COVID-19 lockdown periods of 2020. Containment policies, including social distancing, masking and hand hygiene strengthening in both community and hospital settings are likely to reduce BSIs due to these pathogens.
American Journal of ... arrow_drop_down American Journal of Infection ControlArticle . 2023 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.ajic.2022.09.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu5 citations 5 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert American Journal of ... arrow_drop_down American Journal of Infection ControlArticle . 2023 . Peer-reviewedLicense: Elsevier TDMData sources: Crossrefadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.ajic.2022.09.002&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2023 FrancePublisher:Elsevier BV Funded by:EC | CAREEC| CARELévy, Yves; Wiedemann, Aurélie; Hejblum, Boris P.; Durand, Mélany; Lefebvre, Cécile; Surénaud, Mathieu; Lacabaratz, Christine; Perreau, Matthieu; Foucat, Emile; Déchenaud, Marie; Tisserand, Pascaline; Blengio, Fabiola; Hivert, Benjamin; Gauthier, Marine; Cervantes-Gonzalez, Minerva; Bachelet, Delphine; Laouénan, Cédric; Bouadma, Lila; Timsit, Jean-François; Yazdanpanah, Yazdan; Pantaleo, Giuseppe; Hocini, Hakim; Thiébaut, Rodolphe;The identification of patients with coronavirus disease 2019 and high risk of severe disease is a challenge in routine care. We performed cell phenotypic, serum, and RNA sequencing gene expression analyses in severe hospitalized patients (n = 61). Relative to healthy donors, results showed abnormalities of 27 cell populations and an elevation of 42 cytokines, neutrophil chemo-attractants, and inflammatory components in patients. Supervised and unsupervised analyses revealed a high abundance of CD177, a specific neutrophil activation marker, contributing to the clustering of severe patients. Gene abundance correlated with high serum levels of CD177 in severe patients. Higher levels were confirmed in a second cohort and in intensive care unit (ICU) than non-ICU patients (P < 0.001). Longitudinal measurements discriminated between patients with the worst prognosis, leading to death, and those who recovered (P = 0.01). These results highlight neutrophil activation as a hallmark of severe disease and CD177 assessment as a reliable prognostic marker for routine care. Immunology; Virology Graphical abstract
iScience arrow_drop_down iScienceArticle . 2021Full-Text: http://europepmc.org/articles/PMC8189740Data sources: PubMed CentralINRIA a CCSD electronic archive server; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2021License: CC BY NCHAL - UPEC / UPEM; HAL-Inserm; Hal-DiderotArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.isci.2022.105715&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 19 citations 19 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert iScience arrow_drop_down iScienceArticle . 2021Full-Text: http://europepmc.org/articles/PMC8189740Data sources: PubMed CentralINRIA a CCSD electronic archive server; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2021License: CC BY NCHAL - UPEC / UPEM; HAL-Inserm; Hal-DiderotArticle . 2021add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.isci.2022.105715&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 FrancePublisher:Elsevier BV Berger, Bastien; Hazzan, Marc; Kamar, Nassim; Francois, Hélène; Matignon, Marie; Greze, Clarisse; Gatault, Philippe; Frimat, Luc; Westeel, Pierre; Goutaudier, Valentin; Snanoudj, Renaud; Colosio, Charlotte; Sicard, Antoine; Bertrand, Dominique; Mousson, Christiane; Bamoulid, Jamal; Malvezzi, Paolo; Thierry, Antoine; Anglicheau, Dany; Couzi, Lionel; Chemouny, Jonathan; Duveau, Agnes; Moal, Valerie; Le Meur, Yannick; Blancho, Gilles; Tourret, Jérôme; Mariat, Christophe; Rerolle, Jean-Philippe; Bouvier, Nicolas; Caillard, Sophie; Thaunat, Olivier;Introduction - SARS-CoV-2 pandemic evolved in 2 consecutive waves during 2020. Improvements in the management of COVID-19 led to a reduction in mortality rates among hospitalized patients during the second wave. Whether this progress benefited kidney transplant recipients (KTRs), a population particularly vulnerable to severe COVID-19, remained unclear. Methods - In France, 957 KTRs were hospitalized for COVID-19 in 2020 and their data were prospectively collected into the French Solid Organ Transplant (SOT) COVID registry. The presentation, management, and outcomes of the 359 KTRs diagnosed during the first wave were compared to those of the 598 of the second wave. Results - Baseline comorbidities were similar between KTRs of the 2 waves. Maintenance immunosuppression was reduced in most patients but withdrawal of antimetabolite (73.7% vs. 58.4%, < 0.001) or calcineurin inhibitor (32.1% vs. 16.6%, < 0.001) was less frequent during the second wave. Hydroxychloroquine and azithromycin that were commonly used during the first wave (21.7% and 30.9%, respectively) but were almost abandoned during the second wave. In contrast, the use of high dose corticosteroids doubled (19.5% vs. 41.6%, < 0.001). Despite these changing trends in COVID-19 management, 60-day mortality was not statistically different between the 2 waves (25.3% vs. 23.9%; Log Rank, = 0.48) and COVID-19 hospitalization period was not associated with death due to COVID-19 in multivariate analysis (Hazard ratio 0.89, 95% confidence interval 0.67-1.17, = 0.4). Conclusion - We conclude that changing of therapeutic trends during 2020 did not reduce COVID-19 related mortality among KTRs. Our data indirectly support the importance of vaccination and neutralizing monoclonal anti-SARS-CoV-2 antibodies to protect KTRS from severe COVID-19. International audience
Kidney International... arrow_drop_down Kidney International ReportsArticle . 2022 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefHAL-Rennes 1; HAL-ENS-LYON; HAL - Université de Lille; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BY NC NDHAL-Rennes 1; HAL - UPEC / UPEM; HAL-ENS-LYONArticle . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.ekir.2022.09.007&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 2 citations 2 popularity Top 10% influence Average impulse Average Powered by BIP!more_vert Kidney International... arrow_drop_down Kidney International ReportsArticle . 2022 . Peer-reviewedLicense: CC BY NC NDData sources: CrossrefHAL-Rennes 1; HAL-ENS-LYON; HAL - Université de Lille; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BY NC NDHAL-Rennes 1; HAL - UPEC / UPEM; HAL-ENS-LYONArticle . 2022add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.ekir.2022.09.007&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Preprint 2022 France EnglishPublisher:HAL CCSD Authors: Kloeckner, Benoît; Tolle, Pierrick;Kloeckner, Benoît; Tolle, Pierrick;HAL-ENS-LYON; Mémoir... arrow_drop_down All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od______3393::0c2bc862a654ac3931ebfa014d78dde2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert HAL-ENS-LYON; Mémoir... arrow_drop_down All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od______3393::0c2bc862a654ac3931ebfa014d78dde2&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Other literature type , Article 2022 FrancePublisher:Informa UK Limited Raffaele Brustia; Giuliana Amaddeo; Rami Rhaiem; Eric Levesque; Antoine Monsel; Vanessa Baaroun; Mylène Dimmock; Marc-Antoine Rousseau; Oriane Wagner-Ballon; Francoise Botterel; Pascal Andujar; Daniele Sommacale;International audience; Background: The SARS-CoV-2 (COVID-19) pandemic required a rapid surge of healthcare capacity to face a growing number of critically ill patients. For this reason, a support reserve of physicians, including surgeons, were required to be reassigned to offer support.Objective: To realize a survey on the educational programs deployed (face-to-face or e-learning focusing on infective area, basic gestures, COVID clinical management and intensive care medicine), and their impact on behavior change (Kirkpatrick 3) of the target population of surgeons, measured on a five modalities Likert scale.Design: Cross-sectional online e-survey (NCT04732858) within surgeons from the Assistance Publique - Hôpitaux de Paris network, metropolitan area of Paris, France.Results: Cross-sectional e-Survey: among 382 surgeons invited, 37 (9.7%) participated. The effectiveness of the educational interventions on behavior changes was rated within the highest region of the Likert scale by 15% (n = 3) and 22% (n = 6) for 'e-learning' and 'face-to-face' delivery modes, respectively.Conclusions: Despite the low response rate, this survey suggests an overall low impact on behaviour change among responders affiliated to a surgical discipline.
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/00015458.2022.2145720&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess RoutesGreen bronze 0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1080/00015458.2022.2145720&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 France, BelgiumPublisher:Rockefeller University Press Funded by:EC | EVAg, NIH | Monogenic basis of resist..., EC | EASI-Genomics +4 projectsEC| EVAg ,NIH| Monogenic basis of resistance to SARS-CoV2 and predisposition to severe COVID-19 ,EC| EASI-Genomics ,EC| MORE2ADA2 ,NIH| Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success ,ANR| COVIFERON ,NIH| Inborn errors of immunity in patients with life-threatening COVID-19Aurélien Sokal; Paul Bastard; Pascal Chappert; Giovanna Barba-Spaeth; Slim Fourati; Alexis Vanderberghe; Pauline Lagouge-Roussey; Isabelle Meyts; Adrian Gervais; Magali Bouvier-Alias; Imane Azzaoui; Ignacio Fernández; Andréa de la Selle; Qian Zhang; Lucy Bizien; Isabelle Pellier; Agnès Linglart; Anya Rothenbuhler; Estelle Marcoux; Raphael Anxionnat; Nathalie Cheikh; Juliane Léger; Blanca Amador-Borrero; Fanny Fouyssac; Vanessa Menut; Jean-Christophe Goffard; Caroline Storey; Caroline Demily; Coralie Mallebranche; Jesus Troya; Aurora Pujol; Marie Zins; Pierre Tiberghien; Paul E. Gray; Peter McNaughton; Anna Sullivan; Jane Peake; Romain Levy; Laetitia Languille; Carlos Rodiguez-Gallego; Bertrand Boisson; Sébastien Gallien; Bénédicte Neven; Marc Michel; Bertrand Godeau; Laurent Abel; Felix A. Rey; Jean-Claude Weill; Claude-Agnès Reynaud; Stuart G. Tangye; Jean-Laurent Casanova; Matthieu Mahévas;doi: 10.1084/jem.20220258
pmid: 36342455
Inborn and acquired deficits of type I interferon (IFN) immunity predispose to life-threatening COVID-19 pneumonia. We longitudinally profiled the B cell response to mRNA vaccination in SARS-CoV-2 naive patients with inherited TLR7, IRF7, or IFNAR1 deficiency, as well as young patients with autoantibodies neutralizing type I IFNs due to autoimmune polyendocrine syndrome type-1 (APS-1) and older individuals with age-associated autoantibodies to type I IFNs. The receptor-binding domain spike protein (RBD)-specific memory B cell response in all patients was quantitatively and qualitatively similar to healthy donors. Sustained germinal center responses led to accumulation of somatic hypermutations in immunoglobulin heavy chain genes. The amplitude and duration of, and viral neutralization by, RBD-specific IgG serological response were also largely unaffected by TLR7, IRF7, or IFNAR1 deficiencies up to 7 mo after vaccination in all patients. These results suggest that induction of type I IFN is not required for efficient generation of a humoral response against SARS-CoV-2 by mRNA vaccines. ispartof: JOURNAL OF EXPERIMENTAL MEDICINE vol:220 issue:1 ispartof: location:United States status: published
The Journal of Exper... arrow_drop_down HAL Descartes; HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2023License: CC BY NC SAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1084/jem.20220258&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routeshybrid 15 citations 15 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert The Journal of Exper... arrow_drop_down HAL Descartes; HAL-Pasteur; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2023License: CC BY NC SAadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1084/jem.20220258&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Conference object 2022 France FrenchPublisher:HAL CCSD Delaplace, Manon; Huet, Hélène; Adèle, Gambino; Allee, Chantal; Brown, Paul; Ahmed-Belkacem, Abdelhakim; Le Poder, Sophie;AMI transversalité CycloCov; National audience
Mémoires en Sciences... arrow_drop_down Mémoires en Sciences de l'Information et de la CommunicationConference object . 2022All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______212::576fc99dd1b1994c22780c224766a024&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert Mémoires en Sciences... arrow_drop_down Mémoires en Sciences de l'Information et de la CommunicationConference object . 2022All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od_______212::576fc99dd1b1994c22780c224766a024&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 France EnglishPublisher:HAL CCSD Loubet, Paul; Wittkop, Linda; Ninove, Laetitia; Chalouni, Mathieu; Barrou, Benoit; Blay, Jean-Yves; Hourmant, Maryvonne; Thouvenot, Eric; Laville, Martine; Laviolle, Bruno; Lelievre, Jean-Daniel; Morel, Jacques; Quoc, Stéphanie Nguyen; Spano, Jean-Philippe; Terrier, Benjamin; Thiebaut, Anne; Viallard, Jean-Francois; Vrtovsnik, François; Circosta, Sophie; Esterle, Laure; Levier, Axel; Vanhems, Philippe; Tartour, Eric; Parfait, Beatrice; de Lamballerie, Xavier; Launay, Odile;Objectives - We aimed to investigate the 1-month humoral response to two or three doses of a messenger RNA coronavirus disease 2019 (COVID-19) vaccine as a primary vaccination regimen in specific populations compared with that in healthy adults. Methods - Agence Nationale Recherche contre le Sida (ANRS)0001S-COV-POPART (NCT04824651) is a French nation-wide, multi-centre, prospective, observational cohort study assessing the immune response to COVID-19 vaccines routinely administered to 11 sub-groups of patients with chronic conditions and two control groups. Patients and controls who received at least two vaccine doses and whose results 1 month after the second dose were available were included. The humoral response was assessed 1 month after the first, second and third doses (if applicable) based on the percentage of responders (positive for anti-Spike severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2] IgG antibodies), geometric means of anti-Spike SARS-CoV-2 IgG antibodies (enzyme-linked immunosorbent assay) and proportion of participants with anti-SARS-CoV-2-specific neutralizing antibodies (in vitro neutralization assay for the original SARS-CoV-2 strain). All analyses were centralized. Results - We included 4091 participants in this analysis: 2979 participants from specific sub-populations and 1112 controls. Only 522 (17.5%) participants from the specific populations received three doses as a primary vaccination regimen. Patients living with human immunodeficiency virus, cancer and diabetes had high percentages of responders after two doses, whereas patients with solid organ transplants, allogeneic hematopoietic stem cell transplants and hypogammaglobulinaemia had the lowest percentage of responders (35.9% [95% CI, 29.2-43.0], 57.4% [95% CI, 48.1-66.3] and 77.1% [95% CI, 65.6-86.3], respectively). In those who received the third dose, the percentage of responders reached 54.2% (95% CI, 42.9-65.2) (vs. 32.3% [95% CI, 16.7-51.4] after 2 doses) among those with solid organ transplants and 73.9% (95% CI, 58.9-85.7) (vs. 56.1% [95% CI, 46.2-65.7] after 2 doses) among those with hematopoietic stem cell transplants. Similar results were found with anti-SARS-CoV-2-specific neutralizing antibodies. Conclusions - A lower humoral response to COVID-19 vaccines was observed in the specific populations compared with that in the controls. The third dose of this vaccine in the primary regimen had a positive effect on the percentages of patients who developed anti-Spike IgG antibodies and specific neutralizing antibodies. International audience
HAL-Rennes 1; HAL-In... arrow_drop_down All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od______4325::642934251711e113b71941bacb041f1c&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu0 citations 0 popularity Average influence Average impulse Average Powered by BIP!more_vert HAL-Rennes 1; HAL-In... arrow_drop_down All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=od______4325::642934251711e113b71941bacb041f1c&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 FrancePublisher:Elsevier BV Funded by:EC | EVAgEC| EVAgAuthors: Laplantine, Emmanuel; Chable-Bessia, Christine; Oudin, Anne; Swain, Jitendryia; +17 AuthorsLaplantine, Emmanuel; Chable-Bessia, Christine; Oudin, Anne; Swain, Jitendryia; Soria, Adèle; Merida, Peggy; Gourdelier, Manon; Mestiri, Sarra; Besseghe, Indira; Bremaud, Erwan; Neyret, Aymeric; Lyonnais, Sebastien; Favard, Cyril; Benaroch, Philippe; Hubert, Mathieu; Schwartz, Olivier; Guerin, Maryse; Danckaert, Anne; del Nery, Elaine; Muriaux, Delphine; Weil, Robert;Patients with severe COVID-19 show an altered immune response that fails to control the viral spread and suffer from exacerbated inflammatory response, which eventually can lead to death. A major challenge is to develop an effective treatment for COVID-19. NF-κB is a major player in innate immunity and inflammatory process. By a high-throughput screening approach, we identified FDA-approved compounds that inhibit the NF-κB pathway and thus dampen inflammation. Among these, we show that Auranofin prevents post-translational modifications of NF-κB effectors and their recruitment into activating complexes in response to SARS-CoV-2 infection or cytokine stimulation. In addition, we demonstrate that Auranofin counteracts several steps of SARS-CoV-2 infection. First, it inhibits a raft-dependent endocytic pathway involved in SARS-CoV-2 entry into host cells; Second, Auranofin alters the ACE2 mobility at the plasma membrane. Overall, Auranofin should prevent SARS-CoV-2 infection and inflammatory damages, offering new opportunities as a repurposable drug candidate to treat COVID-19. International audience
iScience arrow_drop_down HAL-Pasteur; HAL-Inserm; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BYFull-Text: https://hal.science/hal-03827370/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.isci.2022.105066&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.euAccess Routesgold 7 citations 7 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert iScience arrow_drop_down HAL-Pasteur; HAL-Inserm; Mémoires en Sciences de l'Information et de la CommunicationArticle . 2022License: CC BYFull-Text: https://hal.science/hal-03827370/documentadd ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.isci.2022.105066&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eudescription Publicationkeyboard_double_arrow_right Article 2022 FrancePublisher:Elsevier BV Ming Liu; Zhongzheng Liu; Feng Chu; Alexandre Dolgui; Chengbin Chu; Feifeng Zheng;The outbreak of extraordinary disruptive events, e.g., the COVID-19 pandemic, has greatly impacted the orderly operation in global supply chains (SCs), and may lead to the SC breakdown. Regulatory actions, such as government interventions during the pandemic, can greatly mitigate the disruption propagation (i.e., the ripple effect) and improve SC viability. However, existing works that focus on the disruption propagation management have not considered the possibility of such interventions. Motivated by the fact, in this study, we investigate a new disruption propagation management problem in a multi-echelon SC with limited intervention budget. The aim is to minimize disruption risk measured by the disrupted probability of target participants in the SC. For the problem, a novel approach, combining the Causal Bayesian Network (CBN), the do-calculus and the mathematical programming, is developed. Specially, two mixed-integer non-linear programming models are constructed to determine appropriate interventions. To enhance the proposed mathematical models, two valid inequalities are proposed. Then, a problem-specific genetic algorithm (GA) is developed for handling large-scale problem instances. Numerical experiments on a case study and randomly generated instances are conducted to evaluate the efficiency of the proposed models, the valid inequalities and the GA. Based on experiment analysis, managerial insights are drawn. International audience
add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.omega.2022.102683&type=result"></script>'); --> </script>
For further information contact us at helpdesk@openaire.eu19 citations 19 popularity Top 10% influence Average impulse Top 10% Powered by BIP!more_vert add ClaimPlease grant OpenAIRE to access and update your ORCID works.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.This Research product is the result of merged Research products in OpenAIRE.
You have already added works in your ORCID record related to the merged Research product.All Research productsarrow_drop_down <script type="text/javascript"> <!-- document.write('<div id="oa_widget"></div>'); document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=10.1016/j.omega.2022.102683&type=result"></script>'); --> </script>
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